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1. 发明申请

US20080044472A1 Photoresponsive Hydrogels 审中-公开
标题翻译：光反应性水凝胶
公开(公告)号：US20080044472A1
公开(公告)日：2008-02-21
申请号：US10587229
申请日：2005-01-24
申请人： Antonio Garcia , Rohit Rosario , John Gust , Mark Hayes , Manuel Marquez , Zhibing Hu , Tong Cai
发明人： Antonio Garcia , Rohit Rosario , John Gust , Mark Hayes , Manuel Marquez , Zhibing Hu , Tong Cai
IPC分类号： A61K31/407 , A61K31/711 , A61K45/00 , A61K9/14 , A61P29/00
CPC分类号： C08F2/50 , A61K47/34
摘要： Disclosed are photoresponsive hydrogels. The compositions disclosed herein can be prepared by polymerizing a hydrogel precursor and a spiropyran. The properties of the disclosed compositions can be changed by exposure to light, pH, and temperature. Methods of using the disclosed compositions to deliver pharmaceutical actives are also disclosed.
摘要翻译：公开了光响应水凝胶。本文公开的组合物可以通过聚合水凝胶前体和螺吡喃来制备。所公开的组合物的性质可以通过暴露于光，pH和温度而改变。还公开了使用所公开的组合物递送药物活性物质的方法。

2. 发明申请

US20100255059A1 Artificial micro-gland 审中-公开
标题翻译：人造微腺
公开(公告)号：US20100255059A1
公开(公告)日：2010-10-07
申请号：US12726158
申请日：2010-03-17
申请人： Manuel Marquez , Samantha M. Marquez , Antonio Garcia
发明人： Manuel Marquez , Samantha M. Marquez , Antonio Garcia
IPC分类号： A61K35/14 , A61K9/00 , A61K35/16 , A61K35/18 , A61K35/12 , A61P5/00 , C12N5/07 , C12N5/0789 , C12N5/073 , C12N5/09 , C12N5/078
CPC分类号： C12N5/0062 , A61F2/022 , A61K35/28 , A61K35/36 , A61K35/39 , A61K35/54 , A61L27/3804 , A61L27/60 , A61L2400/12
摘要： A micro-scale artificial gland is disclosed in the form of an independent unit for promoting biological activity. The artificial gland includes cells formed in a membrane enclosing a reservoir. The reservoir is a bio-reactor capable of containing a product of activity of the cells. The reservoir comprises a gas, a liquid, and a gel and preferably also contains nanoparticles, a buffer, a surfactant, and, a gel precursor. The reservoir may also contain cells. Nanoparticles may also surround the artificial gland to form a protective coating. A variety of methods are disclosed for making the artificial gland by directed assembly of cells into the artificial micro-gland by gel, liquid or bubble templating. All involve coating the surface of gel, droplet or bubble with the living cells and the stabilizing the cells on the surface of gels, droplets or bubbles.
摘要翻译：微生物人工腺体以用于促进生物活性的独立单元的形式被公开。人造腺包括在包围储存器的膜中形成的细胞。储层是能够容纳细胞活性产物的生物反应器。储存器包括气体，液体和凝胶，并且优选地还含有纳米颗粒，缓冲液，表面活性剂和凝胶前体。贮存器还可以含有细胞。纳米颗粒也可以围绕人造腺体形成保护性涂层。公开了通过凝胶，液体或气泡模板将细胞定向组装到人造微腺体中来制备人造腺体的各种方法。所有这些都涉及用活细胞涂覆凝胶表面，液滴或气泡，并将细胞稳定在凝胶，液滴或气泡表面。

3. 发明申请

US20180346873A1 Artificial micro-gland 审中-公开
公开(公告)号：US20180346873A1
公开(公告)日：2018-12-06
申请号：US16048423
申请日：2018-07-30
申请人： Manuel Marquez , Samantha M. Marquez , Antonio Garcia
发明人： Manuel Marquez , Samantha M. Marquez , Antonio Garcia
IPC分类号： C12N5/00 , A61K35/39 , A61K35/36 , A61F2/02 , A61L27/38 , A61K35/54 , A61K35/28 , A61L27/60
CPC分类号： C12N5/0062 , A61F2/022 , A61K35/28 , A61K35/36 , A61K35/39 , A61K35/54 , A61L27/3804 , A61L27/60 , A61L2400/12
摘要： A micro-scale artificial gland is disclosed in the form of an independent unit for promoting biological activity. The artificial gland includes cells formed in a membrane enclosing a reservoir. The reservoir is a bio-reactor capable of containing a product of activity of the cells. The reservoir comprises a gas, a liquid, and a gel and preferably also contains nanoparticles, a buffer, a surfactant, and, a gel precursor. The reservoir may also contain cells. Nanoparticles may also surround the artificial gland to form a protective coating. A variety of methods are disclosed for making the artificial gland by directed assembly of cells into the artificial micro-gland by gel, liquid or bubble templating. All involve coating the surface of gel, droplet or bubble with the living cells and the stabilizing the cells on the surface of gels, droplets or bubbles.

4. 发明申请

US20050032051A1 Rapid flow-based immunoassay microchip 审中-公开
标题翻译：快速流式免疫测定微芯片
公开(公告)号：US20050032051A1
公开(公告)日：2005-02-10
申请号：US10296489
申请日：2001-06-19
申请人： Mark Hayes , Nolan Polson , Anil Vuppu , Timothy Crowley , Antonio Garcia
发明人： Mark Hayes , Nolan Polson , Anil Vuppu , Timothy Crowley , Antonio Garcia
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/543
CPC分类号： G01N33/54326 , G01N33/54333 , G01N2446/00
摘要： A microimmunoassay arrangement including paramagnetic particles having labeled antibody held in a microchannel by an external magnetic field provides rapid analysis using small sample volumes.
摘要翻译：包含具有通过外部磁场保持在微通道中的标记抗体的顺磁性颗粒的微量免疫测定装置提供使用小样品体积的快速分析。

5. 发明申请

US20120253518A1 METHODS AND SYSTEMS FOR DRILLING BOREHOLES 有权
标题翻译：钻孔机的方法和系统
公开(公告)号：US20120253518A1
公开(公告)日：2012-10-04
申请号：US13524623
申请日：2012-06-15
申请人： Edward Curtis Stacy, II , Antonio Garcia
发明人： Edward Curtis Stacy, II , Antonio Garcia
IPC分类号： G05B19/048
CPC分类号： E21B44/04 , E21B7/00 , E21B44/00
摘要： A computer-readable medium including program instructions for drilling a borehole. When the program instructions are executed by one or more processors of a computer system operatively associated with a drill rig, the program instructions cause the processor to carry out the steps of initiating a drilling phase and monitoring a drill parameter during the drilling phase. The drill parameter includes at least one of drill rotational speed, drill torque or number of drill retractions. The program instructions further cause the processor to carry out the step of determining whether the monitored drill parameter is within a predetermined specification for the monitored drill parameter in order to choose a drilling phase defect mitigation routine. After implementing the drilling phase defect mitigation routine, the processors carry out the step of resuming the drilling phase.
摘要翻译：一种包括用于钻孔的程序指令的计算机可读介质。当程序指令由与钻机操作地相关联的计算机系统的一个或多个处理器执行时，程序指令使处理器执行在钻井阶段期间启动钻井阶段和监测钻探参数的步骤。钻头参数包括钻头旋转速度，钻头扭矩或钻孔回缩数量中的至少一个。程序指令进一步导致处理器执行确定监视的钻探参数是否在监视的钻探参数的预定规格内以选择钻井阶段缺陷减轻程序的步骤。在实施钻井阶段缺陷缓解程序后，处理器执行恢复钻井阶段的步骤。

6. 发明授权

US08134700B2 Systems and methods for inspection of stents 有权
标题翻译：用于支架检查的系统和方法
公开(公告)号：US08134700B2
公开(公告)日：2012-03-13
申请号：US13244424
申请日：2011-09-24
申请人： Ian Cameron , Andrew David Coppin Maw , Hong Zhang , Calden Wloka , Sidney Watterodt , Sang joon Park , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Bryan D. Glenn
发明人： Ian Cameron , Andrew David Coppin Maw , Hong Zhang , Calden Wloka , Sidney Watterodt , Sang joon Park , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Bryan D. Glenn
IPC分类号： G01N21/00
CPC分类号： G01N21/952 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2002/91575 , A61F2230/0054 , A61F2240/008
摘要： A system and method for inspecting stents can involve an inspection camera to take an image of the stent and a computer system for analyzing the image to determine the presence of any coating defects. The determination can be made by masking out a portion of the stent, identifying deviations from a strut edge, and/or highlighting features protruding from a stent external boundary defining an outer diameter. The image can be taken after a focus feedback camera determines the position of the stent.
摘要翻译：用于检查支架的系统和方法可以包括检查相机以拍摄支架的图像和用于分析图像的计算机系统以确定是否存在任何涂层缺陷。可以通过掩盖支架的一部分，识别与支柱边缘的偏差和/或突出从限定外径的支架外部边界突出的特征来进行确定。在聚焦反馈相机确定支架的位置后，可以拍摄图像。

7. 发明授权

US07853340B2 Method for aligning a stent with a stent support 有权
标题翻译：将支架对准支架支架的方法
公开(公告)号：US07853340B2
公开(公告)日：2010-12-14
申请号：US12558059
申请日：2009-09-11
申请人： Sang joon Park , Shaulaine Choo , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Thomas David Esbeck , Bryan D. Glenn
发明人： Sang joon Park , Shaulaine Choo , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Thomas David Esbeck , Bryan D. Glenn
IPC分类号： G05B13/02 , A61F2/04 , A61F2/06 , G06F19/00 , A61F5/04
CPC分类号： A61F2/82 , A61F2/91 , A61F2250/0067 , B23K2103/42 , B23K2103/50 , Y10T29/4978
摘要： A method for aligning a stent with a stent support includes the steps of (1) placing a stent support and a stent mounted on the stent support in a vertically position with the stent support's first support element at a lower position and the stent support's second support element at an upper position; (2) obtaining a digital image of the stent support and stent; (3) analyzing the digital image of the stent support and stent to compute the vertical position of the stent's upper end; (4) computing a desired position of the second support element based on the position of the stent's upper end; and (5) using a positioning device to move the second support element to the desired position. The movement of the second support element causes the conical sections of the first and second support elements to engage the respective ends of the stent to center the stent around a core element of the stent support and to secure the stent in a longitudinal direction of the stent support.
摘要翻译：用于使支架与支架支架对准的方法包括以下步骤：（1）将支架支架和安装在支架支架上的支架放置在支架支架的第一支撑元件处于较低位置的垂直位置，支架支架的第二支撑件元素在上位; （2）获得支架支架和支架的数字图像; （3）分析支架支架和支架的数字图像，计算支架上端的垂直位置; （4）基于支架的上端的位置计算第二支撑元件的期望位置; 和（5）使用定位装置将第二支撑元件移动到所需位置。第二支撑元件的运动导致第一和第二支撑元件的锥形部分接合支架的相应端部，以使支架围绕支架支架的芯元件居中，并将支架固定在支架的纵向方向上支持。

8. 发明申请

US20100221409A1 Stent Fixture Having Rounded Support Structures and Method for Use Thereof 有权
标题翻译：具有圆形支撑结构的支架及其使用方法
公开(公告)号：US20100221409A1
公开(公告)日：2010-09-02
申请号：US12778914
申请日：2010-05-12
申请人： Nathan Harold , Antonio Garcia , Andrew Tochterman
发明人： Nathan Harold , Antonio Garcia , Andrew Tochterman
IPC分类号： B05D1/02
CPC分类号： B05B13/0207 , B05B13/0228 , B05B13/0235
摘要： A stent fixture for supporting a stent during the application of a coating substance is provided.
摘要翻译：提供了一种用于在施加涂层物质期间支撑支架的支架固定器。

9. 发明授权

US07606625B2 Method and device for aligning a stent with a stent support 有权
标题翻译：用于将支架对准支架支架的方法和装置
公开(公告)号：US07606625B2
公开(公告)日：2009-10-20
申请号：US11764015
申请日：2007-06-15
申请人： Sang joon Park , Shaulaine Choo , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Thomas David Esbeck , Bryan D. Glenn
发明人： Sang joon Park , Shaulaine Choo , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Thomas David Esbeck , Bryan D. Glenn
IPC分类号： G05B13/02 , A61F2/06 , G06F19/00 , A61F5/04
CPC分类号： A61F2/82 , A61F2/91 , A61F2250/0067 , B23K2103/42 , B23K2103/50 , Y10T29/4978
摘要： A method for aligning a stent with a stent support includes the steps of (1) placing a stent support and a stent mounted on the stent support in a vertically position with the stent support's first support element at a lower position and the stent support's second support element at an upper position; (2) obtaining a digital image of the stent support and stent; (3) analyzing the digital image of the stent support and stent to compute the vertical position of the stent's upper end; (4) computing a desired position of the second support element based on the position of the stent's upper end; and (5) using a positioning device to move the second support element to the desired position. The movement of the second support element causes the conical sections of the first and second support elements to engage the respective ends of the stent to center the stent around a core element of the stent support and to secure the stent in a longitudinal direction of the stent support.
摘要翻译：用于使支架与支架支架对准的方法包括以下步骤：（1）将支架支架和安装在支架支架上的支架放置在支架支架的第一支撑元件处于较低位置的垂直位置，支架支架的第二支撑件元素在上位; （2）获得支架支架和支架的数字图像; （3）分析支架支架和支架的数字图像，计算支架上端的垂直位置; （4）基于支架的上端的位置计算第二支撑元件的期望位置; 和（5）使用定位装置将所述第二支撑元件移动到期望的位置。第二支撑元件的运动导致第一和第二支撑元件的锥形部分接合支架的相应端部，以使支架围绕支架支架的芯元件居中，并将支架固定在支架的纵向方向上支持。

10. 发明申请

US20080312728A1 METHOD AND DEVICE FOR ALIGNING A STENT WITH A STENT SUPPORT 有权
标题翻译：用于对具有支撑的支架进行校准的方法和装置
公开(公告)号：US20080312728A1
公开(公告)日：2008-12-18
申请号：US11764015
申请日：2007-06-15
申请人： Sang joon Park , Shaulaine Choo , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Thomas David Esbeck , Bryan D. Glenn
发明人： Sang joon Park , Shaulaine Choo , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Thomas David Esbeck , Bryan D. Glenn
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/91 , A61F2250/0067 , B23K2103/42 , B23K2103/50 , Y10T29/4978
摘要： A method for aligning a stent with a stent support includes the steps of (1) placing a stent support and a stent mounted on the stent support in a vertically position with the stent support's first support element at a lower position and the stent support's second support element at an upper position; (2) obtaining a digital image of the stent support and stent; (3) analyzing the digital image of the stent support and stent to compute the vertical position of the stent's upper end; (4) computing a desired position of the second support element based on the position of the stent's upper end; and (5) using a positioning device to move the second support element to the desired position. The movement of the second support element causes the conical sections of the first and second support elements to engage the respective ends of the stent to center the stent around a core element of the stent support and to secure the stent in a longitudinal direction of the stent support.
摘要翻译：用于使支架与支架支架对准的方法包括以下步骤：（1）将支架支架和安装在支架支架上的支架放置在支架支架的第一支撑元件处于较低位置的垂直位置，支架支架的第二支撑件元素在上位; （2）获得支架支架和支架的数字图像; （3）分析支架支架和支架的数字图像，计算支架上端的垂直位置; （4）基于支架的上端的位置计算第二支撑元件的期望位置; 和（5）使用定位装置将第二支撑元件移动到所需位置。第二支撑元件的运动导致第一和第二支撑元件的锥形部分接合支架的相应端部，以使支架围绕支架支架的芯元件居中，并将支架固定在支架的纵向方向上支持。

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