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1. 发明申请

US20130345280A1 Methods And Compositions Employing Bicifadine For Treating Disability Or Functional Impairment Associated With Acute Pain, Chronic Pain, Or Neuropathic Disorders 有权
标题翻译：用于治疗与急性疼痛，慢性疼痛或神经性疾病相关的残疾或功能性损害的二百里加的方法和组合
公开(公告)号：US20130345280A1
公开(公告)日：2013-12-26
申请号：US13907920
申请日：2013-06-02
申请人： Arnold S. Lippa , Warren Stern , Janet Codd , Brian Boland , Johnson Lim
发明人： Arnold S. Lippa , Warren Stern , Janet Codd , Brian Boland , Johnson Lim
IPC分类号： A61K9/20 , A61K31/403
CPC分类号： A61K31/403 , A61K9/2054
摘要： Methods and compositions are provided for formulating and administering bicifadine and related compounds to treat or prevent functional impairment and disabilities associated with acute pain, chronic pain, and neuropathic disorders.
摘要翻译：提供方法和组合物用于配制和施用二化蓖苷和相关化合物以治疗或预防与急性疼痛，慢性疼痛和神经性疾病相关的功能障碍和残疾。

2. 发明申请

US20080081834A1 Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders 审中-公开
标题翻译：使用双倍他啶治疗与急性疼痛，慢性疼痛或神经性疾病相关的残疾或功能障碍的方法和组合物
公开(公告)号：US20080081834A1
公开(公告)日：2008-04-03
申请号：US11708951
申请日：2007-02-20
申请人： Arnold Lippa , Warren Stern , Janet Codd , Brian Boland , Johnson Lim
发明人： Arnold Lippa , Warren Stern , Janet Codd , Brian Boland , Johnson Lim
IPC分类号： A61K31/403 , A61P25/00 , A61P43/00
CPC分类号： A61K31/403 , A61K9/2054
摘要： Methods and compositions are provided for formulating and administering bicifadine and related compounds to treat or prevent functional impairment and disabilities associated with acute pain, chronic pain, and neuropathic disorders.
摘要翻译：提供方法和组合物用于配制和施用二化蓖苷和相关化合物以治疗或预防与急性疼痛，慢性疼痛和神经性疾病相关的功能障碍和残疾。

3. 发明申请

US20080027119A1 Methods and compositions employing bicifadine for the treatment of acute pain, chronic pain, and symptoms of neuropathic disorders 审中-公开
标题翻译：采用二西他准治疗急性疼痛，慢性疼痛和神经性疾病症状的方法和组合
公开(公告)号：US20080027119A1
公开(公告)日：2008-01-31
申请号：US11260887
申请日：2005-10-26
申请人： Arnold Lippa , Warren Stern , Janet Codd , Brian Boland , Lim Johnson
发明人： Arnold Lippa , Warren Stern , Janet Codd , Brian Boland , Lim Johnson
IPC分类号： A61K31/403 , A61P25/00
CPC分类号： A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K31/403 , A61K31/439
摘要： Methods and compositions are provided for formulating and administering bicifadine and related compounds to treat acute pain, chronic pain, and symptoms associated with neuropathic disorders.
摘要翻译：提供方法和组合物用于配制和施用二西他准及相关化合物以治疗急性疼痛，慢性疼痛和与神经性疾病相关的症状。

4. 发明授权

US09918958B2 Treatment for hypoxia 有权
公开(公告)号：US09918958B2
公开(公告)日：2018-03-20
申请号：US13547462
申请日：2012-07-12
申请人： Warren Stern
发明人： Warren Stern
IPC分类号： A61K31/341 , A61P11/00
CPC分类号： A61K31/341
摘要： The invention provides a method for treating hypoxia in a normal subject, comprising administering 5-HMF to the subject.

5. 发明申请

US20060100263A1 Antipyretic compositions and methods 审中-公开
标题翻译：解热组合物和方法
公开(公告)号：US20060100263A1
公开(公告)日：2006-05-11
申请号：US11263045
申请日：2005-10-31
申请人： Anthony Basile , Warren Stern
发明人： Anthony Basile , Warren Stern
IPC分类号： A61K31/403
CPC分类号： A61K31/445 , A61K31/403 , A61K45/06 , A61K2300/00
摘要： Methods and compositions containing bicifadine are provided for the treatment and prevention of hyperthermia in mammalian subjects. The methods and compositions may be used to prevent or treat fever, pyresis, menopausal hot flashes; peri menopausal hot flashes, postmenopausal hot flashes, hot flashes caused by anti-estrogen therapy, hot flashes secondary to surgical removal of estrogen producing tissue, hot flashes caused by radiation therapy, malignant hyperthermia, serotonin syndrome, heat stroke, febrile seizures, and neuroleptic malignant syndrome, among other conditions. Additional compositions and methods are provided employing bicifadine to treat pyresis and simultaneously elicit an analgesic response in mammalian subjects. Yet additional compositions and methods are provided which employ bicifadine in combination with a second antipyretic agent, a second analgesic agent, or a different therapeutic agent to yield more effective antipyretic treatment tools, and/or dual activity therapeutic methods and formulations useful to prevent or reduce hyperthermia and one or more additional symptoms (e.g., pain, or depression) in mammalian subjects.
摘要翻译：提供含有二西他汀的方法和组合物用于治疗和预防哺乳动物受试者的热疗。所述方法和组合物可用于预防或治疗发烧，发热，绝经期潮热; 绝经期潮热，绝经后潮热，抗雌激素治疗引起的热潮红，继发于产生雌激素的组织的手术切除的热潮红，放射治疗引起的潮热，恶性高热，血清素综合征，中暑，发热性惊厥和精神安定药恶性综合征等。提供了另外的组合物和方法，其采用二西他准来治疗吡啶并同时在哺乳动物受试者中引发止痛反应。还提供了另外的组合物和方法，其使用二西他定与第二解热剂，第二止痛剂或不同治疗剂组合产生更有效的解热治疗工具，和/或可用于预防或减少的双重活性治疗方法和制剂热疗和哺乳动物受试者中的一种或多种另外的症状（例如疼痛或抑郁症）。

6. 发明申请

US20130018092A1 TREATMENT FOR HYPOXIA 有权
标题翻译：治疗HYPOXIA
公开(公告)号：US20130018092A1
公开(公告)日：2013-01-17
申请号：US13547462
申请日：2012-07-12
申请人： Warren Stern
发明人： Warren Stern
IPC分类号： A61K31/341 , A61P11/00
CPC分类号： A61K31/341
摘要： The invention provides a method for treating hypoxia in a normal subject, comprising administering 5-HMF to the subject.
摘要翻译：本发明提供了一种在正常受试者中治疗缺氧的方法，包括向受试者施用5-HMF。

7. 发明申请

US20080014272A1 Compositions and Methods for Treatment of Chronic Pain Conditions 审中-公开
标题翻译：治疗慢性疼痛病症的组合物和方法
公开(公告)号：US20080014272A1
公开(公告)日：2008-01-17
申请号：US11775721
申请日：2007-07-10
申请人： Phil Skolnick , Warren Stern
发明人： Phil Skolnick , Warren Stern
IPC分类号： A61K31/403 , A61K31/19 , A61K31/44 , A61K9/00 , A61P19/00 , A61P19/02
CPC分类号： A61K31/19 , A61K9/0053 , A61K31/403 , A61K31/44
摘要： The present invention relates to methods, pharmaceutical compositions and kits for treating osteoarthritis associated pain, inflammation and improving function in a patient comprising a first therapeutic agent which comprises bicifadine or a pharmaceutically acceptable salt, enantiomer, solvate, hydrate, polymorph or prodrug thereof and a second therapeutic agent which comprises a non-steroidal anti-inflammatory drug or derivative thereof.
摘要翻译：本发明涉及用于治疗患有骨关节炎相关疼痛，炎症和改善功能的患者的方法，药物组合物和试剂盒，其包含第一治疗剂，其包含二十八烷或其药学上可接受的盐，对映体，溶剂化物，水合物，多晶型物或前药，以及第二治疗剂，其包含非甾体抗炎药或其衍生物。

8. 发明授权

US5997856A Method and compositions for solubilization and stabilization of polypeptides, especially proteins 失效
标题翻译：用于增溶和稳定多肽，尤其是蛋白质的方法和组合物
公开(公告)号：US5997856A
公开(公告)日：1999-12-07
申请号：US373928
申请日：1989-06-29
申请人： Maninder Singh Hora , Joseph Rubinfeld , Warren Stern , Gregory J. Wong
发明人： Maninder Singh Hora , Joseph Rubinfeld , Warren Stern , Gregory J. Wong
IPC分类号： A61K9/08 , A61K9/18 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/28 , A61K38/44 , A61K38/46 , A61K47/40 , A61K47/48 , A61K38/20 , A61K47/26
CPC分类号： B82Y5/00 , A61K47/48969
摘要： The invention provides a method for the solubilization and/or stabilization of polypeptides, especially proteins, using cyclodextrin selected from the group consisting of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of .beta.- and .gamma.-cyclodextrin. Solubilized and/or stabilized compositions comprising a polypeptide, especially a protein, and the selected cyclodextrin are also described.
摘要翻译：本发明提供使用选自β-和γ-环糊精的羟丙基，羟乙基，葡糖基，麦芽糖基和麦芽三糖基衍生物的环糊精来增溶和/或稳定多肽，特别是蛋白质的方法。还描述了包含多肽，特别是蛋白质和所选择的环糊精的增溶和/或稳定的组合物。

9. 发明授权

US5730969A Method and compositions for solubilization and stabilization of polypeptides, especially proteins 失效
标题翻译：用于增溶和稳定多肽，尤其是蛋白质的方法和组合物
公开(公告)号：US5730969A
公开(公告)日：1998-03-24
申请号：US474178
申请日：1995-06-07
申请人： Maninder Singh Hora , Joseph Rubinfeld , Warren Stern , Gregory J. Wong
发明人： Maninder Singh Hora , Joseph Rubinfeld , Warren Stern , Gregory J. Wong
IPC分类号： A61K9/08 , A61K9/18 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/28 , A61K38/44 , A61K38/46 , A61K47/40 , A61K47/48 , A61K38/17 , A61K38/19 , A61K38/20 , A61K38/49
CPC分类号： B82Y5/00 , A61K47/48969
摘要： The invention provides a method for the solubilization and/or stabilization of polypeptides, especially proteins, using a cyclodextrin selected from the group consisting of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of .beta.- and .gamma.-cyclodextrin. Solubilized and/or stabilized compositions comprising a polypeptide, especially a protein, and the selected cyclodextrin are also described.
摘要翻译：本发明提供使用选自β-和γ-环糊精的羟丙基，羟乙基，葡糖基，麦芽糖基和麦芽三糖基衍生物的环糊精来增溶和/或稳定多肽，特别是蛋白质的方法。还描述了包含多肽，特别是蛋白质和所选择的环糊精的增溶和/或稳定的组合物。

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