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1. 发明申请

US20070049570A1 Quinoline derivatives as phosphodiesterase inhibitors 审中-公开
标题翻译：喹啉衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20070049570A1
公开(公告)日：2007-03-01
申请号：US11349701
申请日：2006-02-08
申请人： Anthony Dean , Brian Evans , Sharon Gough , Christopher Lunniss , Alison Redgrave
发明人： Anthony Dean , Brian Evans , Sharon Gough , Christopher Lunniss , Alison Redgrave
IPC分类号： A61K31/56
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译：根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R1，R2，R19，R20和R34如说明书中所述，其制备方法，含有它们的制剂及其在治疗炎症性疾病。

2. 发明申请

US20070142373A1 Quinoline derivatives as phosphodiesterase inhibitors 失效
标题翻译：喹啉衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20070142373A1
公开(公告)日：2007-06-21
申请号：US10557079
申请日：2004-05-19
申请人： Ian Baldwin , Michael Barker , Anthony Dean , Colin Eldred , Brian Evans , Sharon Gough , Stephen Guntrip , Julie Hamblin , Stuart Holman , Paul Jones , Mika Lindvall , Christopher Lunniss , Tracy Redfern , Alison Redgrave , John Robinson , Michael Woodrow
发明人： Ian Baldwin , Michael Barker , Anthony Dean , Colin Eldred , Brian Evans , Sharon Gough , Stephen Guntrip , Julie Hamblin , Stuart Holman , Paul Jones , Mika Lindvall , Christopher Lunniss , Tracy Redfern , Alison Redgrave , John Robinson , Michael Woodrow
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译：根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 19，R 20和R 34如说明书中所述，其制备方法，含有他们及其在治疗炎症性疾病中的应用。

3. 发明申请

US20080090822A1 Piperazine Derivatives As Glyt 1 Inhibitors 审中-公开
标题翻译：哌嗪衍生物作为Glyt 1抑制剂
公开(公告)号：US20080090822A1
公开(公告)日：2008-04-17
申请号：US11908149
申请日：2006-03-09
申请人： Daniel Bradley , Clive Branch , Bethany Brown , Wai Chan , Steven Coulton , Martin Gilpin , Sharon Gough , Jacqueline MacRitchie , Howard Marshall , David Nash , Roderick Porter , Anthony Dean , Paul Doyle , Brian Evans , Luigi Stasi
发明人： Daniel Bradley , Clive Branch , Bethany Brown , Wai Chan , Steven Coulton , Martin Gilpin , Sharon Gough , Jacqueline MacRitchie , Howard Marshall , David Nash , Roderick Porter , Anthony Dean , Paul Doyle , Brian Evans , Luigi Stasi
IPC分类号： A61K31/535 , A61K31/497 , A61P25/18 , C07D401/02 , C07D401/14
CPC分类号： C07D213/73 , C07D213/75 , C07D213/85 , C07D215/38 , C07D239/42 , C07D241/44 , C07D295/192 , C07D487/04
摘要： The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
摘要翻译：本发明提供式（I）化合物或其盐或溶剂合物：其中R 1，n，X，Y和Z如说明书中所定义，以及这些化合物的用途。该化合物抑制GlyT1转运蛋白并且可用于治疗某些神经和神经精神障碍，包括精神分裂症。

4. 发明申请

US20060178416A1 Quinoline derivatives as phosphodiesterase inhibitors 失效
公开(公告)号：US20060178416A1
公开(公告)日：2006-08-10
申请号：US11349677
申请日：2006-02-08
申请人： Michael Barker , Anthony Dean , Brian Evans , Stuart Holman , Michael Woodrow
发明人： Michael Barker , Anthony Dean , Brian Evans , Stuart Holman , Michael Woodrow
IPC分类号： A01N43/50
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

5. 发明授权

US08595081B2 Method and system for efficient customized manufacture of shoes 有权
标题翻译：高效定制鞋子的方法和系统
公开(公告)号：US08595081B2
公开(公告)日：2013-11-26
申请号：US13122705
申请日：2009-09-28
申请人： Anthony Dean , Thomas Berend , Ciro Fusco
发明人： Anthony Dean , Thomas Berend , Ciro Fusco
IPC分类号： G06Q30/00
CPC分类号： A43B3/24 , G06Q10/06 , G06Q30/0621
摘要： Customized articles of footwear are produced by defining options that can be selected by a customer when submitting a custom order. These options typically include model options, functional options, and aesthetic options. These options are created by a design source, such as a shoe designer within a particular market, and presented to the customer when making the order. Upon a customer selecting one or more of the options at a user interface, the selected options are converted to specifications associated with the order. A work-load engine is employed to generate, based on the specifications, a work order that includes a dataflow for selecting appropriate stations on a manufacturing floor to participate in a manufacturing process, and a workflow for instructing each of the appropriate stations to perform a sequence of operations, within the manufacturing process, that result in fabricating individual components of the article of footwear according to the order.
摘要翻译：定制的鞋类物品是通过定义在客户提交定制订单时可以选择的选项来生成的。这些选项通常包括模型选项，功能选项和审美选项。这些选项由设计来源（例如特定市场中的鞋设计师）创建，并在订单时呈现给客户。在客户选择用户界面中的一个或多个选项时，所选择的选项将转换为与订单相关的规格。使用工作负载引擎来根据规格生成包括用于在制造车间选择合适的站参与制造过程的数据流的工作订单，以及用于指示每个适当的站执行一个在制造过程中的操作顺序，其导致根据顺序制造鞋类物品的各个部件。

6. 发明申请

US20110232135A1 Systems And Methods For Utilizing Phylon Biscuits To Produce A Regionalized-Firmness Midsole 有权
标题翻译：利用饼干饼干制作区域化坚固中底的系统与方法
公开(公告)号：US20110232135A1
公开(公告)日：2011-09-29
申请号：US13122697
申请日：2009-09-28
申请人： Anthony Dean , Thomas Berend , Bret Liebeno
发明人： Anthony Dean , Thomas Berend , Bret Liebeno
IPC分类号： A43B13/14 , B29C65/00
CPC分类号： A43B13/42 , A43B13/04 , A43B13/125 , A43B13/16 , A43B13/188 , B29C44/0461 , B29D35/128 , B29D35/142 , B29L2031/50 , Y10T156/10
摘要： A method for producing a regionalized-firmness midsole utilizing a heat press, and a description of the resultant product, are provided. Initially, the method involves providing a plurality of pre-formed phylon biscuits. Typically, the plurality of biscuits includes at least a first biscuit that has a first density and a second biscuit that has a second density. The method may further include the steps of arranging the biscuits into a receiving area of the heat press, and integrating the plurality of biscuits to form the midsole by activating the heat press. Integrating the biscuits includes raising the biscuits above a threshold temperature, and causing the biscuits to expand such that each of the plurality of biscuits couples with another of the biscuits to form a midsole with two or more degrees of firmness located at distributed regions thereon.
摘要翻译：提供一种利用热压机生产区域性硬度中底的方法以及所得产品的描述。最初，该方法包括提供多个预先形成的飞纶饼干。通常，多个饼干至少包括具有第一密度的第一饼干和具有第二密度的第二饼干。该方法还可以包括以下步骤：将饼干设置到热压机的接收区域中，并且通过激活热压机将多个饼干整合以形成中底。整合饼干包括将饼干升高到高于阈值温度，并使饼干膨胀，使得多个饼干中的每个饼干与另一个饼干结合，形成具有位于其上分布区域的两个或多个坚固度的中底。

7. 发明授权

US07631637B2 System for improving fuel utilization 失效
标题翻译：提高燃油利用率的系统
公开(公告)号：US07631637B2
公开(公告)日：2009-12-15
申请号：US11421698
申请日：2006-06-01
申请人： Raymond Bryce Bushnell , Anthony Dean , Danny Robert Lewis
发明人： Raymond Bryce Bushnell , Anthony Dean , Danny Robert Lewis
IPC分类号： F02M31/00
CPC分类号： F02M31/045 , Y02T10/126
摘要： A vapor fuel air mixture supply system for a combustion engine, whereby the mixture of air and fuel vapor is elevated in temperature prior to combustion. The liquid fuel may be vaporized in a fractionation process and further heated to enhance flame speed combustion and improve efficiency of the system.
摘要翻译：一种用于内燃机的蒸汽燃料空气混合物供应系统，由此空气和燃料蒸汽的混合物在燃烧之前升高温度。液体燃料可以在分馏过程中蒸发并进一步加热以提高火焰速度燃烧并提高系统的效率。

8. 发明申请

US20070277791A1 SYSTEM FOR IMPROVING FUEL UTILIZATION 失效
标题翻译：改善燃油利用的系统
公开(公告)号：US20070277791A1
公开(公告)日：2007-12-06
申请号：US11421698
申请日：2006-06-01
申请人： Raymond Bryce Bushnell , Anthony Dean , Danny Robert Lewis
发明人： Raymond Bryce Bushnell , Anthony Dean , Danny Robert Lewis
IPC分类号： F02G5/00 , F02B43/00
CPC分类号： F02M31/045 , Y02T10/126
摘要： A vapor fuel air mixture supply system for a combustion engine, whereby the mixture of air and fuel vapor is elevated in temperature prior to combustion. The liquid fuel may be vaporized in a fractionation process and further heated to enhance flame speed combustion and improve efficiency of the system.
摘要翻译：一种用于内燃机的蒸汽燃料空气混合物供应系统，由此空气和燃料蒸汽的混合物在燃烧之前升高温度。液体燃料可以在分馏过程中蒸发并进一步加热以提高火焰速度燃烧并提高系统的效率。

9. 发明申请

US20070144179A1 Shaped walls for enhancement of deflagration-to-detonation transition 有权
标题翻译：形状的墙壁，用于加强爆燃转爆
公开(公告)号：US20070144179A1
公开(公告)日：2007-06-28
申请号：US11315407
申请日：2005-12-22
申请人： Pierre Pinard , Venkat Tangirala , Adam Rasheed , Anthony Dean , Ronald Bunker , David Chapin
发明人： Pierre Pinard , Venkat Tangirala , Adam Rasheed , Anthony Dean , Ronald Bunker , David Chapin
IPC分类号： F23R7/00
CPC分类号： F23R7/00
摘要： A detonation chamber for a pulse detonation combustor including: a plurality of dimples disposed on at least a portion of an inner surface of the detonation chamber wherein the plurality of dimples enhance a turbulence of a fluid flow through the detonation chamber
摘要翻译：一种用于脉冲爆震燃烧器的爆轰室，包括：多个凹坑，其设置在所述爆炸室的内表面的至少一部分上，其中所述多个凹坑增强了通过所述爆轰室的流体流动的紊流

10. 发明申请

US20070137172A1 Geometric configuration and confinement for deflagration to detonation transition enhancement 审中-公开
标题翻译：几何配置和限制爆燃到爆炸过渡增强
公开(公告)号：US20070137172A1
公开(公告)日：2007-06-21
申请号：US11304889
申请日：2005-12-16
申请人： Adam Rasheed , Anthony Dean , Venkat Tangirala , David Chapin
发明人： Adam Rasheed , Anthony Dean , Venkat Tangirala , David Chapin
IPC分类号： F02C5/00
CPC分类号： F02C5/00 , F02K7/02 , F23R3/14 , F23R3/16 , F23R7/00 , Y02T50/675
摘要： A pulse detonation combustor is provided with a fuel-air mixer located upstream from a detonation chamber. A fuel-air mixture exits the fuel-air mixer and enters the detonation chamber, where it is ignited by an ignition source. The flow from the fuel-air mixer passes over the surface of a center body, which extends downstream from the fuel-air mixer. The surface of the center body contains at least one turbulence generator, which imparts additional turbulence in the fuel-air mixture passing through the chamber. The turbulence generator aids in the mixing of the fuel and air of the fuel-air mixture to enhance the deflagration to detonation transition within the pulse detonation combustor.
摘要翻译：脉冲爆震燃烧器设置有位于爆炸室上游的燃料 - 空气混合器。燃料 - 空气混合物离开燃料空气混合器并进入爆燃室，在那里它被点火源点燃。来自燃料空气混合器的流动通过在燃料 - 空气混合器下游延伸的中心体的表面。中心体的表面包含至少一个湍流发生器，其在通过腔室的燃料 - 空气混合物中施加额外的湍流。湍流发生器有助于燃料 - 空气混合物的燃料和空气的混合，以增强脉冲爆震燃烧器内爆燃转化的爆燃。

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