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1. 发明申请

US20060058863A1 Polymer-based stent assembly 有权
标题翻译：基于聚合物的支架组件
公开(公告)号：US20060058863A1
公开(公告)日：2006-03-16
申请号：US10508739
申请日：2004-04-02
申请人： Antoine LaFont , Serge Sante , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine LaFont , Serge Sante , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： A61F2/84 , A61F2/94
CPC分类号： A61F2/82 , A61F2/958 , A61F2002/9522 , A61F2210/0004 , A61L31/06 , C08L67/04
摘要： Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.
摘要翻译：提供了一种制备基于聚合物的支架组件的方法，其包括可膨胀的气囊导管和抗放松相关的负反冲的基于聚合物的支架。该方法包括将最终预定形状和直径的聚合物圆柱形装置加热到足够高于聚合物的玻璃化转变温度（Tg）的温度，并且足以消除聚合物圆柱形装置的先前处理的任何记忆的时间，以及然后淬灭聚合物圆柱形装置，以提供具有最终预定直径和形状的记忆的受过教育的聚合物圆柱形装置，将受过教育的圆柱形装置安装在可充气气囊导管上，通过加热至或在其上的温度减小受过教育的圆柱形装置的直径，稍微高于聚合物的Tg，同时在圆柱形装置的壁的外表面上均匀地施加压力，然后将圆柱形装置冷却到聚合物的Tg以下，以提供包括可充气气囊导管和可扩展的受过教育的，聚合物支架紧贴且稳定地设置在其上。还提供了包括充气气囊和基于聚合物的支架的组件，其基本上抵抗紧贴在气囊上的松弛相关反冲。

2. 发明授权

US07743481B2 Stent crimping 有权
标题翻译：支架压接
公开(公告)号：US07743481B2
公开(公告)日：2010-06-29
申请号：US10541421
申请日：2005-06-02
申请人： Antoine Lafont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine Lafont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： B21D39/00 , B23P19/04
CPC分类号： A61F2/95 , A61F2002/9522 , Y10T29/49927 , Y10T29/53657
摘要： Methods of crimping polymeric stents that simultaneously apply a radial force to the stent to reduce the diameter of the stent and a longitudinal force to elongate of the stent. According to one such method, a stent is inserted into an elastic tube having an inner surface that defines a passage. The tube is pulled to cause stretching of the tube. When the tube is stretched, the inner surface of the tube engages an outer surface of the stent and applies simultaneous longitudinal and radial forces to the outer surface of the stent. The simultaneously applied longitudinal and radial forces simultaneously reduce a radial extent of the stent and increase a longitudinal extent of the stent.
摘要翻译：卷曲聚合物支架的方法，其同时向支架施加径向力以减小支架的直径和对支架延伸的纵向力。根据一种这样的方法，将支架插入具有限定通道的内表面的弹性管中。拉动管以引起管的拉伸。当管被拉伸时，管的内表面接合支架的外表面并且对支架的外表面施加同时的纵向和径向力。同时施加的纵向和径向力同时减小支架的径向范围并增加支架的纵向范围。

3. 发明申请

US20080028594A1 Stent Crimping 有权
标题翻译：支架压接
公开(公告)号：US20080028594A1
公开(公告)日：2008-02-07
申请号：US10541421
申请日：2005-06-02
申请人： Antoine Lafont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine Lafont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： B29C55/22 , B23P19/04
CPC分类号： A61F2/95 , A61F2002/9522 , Y10T29/49927 , Y10T29/53657
摘要： Methods of crimping polymeric stents that simultaneously apply a radial force to the stent to reduce the diameter of the stent and a longitudinal force to elongate of the stent. According to one such method, a stent is inserted into an elastic tube having an inner surface that defines a passage. The tube is pulled to cause stretching of the tube. When the tube is stretched, the inner surface of the tube engages an outer surface of the stent and applies simultaneous longitudinal and radial forces to the outer surface of the stent. The simultaneously applied longitudinal and radial forces simultaneously reduce a radial extent of the stent and increase a longitudinal extent of the stent.
摘要翻译：卷曲聚合物支架的方法，其同时向支架施加径向力以减小支架的直径和对支架延伸的纵向力。根据一种这样的方法，将支架插入具有限定通道的内表面的弹性管中。拉动管以引起管的拉伸。当管被拉伸时，管的内表面接合支架的外表面并且对支架的外表面施加同时的纵向和径向力。同时施加的纵向和径向力同时减小支架的径向范围并增加支架的纵向范围。

4. 发明授权

US09283094B2 Polymer-based stent assembly 有权
公开(公告)号：US09283094B2
公开(公告)日：2016-03-15
申请号：US12764447
申请日：2010-04-21
申请人： Antoine LaFont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine LaFont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： A61F2/06 , A61F2/82 , A61L31/06 , A61F2/958 , A61F2/95
CPC分类号： A61F2/82 , A61F2/958 , A61F2002/9522 , A61F2210/0004 , A61L31/06 , C08L67/04
摘要： Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.

5. 发明申请

US20100204778A1 POLYMER-BASED STENT ASSEMBLY 审中-公开
标题翻译：基于聚合物的固定装置
公开(公告)号：US20100204778A1
公开(公告)日：2010-08-12
申请号：US12764447
申请日：2010-04-21
申请人： Antoine LaFont , Serge Piranda Statice Sante , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine LaFont , Serge Piranda Statice Sante , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/958 , A61F2002/9522 , A61F2210/0004 , A61L31/06 , C08L67/04
摘要： Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.
摘要翻译：提供了一种制备基于聚合物的支架组件的方法，其包括可膨胀的气囊导管和抗放松相关的负反冲的基于聚合物的支架。该方法包括将最终预定形状和直径的聚合物圆柱形装置加热到足够高于聚合物的玻璃化转变温度（Tg）的温度，并且足以消除聚合物圆柱形装置的先前处理的任何记忆的时间，以及然后淬灭聚合物圆柱形装置，以提供具有最终预定直径和形状的记忆的受过教育的聚合物圆柱形装置，将受过教育的圆柱形装置安装在可充气气囊导管上，通过加热至或在其上的温度减小受过教育的圆柱形装置的直径，稍微高于聚合物的Tg，同时在圆柱形装置的壁的外表面上均匀地施加压力，然后将圆柱形装置冷却到聚合物的Tg以下，以提供包括可充气气囊导管和可扩展的受过教育的，聚合物支架紧贴且稳定地设置在其上。还提供了包括充气气囊和基于聚合物的支架的组件，其基本上抵抗紧贴在气囊上的松弛相关反冲。

6. 发明授权

US07731740B2 Polymer-based stent assembly 有权
标题翻译：基于聚合物的支架组件
公开(公告)号：US07731740B2
公开(公告)日：2010-06-08
申请号：US10508739
申请日：2004-04-02
申请人： Antoine LaFont , Serge Piranda Statice Sante , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine LaFont , Serge Piranda Statice Sante , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/958 , A61F2002/9522 , A61F2210/0004 , A61L31/06 , C08L67/04
摘要： Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.
摘要翻译：提供了一种制备基于聚合物的支架组件的方法，其包括可膨胀的气囊导管和抗放松相关的负反冲的基于聚合物的支架。该方法包括将最终预定形状和直径的聚合物圆柱形装置加热到足够高于聚合物的玻璃化转变温度（Tg）的温度，并且足以消除聚合物圆柱形装置的先前处理的任何记忆的时间，以及然后淬灭聚合物圆柱形装置，以提供具有最终预定直径和形状的记忆的受过教育的聚合物圆柱形装置，将受过教育的圆柱形装置安装在可充气气囊导管上，通过加热至或在其上的温度减小受过教育的圆柱形装置的直径，稍微高于聚合物的Tg，同时在圆柱形装置的壁的外表面上均匀地施加压力，然后将圆柱形装置冷却到聚合物的Tg以下，以提供包括可充气气囊导管和可扩展的受过教育的，聚合物支架紧贴且稳定地设置在其上。还提供了包括充气气囊和基于聚合物的支架的组件，其基本上抵抗紧贴在气囊上的松弛相关反冲。

7. 发明授权

US07964136B2 Method of sterilizing polymeric struts and stents 有权
标题翻译：消毒聚合物支柱和支架的方法
公开(公告)号：US07964136B2
公开(公告)日：2011-06-21
申请号：US12282680
申请日：2007-03-13
申请人： Patrick Sabaria
发明人： Patrick Sabaria
IPC分类号： A61L2/00 , B01J19/08 , G01N23/00 , H01J27/00 , A61N5/00 , A61M31/00 , A61F2/06 , B65D81/24 , B65D73/00 , A61B17/06
CPC分类号： A61F2/82 , A61B90/39 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2250/003 , A61F2250/0098 , A61L31/148 , A61L31/18
摘要： It has been determined that gamma sterilization of biodegradable polymer stents does not cause significant polymer cross-linking and collapse. Using sufficient spacing can lead to stents that display little if any detrimental effects from the procedure. In certain embodiments, using structures in the general region of about 100 micron spacing between the struts leads to highly functional stents that do not fuse. Further, the resulting stent has radially homogenous mechanical properties. Therefore, the stent has a uniform expansion within the lumen.
摘要翻译：已经确定可生物降解的聚合物支架的γ灭菌不会导致显着的聚合物交联和崩解。使用足够的间距可能会导致支架显示，如果有任何不利影响的程序。在某些实施例中，使用在支柱之间的约100微米间距的一般区域中的结构导致不融合的高度功能的支架。此外，所得的支架具有径向均匀的机械性能。因此，支架在内腔内具有均匀的膨胀。

8. 发明申请

US20090105800A1 METHODS OF MINIMIZING STENT CONTRACTION FOLLOWING DEPLOYMENT 审中-公开
标题翻译：根据部署最小化STENT合约的方法
公开(公告)号：US20090105800A1
公开(公告)日：2009-04-23
申请号：US12282715
申请日：2007-03-13
申请人： Patrick Sabaria
发明人： Patrick Sabaria
IPC分类号： A61F2/06 , B29C43/02
CPC分类号： A61F2/82 , A61B90/39 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2250/003 , A61F2250/0098 , A61L31/148 , A61L31/18
摘要： The present invention provides methods for fabricating a stent using a preheating stage. The inventors have found a fabrication methods that result in the same and/or better product quality stent using a single step process performed at a temperature of below 65° C., more preferably below 60° C., most preferably below 55° C. Stent fabrication under such reduced temperature conditions reduces the exposure of the stent to adverse temperature conditions, thereby enabling the greater retention of the polymer's memory. Further, upon expansion, the stent does not contract to a smaller diameter but instead remains at a constant diameter or increases to a larger diameter.
摘要翻译：本发明提供使用预热阶段制造支架的方法。发明人已经发现了一种制造方法，其使用在低于65℃，更优选低于60℃，最优选低于55℃的温度下进行的单步骤方法得到相同和/或更好的产品质量支架。在这种降低温度条件下的支架制造减少了支架暴露于不利的温度条件，从而使得聚合物的记忆力保持较大。此外，在膨胀时，支架不会收缩到更小的直径，而是保持在恒定的直径或增加到更大的直径。

9. 发明授权

US09078957B2 Methods of polymeric stent surface smoothing and resurfacing to reduce biologically active sites 有权
标题翻译：聚合物支架表面平滑和表面重建以减少生物活性位点的方法
公开(公告)号：US09078957B2
公开(公告)日：2015-07-14
申请号：US12282752
申请日：2007-04-11
申请人： Patrick Sabaria
发明人： Patrick Sabaria
IPC分类号： B44C1/22 , A61L31/10 , A61L31/06 , A61L31/14
CPC分类号： A61L31/10 , A61L31/06 , A61L31/148
摘要： The present invention provides methods for fabricating a stent using a chemical treatment to smooth, polish or strengthen the stent. One such treatment involves exposing the stent to acetone or a similar solvent. In certain embodiments, the additional step comprises placing the stent in a bath containing acetone, or a similar solvent, where the bath also contains the polymer the stent is composed of. The acetone bath step may be conducted at a temperature that is below the glass transition temperature. The present invention also provides for methods of fabricating a stent using an acetone bath that comprises poly (lactic) acid. Other embodiments provide for methods of fabricating a stent using an acetone bath that comprises poly (lactic) acid and polyethylene glycol.
摘要翻译：本发明提供使用化学处理来制造支架以平滑，抛光或加强支架的方法。一种这样的治疗包括将支架暴露于丙酮或类似溶剂。在某些实施方案中，附加步骤包括将支架置于含有丙酮或类似溶剂的浴中，其中浴还含有由支架组成的聚合物。丙酮浴步骤可以在低于玻璃化转变温度的温度下进行。本发明还提供了使用包含聚（乳酸）的丙酮浴制造支架的方法。其他实施方案提供了使用包含聚（乳酸）和聚乙二醇的丙酮浴来制造支架的方法。

10. 发明申请

US20090133817A1 STENT MANUFACTURING METHODS 审中-公开
标题翻译： STENT制造方法
公开(公告)号：US20090133817A1
公开(公告)日：2009-05-28
申请号：US12282727
申请日：2007-06-19
申请人： Patrick Sabaria
发明人： Patrick Sabaria
IPC分类号： B32B37/00 , B29C39/00
CPC分类号： B29C41/36 , A61F2/82 , B29C33/3878 , B29C33/405 , B29C33/424 , B29C33/50 , B29C39/006 , B29C39/24 , B29C39/34 , B29C41/386 , B29C45/261 , B29C45/372 , B29K2067/043 , B29K2067/046 , B29K2995/006 , B29L2031/7532
摘要： A novel method of manufacturing stents by use of molds (1101) made of a biocompatible, flexible material, preferably silicone. Some embodiments use silicone polymers; a two-dimensional, waffle mold; injection molds whereby the core of the injection mold is silicone polymer. In some embodiments, the stent polymer or particles of stent polymers are injected into the mold, around a cylinder of silicone, to form a three-dimensional stent. In some embodiments, particles of silicone polymer are mechanically forced into the negative spaces and then fused together to form the finished product. In other embodiments, metal stents or metal molds are used to manufacture a reverse mold. The reverse mold (901) is then used to create positive silicone molds. The silicone molds can subsequently be used by any means to make polymer stents, lending themselves to automation.
摘要翻译：一种通过使用由生物相容的柔性材料（优选硅酮）制成的模具（1101）制造支架的新型方法。一些实施方案使用硅氧烷聚合物; 二维华夫饼模具; 注射模具，由此注射模具的芯部是硅氧烷聚合物。在一些实施方案中，将支架聚合物或支架聚合物颗粒注入模具中，围绕硅树脂圆柱体，以形成三维支架。在一些实施方案中，硅氧烷聚合物的颗粒被机械地强制进入负空间，然后熔合在一起以形成成品。在其他实施例中，金属支架或金属模具用于制造反模具。然后将反模具（901）用于产生阳性硅模具。随后可以通过任何方式使用硅氧烷模具制备聚合物支架，从而实现自动化。

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