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1. 发明授权

US07235644B2 Vaccine against Gram-negative bacterial infections 失效
标题翻译：疫苗对革兰氏阴性细菌感染
公开(公告)号：US07235644B2
公开(公告)日：2007-06-26
申请号：US11375215
申请日：2006-03-15
申请人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： C07K16/00 , A61K39/40 , A61K39/395 , A61K38/16
CPC分类号： A61K39/095 , A61K39/0258 , A61K2039/522 , Y02A50/474 , Y10S424/803 , Y10S530/806 , Y10S530/825
摘要： A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
摘要翻译：有效诱导产生免疫第二受试者的抗体的抗体被动物抗革兰氏阴性细菌感染和LPS介导的病理学的疫苗包含在源自大肠杆菌的纯化的，解毒的LPS之间形成的非共价多价复合物，以及来源于脑膜炎奈瑟氏球菌的纯化外膜蛋白。相同的疫苗也将主动免疫宿主受试者免受革兰氏阴性细菌感染和LPS介导的病理学。脑膜炎球菌感染被包括在受疫苗保护的革兰氏阴性细菌感染中。

2. 发明授权

US07018636B1 Vaccine against Gram-negative bacterial infections 失效
公开(公告)号：US07018636B1
公开(公告)日：2006-03-28
申请号：US08886044
申请日：1997-06-30
申请人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K39/385 , A61K39/02 , A61K39/095 , A01N43/04 , C07H1/00
CPC分类号： A61K39/095 , A61K39/0258 , A61K2039/522 , Y02A50/474 , Y10S424/803 , Y10S530/806 , Y10S530/825
摘要： A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.

3. 发明授权

US07025963B1 Vaccine against Gram-negative bacterial infections 失效
公开(公告)号：US07025963B1
公开(公告)日：2006-04-11
申请号：US08467047
申请日：1995-06-06
申请人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K39/40 , A61K39/395 , A61K39/108 , A61K39/112
CPC分类号： A61K39/095 , A61K39/0258 , A61K2039/522 , Y02A50/474 , Y10S424/803 , Y10S530/806 , Y10S530/825
摘要： A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.

4. 发明申请

US20060159702A1 Vaccine against Gram-negative bacterial infections 失效
标题翻译：疫苗对革兰氏阴性细菌感染
公开(公告)号：US20060159702A1
公开(公告)日：2006-07-20
申请号：US11375215
申请日：2006-03-15
申请人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K39/116
CPC分类号： A61K39/095 , A61K39/0258 , A61K2039/522 , Y02A50/474 , Y10S424/803 , Y10S530/806 , Y10S530/825
摘要： A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
摘要翻译：有效诱导产生免疫第二受试者的抗体的抗体被动物抗革兰氏阴性细菌感染和LPS介导的病理学的疫苗包含在源自大肠杆菌的纯化的，解毒的LPS之间形成的非共价多价复合物，以及来源于脑膜炎奈瑟氏球菌的纯化外膜蛋白。相同的疫苗也将主动免疫宿主受试者免受革兰氏阴性细菌感染和LPS介导的病理学。脑膜炎球菌感染被包括在受疫苗保护的革兰氏阴性细菌感染中。

5. 发明授权

US06902743B1 Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包裹的生物活性物质的治疗和预防感染
公开(公告)号：US06902743B1
公开(公告)日：2005-06-07
申请号：US09055505
申请日：1998-04-06
申请人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K9/16 , A61K9/50 , A61K38/17 , A61K9/14 , A61K39/40 , A61K9/48 , A61K9/26
CPC分类号： A61K9/5026 , A61K9/1611 , A61K9/1617 , A61K9/1641 , A61K9/1647 , A61K38/1709 , Y02A50/414 , Y02A50/423 , Y02A50/478 , Y02A50/48 , Y02A50/491
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。该微胶囊包含多肽或其它生物活性剂的核心，其包封在聚（丙交酯/乙交酯）共聚物基质中，其具有90/10至40/60的丙交酯/乙交酯的摩尔组成，其可含有药学上可接受的佐剂，作为未加帽的游离羧基端基和封端形式的混合物，其比例为100/0至1/99。

6. 发明授权

US09204620B2 Post surgical treatment for quadrupeds 有权
标题翻译：手术治疗四足
公开(公告)号：US09204620B2
公开(公告)日：2015-12-08
申请号：US13998591
申请日：2013-11-15
申请人： Laura Mary Hamilton , Marlene H Palmer , David G Douglas , Alan Cross
发明人： Laura Mary Hamilton , Marlene H Palmer , David G Douglas , Alan Cross
IPC分类号： A01K13/00 , A61D9/00
CPC分类号： A01K13/006 , A61D9/00
摘要： The present invention relates to a protective garment for dogs and cats or other quadrupeds. Specifically, the garment is designed to protect wounds, incisions, surgical sites, and related lesions on the animal's body including thoracic and pelvic limbs, truncal area, and head and neck. Additionally the garment is designed to allow attachment of drain suction and similar medical devices.
摘要翻译：本发明涉及用于狗和猫或其他四足动物的防护服。具体来说，服装设计用于保护动物身体上的伤口，切口，手术部位和相关病变，包括胸部和盆腔四肢，截面区域，头颈部。此外，衣服被设计成允许排水抽吸和类似医疗装置的附接。

7. 发明授权

US09988426B2 Broad spectrum conjugate vaccine to prevent Klebsiella pneumoniae and Pseudomonas aeruginosa infections 有权
公开(公告)号：US09988426B2
公开(公告)日：2018-06-05
申请号：US15509041
申请日：2015-09-18
申请人： Raphael Simon , Alan Cross , Sharon Tennant
发明人： Raphael Simon , Alan Cross , Sharon Tennant
IPC分类号： C07K14/21 , C07K14/26 , A61K39/104 , A61K39/108 , A61K47/48 , A61K39/00
CPC分类号： C07K14/26 , A61K39/0266 , A61K39/104 , A61K39/116 , A61K47/4833 , A61K47/61 , A61K47/646 , A61K2039/70 , C07K14/21 , C07K2319/00
摘要： The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

8. 发明申请

US20120250931A1 SHALLOW SPEAKER 有权
标题翻译： SHOWOW SPEAKER
公开(公告)号：US20120250931A1
公开(公告)日：2012-10-04
申请号：US13078993
申请日：2011-04-03
申请人： Brad Michael Diedrich , Chad Aarron Kautz , Alan Cross
发明人： Brad Michael Diedrich , Chad Aarron Kautz , Alan Cross
IPC分类号： H04R1/00
CPC分类号： H04R7/12 , H04R7/18 , H04R9/025 , H04R31/003 , H04R31/006
摘要： An improved shallow speaker is disclosed having a molded diaphragm with an outer, depending, annular cylindrical subcone that connects to a channel formed in the outer perimeter of the spider. Embodiments for round and cornered (polygonal, etc.) speakers are provided. The top plate has a raised outer annular portion for receiving an annular spider flange with or without screw holes for clamping the inner spider flange with a spider ring. In the cornered speaker embodiments, flanges extend from the cylindrical portions to the cornered portions including from a diaphragm inner glue flange over the depressed central portion and from the annular cylindrical subcone both outwardly and inwardly to top diaphragm portions. Routing of the tinsel may be through one or more openings in the annular cylindrical subcone and along the diaphragm inner surfaces, with channels in or on those surfaces for securely routing the tinsel.
摘要翻译：公开了一种改进的浅扬声器，其具有模制隔膜，其具有连接到形成在所述蜘蛛的外周边中的通道的外部，垂直的环形圆柱形子。提供了圆形和角形（多边形等）扬声器的实施例。顶板具有凸起的外部环形部分，用于接收具有或不具有螺钉孔的环形蜘蛛凸缘，用于将带有蜘蛛环的内部蜘蛛凸缘夹紧。在角落式扬声器的实施例中，凸缘从圆柱形部分延伸到角部，包括从凹陷的中心部分上方的隔膜内部胶合凸缘，以及环形圆柱形子系统向外和向内至顶部隔膜部分。金属丝的布线可以通过环形圆柱形子系统中的一个或多个开口，并且沿着膜片内表面，在这些表面中或其上的通道用于安全地布线金属丝。

9. 发明申请

US20110255711A1 Lighting and Audio Communication System 有权
标题翻译：照明和音频通信系统
公开(公告)号：US20110255711A1
公开(公告)日：2011-10-20
申请号：US12752560
申请日：2010-04-01
申请人： Loyd L. Ivey , Bruce Marlin , Alan Cross , Brad Diedrich
发明人： Loyd L. Ivey , Bruce Marlin , Alan Cross , Brad Diedrich
IPC分类号： H03G3/00 , H04R1/02
CPC分类号： H04R1/028 , F21S8/026 , F21V33/0056 , F21Y2115/10
摘要： A lighting and communication system with a horn enclosure for recessed ceiling panel or wall mounting, including a speaker with a horn expansion area to direct sound waves from the speaker to a horn enclosure front, at least one light enclosure located within the horn enclosure, the light enclosure defining a light cavity which is separated from said horn expansion area, with a light source inside the light cavity. The light source can be an LED array, which is capable of displaying text, colors or patterns in response to a control system signal.
摘要翻译：一种照明和通信系统，其具有用于凹陷天花板或墙壁安装的喇叭外壳，包括具有喇叭扩展区域的扬声器，以将来自扬声器的声波引导到喇叭外壳前面，至少一个位于喇叭外壳内的灯罩，限定了与所述喇叭扩展区分离的光腔的光罩，在光腔内部具有光源。光源可以是LED阵列，其能够响应于控制系统信号显示文本，颜色或图案。

10. 发明申请

US20050151046A1 Seat weight measurement system 有权
标题翻译：座椅重量测量系统
公开(公告)号：US20050151046A1
公开(公告)日：2005-07-14
申请号：US11048131
申请日：2005-02-01
申请人： Gary Casey , Alan Cross
发明人： Gary Casey , Alan Cross
IPC分类号： G01G19/12 , B60N2/07 , B60N2/90 , B60R21/16 , B60R22/46 , G01G19/414 , G01G19/52 , B60N2/32
CPC分类号： G01G19/4142 , B60N2/0705 , B60N2/0715 , B60N2/0732
摘要： A weight measurement system is disclosed for measuring the weight of an occupant in a vehicle seat. In a preferred embodiment, a sensor is positioned at the rear portion of the vehicle seat and a load transfer link is used to transfer the weight from the front portion of the vehicle seat to the rear portion, to be measured by the sensor. The transfer link is a selectively compliant beam having a first rigid section and a second rigid section connected to each other via a flexible area. The first and second rigid sections preferably include wing portions for increasing the rigidity of the sections. The flexible area is more compliant than the rigid sections. The load transfer link is configured to transition a load placed on the front portion of the link to the rear portion. In a more preferred embodiment of the invention, the load transfer link is made of a high strength, low alloy steel.
摘要翻译：公开了一种用于测量车辆座椅中的乘客的重量的重量测量系统。在优选实施例中，传感器位于车辆座椅的后部，并且使用负载传递连杆将重物从车辆座椅的前部转移到后部，由传感器测量。转移连杆是具有第一刚性部分和通过柔性区域相互连接的第二刚性部分的选择性柔性梁。第一和第二刚性部分优选地包括用于增加部分的刚度的翼部。柔性区域比刚性区段更柔顺。负载传递连杆构造成将放置在连杆的前部上的负载转移到后部。在本发明的更优选实施例中，载荷传递连杆由高强度低合金钢制成。

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