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1. 发明申请

US20080139501A1 Hyaluronic Acid Linked With a Polymer of an Alpha Hydroxy Acid 审中-公开
标题翻译：与α-羟基酸的聚合物连接的透明质酸
公开(公告)号：US20080139501A1
公开(公告)日：2008-06-12
申请号：US11722729
申请日：2005-12-23
申请人： Khadija Schwach Abdellaoui , Michel Vert , Laurent Pravata
发明人： Khadija Schwach Abdellaoui , Michel Vert , Laurent Pravata
IPC分类号： A61K31/728 , C08F251/00 , A61K8/73
CPC分类号： C08B37/0072 , A61K8/735 , A61K8/85 , A61K31/715 , A61K31/728 , A61K2800/57 , A61Q19/00
摘要： The invention concerns a product comprising hyaluronic acid or a salt thereof, wherein the hyaluronic acid has been partially or fully linked or crosslinked with a polymer of an alpha hydroxy acid. The invention also concerns manufacture of the product, uses of the product of the invention in the field of biodegradable plastic materials for the preparation of sanitary and surgical articles, in the pharmaceutical and cosmetic fields; including the various articles made with the same in such fields.
摘要翻译：本发明涉及包含透明质酸或其盐的产品，其中透明质酸已经与α-羟基酸的聚合物部分或完全连接或交联。本发明还涉及产品的制造，本发明的产品在可生物降解的塑料材料领域中的用途，用于在制药和化妆品领域制备卫生和外科用品; 包括在这些领域制作的各种文章。

2. 发明授权

US5662938A Bioresorbable-polymer microspheres of hydroxy acid polymer free from surfactant, their preparation and their application as a drug 失效
标题翻译：羟基酸聚合物的生物可吸收聚合物微球体不含表面活性剂，其制备及其作为药物的应用
公开(公告)号：US5662938A
公开(公告)日：1997-09-02
申请号：US347380
申请日：1995-01-19
申请人： Michel Vert , Jean Coudane , Christine Ustariz , Gregoire Schwach
发明人： Michel Vert , Jean Coudane , Christine Ustariz , Gregoire Schwach
IPC分类号： A61K9/16 , A61K47/34 , G01R33/035 , H01L39/22
CPC分类号： G01R33/0354 , A61K9/1647 , Y10T428/2982
摘要： Bioresorbable microspheres and a process for making microspheres are provided. The microspheres are made of poly(hydroxy acid) having a bimodal distribution; at least one poly(hydroxy acid) having molecular mass of at least 20,000 and at least one poly(hydroxy acid) having a molecular mass of less than 5,000. The microspheres may contain an active substance for gradual release into a biosystem.
摘要翻译： PCT No.PCT / FR93 / 00576 Sec。 371日期1995年1月19日 102（e）日期1995年1月19日PCT Filed 1993年6月15日PCT公布。公开号WO93 / 25191 日期1993年12月23日提供了可再吸收的微球和制备微球的方法。微球由具有双峰分布的聚（羟基酸）制成; 分子量至少为20,000的至少一种聚（羟基酸）和至少一种分子量小于5,000的聚（羟基酸）。微球可以含有用于逐渐释放到生物系统中的活性物质。

3. 发明授权

US09283094B2 Polymer-based stent assembly 有权
公开(公告)号：US09283094B2
公开(公告)日：2016-03-15
申请号：US12764447
申请日：2010-04-21
申请人： Antoine LaFont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine LaFont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： A61F2/06 , A61F2/82 , A61L31/06 , A61F2/958 , A61F2/95
CPC分类号： A61F2/82 , A61F2/958 , A61F2002/9522 , A61F2210/0004 , A61L31/06 , C08L67/04
摘要： Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.

4. 发明申请

US20100260848A1 SYSTEM FOR CONTROLLED RELEASE OF AN ACTIVE PRINCIPLE AND METHOD FOR PREPARATION 有权
标题翻译：用于控制释放活性原理的系统和制备方法
公开(公告)号：US20100260848A1
公开(公告)日：2010-10-14
申请号：US12669252
申请日：2008-07-18
申请人： Michel Vert , Laurent Leclercq , Mahfoud Boustta
发明人： Michel Vert , Laurent Leclercq , Mahfoud Boustta
IPC分类号： A61K9/00 , A61K38/08 , A61P35/00 , A61P29/00
CPC分类号： A61K47/48207 , A61K9/204 , A61K9/2045 , A61K9/7007 , A61K47/593 , A61K47/645
摘要： A system for controlled release of an active principle, includes at least (a) a degradable polymer matrix which produces acid compounds and (b) at least one acid-sensitive complex of an active principle having at least one electrostatic charge and a complexing polyelectrolyte partner of opposite charge which complexes with the active principle. A method for preparation of such a system is described. The release of the active principle (7P) is prolonged over 18 days (ternary system PMLA/7P/PLAGA) in comparison to binary systems (7P/PLAGA) and (PMLA/7P).
摘要翻译：用于控制释放活性成分的体系包括至少（a）产生酸化合物的可降解聚合物基质和（b）至少一种具有至少一个静电荷的活性成分的酸敏感复合物和络合的聚电解质配偶体相反的电荷与活性成分复合。描述了这种系统的制备方法。与二元系统（7P / PLAGA）和（PMLA / 7P）相比，有效原理（7P）的释放延长了18天（三元系统PMLA / 7P / PLAGA）。

5. 发明申请

US20080028594A1 Stent Crimping 有权
标题翻译：支架压接
公开(公告)号：US20080028594A1
公开(公告)日：2008-02-07
申请号：US10541421
申请日：2005-06-02
申请人： Antoine Lafont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine Lafont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： B29C55/22 , B23P19/04
CPC分类号： A61F2/95 , A61F2002/9522 , Y10T29/49927 , Y10T29/53657
摘要： Methods of crimping polymeric stents that simultaneously apply a radial force to the stent to reduce the diameter of the stent and a longitudinal force to elongate of the stent. According to one such method, a stent is inserted into an elastic tube having an inner surface that defines a passage. The tube is pulled to cause stretching of the tube. When the tube is stretched, the inner surface of the tube engages an outer surface of the stent and applies simultaneous longitudinal and radial forces to the outer surface of the stent. The simultaneously applied longitudinal and radial forces simultaneously reduce a radial extent of the stent and increase a longitudinal extent of the stent.
摘要翻译：卷曲聚合物支架的方法，其同时向支架施加径向力以减小支架的直径和对支架延伸的纵向力。根据一种这样的方法，将支架插入具有限定通道的内表面的弹性管中。拉动管以引起管的拉伸。当管被拉伸时，管的内表面接合支架的外表面并且对支架的外表面施加同时的纵向和径向力。同时施加的纵向和径向力同时减小支架的径向范围并增加支架的纵向范围。

6. 发明申请

US20080027455A1 Composition for Injectable Cement Useful as Bone Replacement 有权
标题翻译：可注射水泥用作骨骼替代物的组合物
公开(公告)号：US20080027455A1
公开(公告)日：2008-01-31
申请号：US11579535
申请日：2005-04-29
申请人： Philippe Boudeville , Michel Vert , Sylvie Munier
发明人： Philippe Boudeville , Michel Vert , Sylvie Munier
IPC分类号： A61B17/58 , A61L24/00 , A61L27/42
CPC分类号： A61L24/0063 , A61L27/425 , A61L2400/06 , A61L2430/02
摘要： The invention relates to a composition for injectable cement, comprising a mineral sold phase, a separate liquid phase and, optionally, microparticles of a biocompatible and biodegradable polymer. The mineral solid phase comprises a mixture of powders with the molar composition: (CP)6 (CaO)y (SrCO3)z, [CP being CaHPO42H2O, CaHPO4, Ca1-xSrxHPO4, an equimolar mixture of bis(Ca(H2PO4)2, H2O and CaO, or a mixture of two or three of said compounds] and y+z=4?1. The liquid phase comprises pure apyrogeneic water or a saline aqueous solution with pH 4 to 9. The ratio L/P [volume of liquid phase/mass of solid mineral phase] is at least 0.4 ml/g. The above is of application as bone replacement.
摘要翻译：本发明涉及一种用于可注射水泥的组合物，其包含矿物质相，独立的液相和任选的生物相容性和生物可降解聚合物的微粒。矿物固相包含具有以下摩尔组成的粉末的混合物：（CP）6（CaO）y（SrCO 3）z，[CP 是CaHPO 4，2H 2 O，CaHPO 4，Ca 1-x Sr x HPO 4，（Ca（H 2）2 H 2）2 H 2 O 2的等摩尔混合物和 CaO，或两种或三种所述化合物的混合物]和y + z = 4？1，液相包括纯的apyrogeneic水或pH4至9的盐水溶液.L / P比率（液相体积 /质量的固体矿物相]至少为0.4ml / g。上述用作骨替代物。

7. 发明申请

US20060058863A1 Polymer-based stent assembly 有权
标题翻译：基于聚合物的支架组件
公开(公告)号：US20060058863A1
公开(公告)日：2006-03-16
申请号：US10508739
申请日：2004-04-02
申请人： Antoine LaFont , Serge Sante , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine LaFont , Serge Sante , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： A61F2/84 , A61F2/94
CPC分类号： A61F2/82 , A61F2/958 , A61F2002/9522 , A61F2210/0004 , A61L31/06 , C08L67/04
摘要： Methods for preparing a polymer-based stent assembly comprising an inflatable balloon catheter and a polymer-based stent resistant to relaxation-related negative recoil are provided. The methods comprise heating a polymeric cylindrical device which is at a final predetermined shape and diameter to a temperature sufficiently above the glass transition temperature (Tg) of the polymer and for a time sufficient to erase any memory of previous processing of the polymeric cylindrical device and then quenching the polymeric cylindrical device to provide an educated polymeric cylindrical device having a memory of the final predetermined diameter and shape, mounting the educated cylindrical device on an inflatable balloon catheter, reducing the diameter of the educated cylindrical device by heating to a temperature at or slightly above the Tg of the polymer while evenly applying pressure on the exterior surface of the wall of the cylindrical device, and then cooling the cylindrical device below the Tg of the polymer to provide a stent assembly comprising an inflatable balloon catheter and an expandable, educated, polymeric stent snugly and stably disposed thereon. Assemblies comprising an inflatable balloon and a polymer based stent that is substantially resistant to relaxation related recoil mounted snugly on the balloon are also provided.
摘要翻译：提供了一种制备基于聚合物的支架组件的方法，其包括可膨胀的气囊导管和抗放松相关的负反冲的基于聚合物的支架。该方法包括将最终预定形状和直径的聚合物圆柱形装置加热到足够高于聚合物的玻璃化转变温度（Tg）的温度，并且足以消除聚合物圆柱形装置的先前处理的任何记忆的时间，以及然后淬灭聚合物圆柱形装置，以提供具有最终预定直径和形状的记忆的受过教育的聚合物圆柱形装置，将受过教育的圆柱形装置安装在可充气气囊导管上，通过加热至或在其上的温度减小受过教育的圆柱形装置的直径，稍微高于聚合物的Tg，同时在圆柱形装置的壁的外表面上均匀地施加压力，然后将圆柱形装置冷却到聚合物的Tg以下，以提供包括可充气气囊导管和可扩展的受过教育的，聚合物支架紧贴且稳定地设置在其上。还提供了包括充气气囊和基于聚合物的支架的组件，其基本上抵抗紧贴在气囊上的松弛相关反冲。

8. 发明授权

US08709481B2 System for controlled release of an active principle and method for preparation 有权
标题翻译：控制释放活性成分的方法及制备方法
公开(公告)号：US08709481B2
公开(公告)日：2014-04-29
申请号：US12669252
申请日：2008-07-18
申请人： Michel Vert , Laurent Leclercq , Mahfoud Boustta
发明人： Michel Vert , Laurent Leclercq , Mahfoud Boustta
IPC分类号： A61K9/14 , A61K47/48 , A61K9/20
CPC分类号： A61K47/48207 , A61K9/204 , A61K9/2045 , A61K9/7007 , A61K47/593 , A61K47/645
摘要： A system for controlled release of an active principle, includes at least (a) a degradable polymer matrix which produces acid compounds and (b) at least one acid-sensitive complex of an active principle having at least one electrostatic charge and a complexing polyelectrolyte partner of opposite charge which complexes with the active principle. A method for preparation of such a system is described. The release of the active principle (7P) is prolonged over 18 days (ternary system PMLA/7P/PLAGA) in comparison to binary systems (7P/PLAGA) and (PMLA/7P).
摘要翻译：用于控制释放活性成分的体系包括至少（a）产生酸化合物的可降解聚合物基质和（b）至少一种具有至少一个静电荷的活性成分的酸敏感复合物和络合的聚电解质配偶体相反的电荷与活性成分复合。描述了这种系统的制备方法。与二元系统（7P / PLAGA）和（PMLA / 7P）相比，有效原理（7P）的释放延长了18天（三元系统PMLA / 7P / PLAGA）。

9. 发明授权

US07743481B2 Stent crimping 有权
标题翻译：支架压接
公开(公告)号：US07743481B2
公开(公告)日：2010-06-29
申请号：US10541421
申请日：2005-06-02
申请人： Antoine Lafont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
发明人： Antoine Lafont , Serge Piranda , Patrick Sabaria , Tahmer Sharkawi , Michel Vert
IPC分类号： B21D39/00 , B23P19/04
CPC分类号： A61F2/95 , A61F2002/9522 , Y10T29/49927 , Y10T29/53657
摘要： Methods of crimping polymeric stents that simultaneously apply a radial force to the stent to reduce the diameter of the stent and a longitudinal force to elongate of the stent. According to one such method, a stent is inserted into an elastic tube having an inner surface that defines a passage. The tube is pulled to cause stretching of the tube. When the tube is stretched, the inner surface of the tube engages an outer surface of the stent and applies simultaneous longitudinal and radial forces to the outer surface of the stent. The simultaneously applied longitudinal and radial forces simultaneously reduce a radial extent of the stent and increase a longitudinal extent of the stent.
摘要翻译：卷曲聚合物支架的方法，其同时向支架施加径向力以减小支架的直径和对支架延伸的纵向力。根据一种这样的方法，将支架插入具有限定通道的内表面的弹性管中。拉动管以引起管的拉伸。当管被拉伸时，管的内表面接合支架的外表面并且对支架的外表面施加同时的纵向和径向力。同时施加的纵向和径向力同时减小支架的径向范围并增加支架的纵向范围。

10. 发明申请

US20090291116A1 Biocompatible and Biodegradable Porous Matrix in Particular Useful for Tissue Reconstruction 审中-公开
标题翻译：生物相容性和生物降解性多孔基质特别适用于组织重建
公开(公告)号：US20090291116A1
公开(公告)日：2009-11-26
申请号：US12083347
申请日：2006-10-10
申请人： Daniel Casellas , Henri Garreau , Xavier Garric , Jean-Pierre Moles , Michel Vert
发明人： Daniel Casellas , Henri Garreau , Xavier Garric , Jean-Pierre Moles , Michel Vert
IPC分类号： A61L31/16 , C08J9/00 , C12N5/00 , C12Q1/02 , A61K35/12
CPC分类号： A61L27/18 , A61L27/3804 , A61L27/3843 , A61L27/56 , A61L27/60 , C08J9/08 , C08J2207/10 , C08J2367/04 , C08J2371/02 , C08L67/04 , C08L71/02
摘要： The invention mainly concerns a biocompatible and biodegradable porous matrix, characterized in that it is made of a three-block sequenced copolymer of formula (I): X G Y (I), wherein: G is a non-hydroxylated hydrophilic linear block, and X and Y represent respectively a hydrophobic linear polyester block. The invention further concerns the use of said matrix for coating tissue reconstruction after loss of substance or bioactive dressings.
摘要翻译：本发明主要涉及生物相容性和可生物降解的多孔基质，其特征在于其由式（I）的三嵌段测序共聚物：XGY（I）制成，其中：G是非羟基化亲水直链嵌段，X和 Y分别表示疏水性线性聚酯嵌段。本发明还涉及使用所述基质在物质或生物活性敷料损失后涂覆组织重建。

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