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1. 发明授权

US6136960A Method for evaluation of the ratio of amounts of biomolecules or their sub-populations in a mixture 有权
标题翻译：用于评价混合物中生物分子或其亚种群的量的比例的方法
公开(公告)号：US6136960A
公开(公告)日：2000-10-24
申请号：US135751
申请日：1998-08-18
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： B01D11/00 , B01D15/00 , C07C1/02 , G01N1/00 , G01N1/18 , G01N21/00 , G01N31/00 , G01N33/53 , G01N33/536 , G01N33/537 , G01N33/573 , G01N33/68 , G01N33/72 , G07D231/00
CPC分类号： G01N33/6842 , G01N33/6803 , Y10S435/81 , Y10S435/813 , Y10T436/10 , Y10T436/105831 , Y10T436/25 , Y10T436/25375
摘要： The present invention is directed to a method of determining the ratio of the concentration or amounts of two or more chemical compounds and/or biopolymers, or of the relative amounts of sub-populations of closely structurally related compounds, in a multi-component mixture, extract, system, and the like using an analytical physicochemical process. The method is based on distribution of the components of the mixture (system, extract, etc.) between two or more immiscible phases and the subsequent determination of the total amounts (concentrations) of biopolymers (chemical compounds) or of the amounts (concentrations) of one or more component(s) or sub-populations of the system in the phases. The ratio between these concentrations is defined therein as the partition coefficient. The partition coefficient is used as a measure of the ratio of the amounts of two or more biopolymers (chemical compounds) or their sub-populations in a multi-component mixture (extract, system, etc.), when calibrated against a series of sample systems of the same type with varied ratios of components.
摘要翻译：本发明涉及一种确定多组分混合物中两种或更多种化合物和/或生物聚合物的浓度或量的比例或紧密结构相关化合物的亚种群的相对量的比率的方法，提取物，系统等使用分析物理化学过程。该方法基于两个或多个不混溶相之间的混合物组分（体系，提取物等）的分布以及随后测定生物聚合物（化合物）或量（浓度）的总量（浓度）的阶段中系统的一个或多个组件或子群体。这些浓度之间的比例定义为分配系数。当对一系列样品进行校准时，分配系数用作多组分混合物（提取物，系统等）中的两种或更多种生物聚合物（化合物）或其亚种群的量的比率的量度相同类型的系统具有不同比例的部件。

2. 发明申请

US20120088692A1 SYSTEMS AND METHODS FOR CHARACTERIZATION OF MOLECULES 审中-公开
标题翻译：用于表征分子的系统和方法
公开(公告)号：US20120088692A1
公开(公告)日：2012-04-12
申请号：US13316625
申请日：2011-12-12
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： C40B30/10 , G01N33/566
CPC分类号： G01N33/57434 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/96441 , G01N2333/96455 , G16B5/00 , G16B20/00 , G16C20/30 , G16H50/50
摘要： The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as distinguishing between the mixtures of the molecules using the systems and methods of the invention can also be used, in some cases, for further fractionation and/or characterization of the biomolecules and/or other molecules, using techniques such as single-step or multiple-step extraction, and/or by liquid-liquid partition chromatography. The methods could also be used for discovering and identifying markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常提供用于检测，鉴定或表征两种或更多种由分子组成的混合物的性质或行为之间的差异的系统和方法，包括生物分子和/或能够与生物分子相互作用的分子，使用诸如分区使用本发明的系统和方法区分分子的混合物所建立的实验条件也可以在某些情况下用于进一步分级和/或表征生物分子和/或其他分子，使用诸如单一 - 步骤或多步萃取，和/或通过液 - 液分配色谱法。该方法还可用于发现和识别与特定诊断相关的标记，并且可以在诊断筛选期间发现和鉴定后用于筛选此类标记物。

3. 发明授权

US08099242B2 Systems and methods for characterization of molecules 有权
标题翻译：表征分子的系统和方法
公开(公告)号：US08099242B2
公开(公告)日：2012-01-17
申请号：US11818911
申请日：2007-06-15
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/48 , G01N31/00 , C12Q1/00
CPC分类号： G01N33/57434 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/96441 , G01N2333/96455 , G06F19/00 , G06F19/12 , G06F19/18 , G06F19/704 , G16H50/50
摘要： The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as distinguishing between the mixtures of the molecules using the systems and methods of the invention can also be used, in some cases, for further fractionation and/or characterization of the biomolecules and/or other molecules, using techniques such as single-step or multiple-step extraction, and/or by liquid-liquid partition chromatography. The methods could also be used for discovering and identifying markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常提供用于检测，鉴定或表征两种或更多种由分子组成的混合物的性质或行为之间的差异的系统和方法，包括生物分子和/或能够与生物分子相互作用的分子，使用诸如分区使用本发明的系统和方法区分分子的混合物所建立的实验条件也可以在某些情况下用于进一步分级和/或表征生物分子和/或其他分子，使用诸如单一 - 步骤或多步萃取，和/或通过液 - 液分配色谱法。该方法还可用于发现和识别与特定诊断相关的标记，并且可以在诊断筛选期间发现和鉴定后用于筛选此类标记物。

4. 发明授权

US08437964B2 Systems and methods involving data patterns such as spectral biomarkers 有权
标题翻译：涉及数据模式如光谱生物标志物的系统和方法
公开(公告)号：US08437964B2
公开(公告)日：2013-05-07
申请号：US13214343
申请日：2011-08-22
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/48
CPC分类号： G01N33/6848
摘要： The present invention is generally related to the separation, fractionation, and/or characterization of molecules and/or biomolecules in one or more mixtures. After fractionation, different phases of a partitioning system can be analyzed via an analytical technique such as spectral analysis, chromatography, or the like, to produce a spectrum or other symbolic representation of the species after fractionation, and the spectra of the various fractions/phases compared to define a comparative spectrum as a marker or otherwise providing information about the sample, including such information that is independent of the original level of abundance of the molecules in the mixture. Comparative spectra of various samples can be compared to each other and/or to controls or reference spectra and/or comparative spectra to determine a variety of information. In some embodiments, the methods can be used for discovering and/or identifying patterns in a mixture of species and/or corresponding patterns of species in a second mixture, where each mixture of species originates from biological systems with different physiological conditions as markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常涉及一种或多种混合物中分子和/或生物分子的分离，分级和/或表征。分馏后，分析系统的不同阶段可以通过分析技术（如光谱分析，色谱法等）进行分析，以产生分级后的物种的光谱或其他符号表示，以及各种馏分/相的光谱比较将比较光谱定义为标记物或以其他方式提供关于样品的信息，包括独立于混合物中分子丰度的原始水平的信息。可以将各种样品的比较光谱彼此进行比较和/或控制或参考光谱和/或比较光谱以确定各种信息。在一些实施方案中，所述方法可用于在第二混合物中发现和/或识别物种和/或物种的相应模式的混合物中的模式，其中每种物质混合物源自具有不同生理条件的生物系统作为与特异性诊断，并且可以用于在诊断筛选期间发现和鉴定后筛选这些标记物。

5. 发明授权

US08932862B2 Method for measuring solubility 有权
标题翻译：溶解度测定方法
公开(公告)号：US08932862B2
公开(公告)日：2015-01-13
申请号：US10779164
申请日：2004-02-13
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N31/00 , G01N21/64 , G01N21/76 , G01N21/75
CPC分类号： G01N21/75 , G01N21/76 , Y10T436/17 , Y10T436/176152 , Y10T436/18 , Y10T436/188 , Y10T436/235
摘要： A method of determining the solubility of a compound in a selected solvent is provided that does not require determination of, or use of, standards having known concentrations of the compound. In one aspect, the method can include preparation of a mixture where not all of a compound is dissolved in the provided solvent, separating undissolved compound from the solvent, and direct determination of the amount of the compound dissolved in the solvent. Methods adapted for use include those where a multiplicity of compounds or solvents are tested in parallel. Devices adapted for these methods are also provided by the present disclosure.
摘要翻译：提供了确定化合物在所选溶剂中的溶解度的方法，其不需要测定或使用具有已知浓度的化合物的标准品。一方面，该方法可以包括制备其中并不全部化合物溶解在所提供的溶剂中的混合物，从溶剂中分离未溶解的化合物，并直接测定溶解在溶剂中的化合物的量。适用的方法包括并行测试多种化合物或溶剂的方法。适用于这些方法的装置也由本公开提供。

6. 发明授权

US08211714B2 Characterization of molecules 有权
标题翻译：分子的表征
公开(公告)号：US08211714B2
公开(公告)日：2012-07-03
申请号：US13110345
申请日：2011-05-18
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/536
CPC分类号： G01N33/5375 , G01N33/53 , G01N33/68 , Y10T436/10 , Y10T436/105831
摘要： The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize species, characterize interactions, and/or identify species that could be useful in a variety of settings. Signatures can be obtained using aqueous multi-phase partitioning and can be used to predict molecular interactions for applications such as drug discovery. A plurality of aqueous multi-phase partitioning arrangements can define an overall system providing an information-intensive signature, maximizing precision and sensitivity.
摘要翻译：本发明涉及获得物种（包括化学，生物或生物化学分子）的签名和/或物种之间的相互作用的签名，并使用它们来表征物种，表征相互作用，和/或识别可在各种设置中有用的物种。可以使用水性多相分配获得签名，并且可以用于预测用于药物发现的应用的分子相互作用。多个水性多相分配装置可以定义提供信息密集型签名的整体系统，从而使精度和灵敏度最大化。

7. 发明申请

US20110297824A1 SYSTEMS AND METHODS INVOLVING DATA PATTERNS SUCH AS SPECTRAL BIOMARKERS 有权
标题翻译：涉及数据模式的系统和方法如光谱生物标志物
公开(公告)号：US20110297824A1
公开(公告)日：2011-12-08
申请号：US13214343
申请日：2011-08-22
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： H01J49/26
CPC分类号： G01N33/6848
摘要： The present invention is generally related to the separation, fractionation, and/or characterization of molecules and/or biomolecules in one or more mixtures. After fractionation, different phases of a partitioning system can be analyzed via an analytical technique such as spectral analysis, chromatography, or the like, to produce a spectrum or other symbolic representation of the species after fractionation, and the spectra of the various fractions/phases compared to define a comparative spectrum as a marker or otherwise providing information about the sample, including such information that is independent of the original level of abundance of the molecules in the mixture. Comparative spectra of various samples can be compared to each other and/or to controls or reference spectra and/or comparative spectra to determine a variety of information. In some embodiments, the methods can be used for discovering and/or identifying patterns in a mixture of species and/or corresponding patterns of species in a second mixture, where each mixture of species originates from biological systems with different physiological conditions as markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常涉及一种或多种混合物中分子和/或生物分子的分离，分级和/或表征。分馏后，分析系统的不同阶段可以通过分析技术（如光谱分析，色谱法等）进行分析，以产生分级后的物种的光谱或其他符号表示，以及各种馏分/相的光谱比较将比较光谱定义为标记物或以其他方式提供关于样品的信息，包括独立于混合物中分子丰度的原始水平的信息。可以将各种样品的比较光谱彼此进行比较和/或控制或参考光谱和/或比较光谱以确定各种信息。在一些实施方案中，所述方法可用于在第二混合物中发现和/或识别物种和/或物种的相应模式的混合物中的模式，其中每种物质混合物源自具有不同生理条件的生物系统作为与特异性诊断，并且可以用于在诊断筛选期间发现和鉴定后筛选这些标记物。

8. 发明授权

US08041513B2 Systems and methods involving data patterns such as spectral biomarkers 有权
标题翻译：涉及数据模式如光谱生物标志物的系统和方法
公开(公告)号：US08041513B2
公开(公告)日：2011-10-18
申请号：US11641611
申请日：2006-12-19
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/48
CPC分类号： G01N33/6848
摘要： The present invention is generally related to the separation, fractionation, and/or characterization of molecules and/or biomolecules in one or more mixtures. After fractionation, different phases of a partitioning system can be analyzed via an analytical technique such as spectral analysis, chromatography, or the like, to produce a spectrum or other symbolic representation of the species after fractionation, and the spectra of the various fractions/phases compared to define a comparative spectrum as a marker or otherwise providing information about the sample, including such information that is independent of the original level of abundance of the molecules in the mixture. Comparative spectra of various samples can be compared to each other and/or to controls or reference spectra and/or comparative spectra to determine a variety of information. In some embodiments, the methods can be used for discovering and/or identifying patterns in a mixture of species and/or corresponding patterns of species in a second mixture, where each mixture of species originates from biological systems with different physiological conditions as markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常涉及一种或多种混合物中分子和/或生物分子的分离，分级和/或表征。分馏后，分析系统的不同阶段可以通过分析技术（如光谱分析，色谱法等）进行分析，以产生分级后的物种的光谱或其他符号表示，以及各种馏分/相的光谱将比较光谱定义为标记物或以其他方式提供关于样品的信息，包括独立于混合物中分子丰度的原始水平的信息。可以将各种样品的比较光谱彼此进行比较和/或控制或参考光谱和/或比较光谱以确定各种信息。在一些实施方案中，所述方法可用于在第二混合物中发现和/或识别物种和/或物种的相应模式的混合物中的模式，其中每种物质混合物源自具有不同生理条件的生物系统作为与特异性诊断，并且可以用于在诊断筛选期间发现和鉴定后筛选这些标记物。

9. 发明授权

US5734024A Method for determining the biological activity of recombinant human growth hormone 失效
标题翻译：确定重组人生长激素生物活性的方法
公开(公告)号：US5734024A
公开(公告)日：1998-03-31
申请号：US635384
申请日：1996-04-19
申请人： Boris Y. Zaslavsky
发明人： Boris Y. Zaslavsky
IPC分类号： A61K38/00 , C07K14/61 , C07K1/14 , C07K1/20
CPC分类号： C07K14/61 , A61K38/00
摘要： A method is provided for determination of the biological activity, purity and/or homogeneity of recombinant human growth hormone ("rhGH") using an analytical chemistry test. The method is based on distribution of the rhGH between two or more immiscible aqueous phases and the subsequent determination of the ratio of rhGH concentration in the phases. The ratio is then used as a relative measure of biological activity, homogeneity, and purity, when calibrated against a sample of rhGH that was previously characterized with respect to its activity, homogeneity and purity. Typical applications of this test include quality control, quality assurance, biological identity testing, etc.
摘要翻译：提供了一种使用分析化学测试来测定重组人生长激素（“rhGH”）的生物活性，纯度和/或均一性的方法。该方法基于rhGH在两个或更多个不混溶的水相之间的分布和随后测定相中rhGH浓度的比例。然后将该比值用作生物活性，均匀性和纯度的相对量度，当相对于其活性，均匀性和纯度先前表征的rhGH样品进行校准时。该测试的典型应用包括质量控制，质量保证，生物身份测试等。

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