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1. 发明授权

US07618937B2 Peptidomimetic polymers for antifouling surfaces 有权
标题翻译：用于防污表面的拟肽聚合物
公开(公告)号：US07618937B2
公开(公告)日：2009-11-17
申请号：US11280107
申请日：2005-11-16
申请人： Phillip B. Messersmith , Annelise Barron , Andrea Statz , Robert Meagher
发明人： Phillip B. Messersmith , Annelise Barron , Andrea Statz , Robert Meagher
IPC分类号： A61K38/00 , A01N37/18 , A61M36/14 , A61K51/00 , D21H19/50 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K2/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K17/14 , C08G69/00 , C09D5/1637
摘要： Peptidomimetic polymers comprising one or more DOPA moieties and related coatings and composites.
摘要翻译：包含一种或多种DOPA部分和相关涂料和复合材料的拟肽聚合物。

2. 发明授权

US07531073B2 Sparsely cross-linked nanogels: a novel polymer structure for microchannel DNA sequencing 有权
标题翻译：稀疏交联的纳米凝胶：用于微通道DNA测序的新型聚合物结构
公开(公告)号：US07531073B2
公开(公告)日：2009-05-12
申请号：US12137291
申请日：2008-06-11
申请人： Annelise Barron , Erin Doherty
发明人： Annelise Barron , Erin Doherty
IPC分类号： G01N27/26
CPC分类号： C08F265/10 , C08L51/003 , C12N15/101 , C08L2666/02
摘要： The present invention is generally directed to novel polymeric materials for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The present invention further provides methods for generating such novel polymers, and related methods of their use.
摘要翻译：本发明一般涉及用于核酸的电泳分离的新型聚合物材料。特别地，新型聚合物材料是稀疏交联的纳米凝胶，溶解在水性缓冲液中以形成具有中等至高粘度的溶液。本发明还提供了生产这种新型聚合物的方法及其使用的相关方法。

3. 发明申请

US20070265395A1 Physically crosslinked copolymer compounds and related compositions and methods for electrophoretic separation 有权
标题翻译：物理交联共聚物化合物及相关组合物和电泳分离方法
公开(公告)号：US20070265395A1
公开(公告)日：2007-11-15
申请号：US11803278
申请日：2007-05-14
申请人： Thomas Chiesl , Annelise Barron
发明人： Thomas Chiesl , Annelise Barron
IPC分类号： C08L27/04
CPC分类号： C08F20/56 , C08F220/56 , C08F220/58
摘要： Linear acrylamide copolymer compounds which can comprise monomeric components comprising at least one N-substituted moiety capable of physical cross-linking, and related compositions and methods of use.
摘要翻译：可以包含包含至少一个能够物理交联的N-取代部分的单体组分的线性丙烯酰胺共聚物化合物，以及相关组合物和使用方法。

4. 发明授权

US06455682B1 DNA mobility modifier 有权
标题翻译： DNA迁移率调节剂
公开(公告)号：US06455682B1
公开(公告)日：2002-09-24
申请号：US09488472
申请日：2000-01-20
申请人： Annelise Barron
发明人： Annelise Barron
IPC分类号： C07H1900
CPC分类号： B82Y30/00 , C07H19/00 , C07H21/00 , C07H21/02 , C12Q1/68 , C12Q1/6869 , C12Q2565/125 , C12Q2525/203
摘要： Polyamides comprising at least one hydrophilic C1-C10 hydrocarbyl substituent on an amide nitrogen atom, and methods for producing and using the same is provided. In particular, polyamides of the formula: and methods for using the same for altering the ratio of charge/translational frictional drag of binding polymers to allow electrophoretic separation of polynucleotides or analogs thereof in a non-sieving liquid medium is provided, where a, q, L1, P1, Q1, R, R1, R10 and R11 are those described herein.
摘要翻译：提供了包含至少一个酰胺氮原子上的亲水性C1-C10烃基取代基的聚酰胺及其制备和使用方法。特别地，具有下式的聚酰胺及其用于改变结合聚合物的电荷/平移摩擦阻力比以允许非筛选液体介质中的多核苷酸或其类似物进行电泳分离的方法，其中a，q ，L1，P1，Q1，R，R1，R10和R11是本文所述的那些。

5. 发明申请

US20130004453A1 NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME 有权
标题翻译：尼龙-3聚合物和含有同种异构体的合成肺表面活性剂组合物
公开(公告)号：US20130004453A1
公开(公告)日：2013-01-03
申请号：US13634576
申请日：2011-03-17
申请人： Samuel H. Gellman , Shannon S. Stahl , Brendan P. Mowery , Annelise Barron , Michelle Dohm
发明人： Samuel H. Gellman , Shannon S. Stahl , Brendan P. Mowery , Annelise Barron , Michelle Dohm
IPC分类号： C08G69/22 , A61K31/785 , A61P11/00 , C08G69/48
CPC分类号： A61K31/785 , A61K9/0082 , A61K47/32 , C08G69/22 , C08L77/02
摘要： Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins Band C (SP-B and SP-C), two helical and amphiphilic proteins that are clitical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restlicted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-R mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, arc prepared by ling-opening polymelization of 13-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B.
摘要翻译：近来，非天然低聚物已经表现出作为肺表面活性蛋白质C（SP-B和SP-C）的功能类似物的前景，两种螺旋和两亲性蛋白质对于正常呼吸是关键的。 SP-B和SP-C的非天然模拟物的产生以前已经被逐步地排列为序列特异性合成，其导致旨在表现特定结构特性的离散低聚物。本文提出了基于含有阳离子和亲脂亚单元的序列无规共聚物的SP-R模拟的替代方法。这些材料是尼龙-3族的成员，通过开启13-内酰胺的多聚化来制备。最好的尼龙-3聚合物在混合脂质膜中显示出有希望的体外表面活性剂活性。脉冲气泡表面测量数据表明，含有最多表面活性聚合物的膜具有超过旨在模拟SP-B的离散肽的吸附和动态循环性能。

6. 发明申请

US20060241281A1 Peptidomimetic polymers for antifouling surfaces 有权
公开(公告)号：US20060241281A1
公开(公告)日：2006-10-26
申请号：US11280107
申请日：2005-11-16
申请人： Phillip Messersmith , Annelise Barron , Andrea Statz , Robert Meagher
发明人： Phillip Messersmith , Annelise Barron , Andrea Statz , Robert Meagher
IPC分类号： A61K38/16 , C07K16/00 , C07K7/08 , C07K7/06
CPC分类号： C07K2/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K17/14 , C08G69/00 , C09D5/1637
摘要： Peptidomimetic polymers comprising one or more DOPA moieties and related coatings and composites.

7. 发明申请

US20060177840A1 Methods for separation of polymeric compounds 有权
标题翻译：聚合物分离方法
公开(公告)号：US20060177840A1
公开(公告)日：2006-08-10
申请号：US11241990
申请日：2005-10-04
申请人： Gary Slater , Laurette McCormick , Annelise Barron , Robert Meagher
发明人： Gary Slater , Laurette McCormick , Annelise Barron , Robert Meagher
IPC分类号： C12Q1/68 , C07K1/26
CPC分类号： C07K1/13 , C07K1/26 , C12Q1/6816 , C12Q2525/185 , C12Q2565/125
摘要： Recently two techniques using free solution electrophoresis to separate charged-uncharged polymer conjugates have proven successful: End Labeled Free Solution Electrophoresis (ELFSE) for DNA sequencing, and Free Solution Conjugate Electrophoresis (FSCE) for molar mass profiling of uncharged polymers. Previous attempts have been made to analyze experimental data generated by these new techniques for the electrophoresis of molecules with varying charge distributions. However, the importance of the ends of the polymers in determining the polymer's overall mobility was neglected in previous work. Through a careful investigation and a reanalysis of the experimental data, it is determined here that this “end effect” critically impacts the behavior of polymers and charged-uncharged polymer conjugates during electrophoresis. In this way, the invention provides for methods that exploit this “end effect” for the separation of polymeric molecules on the basis of size, including for example DNA separation and sequencing techniques.
摘要翻译：最近，使用自由溶液电泳分离带电荷的聚合物共轭物的两种技术已被证明是成功的：用于DNA测序的末端标记的游离溶液电泳（ELFSE）和用于不带电聚合物的摩尔质谱分析的游离溶液共轭电泳（FSCE）。以前曾经尝试分析由这些新技术产生的用于具有不同电荷分布的分子的电泳产生的实验数据。然而，聚合物末端在确定聚合物整体流动性方面的重要性在以前的工作中被忽略。通过对实验数据的仔细研究和重新分析，这里确定，这种“最终效应”严重影响聚合物和带电荷电聚合物共轭物在电泳过程中的行为。以这种方式，本发明提供了利用基于大小（包括例如DNA分离和测序技术）分离聚合物分子的这种“最终效应”的方法。

8. 发明授权

US09044392B2 Nylon-3 co-polymers and synthetic lung surfactant compositions containing same 有权
标题翻译：尼龙-3共聚物和含有它们的合成肺表面活性剂组合物
公开(公告)号：US09044392B2
公开(公告)日：2015-06-02
申请号：US13634576
申请日：2011-03-17
申请人： Samuel H. Gellman , Shannon S. Stahl , Brendan P. Mowery , Annelise Barron , Michelle Dohm
发明人： Samuel H. Gellman , Shannon S. Stahl , Brendan P. Mowery , Annelise Barron , Michelle Dohm
IPC分类号： C08G69/22 , A61K31/785 , A61P11/00 , C08G69/48 , A61K9/00 , A61K47/32 , C08L77/02
CPC分类号： A61K31/785 , A61K9/0082 , A61K47/32 , C08G69/22 , C08L77/02
摘要： Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins Band C (SP-B and SP-C), two helical and amphiphilic proteins that are clitical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restlicted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-R mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, arc prepared by ling-opening polymelization of 13-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B.
摘要翻译：近来，非天然低聚物已经表现出作为肺表面活性蛋白质C（SP-B和SP-C）的功能类似物的前景，两种螺旋和两亲性蛋白质对于正常呼吸是关键的。 SP-B和SP-C的非天然模拟物的产生以前已经被逐步地排列为序列特异性合成，其导致旨在表现特定结构特征的离散低聚物。本文提出了基于含有阳离子和亲脂亚单元的序列无规共聚物的SP-R模拟的替代方法。这些材料是尼龙-3族的成员，通过开启13-内酰胺的多聚化来制备。最好的尼龙-3聚合物在混合脂质膜中显示出有希望的体外表面活性剂活性。脉冲气泡表面测量数据表明，含有最多表面活性聚合物的膜具有超过旨在模拟SP-B的离散肽的吸附和动态循环性能。

9. 发明授权

US07399396B2 Sparsely cross-linked nanogels: a novel polymer structure for microchannel DNA sequencing 有权
标题翻译：稀疏交联的纳米凝胶：用于微通道DNA测序的新型聚合物结构
公开(公告)号：US07399396B2
公开(公告)日：2008-07-15
申请号：US11037561
申请日：2005-01-18
申请人： Annelise Barron , Erin Doherty
发明人： Annelise Barron , Erin Doherty
IPC分类号： G01N27/26
CPC分类号： C08F265/10 , C08L51/003 , C12N15/101 , C08L2666/02
摘要： The present invention is generally directed to novel polymeric mateirals for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The present invention further provides methods for generating such novel polymers, and related methods of their use.
摘要翻译：本发明一般涉及用于核酸的电泳分离的新型聚合物材料。特别地，新型聚合物材料是稀疏交联的纳米凝胶，溶解在水性缓冲液中以形成具有中等至高粘度的溶液。本发明还提供了生产这种新型聚合物的方法及其使用的相关方法。

10. 发明申请

US20090011420A1 SPARSELY CROSS-LINKED NANOGELS: A NOVEL POLYMER STRUCTURE FOR MICROCHANNEL DNA SEQUENCING 有权
标题翻译：极细的交联纳米粒子：用于微信号DNA测序的新型聚合物结构
公开(公告)号：US20090011420A1
公开(公告)日：2009-01-08
申请号：US12137291
申请日：2008-06-11
申请人： Annelise Barron , Erin Doherty
发明人： Annelise Barron , Erin Doherty
IPC分类号： C12Q1/68
CPC分类号： C08F265/10 , C08L51/003 , C12N15/101 , C08L2666/02
摘要： The present invention is generally directed to novel polymeric materials for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The present invention further provides methods for generating such novel polymers, and related methods of their use.
摘要翻译：本发明一般涉及用于核酸的电泳分离的新型聚合物材料。特别地，新型聚合物材料是稀疏交联的纳米凝胶，溶解在水性缓冲液中以形成具有中等至高粘度的溶液。本发明还提供了生产这种新型聚合物的方法及其使用的相关方法。

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