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1. 发明授权

US06689065B2 Ultrasonography 失效
标题翻译：超声检查
公开(公告)号：US06689065B2
公开(公告)日：2004-02-10
申请号：US10162126
申请日：2002-06-04
申请人： Anne Kirsti Aksnes , Morten Eriksen , Else Kruger Hagen , Audun Tornes
发明人： Anne Kirsti Aksnes , Morten Eriksen , Else Kruger Hagen , Audun Tornes
IPC分类号： A61B806
CPC分类号： A61B8/06 , A61B8/12 , A61B8/481 , A61B8/543
摘要： Prostate abnormalities such as cancer may be detected by ultrasonic determination of the in-flow kinetics of contrast agent-containing blood in the prostate and/or by observation of disease-related asymmetries in the the spoke-like vascular pattern of the prostate.
摘要翻译：可以通过超声波测定前列腺中含有造影剂的血液的流动动力学和/或通过观察前列腺的轮状血管图案中的疾病相关不对称来检测前列腺异常，例如癌症。

2. 发明授权

US06428479B1 Ultrasonography of the prostate 失效
标题翻译：前列腺超声检查
公开(公告)号：US06428479B1
公开(公告)日：2002-08-06
申请号：US09597406
申请日：2000-06-19
申请人： Anne Kirsti Aksnes , Morten Eriksen , Else Kruger Hagen , Audun Tornes
发明人： Anne Kirsti Aksnes , Morten Eriksen , Else Kruger Hagen , Audun Tornes
IPC分类号： A61B800
CPC分类号： A61B8/06 , A61B8/12 , A61B8/481 , A61B8/543
摘要： Prostate abnormalities such as cancer may be detected by ultrasonic determination of the in-flow kinetics of contrast agent-containing blood in the prostate and/or by observation of disease-related asymmetries in the spoke-like vascular pattern of the prostate.
摘要翻译：可以通过超声波测定前列腺中含有造影剂的血液的流动动力学和/或通过观察前列腺的轮状血管图案中的疾病相关不对称性来检测前列腺癌的异常。

3. 发明授权

US07892522B2 Contrast agents 有权
标题翻译：对比剂
公开(公告)号：US07892522B2
公开(公告)日：2011-02-22
申请号：US09950985
申请日：2001-09-13
申请人： David Johnson , Jonny Østensen , Morten Eriksen , Audun Tornes , Sigmund Frigstad , Harald Dugstad , Jo Klaveness , Pål Rongved , Roald Skurtveit , Jorunn Brænden
发明人： David Johnson , Jonny Østensen , Morten Eriksen , Audun Tornes , Sigmund Frigstad , Harald Dugstad , Jo Klaveness , Pål Rongved , Roald Skurtveit , Jorunn Brænden
IPC分类号： A61B8/00 , A61K9/127 , A61B8/14
CPC分类号： A61K49/223
摘要： Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.
摘要翻译：超声造影剂包括生物相容性气体的微泡，例如卤化物或全氟化碳，通过可调节的两亲性材料稳定，例如。成膜脂质如磷脂，特别是带负电荷的磷脂如磷脂酰丝氨酸，可以在静脉内给药后在肝脏中产生延长的对比度产生停留时间。

4. 发明申请

US20070066893A1 Method 审中-公开
标题翻译：方法
公开(公告)号：US20070066893A1
公开(公告)日：2007-03-22
申请号：US10558597
申请日：2004-12-03
申请人： Morten Eriksen , Lars Hoff , Henrik Rasmussen , Audun Tornes , Jonny Ostensen
发明人： Morten Eriksen , Lars Hoff , Henrik Rasmussen , Audun Tornes , Jonny Ostensen
IPC分类号： A61B6/00
CPC分类号： A61B5/415 , A61B5/1075 , A61B5/418 , A61B8/481 , A61K49/225
摘要： The present invention relates to a method of processing ultrasound images from a subject preadministered with an ultrasound contrast agent wherein quantitative measures of the contrast enhancement pattern of said lymph nodes are generated. The lymphatic system is made of vessels or ducts that begin in tissues and are designed to carry lymph fluid to local lymph nodes where the fluid is filtered and processed and sent to the next lymph node down the line until the fluid reaches the thoracic duct where it enters the blood stream. Lymph fluid which enters the lymph vessels carries with it substances and materials from the tissue, e.g. antigens, particles and cells. The lymph nodes process the lymph fluid by sieving it and macrophages inside the nodes remove particulate and cell material carried by the lymph fluid via phagocytosis.
摘要翻译：本发明涉及一种处理来自预先给予超声造影剂的受试者的超声图像的方法，其中产生所述淋巴结的对比度增强模式的定量测量。淋巴系统由在组织中开始并被设计成将淋巴液携带到淋巴结的淋巴管构成，其中流体被过滤和处理，并被送到下一个淋巴结，直到流体到达胸廓管进入血液流。进入淋巴管的淋巴液携带来自组织的物质和物质，例如，抗原，颗粒和细胞。淋巴结通过筛选淋巴液和淋巴结内的巨噬细胞通过吞噬除去淋巴液携带的颗粒和细胞物质。

5. 发明授权

US07083566B2 Grooved brachytherapy sources 有权
公开(公告)号：US07083566B2
公开(公告)日：2006-08-01
申请号：US10275373
申请日：2001-04-12
申请人： Audun Tornes , Morten Eriksen
发明人： Audun Tornes , Morten Eriksen
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61B2090/3925 , A61N2005/1024
摘要： Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of the outer surface of the container is grooved, preferably with a curved groove. The grooved outer surface is preferably substantially free from angularities. Such grooves enhance the echogenicity of the source using medical ultrasound at a greater range of angles to the ultrasound probe, thus enhancing the ultrasound visibility of the source. Preferred radioisotopes are palladium-103 and iodine-125.

6. 发明授权

US06595925B1 In or relating to contrast agents 失效
标题翻译：在或与造影剂有关
公开(公告)号：US06595925B1
公开(公告)日：2003-07-22
申请号：US09503165
申请日：2000-02-14
申请人： Jonny Østensen , Morten Eriksen , Audun Tornes , Sigmund Frigstad
发明人： Jonny Østensen , Morten Eriksen , Audun Tornes , Sigmund Frigstad
IPC分类号： A61B814
CPC分类号： A61K49/223
摘要： Ultrasound imaging using gas microbubble-containing contrast agents may be performed in the recirculating phase following admixture of the contrast agent with the blood pool, thereby prolonging the useful imaging time window compared to that conventionally obtained during the backscatter signal peak resulting from first pass of a contrast agent bolus. The length of the time window may further be increased by imaging at ultrasound frequencies of 2 MHz or less, particularly by harmonic imaging at transmit frequencies less than the resonance frequencies of the gas microbubbles.
摘要翻译：使用气体微泡造影剂的超声成像可以在造影剂与血液池混合之后的再循环阶段中进行，从而延长了有用的成像时间窗口，与之前获得的反向散射信号峰值相比，造影剂推注。特别是通过低于气体微泡的共振频率的发射频率下的谐波成像，可以进一步通过在2MHz或更小的超声频率下成像来增加时间窗口的长度。

7. 发明授权

US08182790B2 Contrast agents 有权
标题翻译：对比剂
公开(公告)号：US08182790B2
公开(公告)日：2012-05-22
申请号：US11719662
申请日：2005-11-21
申请人： Dagfinn Lovhaug , Morten Eriksen , Hege B. Fjerdingstad , Andrew Healey
发明人： Dagfinn Lovhaug , Morten Eriksen , Hege B. Fjerdingstad , Andrew Healey
IPC分类号： A61K49/00
CPC分类号： A61K49/0056 , A61K49/0002 , A61K49/0021 , A61K49/0032 , A61K49/085 , A61K49/14 , A61K51/0497
摘要： A contrast agent of the general formula (I): Z1-L-V-Z2 (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or animal body, V is a targeting moiety with binding affinity for areas of collagen formation, L is a covalent bond, a biomodifier or a linker moiety.
摘要翻译：通式（I）的对比剂：Z1-LV-Z2（I）其中存在Z1和Z2中的至少一个并且在人或动物体的体内成像中可检测到相等或不同的报告分子部分，V是具有对胶原形成区域具有结合亲和力的靶向部分，L是共价键，生物修饰剂或接头部分。

8. 发明申请

US20070134155A1 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US20070134155A1
公开(公告)日：2007-06-14
申请号：US10559886
申请日：2004-11-05
申请人： Alan Cuthbertson , Bard Indrevoll , Morten Eriksen
发明人： Alan Cuthbertson , Bard Indrevoll , Morten Eriksen
IPC分类号： A61K51/00 , C07K7/06
CPC分类号： A61K51/08 , A61K38/085 , A61K49/0043 , A61K49/0056 , A61K51/088 , C07K7/14
摘要： The invention comprises pharmaceuticals of formula (I) Z-(L)n-V, wherein V denotes a peptide, L denotes an optional linker, Z denotes a group that optionally can carry an imaging moiety M, n denotes 0 or 1. The pharmaceuticals are active as therapeutic agents for the treatment of heart failure, cardiac arrhythmias and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis and are also useful as diagnostic agents for the diagnosis of heart failure and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis.
摘要翻译：本发明包括式（I）Z-（L）-N-V的药物，其中V表示肽，L表示任选的接头，Z表示任选地可携带成像部分M的基团， n表示0或1.药物作为治疗心力衰竭的治疗剂是有活性的，心律不齐，纤维化突出如COPD，肝纤维化和动脉粥样硬化等疾病，也可用作诊断心力衰竭的诊断剂，纤维化疾病如COPD，肝纤维化和动脉粥样硬化等疾病突出。

9. 发明授权

US06632176B2 Products and methods for brachytherapy 失效
标题翻译：近距离放射疗法的产品和方法
公开(公告)号：US06632176B2
公开(公告)日：2003-10-14
申请号：US09860011
申请日：2001-05-17
申请人： Gregory McIntire , Robert Snow , Edward Bacon , Morten Eriksen , Auden Tornes , Geraldine Cooney , Virginia Ann Gates , Joel Cornacoff , Christopher Black
发明人： Gregory McIntire , Robert Snow , Edward Bacon , Morten Eriksen , Auden Tornes , Geraldine Cooney , Virginia Ann Gates , Joel Cornacoff , Christopher Black
IPC分类号： A61B800
CPC分类号： A61N5/1027 , A61B2090/3925 , A61N2005/1024 , G21G4/08
摘要： Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patient's body. Preferred radioisotopes are palladium-103 and iodine-125.
摘要翻译：用于近距离放射治疗的放射源，优选放射性种子，其包括在密封的生物相容性容器内的放射性同位素，其中容器的表面的至少一部分被粗糙化，成形或以其它方式处理，使得其不再光滑。表面处理可以增强源的超声可见性和/或减少一旦植入患者体内的源迁移的趋势。优选的放射性同位素是钯-103和碘-125

10. 发明授权

US08337430B2 Coil system and method for obtaining volumetric physiological measurements 有权
公开(公告)号：US08337430B2
公开(公告)日：2012-12-25
申请号：US13545511
申请日：2012-07-10
申请人： Morten Eriksen
发明人： Morten Eriksen
IPC分类号： A61B5/103 , A61B5/117
CPC分类号： A61B5/091 , A61B5/0806 , A61B5/1073 , A61B5/1126 , A61B5/1135 , A61B5/4818 , A61B5/6804 , A61B5/7214 , A61B5/7278 , A61B5/742 , A61B90/98 , A61B2090/063 , A61B2560/0276 , A61B2562/08
摘要： A coil device is provided having a member adapted to extend around and conform to an outer surface of a subject and a conductor adapted to extend only once around a first portion of the subject. The coil device can be positioned about the subject in order to measure a volume of the subject. When placed about the subject in the presence of a relatively homogeneous magnetic field, the conductor can generate a signal indicative of a volume of the first portion of the subject. The coil device may also include two or more conductors separately generating signals indicating volumes of two or more corresponding portions of the subject. In some cases the coil device includes associated authorization data that can limit use of the coil device. Systems and methods incorporating the coil device are also provided.

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