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    • 3. 发明申请
    • Materials and Methods for Modulating Arginine Metabolism
    • 调节精氨酸代谢的材料和方法
    • US20120316121A1
    • 2012-12-13
    • US13524899
    • 2012-06-15
    • Ann de Wees Allen
    • Ann de Wees Allen
    • A61K31/70A61P3/10A61P9/00A61P9/10A61P3/06A61P3/04
    • A61K31/198A61K31/70A61K2300/00
    • The present invention provides novel compositions and methods for their production and use in modulating arginine metabolism to treat biological conditions. The biological condition is preferably one associated with dysregulated arginine metabolism and/or abnormal endogenous levels of substances resulting from or involved in arginine metabolism. The subject invention provides compositions that modulate levels of arginine or levels of substances that are derived from arginine in vivo via pre-selected signal transduction/metabolic pathways. In one embodiment, compositions comprising arginine and a glycoside are provided. The compositions and methods of the invention are able to select and prompt a particular metabolic pathway in which the arginine is to be used as a substrate.
    • 本发明提供了其生产和用于调节精氨酸代谢以治疗生物学条件的新型组合物和方法。 生物学条件优选与精氨酸代谢异常调节和/或由精氨酸代谢引起或参与精氨酸代谢的异常内源水平有关。 本发明提供了通过预先选择的信号转导/代谢途径调节精氨酸水平或通过体内衍生自精氨酸的物质水平的组合物。 在一个实施方案中,提供了包含精氨酸和糖苷的组合物。 本发明的组合物和方法能够选择并提示将精氨酸用作底物的特定代谢途径。