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1. 发明申请

US20100303861A1 Live Attenuated Vaccine Strain for Prevention of Tularemia 审中-公开
标题翻译：活减毒疫苗用于预防减肥
公开(公告)号：US20100303861A1
公开(公告)日：2010-12-02
申请号：US11992429
申请日：2006-09-22
申请人： Arthur O. Tzianabos , Dennis L. Kasper , Shite Sebastian , Eric Rubin , Simon T. Dillon
发明人： Arthur O. Tzianabos , Dennis L. Kasper , Shite Sebastian , Eric Rubin , Simon T. Dillon
IPC分类号： A61K39/02 , A61P31/04 , C12N15/74 , C12Q1/02 , G01N33/53 , C12Q1/68
CPC分类号： A61K39/0208 , A61K2039/522 , A61K2039/54 , A61K2039/543 , C12Q1/18 , C12Q1/25 , G01N33/573 , G01N2400/50 , Y02A50/405
摘要： The invention provides live attenuated avirulent strains of Francisella tularensis, as well as methods for their preparation and use in protecting a mammal against infection with F. tularensis and against tularemia.
摘要翻译：本发明提供了西拉氏弧菌的活的减毒无毒力菌株，以及它们的制备方法和用于保护哺乳动物免受土拉氏木霉感染和抗土壤热病的方法。

2. 发明申请

US20120315264A1 ZWITTERIONIC IMMUNOMODULATORS FOR THE TEATMENT OF ASTHMA AND ALLERGY 审中-公开
标题翻译：用于治疗哮喘和过敏症的免疫调节剂
公开(公告)号：US20120315264A1
公开(公告)日：2012-12-13
申请号：US13316744
申请日：2011-12-12
申请人： Arthur O. Tzianabos , Dennis L. Kasper
发明人： Arthur O. Tzianabos , Dennis L. Kasper
IPC分类号： A61K39/35 , A61K31/732 , A61P11/06 , A61K39/395 , A61K39/02 , A61K31/715 , A61K38/17
CPC分类号： A61K31/726 , A61K9/0075 , A61K31/715 , A61K35/744 , A61K38/164 , A61K39/35 , A61K45/06 , A61K2039/55583 , Y02A50/484 , A61K2300/00
摘要： Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.
摘要翻译：提供了治疗和预防哮喘和过敏症状的方法和产品。方法和产物与某些天然存在和合成的两性离子聚合物有关，这些两性离子聚合物被发现诱导某些T调节（Treg）细胞并在体外和体内发挥免疫抑制作用。

3. 发明授权

US07026285B2 Immunomodulating polymers 有权
标题翻译：免疫调节聚合物
公开(公告)号：US07026285B2
公开(公告)日：2006-04-11
申请号：US10848779
申请日：2004-05-19
申请人： Arthur O. Tzianabos , Dennis L. Kasper , Andrew B. Onderdonk , Julia Ying Wang
发明人： Arthur O. Tzianabos , Dennis L. Kasper , Andrew B. Onderdonk , Julia Ying Wang
IPC分类号： A61K47/36 , A61K47/42
CPC分类号： A61K31/715 , A61K31/785 , A61K35/742 , A61K38/00 , A61K45/06
摘要： Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
摘要翻译：用于诱导IL-2分泌，诱导IL-10分泌，激活T细胞，抑制对特异性抗原的IgG抗体应答，促进同种异体移植物存活，减少术后外科粘连形成以及防止与手术，创伤或疾病相关的脓肿形成的方法和产品提供宿主脓肿形成的易感性。本发明的方法是使用免疫调节剂完成的，所述免疫调节剂是具有至少两个重复电荷基序的聚合物，所述至少两个重复电荷基序至少隔开一定的最小距离。

4. 发明授权

US07166455B2 Method for overexpression of zwitterionic polysaccharides 有权
公开(公告)号：US07166455B2
公开(公告)日：2007-01-23
申请号：US10388390
申请日：2003-03-13
申请人： Laurie E. Comstock , Michael J. Coyne , Dennis L. Kasper , Arthur O. Tzianabos , Katja G. Weinacht
发明人： Laurie E. Comstock , Michael J. Coyne , Dennis L. Kasper , Arthur O. Tzianabos , Katja G. Weinacht
IPC分类号： C12N1/12 , C12N1/20 , C12P21/06 , C12P19/04
CPC分类号： C12P19/04 , C07K14/195 , C07K2319/00
摘要： The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.

5. 发明授权

US5679654A Capsular polysaccharide immunomodulator 失效
公开(公告)号：US5679654A
公开(公告)日：1997-10-21
申请号：US301271
申请日：1994-09-02
申请人： Arthur O. Tzianabos , Andrew B. Onderdonk , Dennis L. Kasper
发明人： Arthur O. Tzianabos , Andrew B. Onderdonk , Dennis L. Kasper
IPC分类号： A61K39/114 , A61K31/715 , A61K31/725 , A61K31/73 , A61K39/02
CPC分类号： A61K39/0216 , A61K39/114 , Y10S424/831
摘要： Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.

6. 发明授权

US07803602B2 Method for overexpression of zwitterionic polysaccharides 有权
标题翻译：两性离子多糖过表达方法
公开(公告)号：US07803602B2
公开(公告)日：2010-09-28
申请号：US11894552
申请日：2007-08-20
申请人： Laurie E. Comstock , Katja G. Weinacht , Michael J. Coyne , Dennis L. Kasper , Arthur O. Tzianabos
发明人： Laurie E. Comstock , Katja G. Weinacht , Michael J. Coyne , Dennis L. Kasper , Arthur O. Tzianabos
IPC分类号： C12N1/20 , C12N15/87 , C12N15/74 , C12P21/06 , C12P19/04 , C12P19/34 , A01N63/00
CPC分类号： C12P19/04 , C07K14/195 , C07K2319/00
摘要： The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
摘要翻译：本发明涉及用于生产和选择组成型表达特定荚膜多糖或仅选择的荚膜多糖的脆弱杆菌的新突变菌株的方法; 针对组成型表达特定荚膜多糖或仅选择的荚膜多糖的脆弱脆弱病毒的新突变菌株的组合物; 改进单个荚膜多糖纯化方法; 以及针对新的res02和inv19基因及其基因产物的组合物。显着地，本发明提供了以高产率过量表达和纯化免疫调节荚膜多糖A（PSA）的方法和组合物。

7. 发明授权

US07083777B1 Immunomodulating polymers 有权
标题翻译：免疫调节聚合物
公开(公告)号：US07083777B1
公开(公告)日：2006-08-01
申请号：US09540024
申请日：2000-03-31
申请人： Arthur O. Tzianabos , Dennis L. Kasper , Andrew B. Onderdonk , Ying Wang
发明人： Arthur O. Tzianabos , Dennis L. Kasper , Andrew B. Onderdonk , Ying Wang
IPC分类号： A61K38/16 , A61K38/20
CPC分类号： A61K31/715 , A61K31/785 , A61K35/742 , A61K38/00 , A61K45/06
摘要： A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the positively charged free amino moiety and the negatively charged moiety of each charge motif are separated by at least one neutral amino acid, and wherein the positively charged free amino moiety of one of the charge motifs is separated by a distance of at least 8 amino acids from the positively charged amino moiety of another charge motif, and a pharmaceutically acceptable carrier. Said pharmaceutical composition is useful for inducing IL-2, activating T cells to produce a T helper 1 cytokine profile, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and/or protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation.
摘要翻译：由相同的重复单元组成的药物组合物，每个单元具有由带正电的游离氨基部分和带负电荷的部分组成的电荷基序，其中带电荷的游离氨基部分和每个电荷基序的带负电荷的部分至少分开一个中性氨基酸，并且其中一个电荷基序的带正电荷的游离氨基部分与另一个电荷基序的带正电荷的氨基部分至少8个氨基酸的距离和药学上可接受的载体分开。所述药物组合物可用于诱导IL-2，激活T细胞以产生T辅助细胞1细胞因子谱，抑制IgG抗体对特异性抗原的反应，促进同种异体移植物存活，减少术后外科粘连形成和/或防止与手术，外伤或易导致脓肿形成的疾病。

8. 发明申请

US20110059125A1 ZWITTERIONIC IMMUNOMODULATORS FOR THE TREATMENT OF ASTHMA AND ALLERGY 审中-公开
标题翻译：用于治疗哮喘和过敏症的免疫调节剂
公开(公告)号：US20110059125A1
公开(公告)日：2011-03-10
申请号：US12754948
申请日：2010-04-06
申请人： Arthur O. Tzianabos , Dennis L. Kasper
发明人： Arthur O. Tzianabos , Dennis L. Kasper
IPC分类号： A61K39/385 , A61K39/00 , A61P11/06
CPC分类号： A61K31/726 , A61K9/0075 , A61K31/715 , A61K35/744 , A61K38/164 , A61K39/35 , A61K45/06 , A61K2039/55583 , Y02A50/484 , A61K2300/00
摘要： Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.
摘要翻译：提供了治疗和预防哮喘和过敏症状的方法和产品。方法和产物与某些天然存在和合成的两性离子聚合物有关，这些两性离子聚合物被发现诱导某些T调节（Treg）细胞并在体外和体内发挥免疫抑制作用。

9. 发明授权

US07678558B2 Method for overexpression of zwitterionic polysaccharides 有权
标题翻译：两性离子多糖过表达方法
公开(公告)号：US07678558B2
公开(公告)日：2010-03-16
申请号：US11654246
申请日：2007-01-17
申请人： Laurie E. Comstock , Katja G. Weinacht , Michael J. Coyne , Dennis L. Kasper , Arthur O. Tzianabos
发明人： Laurie E. Comstock , Katja G. Weinacht , Michael J. Coyne , Dennis L. Kasper , Arthur O. Tzianabos
IPC分类号： C12N1/12 , C12P21/06 , C12P19/34 , C12P19/04 , C12N1/20 , A01N63/00 , C07H21/04
CPC分类号： C12P19/04 , C07K14/195 , C07K2319/00
摘要： The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
摘要翻译：本发明涉及用于制备和选择组成型表达特定荚膜多糖或仅选择的荚膜多糖的脆弱脆弱病毒的新突变菌株的方法; 针对组成型表达特定荚膜多糖或仅选择的荚膜多糖的脆弱脆弱病毒的新突变菌株的组合物; 改进单个荚膜多糖纯化方法; 以及针对新型res02和inv19基因及其基因产物的组合物。显着地，本发明提供了以高产率过量表达和纯化免疫调节荚膜多糖A（PSA）的方法和组合物。

10. 发明授权

US5700787A Capsular polysaccharide immunomodulator 失效
标题翻译：荚膜多糖免疫调节剂
公开(公告)号：US5700787A
公开(公告)日：1997-12-23
申请号：US502865
申请日：1995-07-14
申请人： Arthur O. Tzianabos , Andrew B. Onderdonk , Dennis L. Kasper
发明人： Arthur O. Tzianabos , Andrew B. Onderdonk , Dennis L. Kasper
IPC分类号： A61K47/36 , A61K31/715 , A61K39/02 , A61K39/114 , A61P31/04 , A61P37/00 , C08B37/00 , A61K31/725 , A61K31/73 , A61K31/735
CPC分类号： A61K39/02 , A61K39/0216 , A61K39/114 , Y10S424/831
摘要： Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.
摘要翻译：提供了防止脓肿形成的方法和产品，其与手术，创伤或易引起脓肿形成的疾病相关的疾病。还提供了形成免疫调节剂和与其有关的药物组合物的方法。可用于本发明的产品是多糖，包括具有带正电荷的游离氨基和带负电荷的基团的重复单元。优选的多糖是脆弱杆菌荚膜多糖A.

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