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    • 3. 发明授权
    • Single analyte molecule detection by fibre fluorescence probe
    • 通过纤维荧光探针检测单分析物
    • US07657133B2
    • 2010-02-02
    • US11573800
    • 2005-08-18
    • Bert HechtPhilippe HaasAndreas WildMartin HegnerMichel Calame
    • Bert HechtPhilippe HaasAndreas WildMartin HegnerMichel Calame
    • G02B6/00
    • G01Q60/20G01N21/648G01N2021/6484
    • An apparatus for single analyte molecule detection includes: a light source (20) for generating excitation light; a dichroic mirror (22) disposed on a first path of excitation light generated by the light source, wherein the mirror directs excitation light into a fiber aligner (30); an optical transducer coupled to the light source by the fiber aligner, the optical transducer comprising an optical waveguide (40) made of dielectric material having a first dielectrical index; a photon detector (70) disposed to receive fluorescent back radiation, wherein when a test solution having a second dielectric index lower than the first index is provided and comprises one or more target molecules, excitation light is transmitted by the waveguide and exits a waveguide tip disposed in the test solution so as to excite one or more target molecules; subsequently, the waveguide transmits back radiation along a second path to the photon detector that detects the transmitted back radiation.
    • 用于单一分析物分子检测的装置包括:用于产生激发光的光源(20); 分色镜(22),设置在由所述光源产生的激发光的第一路径上,其中所述反射镜将激发光引导到光纤对准器(30)中; 由光纤对准器耦合到光源的光学传感器,所述光学换能器包括由具有第一介电折射率的介电材料制成的光波导(40); 设置为接收荧光反射辐射的光子检测器(70),其中当提供具有低于第一指数的第二介电指数的测试溶液并且包括一个或多个靶分子时,激发光由波导传输并离开波导尖端 放置在测试溶液中以激发一个或多个靶分子; 随后,波导将沿着第二路径的反射辐射传输到检测传输的反射辐射的光子检测器。
    • 9. 发明申请
    • Single Analyte Molecule Detection by Fibre Fluorescemce Probe
    • 纤维荧光探针单分析物分子检测
    • US20080089635A1
    • 2008-04-17
    • US11573800
    • 2005-08-18
    • Bert HechtPhilippe HaasAndreas WildMartin HegnerMichel Calame
    • Bert HechtPhilippe HaasAndreas WildMartin HegnerMichel Calame
    • G02B6/04G01N21/64
    • G01Q60/20G01N21/648G01N2021/6484
    • An apparatus for single analyte molecule detection includes: a light source (20) for generating excitation light; a dichroic mirror (22) disposed on a first path of excitation light generated by the light source, wherein the mirror directs excitation light into a fiber aligner (30); an optical transducer coupled to the light source by the fiber aligner, the optical transducer comprising an optical waveguide (40) made of dielectric material having a first dielectrical index; a photon detector (70) disposed to receive fluorescent back radiation, wherein when a test solution having a second dielectric index lower than the first index is provided and comprises one or more target molecules, excitation light is transmitted by the waveguide and exits a waveguide tip disposed in the test solution so as to excite one or more target molecules; subsequently, the waveguide transmits back radiation along a second path to the photon detector that detects the transmitted back radiation.
    • 用于单一分析物分子检测的装置包括:用于产生激发光的光源(20); 分色镜(22),设置在由所述光源产生的激发光的第一路径上,其中所述反射镜将激发光引导到光纤对准器(30)中; 由光纤对准器耦合到光源的光学传感器,所述光学换能器包括由具有第一介电折射率的介电材料制成的光波导(40); 设置为接收荧光反射辐射的光子检测器(70),其中当提供具有低于第一指数的第二介电指数的测试溶液并且包括一个或多个靶分子时,激发光由波导传输并离开波导尖端 放置在测试溶液中以激发一个或多个靶分子; 随后,波导将沿着第二路径的反射辐射传输到检测传输的反射辐射的光子检测器。