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1. 发明授权

US06902743B1 Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包裹的生物活性物质的治疗和预防感染
公开(公告)号：US06902743B1
公开(公告)日：2005-06-07
申请号：US09055505
申请日：1998-04-06
申请人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
发明人： Jean A. Setterstrom , Thomas R. Tice , Elliot Jacob , Robert H. Reid , John van Hamont , Edgar C. Boedecker , Ramassubbu Jeyanthi , Phil Friden , F. Donald Roberts , Charles E. McQueen , Apurba Bhattacharjee , Alan Cross , Jerald Sadoff , Wendell Zollinger
IPC分类号： A61K9/16 , A61K9/50 , A61K38/17 , A61K9/14 , A61K39/40 , A61K9/48 , A61K9/26
CPC分类号： A61K9/5026 , A61K9/1611 , A61K9/1617 , A61K9/1641 , A61K9/1647 , A61K38/1709 , Y02A50/414 , Y02A50/423 , Y02A50/478 , Y02A50/48 , Y02A50/491
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。该微胶囊包含多肽或其它生物活性剂的核心，其包封在聚（丙交酯/乙交酯）共聚物基质中，其具有90/10至40/60的丙交酯/乙交酯的摩尔组成，其可含有药学上可接受的佐剂，作为未加帽的游离羧基端基和封端形式的混合物，其比例为100/0至1/99。

2. 发明授权

US06844010B1 Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包封的生物活性物质进行治疗和预防感染
公开(公告)号：US06844010B1
公开(公告)日：2005-01-18
申请号：US09618577
申请日：2000-07-18
申请人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
发明人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , A61K38/17 , A61K38/19 , A61K39/00 , A61K39/02 , A61K39/108 , A61K39/29 , F23G5/50 , G05B23/02
CPC分类号： A61K39/292 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K38/09 , A61K38/1729 , A61K39/00 , A61K39/0258 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , C12N2730/10134 , Y02A50/464 , Y02A50/474 , Y02A50/48 , Y02A50/487 , Y02A50/489 , Y02A50/491 , A61K2300/00
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。微胶囊由多肽或其他生物活性剂的核心组成，其包封在聚（丙交酯/乙交酯）共聚物的基质中，其可以含有药学上可接受的佐剂，作为被覆盖的游离羧基端基和封端的共轭物形式范围从100/0至1/99。

3. 发明授权

US06309669B1 Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix 失效
标题翻译：用生物可降解生物相容的聚合物基质包封的生物活性物质进行治疗和预防感染
公开(公告)号：US06309669B1
公开(公告)日：2001-10-30
申请号：US08789734
申请日：1997-01-27
申请人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
发明人： Jean A. Setterstrom , John E. Van Hamont , Robert H. Reid , Elliot Jacob , Ramasubbu Jeyanthi , Edgar C. Boedeker , Charles E. McQueen , Daniel L. Jarboe , Frederick Cassels , William Brown , Curt Thies , Thomas R. Tice , F. Donald Roberts , Phil Friden
IPC分类号： A61K952
CPC分类号： A61K39/292 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K38/09 , A61K38/1729 , A61K39/00 , A61K39/0258 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , C12N2730/10134 , Y02A50/464 , Y02A50/474 , Y02A50/48 , Y02A50/487 , Y02A50/489 , Y02A50/491 , A61K2300/00
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。微胶囊包含多肽或其他生物活性剂的核心，其包封在聚（丙交酯/乙交酯）共聚物基质中，其可以含有药学上可接受的佐剂，作为上覆游离羧基端基和封端形式的共混物范围从100/0至1/99。

4. 发明授权

US07033608B1 “Burst-free” sustained release poly-(lactide/glycolide) microspheres 失效
标题翻译： “无爆发”持续释放聚（丙交酯/乙交酯）微球
公开(公告)号：US07033608B1
公开(公告)日：2006-04-25
申请号：US09337945
申请日：1999-06-22
申请人： Ramasubbu Jevanthi , John E. Van Hamont , Phil Friden , Robert H. Reid , F. Donald Roberts , Charles E. McQueen , Jean A. Setterstrom
发明人： Ramasubbu Jevanthi , John E. Van Hamont , Phil Friden , Robert H. Reid , F. Donald Roberts , Charles E. McQueen , Jean A. Setterstrom
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K9/5031
摘要： Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.
摘要翻译：新型无爆发，持续释放的生物相容性和可生物降解的微胶囊，可以编程为在水性生理环境中从1-100天的可变持续时间释放其活性核心。微胶囊包含多肽核心或其他生物活性剂，其包封在聚（丙交酯/乙交酯）共聚物基质中，作为未封端（游离羧基端基）和封端形式的混合物，其比例范围为100/0至 1/99。

5. 发明授权

US06153210A Use of locally delivered metal ions for treatment of periodontal disease 失效
标题翻译：使用局部输送的金属离子治疗牙周病
公开(公告)号：US06153210A
公开(公告)日：2000-11-28
申请号：US911413
申请日：1997-08-14
申请人： F. Donald Roberts , Phillip M. Friden , Peter Spacciapoli , Eric Nelson
发明人： F. Donald Roberts , Phillip M. Friden , Peter Spacciapoli , Eric Nelson
IPC分类号： A61K9/70 , A61K9/00 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61K33/38 , A61P1/02 , A61P31/00 , A61K31/765 , A61L15/03
CPC分类号： A61K9/0063 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61K33/38
摘要： Periodontal disease can be treated by the administration of metal ions, preferably silver ions, to the site where the microorganisms that cause this disease reside. Administration can be to periodontal pockets or adjacent to exposed tooth roots or alveolar bone during periodontal surgical procedures. The metal ions can be administered in polymeric microparticles, deformable films or microparticles embedded within deformable films. The metal ions are particularly microbiocidal to the bacterial pathogens that are the causative agents of periodontal disease.
摘要翻译：可以通过将金属离子（优选银离子）施用于导致该疾病的微生物所在的部位来治疗牙周病。在牙周手术过程中，可以进行牙周袋或邻近暴露的牙根或牙槽骨。金属离子可以在嵌入可变形膜中的聚合物微粒，可变形膜或微粒中施用。金属离子对作为牙周病的致病因子的细菌病原体特别具有杀微生物作用。

6. 发明授权

US5912230A Anti-fungal and anti-bacterial histatin-based peptides 失效
标题翻译：抗真菌和抗细菌基因组肽
公开(公告)号：US5912230A
公开(公告)日：1999-06-15
申请号：US973559
申请日：1998-03-11
申请人： Frank G. Oppenheim , Tao Xu , F. Donald Roberts , Peter Spacciapoli , Phillip M. Friden
发明人： Frank G. Oppenheim , Tao Xu , F. Donald Roberts , Peter Spacciapoli , Phillip M. Friden
IPC分类号： A61K38/00 , C07K14/47 , A61K38/10 , A61K38/08 , C07K7/06 , C07K7/08
CPC分类号： C07K14/4723 , A61K38/00
摘要： Histatin-based peptides representing defined portions of the amino acid sequences of naturally occurring human histatins and methods for treatment of fungal or bacterial infection are described. These histatin-based peptides represent the active anti-fungal and anti-bacterial region of naturally occurring human histatins.
摘要翻译： PCT No.PCT / US96 / 09374 Sec。 371日期1998年3月11日 102（e）1998年3月11日PCT PCT 1996年6月7日PCT公布。出版物WO96 / 40768 日期：1996年12月19日描述了表达天然存在的人组氨酸的氨基酸序列的定义部分的基于组蛋白的肽以及用于治疗真菌或细菌感染的方法。这些基于组氨素的肽代表天然存在的人组氨酸蛋白酶的活性抗真菌和抗细菌区域。

7. 发明授权

US5885965A Anti-fungal D-amino acid histatin-based peptides 失效
标题翻译：抗真菌D-氨基酸组氨素类肽
公开(公告)号：US5885965A
公开(公告)日：1999-03-23
申请号：US973563
申请日：1998-03-12
申请人： Frank G. Oppenheim , Tao Xu , F. Donald Roberts , Peter Spacciapoli , Phillip M. Friden
发明人： Frank G. Oppenheim , Tao Xu , F. Donald Roberts , Peter Spacciapoli , Phillip M. Friden
IPC分类号： A61K38/00 , C07K14/47 , A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08
CPC分类号： C07K14/4723 , A61K38/00
摘要： D-amino acid histatins and histatin-based peptides and methods for treatment of fungal or bacterial infection are described. These D-amino acid histatins and histatin-based peptides are longer-acting anti-fungal or anti-bacterial agents than their L-enantiomeric analogues.
摘要翻译： PCT No.PCT / US96 / 09962 Sec。 371日期1998年3月12日 102（e）1998年3月12日PCT PCT 1996年6月7日PCT公布。公开号WO96 / 40770 1996年12月19日的日期描述了D-氨基酸组氨酸和基于组氨素的肽以及用于治疗真菌或细菌感染的方法。这些D-氨基酸组氨酸和基于组氨素的肽是比它们的L-对映异构体类似物更长的抗真菌或抗菌剂。

8. 发明授权

US5422382A Substituted xanthene compounds 失效
标题翻译：取代呫吨化合物
公开(公告)号：US5422382A
公开(公告)日：1995-06-06
申请号：US899258
申请日：1992-06-16
申请人： Louis Locatell , Kenneth Norland , F. Donald Roberts , Charles Zepp
发明人： Louis Locatell , Kenneth Norland , F. Donald Roberts , Charles Zepp
IPC分类号： C07D311/82 , C09K11/06 , C08K5/15 , C09K15/06
CPC分类号： C07D311/82 , C09K11/06
摘要： Substituted xanthene compounds are described which are capable of functioning as absorbers in high intensity light protective compositions and in materials used to prevent the transmission of high intensity light at selected wavelengths. Also described are high intensity light protective compositions containing an effective amount of a substituted xanthene compound and a polymeric compound and a material which prevents transmission of high intensity light at wavelengths between about 482 to about 556 nanometers. The material of this invention can be used to make protective eyewear, optical filters, shields for protecting a persons body from high intensity light, or shields for protecting components of an optical instrument from high intensity light.
摘要翻译：描述了取代的呫吨化合物，其能够用作高强度光保护组合物中的吸收剂，以及用于防止在选定波长下传输高强度光的材料。还描述了含有有效量的取代呫吨化合物和高分子化合物的高强度轻质保护组合物以及防止在约482至约556纳米之间的波长传播高强度光的材料。本发明的材料可以用于制造防护眼镜，光学滤镜，用于保护身体免受高强度光的屏蔽，或用于保护光学仪器的部件免受高强度光的屏蔽。

9. 发明授权

US5149830A Substituted xanthene compounds 失效
标题翻译：取代的XANTHENE化合物
公开(公告)号：US5149830A
公开(公告)日：1992-09-22
申请号：US484429
申请日：1990-02-23
申请人： Louis Locatell , Kenneth Norland , F. Donald Roberts , Charles Zepp
发明人： Louis Locatell , Kenneth Norland , F. Donald Roberts , Charles Zepp
IPC分类号： C07D311/82 , C09K11/06
CPC分类号： C07D311/82 , C09K11/06
摘要： Substituted xanthene compounds are described which are capable of functioning as absorbers in high intensity light protective compositions and in materials used to prevent the transmission of high intensity light at selected wavelengths. Also described are high intensity light protective compositions containing an effective amount of a substituted xanthene compound and a polymeric compound and a material which prevents transmission of high intensity light at wavelengths between about 482 to about 556 nanometers. The material of this invention can be used to make protective eyewear, optical filters, shields for protecting a persons body from high intensity light, or shields for protecting components of an optical instrument from high intensity light.
摘要翻译：描述了取代的呫吨化合物，其能够用作高强度光保护组合物中的吸收剂，以及用于防止在选定波长下传输高强度光的材料。还描述了含有有效量的取代呫吨化合物和高分子化合物的高强度轻质保护组合物以及防止在约482至约556纳米之间的波长传播高强度光的材料。本发明的材料可以用于制造防护眼镜，光学滤镜，用于保护身体免受高强度光的屏蔽，或用于保护光学仪器的部件免受高强度光的屏蔽。

10. 发明授权

US06531573B1 Antifungal and antibacterial peptides 失效
标题翻译：抗真菌和抗菌肽
公开(公告)号：US06531573B1
公开(公告)日：2003-03-11
申请号：US08993235
申请日：1997-12-18
申请人： Frank G. Oppenheim , Tao Xu , F. Donald Roberts , Peter Spacciapoli , Phillip M. Friden
发明人： Frank G. Oppenheim , Tao Xu , F. Donald Roberts , Peter Spacciapoli , Phillip M. Friden
IPC分类号： A61K3800
CPC分类号： C07K14/4723 , A61K38/00
摘要： Substantially pure peptides containing between 13 and 20 amino acids, inclusive, having the amino acid sequence: R1-R2-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-R15-R16-R17-R18-R19-R20-R21-R22-R23, where R1 is Asp or is absent; R2 is Ser or is absent; R3 is His or is absent; R4 is Ala; R5 is Lys, Gln, Arg, or another basic amino acid; R6 is Arg, Gln, Lys, or another basic amino acid; R7 is His, Phe, Tyr, Leu, or another hydrophobic amino acid; R8 is His, Phe, Tyr, Leu, or another hydrophobic amino acid; R9 is Gly, Lys, Arg, or another basic amino acid; R10 is Tyr; R11 is Lys, His, Phe, or another hydrophobic amino acid; R12 is Arg, Gln, Lys, or another basic amino acid; R13 is Lys, Gln, Arg, another basic amino acid, or is absent; R14 is Phe or is absent; R15 is His, Phe, Tyr, Leu, another hydrophobic amino acid, or is absent; R16 is Glu or is absent; R17 is Lys or is absent; R18 is His or is absent; R19 is His or is absent; R20 is Ser or is absent; R21 is His or is absent; R22 is Arg or is absent; and R23 is Gly or is absent; and where Gln cannot simultaneously occupy positions R5, R6, R12, and R13 of the amino acid sequence, as well as pharmaceutical compositions containing these peptides and methods for treating fuingal and bacterial infections using these peptides, are disclosed.
摘要翻译：含有13至20个氨基酸，含有氨基酸序列的基本上纯的肽：R1-R2-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-R15-R16 -R17-R18-R19-R20-R21-R22-R23，其中R1是Asp或不存在; R2为Ser或不存在; R3是他或缺席; R4是Ala; R5是Lys，Gln，Arg或另一种碱性氨基酸; R6是Arg，Gln，Lys或另一种碱性氨基酸; R7是His，Phe，Tyr，Leu或另一个疏水性氨基酸; R8是His，Phe，Tyr，Leu或另一个疏水性氨基酸; R9是Gly，Lys，Arg或另一种碱性氨基酸; R10是Tyr; R11为Lys，His，Phe或另一种疏水性氨基酸; R12是Arg，Gln，Lys或另一种碱性氨基酸; R13是Lys，Gln，Arg，另一种碱性氨基酸，或不存在; R14是Phe或不存在; R15是His，Phe，Tyr，Leu，另一个疏水性氨基酸，或不存在; R16是Glu或不存在; R17为Lys或不存在; R18是他或缺席; R19是他或缺席; R20是Ser或不存在; R21是他或缺席; R22为Arg或不存在; 而R23为Gly或不存在; 并且其中Gln不能同时占据氨基酸序列的R5，R6，R12和R13的位置，以及含有这些肽的药物组合物和使用这些肽治疗引发和细菌感染的方法。

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