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    • 3. 发明授权
    • Single analyte molecule detection by fibre fluorescence probe
    • 通过纤维荧光探针检测单分析物
    • US07657133B2
    • 2010-02-02
    • US11573800
    • 2005-08-18
    • Bert HechtPhilippe HaasAndreas WildMartin HegnerMichel Calame
    • Bert HechtPhilippe HaasAndreas WildMartin HegnerMichel Calame
    • G02B6/00
    • G01Q60/20G01N21/648G01N2021/6484
    • An apparatus for single analyte molecule detection includes: a light source (20) for generating excitation light; a dichroic mirror (22) disposed on a first path of excitation light generated by the light source, wherein the mirror directs excitation light into a fiber aligner (30); an optical transducer coupled to the light source by the fiber aligner, the optical transducer comprising an optical waveguide (40) made of dielectric material having a first dielectrical index; a photon detector (70) disposed to receive fluorescent back radiation, wherein when a test solution having a second dielectric index lower than the first index is provided and comprises one or more target molecules, excitation light is transmitted by the waveguide and exits a waveguide tip disposed in the test solution so as to excite one or more target molecules; subsequently, the waveguide transmits back radiation along a second path to the photon detector that detects the transmitted back radiation.
    • 用于单一分析物分子检测的装置包括:用于产生激发光的光源(20); 分色镜(22),设置在由所述光源产生的激发光的第一路径上,其中所述反射镜将激发光引导到光纤对准器(30)中; 由光纤对准器耦合到光源的光学传感器,所述光学换能器包括由具有第一介电折射率的介电材料制成的光波导(40); 设置为接收荧光反射辐射的光子检测器(70),其中当提供具有低于第一指数的第二介电指数的测试溶液并且包括一个或多个靶分子时,激发光由波导传输并离开波导尖端 放置在测试溶液中以激发一个或多个靶分子; 随后,波导将沿着第二路径的反射辐射传输到检测传输的反射辐射的光子检测器。
    • 7. 发明申请
    • Single Analyte Molecule Detection by Fibre Fluorescemce Probe
    • 纤维荧光探针单分析物分子检测
    • US20080089635A1
    • 2008-04-17
    • US11573800
    • 2005-08-18
    • Bert HechtPhilippe HaasAndreas WildMartin HegnerMichel Calame
    • Bert HechtPhilippe HaasAndreas WildMartin HegnerMichel Calame
    • G02B6/04G01N21/64
    • G01Q60/20G01N21/648G01N2021/6484
    • An apparatus for single analyte molecule detection includes: a light source (20) for generating excitation light; a dichroic mirror (22) disposed on a first path of excitation light generated by the light source, wherein the mirror directs excitation light into a fiber aligner (30); an optical transducer coupled to the light source by the fiber aligner, the optical transducer comprising an optical waveguide (40) made of dielectric material having a first dielectrical index; a photon detector (70) disposed to receive fluorescent back radiation, wherein when a test solution having a second dielectric index lower than the first index is provided and comprises one or more target molecules, excitation light is transmitted by the waveguide and exits a waveguide tip disposed in the test solution so as to excite one or more target molecules; subsequently, the waveguide transmits back radiation along a second path to the photon detector that detects the transmitted back radiation.
    • 用于单一分析物分子检测的装置包括:用于产生激发光的光源(20); 分色镜(22),设置在由所述光源产生的激发光的第一路径上,其中所述反射镜将激发光引导到光纤对准器(30)中; 由光纤对准器耦合到光源的光学传感器,所述光学换能器包括由具有第一介电折射率的介电材料制成的光波导(40); 设置为接收荧光反射辐射的光子检测器(70),其中当提供具有低于第一指数的第二介电指数的测试溶液并且包括一个或多个靶分子时,激发光由波导传输并离开波导尖端 放置在测试溶液中以激发一个或多个靶分子; 随后,波导将沿着第二路径的反射辐射传输到检测传输的反射辐射的光子检测器。
    • 9. 发明授权
    • Implantable infusion pump
    • 植入式输液泵
    • US5836915A
    • 1998-11-17
    • US529776
    • 1995-09-18
    • Bernd SteinbachClaus WalterAndreas Wild
    • Bernd SteinbachClaus WalterAndreas Wild
    • A61M5/00A61M5/142A61M37/00
    • A61M5/14276
    • The invention concerns an implantable infusion pump for dosed emission of medicines into the human body comprising a pump chamber formed by an upper chamber portion (3) and a lower chamber portion (2), whereby said pump chamber is divided by a flexible membrane (6) into a pressure chamber (8) and a medicine reservoir (7). Refill apertures (12, 14) covered by septa (13, 15) are further provided. The septa (13, 15) are hermetically clamped by holders (4, 5). According to the invention, catch connections are used as main connections (31, 32, 33) and as ancillary connections (34, 35) for the connection of the pump components (2, 3, 4, 5), whereby the main connections (31, 32, 33) substantially support the interior pressure strain generated under normal operating load and the locked ancillary connections (34, 35) are hereby not or only nimimally brought into operation due to respective arrangement and dimensioning of the catch members. The ancillary connections (34, 35) are only activated in the case of a further pressure increase due to overload or failure of the main connections (31, 32, 33).
    • 本发明涉及一种可植入输液泵,用于药物向人体中的剂量发射,包括由上室部分(3)和下室部分(2)形成的泵室,由此所述泵室由柔性膜(6 )进入压力室(8)和药液贮存器(7)。 进一步提供由隔片(13,15)覆盖的补充孔(12,14)。 隔垫(13,15)由支架(4,5)气密夹紧。 根据本发明,捕捉连接用作主连接件(31,32,33)以及作为用于连接泵部件(2,3,4,5)的辅助连接件(34,35)),由此主连接件 31,32,33)基本上支撑在正常操作负载下产生的内部压力应变,并且锁定的辅助连接(34,35)由于捕捉构件的相应布置和尺寸而不被或仅仅微妙地投入使用。 在由于主连接(31,32,33)的过载或故障引起的进一步的压力增加的情况下,辅助连接(34,35)仅被激活。
    • 10. 发明授权
    • Urine measurement apparatus and method for the determination of the
density of urine
    • 尿液测定装置及尿液密度测定方法
    • US5769087A
    • 1998-06-23
    • US481473
    • 1995-10-19
    • Detlef WestphalKlaus MetznerGunther GrimmUwe LappAndreas WildFranz-Wilhelm Koerdt
    • Detlef WestphalKlaus MetznerGunther GrimmUwe LappAndreas WildFranz-Wilhelm Koerdt
    • G01G23/01A61B5/20G01G17/04G01G23/00A61B5/00
    • G01G23/002A61B5/14507A61B5/208G01G17/04
    • A body fluid measurement apparatus for continually monitoring the body fluids produced by a catheterized patient is disclosed. The apparatus comprises a discharge hose in fluid communication with the patient, a housing that supports the discharge hose, a dripping chamber for temporarily holding the body fluid while temperature and electrical conductivity measurements are made, a force transducer for producing a signal representing the weight of the body fluid mass collected, a container for collecting the body fluid that is suspended from the force transducer, a storage cell power source, and a computer for processing a signal generated by the force transducer, for generating a timing signal, and for computing the patient's body fluid volume flow in a certain time interval. All computed measurements are sent to a display also located on the apparatus. Additionally, two angle sensors, located in two planes orthogonal to one another, provide a signal to the computer for the compensation of the inclined position of the housing and for the compensation of an erroneous measurement of the weight of the body fluids collected. In addition, a method for the automatic monitoring and recording of the corrected volume flow of body fluids produced by a catheterized patient is also disclosed.
    • PCT No.PCT / EP94 / 03671 Sec。 371 1995年10月19日日期 102(e)1995年10月19日日期PCT 1994年11月8日PCT PCT。 公开号WO95 / 1352400 日期1995年5月18日公开了一种用于连续监测由导管患者产生的体液的体液测量装置。 该装置包括与患者流体连通的排出软管,支撑排出软管的壳体,用于在进行温度和电导率测量时暂时保持体液的滴液室,用于产生表示重量的信号的力传感器 收集的体液质量,用于收集从力传感器悬挂的体液的容器,存储单元电源和用于处理由力传感器产生的信号的计算机,用于产生定时信号,并且用于计算 患者体液体积在一定时间间隔内流动。 所有计算的测量值都被发送到也位于设备上的显示器。 另外,位于彼此正交的两个平面中的两个角度传感器向计算机提供信号以补偿壳体的倾斜位置,并补偿对所收集的体液的重量的错误测量。 此外,还公开了一种用于自动监测和记录由导管患者产生的体液的校正体积流量的方法。