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    • 8. 发明授权
    • Carboxy containing monomers
    • 含羧基的单体
    • US5210289A
    • 1993-05-11
    • US856279
    • 1992-03-23
    • Ignazio S. PonticelloRichard C. Sutton
    • Ignazio S. PonticelloRichard C. Sutton
    • C07C69/007C07C323/12C07C323/52C07C323/56C08F12/14G01N33/543
    • C07C69/007C07C323/12C07C323/52C07C323/56C08F12/14G01N33/54313
    • Certain ethylenically unsaturated polymerizable monomers having a reactive carboxy group are useful for preparing homo- and copolymers for a variety of uses, including diagnostic assays. The polymers can be supplied as latex particles in aqueous compositions. The monomers are represented by the structure: ##STR1## wherein: R is hydrogen, halo or alkyl of 1 to 3 carbon atoms,M is hydrogen, an alkali metal ion or an ammonium ion, andL is a linking group having from 8 to 50 atoms in its linking chain, and comprises two or more divalent hydrocarbon groups connected or terminated with one or more nitrogen, oxygen or sulfur atoms, or with one or more groups containing such atoms in the linking chain, provided L has at least one arylene which is not directly connected to the terminal ##STR2## group, and further provided that none of the hydrocarbon groups has non-aromatic unsaturation.
    • 某些具有活性羧基的烯键式不饱和可聚合单体可用于制备各种用途的均聚物和共聚物,包括诊断测定法。 聚合物可以作为水性组合物中的胶乳颗粒提供。 单体由以下结构表示:其中:R是氢,卤素或1至3个碳原子的烷基,M是氢,碱金属离子或铵离子,L是具有8至 其连接链中包含50个原子,并且包含两个或多个与一个或多个氮,氧或硫原子连接或封端的二价烃基,或者在连接链中与一个或多个含有该原子的基团连接,条件是L具有至少一个亚芳基 其不直接连接到终端基团,并且进一步提供没有一个烃基具有非芳族不饱和键。
    • 10. 发明授权
    • Methods of preparing a polymeric latex composition and water-insoluble
biological reagent
    • 制备聚合物胶乳组合物和水不溶性生物试剂的方法
    • US5053443A
    • 1991-10-01
    • US347537
    • 1989-05-04
    • Richard C. Sutton
    • Richard C. Sutton
    • C08J3/215G01N33/543G01N33/569G01N33/58
    • C08J3/215G01N33/54313G01N33/54386G01N33/56911G01N33/585
    • A polymeric latex composition having a hydrophobe incorporated therein can be prepared using a novel latex "loading" method. This method includes providing a loadable latex, providing a hydrophobe dissolved in a water-miscible organic solvent, heating the loadable latex to about 30.degree. to about 90.degree. C. and gradually adding the hydrophobe solution to the heated loadable latex under conditions to keep the hydrophobe in solution and to "load" it into the latex particles. In preferred embodiments, the latex is surfactant-free and has particles which have outer reactive groups which are capable of reacting with free amine or sulfhydryl groups of a biological compound. Such latices can be used to prepare water-insoluble biological reagents having a biological compound attached to the particles.
    • 可以使用新的胶乳“加载”方法制备其中掺入疏水物的聚合物胶乳组合物。 该方法包括提供可加载的胶乳,提供溶解在水可混溶的有机溶剂中的疏水物,将可加载的胶乳加热到约30℃至约90℃,并且在保持该可加载胶乳的条件下逐渐将该疏水物溶液加入到加热的可加载胶乳中 在溶液中疏水,并将其“负载”到胶乳颗粒中。 在优选的实施方案中,胶乳是无表面活性剂的,并且具有能够与生物化合物的游离胺或巯基反应的外部反应性基团的颗粒。 这种胶乳可以用于制备具有附着到颗粒上的生物化合物的水不溶性生物试剂。