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1. 发明申请

US20050112671A1 FRET efficiency methods 审中-公开
标题翻译： FRET效率方法
公开(公告)号：US20050112671A1
公开(公告)日：2005-05-26
申请号：US10984189
申请日：2004-11-08
申请人： Anthony Maletta , Ian McBee , Xiaojian Zhao , Martin Fuchs
发明人： Anthony Maletta , Ian McBee , Xiaojian Zhao , Martin Fuchs
IPC分类号： C07H21/04 , C12N20060101 , C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2525/197
摘要： The invention relates to methods and products for analyzing polymers using FRET. In particular the methods involve improvements in FRET signaling.
摘要翻译：本发明涉及使用FRET分析聚合物的方法和产品。特别地，这些方法涉及改进FRET信号。

2. 发明申请

US20050112595A1 Methods and apparati using single polymer analysis 有权
标题翻译：使用单一聚合物分析的方法和设备
公开(公告)号：US20050112595A1
公开(公告)日：2005-05-26
申请号：US10773084
申请日：2004-02-05
申请人： Xiaojian Zhao , Jeffrey Randall , Bijit Kundu , Jessica Kesty , Steven Gullans , Eugene Chan , Martin Fuchs , Jenny Rooke
发明人： Xiaojian Zhao , Jeffrey Randall , Bijit Kundu , Jessica Kesty , Steven Gullans , Eugene Chan , Martin Fuchs , Jenny Rooke
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , C07H21/02 , C07H21/04 , C12Q1/6818 , C12Q1/6825 , C12Q1/6834 , C12Q2565/101 , C12Q2565/601 , C12Q2521/301 , C12Q2563/107 , C12Q2565/619 , C12Q2565/629 , C12Q2535/125 , C12Q2537/143
摘要： The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.
摘要翻译：本发明涉及用于分析和表征单一聚合物如核酸分子的方法。在优选的实施方案中，使用单分子检测和分析系统分析单分子。

3. 发明授权

US11196322B2 Method for producing an electric motor and electric motor 有权
公开(公告)号：US11196322B2
公开(公告)日：2021-12-07
申请号：US16321627
申请日：2017-06-20
申请人： Martin Fuchs , Johannes Daniel Knöppel , Nils Wilhelm , Alex Wist , David Müller
发明人： Martin Fuchs , Johannes Daniel Knöppel , Nils Wilhelm , Alex Wist , David Müller
IPC分类号： H02K3/50 , H02K11/25
摘要： In a method for manufacturing an electric motor comprising a rotor and a stator a placeholder for a temperature sensor is inserted in the axial direction between a first coil layer and an adjacent second coil layer of a winding head such that the placeholder is situated in a gap-shaped recess extending between the first and the second coil layers, the first coil layer is then pressed onto a circumferential surface of the placeholder and onto the second coil layer and is plastically deformed such that a space between the lateral surfaces of the two coil layers and the circumferential surface of the placeholder is reduced, and a contact surface between the lateral surface of the first coil layer and the circumferential surface of the placeholder is enlarged. By removing the placeholder, a receiving chamber is subsequently formed in the winding head, into which a temperature sensor is then inserted.

4. 发明授权

US08921102B2 Devices and methods for enrichment and alteration of circulating tumor cells and other particles 有权
标题翻译：用于富集和改变循环肿瘤细胞和其他颗粒的装置和方法
公开(公告)号：US08921102B2
公开(公告)日：2014-12-30
申请号：US11322791
申请日：2005-12-29
申请人： Martin Fuchs , Ying-Xin Wang , Yi-Shuian Huang , Neil X. Krueger
发明人： Martin Fuchs , Ying-Xin Wang , Yi-Shuian Huang , Neil X. Krueger
IPC分类号： C12N5/00 , C12N5/02 , C12N13/00 , A01N1/02 , B01L3/00 , G01N33/569 , G01N33/543 , G01N33/574 , B82Y10/00 , B82Y5/00
CPC分类号： G01N33/57484 , B01L3/502707 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , B01L2400/086 , B82Y5/00 , B82Y10/00 , G01N33/54366 , G01N33/56966 , G01N33/57492 , G01N2333/705 , G01N2333/70589 , G01N2333/71 , G01N2800/52
摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.
摘要翻译：本发明的特征在于用于检测，富集和分析循环肿瘤细胞和其他颗粒的装置和方法。本发明进一步具有通过分析来自受试者的细胞样品来诊断受试者中病症例如癌症的方法。

5. 发明申请

US20130324418A1 Analysis Of Rare Cell-Enriched Samples 审中-公开
标题翻译：稀有细胞富集样品的分析
公开(公告)号：US20130324418A1
公开(公告)日：2013-12-05
申请号：US13737730
申请日：2013-01-09
申请人： Martin Fuchs , Ravi Kapur , Mehmet Toner , Zihua Wang
发明人： Martin Fuchs , Ravi Kapur , Mehmet Toner , Zihua Wang
IPC分类号： G01N33/50
CPC分类号： C12Q1/6886 , C12Q2600/156 , G01N1/405 , G01N33/5005 , G01N33/5091 , G01N33/57484 , G01N2015/1006 , G01N2015/1087 , G01N2800/385
摘要： The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g., epithelial cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject by analyzing a cellular sample from the subject.
摘要翻译：本发明涉及用于检测，富集和分析存在于血液中的稀有细胞例如上皮细胞的方法。本发明进一步具有分析稀有细胞以通过分析来自受试者的细胞样品来确定受试者中异常，疾病或病症的存在的方法。

6. 发明申请

US20100054113A1 Method for Selection of an Optimized Number of Subscribers in Mobile Radio Systems 有权
标题翻译：选择移动无线电系统中优化用户数量的方法
公开(公告)号：US20100054113A1
公开(公告)日：2010-03-04
申请号：US11991735
申请日：2006-09-22
申请人： Martin Haardt , Martin Fuchs , Giovanni Del Galdo
发明人： Martin Haardt , Martin Fuchs , Giovanni Del Galdo
IPC分类号： H04L12/26 , H04J11/00
CPC分类号： H04B7/0619 , H04B7/0452
摘要： This invention comprises a method of little complexity for selection of an optimized number of subscribers for transmission in wire-free message transmission systems having a plurality of antennas at the base station and having one or more antennas at the receivers, as well as space-division multiple access (SDMA) in conjunction with multiple access in the time domain or frequency domain. Subscribers with channels with little spatial correlation art selected for operation in the same time slot or frequency slot. In order to increase the throughput of the SDMA transmission method, with the relationship between the group size and the mean transmission power being taken into account. The invention interacts both with SDMA methods which do not allow any interference (Zero Forcing) and with methods with residual interference. It is based on a novel interpretation of the ZF principle with the aid of orthogonal projection matrices, which allow the channel quality to be estimated with much less computation complexity, based on use or the transmission method. The possible subscriber combinations are sorted efficiently with the aid or a tree-like search algorithm. The method makes use of perfect channel knowledge or alternatively averaged channel statistics. Quality of service requirements for the subscriber as well as fairness criteria can be taken into account.
摘要翻译：本发明包括一种在基站具有多个天线并且在接收机处具有一个或多个天线的无线消息传输系统中用于选择用于传输的优化用户数目的复杂度少的方法，以及空分多次访问（SDMA）结合时域或频域中的多次访问。具有少量空间相关艺术的信道的用户被选择用于在相同的时隙或频率槽中操作。为了提高SDMA传输方法的吞吐量，考虑到组大小和平均传输功率之间的关系。本发明与不允许任何干扰（零强制）的SDMA方法和具有残留干扰的方法相互作用。它是借助于正交投影矩阵对ZF原理的一种新颖的解释，这使得基于使用或传输方法，可以以更少的计算复杂度来估计信道质量。可能的用户组合通过辅助或树状搜索算法有效地排序。该方法利用完美的频道知识或平均的频道统计。可以考虑到用户的服务质量要求以及公平性标准。

7. 发明申请

US20080245729A1 Process and Device for Aerobic-Thermophilic Stabilization and Disinfection of Sludge 失效
标题翻译：有氧 - 嗜热稳定和消毒污泥的工艺和装置
公开(公告)号：US20080245729A1
公开(公告)日：2008-10-09
申请号：US10586222
申请日：2006-04-21
申请人： Leonhard Fuchs , Martin Fuchs
发明人： Leonhard Fuchs , Martin Fuchs
IPC分类号： C02F3/12
CPC分类号： C02F3/121 , C02F3/006 , C02F3/1221 , C02F3/26 , C02F11/02 , C02F2209/02 , C02F2209/04 , C02F2209/22 , C02F2209/44 , C02F2301/106 , C02F2303/02 , C02F2303/04 , Y02W10/15 , Y02W10/27
摘要： A process for the stabilization and disinfection of sludge wherein a) raw sludge having a dry matter content of from 3 to 7% by weight is fed continuously or quasi-continuously into a first stage, where it remains for an average retention time of three to ten days under aerobic-thermophilic conditions to obtain a partially stabilized sludge; and b) the partially stabilized sludge is fed into a second stage in which disinfection of the partially stabilized sludge is effected at temperatures of at least 50° C., wherein prior to discharging, there is no charging until the partially stabilized sludge has been disinfected.
摘要翻译：一种用于污泥稳定化和消毒的方法，其中a）将干物质含量为3至7重量％的原始污泥连续或准连续地进料到第一阶段，其中保持平均停留时间为3至在好氧 - 嗜热条件下10天，以获得部分稳定的污泥; 和b）将部分稳定的污泥进料到第二阶段，其中在至少50℃的温度下进行部分稳定的污泥的消毒，其中在排出之前，直到部分稳定的污泥已经被消毒。

8. 发明授权

US07351538B2 Systems and methods for detecting and analyzing polymers 有权
公开(公告)号：US07351538B2
公开(公告)日：2008-04-01
申请号：US11210155
申请日：2005-08-23
申请人： Martin Fuchs , John Harris , Ray Meyers
发明人： Martin Fuchs , John Harris , Ray Meyers
IPC分类号： C12Q1/68 , C12M1/00 , C07H21/02 , C07H21/04
CPC分类号： G01N21/6428 , C12Q1/6816 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , Y10T436/143333 , C12Q2565/102
摘要： A detection system and methods for improving the ability of the detection system to recognize labels that are disposed on a polymer. Embodiments of the invention include schemes for selecting emitters and labels used within the system in a manner that allows an increase in the number of distinct labels that can be used together in a system. In other embodiments, the detection system and methods are directed to identifying portions of a detection signal that may be associated with extra labels residing within a detection zone. In other embodiments, the detection system and methods relate to using wide field imaging detectors while reducing out of focus noise contributions to detection signals of the system. Still, other embodiments relate to the use of linear array detectors to detect labels.

9. 发明申请

US20060228747A1 Systems and methods for detecting and analyzing polymers 有权
标题翻译：用于检测和分析聚合物的系统和方法
公开(公告)号：US20060228747A1
公开(公告)日：2006-10-12
申请号：US11448411
申请日：2006-06-07
申请人： Martin Fuchs , John Harris , Ray Meyer
发明人： Martin Fuchs , John Harris , Ray Meyer
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N21/6428 , C12Q1/6816 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , Y10T436/143333 , C12Q2565/102
摘要： A detection system and methods for improving the ability of the detection system to recognize labels that are disposed on a polymer. Embodiments of the invention include schemes for selecting emitters and labels used within the system in a manner that allows an increase in the number of distinct labels that can be used together in a system. In other embodiments, the detection system and methods are directed to identifying portions of a detection signal that may be associated with extra labels residing within a detection zone. In other embodiments, the detection system and methods relate to using wide field imaging detectors while reducing out of focus noise contributions to detection signals of the system. Still, other embodiments relate to the use of linear array detectors to detect labels
摘要翻译：一种用于提高检测系统识别设置在聚合物上的标签的能力的检测系统和方法。本发明的实施例包括以允许在系统中可以一起使用的不同标签的数量增加的方式选择系统内使用的发射器和标签的方案。在其他实施例中，检测系统和方法旨在识别可能与驻留在检测区域内的额外标签相关联的检测信号的部分。在其他实施例中，检测系统和方法涉及使用宽场成像检测器，同时减少对系统的检测信号的焦点噪声贡献。仍然，其它实施例涉及使用线性阵列检测器来检测标签

10. 发明申请

US20050053944A1 Methods and kit for hybridization anaylsis using peptide nucleic acid probes 审中-公开
标题翻译：使用肽核酸探针进行杂交分析的方法和试剂盒
公开(公告)号：US20050053944A1
公开(公告)日：2005-03-10
申请号：US10636343
申请日：2003-08-07
申请人： Martin Fuchs , Michael Egholm , Heather O'Keefe , Xian-Wei Yao
发明人： Martin Fuchs , Michael Egholm , Heather O'Keefe , Xian-Wei Yao
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , C12Q1/6813 , G01N27/447 , G01N33/566 , C07K14/47
CPC分类号： G01N27/44726 , C12Q1/6813 , G01N27/447 , C12Q2525/113 , C12Q2523/113 , C12Q2565/125 , C12Q2565/629 , C12Q2565/107
摘要： A method composition and apparatus for the hybridization and separation of molecules having a desired target sequence in a sample by contacting a sample of single stranded nucleic acids with a detectable PNA probe having a sequence complementary to the target sequence so that the target sequence, if present, will hybridize with the detectable probe to form a detectable duplex, and then separating the duplex in a denaturing medium from unbound sample components by electrophoresis. The invention also relates to methods compositions and apparatus for the hybridization and separation of molecules having a desired target sequence in a mixed sample of single stranded nucleic acids and their complementary strands by contacting the sample with a detectable PNA probe.
摘要翻译：一种方法组合物和装置，用于通过使单链核酸样品与具有与靶序列互补的序列的可检测PNA探针接触来杂交和分离样品中具有所需靶序列的分子，使得靶序列（如果存在）将与可检测的探针杂交以形成可检测的双链体，然后通过电泳将变性培养基中的双链体与未结合的样品组分分离。本发明还涉及用于通过使样品与可检测的PNA探针接触来在单链核酸及其互补链的混合样品中杂交和分离具有所需靶序列的分子的方法组合物和装置。

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