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1. 发明申请

US20090142805A1 High expression cell line that eliminates gene amplification 审中-公开
标题翻译：消除基因扩增的高表达细胞系
公开(公告)号：US20090142805A1
公开(公告)日：2009-06-04
申请号：US12006960
申请日：2008-01-08
申请人： Anthony DiLeo , William Kopaciewicz
发明人： Anthony DiLeo , William Kopaciewicz
IPC分类号： C12P21/08 , C12P21/00 , C12M1/00
CPC分类号： C12N15/67
摘要： The present invention relates to methods, cell lines and kits for producing high titers of recombinant proteins without the need for gene amplification.
摘要翻译：本发明涉及用于产生高滴度重组蛋白质的方法，细胞系和试剂盒，而不需要基因扩增。

2. 发明授权

US08221522B2 Filter with memory, communication and pressure sensor 有权
标题翻译：过滤器内存，通讯和压力传感器
公开(公告)号：US08221522B2
公开(公告)日：2012-07-17
申请号：US12894652
申请日：2010-09-30
申请人： Anthony DiLeo , John Dana Hubbard
发明人： Anthony DiLeo , John Dana Hubbard
IPC分类号： B01D46/46
CPC分类号： B01D35/143 , B01D61/147 , B01D61/22 , B01D65/102 , B01D65/104 , B01D2201/291 , B01D2201/52 , B01D2201/56 , B01D2311/14 , B01D2313/44
摘要： The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible.
摘要翻译：本发明描述了一种用于精确测量过滤器壳体内的压力的系统和方法。压力传感器和通信装置被联接以便能够在使用中测量和传送过滤器壳体内的压力。该系统可以包括集成通信设备和压力传感器的单个部件。或者，系统可以包括彼此通信的分离的传感器和发射器部件。在另一个实施例中，可以将存储元件添加到系统，从而允许设备存储一组压力值。使用此设备有利于许多应用程序。例如，原位读取压力值的能力允许在没有附加设备的情况下执行完整性测试。此外，可以对多过滤器配置中的各个过滤器进行完整性测试。

3. 发明授权

US08058027B2 Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants 失效
标题翻译：在一种或多种污染物水平降低的情况下生产重组蛋白的细胞培养方法
公开(公告)号：US08058027B2
公开(公告)日：2011-11-15
申请号：US12006984
申请日：2008-01-08
申请人： Anthony DiLeo
发明人： Anthony DiLeo
IPC分类号： C12P21/06 , C12P21/04
CPC分类号： C12P21/02 , C12N2501/48 , C12N2510/02
摘要： The invention relates to cell culture methods, kits and cell lines for producing recombinant products, e.g. therapeutic proteins and antibodies, in the presence of reduced levels of one or more contaminants and further to methods of purifying those products.
摘要翻译：本发明涉及用于生产重组产物的细胞培养方法，试剂盒和细胞系，例如。治疗性蛋白质和抗体，在一种或多种污染物水平降低的情况下，以及进一步纯化这些产物的方法。

4. 发明申请

US20110100134A1 FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR 审中-公开
公开(公告)号：US20110100134A1
公开(公告)日：2011-05-05
申请号：US12984341
申请日：2011-01-04
申请人： Anthony DiLeo , John Dana Hubbard
发明人： Anthony DiLeo , John Dana Hubbard
IPC分类号： G01F1/00
CPC分类号： B01D35/143 , B01D61/147 , B01D61/22 , B01D65/102 , B01D65/104 , B01D2201/291 , B01D2201/52 , B01D2201/56 , B01D2311/14 , B01D2313/44
摘要： The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible.

5. 发明申请

US20110036782A1 FILTER WITH MEMORY, COMMUNICATION AND TEMPERATURE SENSOR 审中-公开
标题翻译：过滤器与记忆，通讯和温度传感器
公开(公告)号：US20110036782A1
公开(公告)日：2011-02-17
申请号：US12703246
申请日：2010-02-10
申请人： Anthony DiLeo
发明人： Anthony DiLeo
IPC分类号： B01D35/143
CPC分类号： B01D46/448 , A61L2/07 , A61L2/28 , B01D29/114 , B01D35/143 , B01D46/429 , B01D46/46 , B01D2201/291 , B01D2201/54 , B01D2201/56
摘要： The present invention describes a system and method for accurately measuring the temperature of a filter element. A temperature transducer, and a communications device are coupled so as to be able to measure and transmit the temperature of a filter element while in use. This system can comprise a single component, integrating both the communication device and the temperature transducer. Alternatively, the system can comprise separate temperature transducer and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of temperature values. The use of this device is beneficial to many applications. For example, the ability to read filter temperatures in situ allows improved Sterilization-In-Place (SIP) protocol compliance, since the temperatures of actual filter elements can be directly measured, rather than interpolated as is done currently.
摘要翻译：本发明描述了一种用于精确测量过滤元件温度的系统和方法。温度传感器和通信设备被耦合以便能够在使用中测量和传输过滤元件的温度。该系统可以包括集成通信设备和温度传感器的单个组件。或者，系统可以包括彼此通信的分开的温度传感器和发射器部件。在另一个实施例中，可以将存储元件添加到系统，从而允许设备存储一组温度值。使用此设备有利于许多应用程序。例如，原位读取过滤器温度的能力可以改善就地杀菌（SIP）协议标准，因为可以直接测量实际过滤器元件的温度，而不是如当前所进行的那样内插。

6. 发明申请

US20100201521A1 SAMPLING SYSTEM 有权
标题翻译：采样系统
公开(公告)号：US20100201521A1
公开(公告)日：2010-08-12
申请号：US12452747
申请日：2008-07-18
申请人： George Adams , John Dana Hubbard , Aaron Burke , Anthony DiLeo
发明人： George Adams , John Dana Hubbard , Aaron Burke , Anthony DiLeo
IPC分类号： G08B13/14
CPC分类号： G01N35/00732 , B01L3/505 , B01L3/545 , B01L2300/022 , C12M33/00 , C12M33/06 , C12M37/00 , G01N1/18 , G01N2001/1031 , G01N2001/205 , G01N2035/00782 , G01N2035/00801
摘要： The present invention uses a wireless memory/communication device at least on the one or more sample storage devices, preferably on both the one or more sample storage devices and the sampling holder, optionally the port on the equipment as well. Data such as that relating to the vessel, the location of the port on the vessel, the device, its manufacture date or lot number, the date of the installation, sterilization and/or taking of a sample along with the person who installed the device and/or took the sample can be read and preferably added to the wireless device when a read/write type of device as these events occur through a scanner/reader/writer device (fixed or hand held). The sample storage device in the laboratory can also then be read and recorded to track the sample storage device's life.
摘要翻译：本发明至少在至少一个或多个样本存储设备上使用无线存储器/通信设备，优选地在一个或多个采样存储设备和采样保持器两者上，可选地，设备上的端口也使用无线存储器/通信设备。与船舶有关的数据，船上港口的位置，设备，其制造日期或批号，安装日期，灭菌和/或采样样品以及安装设备的人员当通过扫描仪/读写器装置（固定或手持）发生这些事件的读/写类型的装置时，可以读取样本并且优选地添加到无线装置。实验室中的样品存储设备也可以被读取和记录，以跟踪样品存储设备的使用寿命。

7. 发明申请

US20110247971A1 FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR 审中-公开
公开(公告)号：US20110247971A1
公开(公告)日：2011-10-13
申请号：US13164894
申请日：2011-06-21
申请人： Anthony DiLeo , John Dana Hubbard
发明人： Anthony DiLeo , John Dana Hubbard
IPC分类号： B01D35/14
CPC分类号： B01D35/143 , B01D61/147 , B01D61/22 , B01D65/102 , B01D65/104 , B01D2201/291 , B01D2201/52 , B01D2201/56 , B01D2311/14 , B01D2313/44
摘要： The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible.

8. 发明申请

US20110026560A1 FILTER WITH MEMORY, COMMUNICATION AND TEMPERATURE SENSOR 审中-公开
公开(公告)号：US20110026560A1
公开(公告)日：2011-02-03
申请号：US12901547
申请日：2010-10-10
申请人： Anthony DiLeo
发明人： Anthony DiLeo
IPC分类号： G01K1/00
CPC分类号： B01D46/448 , A61L2/07 , A61L2/28 , B01D29/114 , B01D35/143 , B01D46/429 , B01D46/46 , B01D2201/291 , B01D2201/54 , B01D2201/56
摘要： The present invention describes a system and method for accurately measuring the temperature of a filter element. A temperature transducer, and a communications device are coupled so as to be able to measure and transmit the temperature of a filter element while in use. This system can comprise a single component, integrating both the communication device and the temperature transducer. Alternatively, the system can comprise separate temperature transducer and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of temperature values. The use of this device is beneficial to many applications. For example, the ability to read filter temperatures in situ allows improved Sterilization-In-Place (SIP) protocol compliance, since the temperatures of actual filter elements can be directly measured, rather than interpolated as is done currently.

9. 发明申请

US20110016953A1 FILTER WITH MEMORY, COMMUNICATION AND PRESSURE SENSOR 审中-公开
公开(公告)号：US20110016953A1
公开(公告)日：2011-01-27
申请号：US12894685
申请日：2010-09-30
申请人： Anthony DiLeo , John Dana Hubbard
发明人： Anthony DiLeo , John Dana Hubbard
IPC分类号： G01N15/08
CPC分类号： B01D35/143 , B01D61/147 , B01D61/22 , B01D65/102 , B01D65/104 , B01D2201/291 , B01D2201/52 , B01D2201/56 , B01D2311/14 , B01D2313/44
摘要： The present invention describes a system and method for accurately measuring the pressure within a filter housing. A pressure sensor and a communications device are coupled so as to be able to measure and transmit the pressure within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the pressure sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of pressure values. The use of this device is beneficial to many applications. For example, the ability to read pressure values in situ allows integrity tests to be performed without additional equipment. In addition, integrity testing for individual filters within multi-filter configurations is possible.

10. 发明申请

US20070256970A1 Porous adsorptive or chromatographic media 有权
标题翻译：多孔吸附或色谱介质
公开(公告)号：US20070256970A1
公开(公告)日：2007-11-08
申请号：US11821059
申请日：2007-06-21
申请人： Anthony DiLeo , Justin McCue , Wilson Moya , Igor Quinones-Garcia , Neil Soice , Volkmar Thom , Sarah Yuan
发明人： Anthony DiLeo , Justin McCue , Wilson Moya , Igor Quinones-Garcia , Neil Soice , Volkmar Thom , Sarah Yuan
IPC分类号： B01J20/22
CPC分类号： B01D15/20 , B01D15/265 , B01D15/361 , B01J20/26 , B01J20/28023 , B01J20/28033 , B01J20/28042 , B01J20/28078 , B01J20/28097 , B01J20/286 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/328 , B01J20/3282 , B01J20/3289 , B01J20/3293 , B01J2220/54 , B01J2220/58 , B01J2220/62
摘要： A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.
摘要翻译：能够吸附过滤具有多孔自支撑基底和一种或多种多孔吸附聚合物涂层的多孔基底，其包含基底孔隙体积的约1至约80％。所得到的底物具有良好的对流和扩散流量和容量。底物可以是交联的，具有一个或多个捕获化学物质连接到其上，并且可用作用于选择性过滤所需物质（包括生物分子例如蛋白质和DNA片段）的色谱介质。

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