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1. 发明授权

US09393734B2 Polyethylene film with high tensile strength and high tensile energy to break 有权
标题翻译：聚乙烯薄膜具有高拉伸强度和高拉伸能量断裂
公开(公告)号：US09393734B2
公开(公告)日：2016-07-19
申请号：US12452526
申请日：2008-07-02
申请人： Anton Peter De Weijer , Hendrik Van De Hee , Martinus Wilhelmus Maria Gemma Peters , Sanjay Rastogi , Bing Wang
发明人： Anton Peter De Weijer , Hendrik Van De Hee , Martinus Wilhelmus Maria Gemma Peters , Sanjay Rastogi , Bing Wang
IPC分类号： B29C55/02 , B29C55/00 , B29C55/04 , D07B1/02 , B29K23/00
CPC分类号： B29C55/005 , B29C55/04 , B29K2023/0683 , D07B1/025 , D07B2201/2003 , D07B2201/2009 , D07B2205/2014 , Y10T428/249921 , Y10T442/10 , D07B2801/10
摘要： The present invention pertains to a UHMWPE film having a tensile strength of at least 2.0 GPa, a tensile energy to break of at least 30 J/g, an Mw of at least 500 000 gram/mole, and a Mw/Mn ratio of at most 6. The film may be manufactured via a process which comprises subjecting a starting UHMWPE with a weight average molecular weight of at least 500 000 gram/mole, an elastic shear modulus determined directly after melting at 160° C. of at most 0.9 MPa, and a Mw/Mn ratio of at most 6 to a compacting step and a stretching step under such conditions that at no point during the processing of the polymer its temperature is raised to a value above its melting point. The film may be used as starting material in any applications where high tensile strength and high energy to break are important. Suitable applications include ballistic applications, ropes, cables, nets, fabrics, and protective applications.
摘要翻译：本发明涉及一种抗拉强度为至少2.0GPa，拉伸断裂能至少为30J / g，Mw至少为500000克/摩尔，Mw / Mn比为该膜可以通过以下方法制造，该方法包括使重均分子量为至少500000克/摩尔的起始UHMWPE，在160℃下熔融后直接测定的弹性剪切模量为至多0.9MPa ，并且在这样的条件下，在聚合物加工过程中任何时候，其温度升高到高于其熔点的值的条件下，Mw / Mn比至多为6的压实步骤和拉伸步骤。在高抗拉强度和高能量破裂重要性的任何应用中，该膜可用作起始材料。合适的应用包括弹道应用，绳索，电缆，网，织物和保护性应用。

2. 发明申请

US20100144224A1 POLYETHYLENE FILM WITH HIGH TENSILE STRENGTH AND HIGH TENSILE ENERGY TO BREAK 有权
标题翻译：聚乙烯薄膜，具有高拉伸强度和高拉伸强度
公开(公告)号：US20100144224A1
公开(公告)日：2010-06-10
申请号：US12452526
申请日：2008-07-02
申请人： Anton Peter De Weijer , Hendrik Van De Hee , Martinus Wilhelmis Maria Gemma Peters , Sanjay Rastogi , Bing Wang
发明人： Anton Peter De Weijer , Hendrik Van De Hee , Martinus Wilhelmis Maria Gemma Peters , Sanjay Rastogi , Bing Wang
IPC分类号： B32B5/02 , B29C55/02 , C08F110/02
CPC分类号： B29C55/005 , B29C55/04 , B29K2023/0683 , D07B1/025 , D07B2201/2003 , D07B2201/2009 , D07B2205/2014 , Y10T428/249921 , Y10T442/10 , D07B2801/10
摘要： The present invention pertains to a UHMWPE film having a tensile strength of at least 2.0 GPa, a tensile energy to break of at least 30 J/g, an Mw of at least 500 000 gram/mole, and a Mw/Mn ratio of at most 6. The film may be manufactured via a process which comprises subjecting a starting UHMWPE with a weight average molecular weight of at least 500 000 gram/mole, an elastic shear modulus determined directly after melting at 160° C. of at most 0.9 MPa, and a Mw/Mn ratio of at most 6 to a compacting step and a stretching step under such conditions that at no point during the processing of the polymer its temperature is raised to a value above its melting point. The film may be used as starting material in any applications where high tensile strength and high energy to break are important. Suitable applications include ballistic applications, ropes, cables, nets, fabrics, and protective applications.
摘要翻译：本发明涉及一种抗拉强度为至少2.0GPa，拉伸断裂能至少为30J / g，Mw至少为500000克/摩尔，Mw / Mn比为该膜可以通过以下方法制造，该方法包括使重均分子量为至少500000克/摩尔的起始UHMWPE，在160℃下熔融后直接测定的弹性剪切模量为至多0.9MPa ，并且在这样的条件下，在聚合物加工过程中任何时候，其温度升高到高于其熔点的值的条件下，Mw / Mn比至多为6的压实步骤和拉伸步骤。在高抗拉强度和高能量破裂重要性的任何应用中，该膜可用作起始材料。合适的应用包括弹道应用，绳索，电缆，网，织物和保护性应用。

3. 发明授权

US08765945B2 Processes of synthesizing dihydropyridophthalazinone derivatives 有权
标题翻译：合成二氢吡啶并酞嗪酮衍生物的方法
公开(公告)号：US08765945B2
公开(公告)日：2014-07-01
申请号：US13023140
申请日：2011-02-08
申请人： Bing Wang , Daniel Chu , Yongbo Liu , Quan Jiang , Lei Lu
发明人： Bing Wang , Daniel Chu , Yongbo Liu , Quan Jiang , Lei Lu
IPC分类号： C07D237/36
CPC分类号： C07D405/06 , C07D249/08 , C07D401/04 , C07D403/06 , C07D471/06
摘要： Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.
摘要翻译：本文提供了合成二氢吡啶并二氮杂萘酮衍生物的方法，例如5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基） 9-二氢-2H-吡啶并[4,3,2-de]酞嗪-3（7H） - 酮及其立体异构体，它们是有效的聚（ADP-核糖）聚合酶（PARP）抑制剂以及新的合成中间体化合物。

4. 发明授权

US08735392B2 Crystalline (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt 有权
标题翻译：结晶（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H-吡啶 [4,3,2-de]酞嗪-3（7H） - 酮甲苯磺酸盐
公开(公告)号：US08735392B2
公开(公告)日：2014-05-27
申请号：US13277607
申请日：2011-10-20
申请人： Bing Wang , Daniel Chu , Yongbo Liu , Shichun Peng
发明人： Bing Wang , Daniel Chu , Yongbo Liu , Shichun Peng
IPC分类号： A01N43/58 , A61K31/495
CPC分类号： C07D471/06
摘要： Provided herein are (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt forms, including crystalline forms, and methods of their preparation. Pharmaceutical compositions comprising a (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt are also provided, as are methods of using (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt to treat a disease or condition, such as a cancer.
摘要翻译：本文提供的是（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H- - 吡啶并[4,3,2-de]酞嗪-3（7H） - 酮甲磺酸盐形式，包括晶型，及其制备方法。包含（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢 - 还提供了使用（8S，9R）-5-氟-8-（4-氟苯基）-9（7H） - 酮的方法，使用2-吡啶并[4,3,2- - （1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H-吡啶并[4,3,2-de]酞嗪-3（7H） - 酮甲苯磺酸盐治疗疾病或病症，如癌症。

5. 发明授权

US08680114B2 AKT protein kinase inhibitors 有权
标题翻译： AKT蛋白激酶抑制剂
公开(公告)号：US08680114B2
公开(公告)日：2014-03-25
申请号：US12567258
申请日：2009-09-25
申请人： Ian S. Mitchell , Keith L. Spencer , Peter Stengel , Yongxin Han , Nicholas C. Kallan , Mark Munson , Guy P. A. Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Rui Xu , Chang Rao , Bing Wang , April L. Bernacki
发明人： Ian S. Mitchell , Keith L. Spencer , Peter Stengel , Yongxin Han , Nicholas C. Kallan , Mark Munson , Guy P. A. Vigers , James Blake , Anthony Piscopio , John Josey , Scott Miller , Dengming Xiao , Rui Xu , Chang Rao , Bing Wang , April L. Bernacki
IPC分类号： A61K31/47 , A01N43/42 , C07D215/00
CPC分类号： C07D239/94 , B41M3/008 , B44F1/10 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , G09F13/16 , Y10T428/24802 , Y10T428/24851 , Y10T428/25 , Y10T428/31507 , Y10T428/31551 , Y10T428/31786 , Y10T428/31855
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供包括分解对映异构体，非对映异构体，溶剂化物和药学上可接受的盐的化合物，其包含式为：A-L-CR，其中CR为环状核心基团，L为连接基团，A如本文所定义。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

6. 发明申请

US20130161333A1 DUAL-DRAINAGE SWITCHING MECHANISM OF WATER TANK 有权
标题翻译：水箱双排水开关机构
公开(公告)号：US20130161333A1
公开(公告)日：2013-06-27
申请号：US13593379
申请日：2012-08-23
申请人： Rongyu ZHANG , Xingdong Wang , Bing Wang
发明人： Rongyu ZHANG , Xingdong Wang , Bing Wang
IPC分类号： B65D90/02
CPC分类号： E03D1/14 , E03D1/35
摘要： A dual-drainage switching mechanism of water tank has: a water container with bottom opening of the inner cavity, an air vent communicating with the inner cavity is arranged on the sealed top; a valve unit used for controlling opens or closes of the air vent; a drain valve controller comprising a partial flush button and a full flush button, and he air vent is opened through the linking and coupling of the full flush button and the valve unit, and the air vent is closed through the linking and coupling of the partial flush button and the valve unit. The dual-draining switch is achieved through hermetically storing or non-hermetically controlling part of water body in the inner cavity of the water container, traditional one-pressing drain valve can be transformed into the draining control mechanism with dual-draining function.
摘要翻译：水箱双排水切换机构具有：内腔底部开口的水容器，密封顶部设有与内腔连通的排气口; 用于控制通风口的打开或关闭的阀单元; 一个排水阀控制器，包括一个部分冲洗按钮和一个完全齐平的按钮，并且通过连接和连接完整的冲洗按钮和阀门单元打开排气孔，通过连接和连接部分冲洗按钮和阀门单元。双排水开关通过水箱内水腔的气密储存或非气密控制部分实现，传统的单压排水阀可以转化为具有双排水功能的排水控制机构。

7. 发明申请

US20120270777A1 LACTOFERRIN AND GUT NEURONAL HEALTH IN ADULTS AND/OR ELDERLY 有权
标题翻译： LACTOFERRIN和GUT神经健康在成人和/或老年
公开(公告)号：US20120270777A1
公开(公告)日：2012-10-25
申请号：US13319656
申请日：2010-05-07
申请人： Magali Faure , Bing Wang , Jeroen Schmitt
发明人： Magali Faure , Bing Wang , Jeroen Schmitt
IPC分类号： A61K38/40 , A61P3/02 , A61P1/04 , A61P25/00 , A61P1/00
CPC分类号： A61K38/40 , A23L2/66 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K35/20 , A23V2250/54248 , A23V2200/322 , A23V2200/32
摘要： The present invention relates generally to the field of neuronal health and neuronal protection. One embodiment of the present invention relates to a composition that can be used for the protection of the enteric nervous system from neurodegeneration. Disorders linked to an impaired enteric nervous system can be treated or prevented by the administration of lactoferrin containing compositions according to the present invention.
摘要翻译：本发明一般涉及神经元健康和神经元保护领域。本发明的一个实施方案涉及可用于保护肠神经系统免于神经变性的组合物。可以通过施用根据本发明的含有乳铁蛋白的组合物来治疗或预防与受损的肠神经系统相关的疾病。

8. 发明申请

US20120171177A1 NUTRITIONAL COMPOSITION FOR SUPPORTING BRAIN DEVELOPMENT AND FUNCTION OF TODDLERS 审中-公开
标题翻译：用于支持脑发育和功能功能的营养组合物
公开(公告)号：US20120171177A1
公开(公告)日：2012-07-05
申请号：US13375079
申请日：2010-06-01
申请人： Jan Biehl , Frederic Destaillats , Laurent Fay , Yoichi Fukushima , Johannes Schmitt , Bing Wang
发明人： Jan Biehl , Frederic Destaillats , Laurent Fay , Yoichi Fukushima , Johannes Schmitt , Bing Wang
IPC分类号： A61K35/74 , A61P25/28
CPC分类号： A23L33/135 , A23L33/12 , A23L33/40 , A23V2002/00 , A23V2250/1868 , A23V2250/1862 , A23V2200/3204 , A23V2200/3202 , A23V2200/322
摘要： The present invention relates to a nutritional composition, in particular directed to toddlers and/or a weaning child, said nutritional composition comprising a protein source, a source of available carbohydrates, a lipid source, at least one probiotic microorganism, and prebiotics, wherein said lipid source comprises DHA (docosahexaenoic acid). The nutritional composition improves cognitive performance, in particular learning and memory of the child. Preferably, the composition comprises iron, zinc, vitamin D and/or sialic acid. Preferably, the composition comprises a source of phospholipids rich in DHA.
摘要翻译：本发明涉及营养组合物，特别是针对幼儿和/或断奶小孩，所述营养组合物包含蛋白质源，可用碳水化合物源，脂质源，至少一种益生菌微生物和益生元，其中所述脂质源包括DHA（二十二碳六烯酸）。营养成分提高认知表现，特别是儿童的学习和记忆能力。优选地，组合物包含铁，锌，维生素D和/或唾液酸。优选地，组合物包含富含DHA的磷脂源。

9. 发明授权

US08175328B2 Two level cross-correlation based system for watermarking continuous digital media 失效
标题翻译：用于水印连续数字媒体的两级互相关系统
公开(公告)号：US08175328B2
公开(公告)日：2012-05-08
申请号：US12775886
申请日：2010-05-07
申请人： Shien-Tai Pan , Bing Wang , Hoai Le , Yi Li , Victor Kai-Chieh Liang , Maurice Chow , Richard Thai
发明人： Shien-Tai Pan , Bing Wang , Hoai Le , Yi Li , Victor Kai-Chieh Liang , Maurice Chow , Richard Thai
IPC分类号： G06K9/00 , H04N7/167
CPC分类号： G06T1/005 , H04N19/42 , H04N19/467 , H04N19/48
摘要： A two level cross-correlation based system for watermarking continuous digital media at the system application level. It is a post-compression process for watermarking where no a priori knowledge of the underlying compression algorithm is required. Per each compressed media frame, a current unique digital signature is generated based on the data from the current compressed frame plus the digital signature that has been previously generated. The signature thus generated is then used in conjunction with the next compressed frame to generate the next unique digital signature. All digital signatures are correlated according to the above process until a “reset” signal is issued. A new chain of correlated digital signatures is produced by the system with a pre-determined initial signature.
摘要翻译：一种基于二级互相关的系统，用于在系统应用级别对连续数字媒体进行水印。它是用于水印的后压缩过程，其中不需要基础压缩算法的先验知识。根据每个压缩媒体帧，基于来自当前压缩帧的数据加上先前生成的数字签名生成当前唯一的数字签名。这样生成的签名然后与下一个压缩帧一起使用，以生成下一个独特的数字签名。所有数字签名根据上述过程相关，直到发出“复位”信号。相关数字签名的新链由系统以预定的初始签名生成。

10. 发明申请

US20100325280A1 Load Balance Connections Per Server In Multi-Core/Multi-Blade System 有权
标题翻译：多核/多刀片系统中每个服务器的负载均衡连接
公开(公告)号：US20100325280A1
公开(公告)日：2010-12-23
申请号：US12489366
申请日：2009-06-22
申请人： Avinash Jindal , Deepak Bansal , Sam Htin Moy , David Cheung , Bing Wang , Mani Kancherla , Sridhar Devarapalli
发明人： Avinash Jindal , Deepak Bansal , Sam Htin Moy , David Cheung , Bing Wang , Mani Kancherla , Sridhar Devarapalli
IPC分类号： G06F15/173 , G06F9/46
CPC分类号： G06F9/5083
摘要： A network device includes a plurality of blades, each having a plurality of CPU cores that process requests received by the network device. Each blade further includes an accumulator circuit. Each accumulator circuit periodically aggregates the local counter values of the CPU cores of the corresponding blade. One accumulator circuit is designated as a master, and the other accumulator circuit(s) are designated as slave(s). The slave accumulator circuits transmit their aggregated local counter values to the master accumulator circuit. The master accumulator circuit aggregates the sets of aggregated local counter values to create a set of global counter values. The master accumulator circuit transmits the global counter values to a management processor (for display), to the CPU cores located on its corresponding blade, and to each of the slave accumulator circuits. Each slave accumulator circuit then transmits the global counter values to the CPU cores located on its corresponding blade.
摘要翻译：网络设备包括多个刀片，每个刀片具有处理由网络设备接收的请求的多个CPU内核。每个叶片还包括一个蓄电池电路。每个累加器电路周期性地聚集相应刀片的CPU内核的本地计数器值。一个累加器电路被指定为主机，另一个累加器电路被指定为从机。从累加器电路将其聚合的本地计数器值发送到主累加器电路。主累加器电路聚合本地计数器值集合以创建一组全局计数器值。主累加器电路将全局计数器值发送到管理处理器（用于显示），发送到位于其相应刀片上的CPU核心以及从属累加器电路中的每一个。然后，每个从属累加器电路将全局计数器值发送到位于其相应刀片上的CPU核心。

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