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1. 发明申请

US20100211135A1 SYSTEMS AND METHODS FOR DELIVERING NEURAL THERAPY CORRELATED WITH PATIENT STATUS 有权
标题翻译：用于输送与患者状态相关的神经治疗的系统和方法
公开(公告)号：US20100211135A1
公开(公告)日：2010-08-19
申请号：US12703683
申请日：2010-02-10
申请人： Anthony V. Caparso , Jon Parker , Andre B. Walker , Yougandh Chitre
发明人： Anthony V. Caparso , Jon Parker , Andre B. Walker , Yougandh Chitre
IPC分类号： A61N1/02
CPC分类号： A61N1/36139 , A61N1/025 , A61N1/3605 , A61N1/36071 , A61N1/36132 , A61N1/37235 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H10/60 , G16H20/40 , G16H20/70
摘要： Therapy systems for treating a patient are disclosed. Representative therapy systems include an implantable pulse generator, a signal delivery device electrically coupled to the pulse generator, and a remote control in electrical communication with the implantable pulse generator. The pulse generator can have a computer-readable medium containing instructions for performing a process that comprises collecting the patient status and stimulation parameter; analyzing the collected patient status and stimulation parameter; and establishing a preference baseline containing a preferred stimulation parameter corresponding to a particular patient status.
摘要翻译：公开了治疗患者的治疗系统。代表性治疗系统包括可植入脉冲发生器，电耦合到脉冲发生器的信号传递装置以及与可植入脉冲发生器电通信的遥控器。脉冲发生器可以具有包含用于执行包括收集患者状态和刺激参数的过程的指令的计算机可读介质; 分析收集的患者状况和刺激参数; 以及建立包含对应于特定患者状态的优选刺激参数的偏好基线。

2. 发明授权

US08355797B2 Systems and methods for delivering neural therapy correlated with patient status 有权
公开(公告)号：US08355797B2
公开(公告)日：2013-01-15
申请号：US12703683
申请日：2010-02-10
申请人： Anthony V. Caparso , Jon Parker , Andre B. Walker , Yougandh Chitre
发明人： Anthony V. Caparso , Jon Parker , Andre B. Walker , Yougandh Chitre
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/025 , A61N1/3605 , A61N1/36071 , A61N1/36132 , A61N1/37235 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H10/60 , G16H20/40 , G16H20/70
摘要： Therapy systems for treating a patient are disclosed. Representative therapy systems include an implantable pulse generator, a signal delivery device electrically coupled to the pulse generator, and a remote control in electrical communication with the implantable pulse generator. The pulse generator can have a computer-readable medium containing instructions for performing a process that comprises collecting the patient status and stimulation parameter; analyzing the collected patient status and stimulation parameter; and establishing a preference baseline containing a preferred stimulation parameter corresponding to a particular patient status.

3. 发明授权

US08509906B2 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 有权
标题翻译：用于产生用于治疗疼痛和/或其他患者病症的异步神经反应的系统和方法
公开(公告)号：US08509906B2
公开(公告)日：2013-08-13
申请号：US13544727
申请日：2012-07-09
申请人： Andre B. Walker , Zi-Ping Fang , Anthony V. Caparso
发明人： Andre B. Walker , Zi-Ping Fang , Anthony V. Caparso
IPC分类号： A61N1/00
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
摘要翻译：公开了用于产生用于治疗疼痛和/或其他患者状况的异步神经反应的系统和方法。根据特定实施例的方法包括选择阈值频率以上的目标刺激频率，阈值频率对应于目标感觉神经群体的神经元的不应期。该方法可以进一步包括通过在刺激频率下将电信号引导到目标感觉神经群体的多个感觉神经元来产生感觉异常感觉，感觉神经群体的个体神经元在不同时间完成相应的单个不应期，导致对电信号的异步感觉神经元响应。

4. 发明授权

US08255057B2 Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions 有权
标题翻译：用于产生用于治疗疼痛和/或其他患者病症的异步神经反应的系统和方法
公开(公告)号：US08255057B2
公开(公告)日：2012-08-28
申请号：US12362244
申请日：2009-01-29
申请人： Zi-Ping Fang , Anthony V. Caparso , Andre B. Walker
发明人： Zi-Ping Fang , Anthony V. Caparso , Andre B. Walker
IPC分类号： A61N1/00
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
摘要翻译：公开了用于产生用于治疗疼痛和/或其他患者状况的异步神经反应的系统和方法。根据特定实施例的方法包括选择阈值频率以上的目标刺激频率，阈值频率对应于目标感觉神经群体的神经元的不应期。该方法可以进一步包括通过在刺激频率下将电信号引导到目标感觉神经群体的多个感觉神经元来产生感觉异常感觉，感觉神经群体的个体神经元在不同时间完成相应的单个不应期，导致对电信号的异步感觉神经元响应。

5. 发明申请

US20130041425A1 SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS 有权
公开(公告)号：US20130041425A1
公开(公告)日：2013-02-14
申请号：US13544727
申请日：2012-07-09
申请人： Zi-Ping Fang , Anthony V. Caparso , Andre B. Walker
发明人： Zi-Ping Fang , Anthony V. Caparso , Andre B. Walker
IPC分类号： A61N1/34
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

6. 发明申请

US20100191307A1 SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS 有权
标题翻译：用于产生异丙酚神经反应以治疗疼痛和/或其他患者病症的系统和方法
公开(公告)号：US20100191307A1
公开(公告)日：2010-07-29
申请号：US12362244
申请日：2009-01-29
申请人： Zi-Ping Fang , Anthony V. Caparso , Andre B. Walker
发明人： Zi-Ping Fang , Anthony V. Caparso , Andre B. Walker
IPC分类号： A61N1/34
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
摘要翻译：公开了用于产生用于治疗疼痛和/或其他患者状况的异步神经反应的系统和方法。根据特定实施例的方法包括选择阈值频率以上的目标刺激频率，阈值频率对应于目标感觉神经群体的神经元的不应期。该方法可以进一步包括通过在刺激频率下将电信号引导到目标感觉神经群体的多个感觉神经元来产生感觉异常感觉，感觉神经群体的个体神经元在不同时间完成相应的单个不应期，导致对电信号的异步感觉神经元响应。

7. 发明申请

US20130211487A1 MULTI-FREQUENCY NEURAL TREATMENTS AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20130211487A1
公开(公告)日：2013-08-15
申请号：US13620307
申请日：2012-09-14
申请人： Zi-Ping Fang , Anthony V. Caparso , Brain J. Erickson , Konstantinos Alataris , Andre B. Walker
发明人： Zi-Ping Fang , Anthony V. Caparso , Brain J. Erickson , Konstantinos Alataris , Andre B. Walker
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/36071 , A61N1/36171 , A61N1/3787
摘要： Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

8. 发明授权

US08630716B2 Systems and methods for providing neural stimulation transitions 有权
标题翻译：用于提供神经刺激过渡的系统和方法
公开(公告)号：US08630716B2
公开(公告)日：2014-01-14
申请号：US13587654
申请日：2012-08-16
申请人： Marina V. Brockway , Paul A. Haefner , Anthony V. Caparso , Wondimeneh Tesfayesus
发明人： Marina V. Brockway , Paul A. Haefner , Anthony V. Caparso , Wondimeneh Tesfayesus
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36117
摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.
摘要翻译：方法实施例包括产生用于神经刺激治疗的神经刺激信号。在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现了升温协议和斜降协议两者。加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。

9. 发明授权

US08494641B2 Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism 有权
标题翻译：可植入神经刺激器，具有整体密封电子外壳，电路基板，单片馈通，引线组件和锚定机构
公开(公告)号：US08494641B2
公开(公告)日：2013-07-23
申请号：US12765712
申请日：2010-04-22
申请人： Carl Lance Boling , Benjamin David Pless , Ryan Powell , Anthony V. Caparso
发明人： Carl Lance Boling , Benjamin David Pless , Ryan Powell , Anthony V. Caparso
IPC分类号： A61N1/34
CPC分类号： A61N1/3606 , A61N1/0526 , A61N1/0546 , A61N1/0551 , A61N1/0558 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36075 , A61N1/36078 , A61N1/36082 , A61N1/37217 , A61N1/375 , A61N1/3754 , A61N1/3787
摘要： An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or other neurological disorders. One aspect of the implantable medical device is that it includes an electronics enclosure, a substrate integral to the electronics enclosure, and a monolithic feed-through integral to the electronics enclosure and the substrate. In some embodiments, the implantable medical device can include a fixation apparatus for attaching the device to a patient.
摘要翻译：为了抑制或预防患者的疼痛，运动障碍，癫痫，脑血管疾病，自身免疫性疾病，睡眠障碍，自主神经障碍，异常代谢状态，肌肉系统疾病和神经精神障碍，提供了可植入医疗装置。可植入医疗装置可以是构造成植入在脑神经上或附近的神经刺激器，以治疗头痛或其它神经障碍。可植入医疗设备的一个方面是其包括电子外壳，与电子外壳一体的基板，以及与电子外壳和基板一体化的整体式馈通。在一些实施例中，可植入医疗装置可以包括用于将装置附接到患者的固定装置。

10. 发明授权

US08457734B2 System and method for neural stimulation 有权
公开(公告)号：US08457734B2
公开(公告)日：2013-06-04
申请号：US11468135
申请日：2006-08-29
申请人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
发明人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

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