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1. 发明授权

US07960542B2 Process for purifying oligonucleotide synthons 有权
标题翻译：纯化寡核苷酸合成酶的方法
公开(公告)号：US07960542B2
公开(公告)日：2011-06-14
申请号：US10539202
申请日：2003-12-16
申请人： Andrew Timothy Boam , Andrew Guy Livingston , Dinesh Nair , Paul McCormac , Stephen Hargreaves
发明人： Andrew Timothy Boam , Andrew Guy Livingston , Dinesh Nair , Paul McCormac , Stephen Hargreaves
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , B01D61/027
摘要： A process for the purification of an oligonucleotide synthon is provided. The process comprises subjecting an organic solution comprising an oligonucleotide synthon and lower molecular weight impurities to nanofiltration whereby the ratio of an oligonucleotide synthon to lower molecular weight impurities in the solution is increased after the nanofiltration. Preferably, the oligonucleotide synthon is a nucleoside phosphoramidite or nucleoside H-phosphonate. The nanofiltration membrane is preferably a polyimide membrane having a molecular weight cut off of 400.
摘要翻译：提供了一种纯化寡核苷酸合成酶的方法。该方法包括使含有寡核苷酸合成子和较低分子量杂质的有机溶液进行纳滤，由此在纳滤后，溶液中寡核苷酸合成子与较低分子量杂质的比例增加。优选地，寡核苷酸合成子是核苷亚磷酰胺或核苷H-膦酸盐。纳滤膜优选为截留分子量为400的聚酰亚胺膜。

2. 发明授权

US10792619B2 Membrane module 有权
公开(公告)号：US10792619B2
公开(公告)日：2020-10-06
申请号：US15486437
申请日：2017-04-13
申请人： Fui Wen Lim , Andrew Guy Livingston , Andrew Timothy Boam
发明人： Fui Wen Lim , Andrew Guy Livingston , Andrew Timothy Boam
IPC分类号： B01D67/00 , B01D61/02 , B01D71/64 , B01D63/10
摘要： The present invention relates to a method for curing adhesives used in the manufacture of membrane modules containing polymeric membranes, particularly polyimide based membranes used for the nanofiltration or ultrafiltration of solutes dissolved in organic solvents using microwaves. To maximise the chemical resistance of the adhesive used in these organic solvent applications, it must be as fully reacted and crosslinked (“cured”) as possible. Typically, thermal processing (heating) of the entire membrane module is used to cure the adhesives. However, the time and temperature required to achieve this high degree of completion of reaction may damage the separation performance of the membrane contained within the membrane module. In one particular aspect, this process utilises microwaves to preferentially promote the curing of epoxy adhesives over the general heating of the membrane module.

3. 发明申请

US20120223014A1 POLYMIDE MEMBRANE 审中-公开
标题翻译：聚合物薄膜
公开(公告)号：US20120223014A1
公开(公告)日：2012-09-06
申请号：US13377200
申请日：2010-06-07
申请人： Andrew Timothy Boam , Andreja Manuela Martins Miranda , Andrew Guy Livingston
发明人： Andrew Timothy Boam , Andreja Manuela Martins Miranda , Andrew Guy Livingston
IPC分类号： B01D71/64 , B01D61/00
CPC分类号： B01D71/64 , B01D61/246 , B01D61/28 , B01D69/10 , B01D2325/02
摘要： A high mass transfer membrane for use in membrane phase contactors to extract a solute from an aqueous phase to a solvent phase and their method of preparation and use are disclosed. The membrane is formed from polyimide by phase inversion and may optionally be crosslinked to maintain stability even in the solvents from which the membranes were formed by phase phase inversion.
摘要翻译：公开了一种用于膜相接触器从水相中提取溶质至溶剂相的高质量转移膜及其制备和使用方法。膜由聚酰亚胺通过相转化形成，并且可以任选地交联以保持即使在通过相转变形成膜的溶剂中也是如此。

4. 发明授权

US06586638B1 Process for removing and recovering of phenolic compounds from aqueous fluids 失效
标题翻译：从含水流体中除去和回收酚类化合物的方法
公开(公告)号：US06586638B1
公开(公告)日：2003-07-01
申请号：US10110946
申请日：2002-08-28
申请人： Shengfu Zhang , Jean-Pierre Arcangeli , Andrew Guy Livingston , Andrew Timothy Boam
发明人： Shengfu Zhang , Jean-Pierre Arcangeli , Andrew Guy Livingston , Andrew Timothy Boam
IPC分类号： C07C3768
CPC分类号： B01D61/246 , C02F1/44 , C02F1/441 , C02F1/442 , C02F1/444 , C07C37/009 , C07C37/70 , C07C37/82 , C07C39/04 , C07C39/07 , C07C39/30 , C07C39/28
摘要： There is provided a process for removing and recovering one or more unassociated phenolic compounds dissolved in aqueous fluid, the process comprising the steps of: (a) transferring the one or more unassociated phenolic compounds from the aqueous fluid to an alkaline stripping solution, wherein transfer of the one or more unassociated phenolic compounds from the aqueous fluid to the alkaline stripping solution occurs across a membrane; wherein the membrane is a non porous, selectively permeable membrane; (b) regulating the volume of alkaline stripping solution employed relative to the volume of aqueous fluid treated so that the total phenolic compound concentration in the alkaline stripping solution, comprising the sum of the dissociated and unassociated phenolic compound concentrations, is above the solubility of the phenolic compounds in the acidified stripping solution of step (d); (c) regulating the pH of the alkaline stripping solution in contact with the membrane to a value at least 0.5 pH units above the acidic dissociation constant of the phenolic compound; (d) adjusting the pH of the phenolic compound containing alkaline stripping solution to a value below the alkaline dissociation constant of the phenolic compound and (e) separating the resulting phenolic compound rich phase and the alkaline stripping solution.
摘要翻译：提供了一种除去和回收溶解在水性流体中的一种或多种未缔合的酚类化合物的方法，该方法包括以下步骤：（a）将一种或多种未缔合的酚类化合物从水性流体转移到碱性剥离溶液中，其中转移的一种或多种未缔合的酚类化合物从水性液体到碱性剥离溶液发生在膜上; 其中所述膜是非多孔的，选择性可渗透的膜; （b）相对于所处理的水性流体的体积调节所用的碱性剥离溶液的体积，使碱性剥离溶液中含有解离和未缔合的酚类化合物浓度之和的总酚类化合物浓度高于在步骤（d）的酸化汽提溶液中的酚类化合物; （c）将与膜接触的碱性剥离溶液的pH调节至高于酚类化合物的酸解离常数的至少0.5个pH单位的值; （d）将含有碱性剥离溶液的酚类化合物的pH调节至低于酚类化合物的碱解离常数的值，和（e）分离所得的酚类化合物相和碱性剥离溶液。

5. 发明申请

US20140199679A1 BIOREACTOR 审中-公开
公开(公告)号：US20140199679A1
公开(公告)日：2014-07-17
申请号：US13989165
申请日：2011-11-24
申请人： Nicki Panoskaltsis , Hugo Miguel Magalhäes Macedo , Maria Teresa Mortera Blanco , Athanasios Mantalaris , Andrew Guy Livingston
发明人： Nicki Panoskaltsis , Hugo Miguel Magalhäes Macedo , Maria Teresa Mortera Blanco , Athanasios Mantalaris , Andrew Guy Livingston
IPC分类号： C12N5/078 , C12M1/00
CPC分类号： C12N5/0641 , C12M25/10 , C12M25/14 , C12M29/10 , C12M29/16 , C12M47/04
摘要： A bioreactor for the formation of mature blood cells from haematopoietic stem cells is disclosed. The bioreactor comprises a first zone and a second zone. The first zone and the second zone are separated by a first membrane. The first membrane allows the preferential passage of red blood cells relative to the haematopoietic stem cells and their 5 other progeny excluding red blood cells. The first membrane is formed by at least a separating layer and a porous layer, where the porous layer is in contact with the first zone, such that the haematopoietic stem cells can be grown in the porous layer. The bioreactor comprises a third zone. The first zone and the third zone are separated by a second membrane, and the second membrane allows the passage of nutrients from the 10 third zone to the first zone and the passage of metabolites of the cells from the first zone to the third zone, while substantially preventing the passage of growth factors from the first zone to the third zone.
摘要翻译：公开了一种用于从造血干细胞形成成熟血细胞的生物反应器。生物反应器包括第一区和第二区。第一区和第二区被第一膜隔开。第一个膜允许红细胞相对于造血干细胞及其5个除红细胞以外的其他子代优先通过。第一膜由至少分离层和多孔层形成，其中多孔层与第一区接触，使得造血干细胞可以在多孔层中生长。生物反应器包括第三区。第一区域和第三区域被第二膜隔开，并且第二膜允许营养物从第10区域传递到第一区域，并使细胞的代谢物从第一区段传递到第三区域，同时基本上防止生长因子从第一区到第三区的通过。

6. 发明申请

US20130072691A1 MEMBRANE ENHANCED POLYMER SYNTHESIS 审中-公开
标题翻译：膜增强聚合物合成
公开(公告)号：US20130072691A1
公开(公告)日：2013-03-21
申请号：US13699848
申请日：2011-05-25
申请人： Andrew Guy Livingston , Piers Robert James Gaffney , Renato Campos Vasconcelos
发明人： Andrew Guy Livingston , Piers Robert James Gaffney , Renato Campos Vasconcelos
IPC分类号： C08G65/333
CPC分类号： C08G65/33341 , C08G65/325 , C08G65/331 , C08G65/3326 , C08G65/333 , C08G65/33306 , C08L2203/02
摘要： This invention relates to the synthesis of polymers. More specifically, the present invention relates to the synthesis of heterobifunctional polymers and polymers with narrow and mono-disperse molecular weight distributions, and especially to the application of membranes to the synthesis of these polymers.
摘要翻译：本发明涉及聚合物的合成。更具体地说，本发明涉及具有窄和单分散分子量分布的异双官能聚合物和聚合物的合成，特别涉及膜对合成这些聚合物的应用。

7. 发明申请

US20120077255A1 PROCESS FOR EXTRACTING FATTY ACIDS FROM AQUEOUS BIOMASS IN A MEMBRANE CONTACTOR MODULE 有权
标题翻译：在膜接触器模块中从酸性生物质中提取脂肪酸的方法
公开(公告)号：US20120077255A1
公开(公告)日：2012-03-29
申请号：US13377516
申请日：2010-06-10
申请人： Andreia Manuela Martins Miranda , Eddy G. Torp , Igna Marie Aasen , Andrew Guy Livingston
发明人： Andreia Manuela Martins Miranda , Eddy G. Torp , Igna Marie Aasen , Andrew Guy Livingston
IPC分类号： C11C1/00 , C11B3/02 , C11B3/16
CPC分类号： C12N9/20 , B01D61/00 , B01D71/64 , B01D2315/16 , C11B1/025 , C11B1/10 , C11C1/04 , C11C3/003 , C12P7/6418 , C12P7/6427 , Y02P20/125
摘要： The present invention relates to a new process for extracting fatty acids from aqueous biomass in a membrane contactor module. The present invention also relates to an integrated process combining biomass concentration and/or diafiltration and fatty acid extraction in said membrane contactor module.
摘要翻译：本发明涉及一种在膜接触器模块中从含水生物质中提取脂肪酸的新方法。本发明还涉及在所述膜接触器模块中组合生物质浓度和/或渗滤和脂肪酸提取的综合方法。

8. 发明授权

US07726398B2 Water flooding method 有权
标题翻译：水驱法
公开(公告)号：US07726398B2
公开(公告)日：2010-06-01
申请号：US11921569
申请日：2006-06-15
申请人： Ian Ralph Collins , Kang Li , Andrew Guy Livingston , John Dale Williams
发明人： Ian Ralph Collins , Kang Li , Andrew Guy Livingston , John Dale Williams
IPC分类号： E21B43/20 , E21B43/40
CPC分类号： E21B43/20
摘要： A method of recovering hydrocarbons from a porous subterranean hydrocarbon-bearing formation by: (a) reducing the salinity of a saline source water by reverse osmosis using a membrane having a first surface and a second surface by (i) feeding the saline source water to the first surface of the membrane, and (ii) removing treated water of reduced salinity from the second surface of the membrane; and (b) injecting the treated water into the formation; wherein the membrane is selectively permeable to water over dissolved solids such that when (i) the saline source water has a total dissolved solids content of at least 17,500 ppm, and (ii) the applied pressure across the membrane is greater than the osmotic pressure across the membrane and lies within the range 45 to 90 bar (4.5 to 9.0 M Pa), the total dissolved solids content of the treated water is in the range 500 to 5000 ppm.
摘要翻译：一种通过以下方法从多孔地下含烃地层中回收烃的方法：（a）通过使用具有第一表面和第二表面的膜通过反渗透来降低盐水源的盐度，所述膜通过（i）将盐水源供给到膜的第一表面，和（ii）从膜的第二表面去除盐度降低的处理水; 和（b）将经处理的水注入地层; 其中所述膜选择性地可透过水溶解的固体，使得当（i）所述盐水源具有至少17,500ppm的总溶解固体含量时，以及（ii）所述膜上施加的压力大于所述渗透压该膜位于45至90巴（4.5至9.0MPa）的范围内，处理水的总溶解固体含量在500至5000ppm的范围内。

9. 发明授权

US09127123B2 Membrane enhanced polymer synthesis 有权
标题翻译：膜增强聚合物合成
公开(公告)号：US09127123B2
公开(公告)日：2015-09-08
申请号：US13699848
申请日：2011-05-25
申请人： Andrew Guy Livingston , Piers Robert James Gaffney , Renato Campos Vasconcelos
发明人： Andrew Guy Livingston , Piers Robert James Gaffney , Renato Campos Vasconcelos
IPC分类号： C08G65/34 , C08G65/46 , C08G65/333 , C08G65/325 , C08G65/331 , C08G65/332
CPC分类号： C08G65/33341 , C08G65/325 , C08G65/331 , C08G65/3326 , C08G65/333 , C08G65/33306 , C08L2203/02
摘要： This invention relates to the synthesis of polymers. More specifically, the present invention relates to the synthesis of heterobifunctional polymers and polymers with narrow and mono-disperse molecular weight distributions, and especially to the application of membranes to the synthesis of these polymers.
摘要翻译：本发明涉及聚合物的合成。更具体地说，本发明涉及具有窄和单分散分子量分布的异双官能聚合物和聚合物的合成，特别涉及膜对合成这些聚合物的应用。

10. 发明申请

US20130112619A1 SOLVENT RESISTANT POLYAMIDE NANOFILTRATION MEMBRANES 审中-公开
标题翻译：耐溶剂聚酰胺纳米膜
公开(公告)号：US20130112619A1
公开(公告)日：2013-05-09
申请号：US13810935
申请日：2011-07-19
申请人： Andrew Guy Livingston , Yogesh Suresh Bhole , Maria Fernanda Jimenez Solomon
发明人： Andrew Guy Livingston , Yogesh Suresh Bhole , Maria Fernanda Jimenez Solomon
IPC分类号： B01D69/12
CPC分类号： B01D67/0088 , B01D61/022 , B01D61/027 , B01D69/105 , B01D69/12 , B01D69/125 , B01D71/56 , B01D71/64 , B01D2325/022
摘要： The present invention relates to a composite membrane for nanofiltration of a feed stream solution comprising a solvent and dissolved solutes and showing preferential rejection of the solutes. The composite membrane comprises a thin polymeric film formed by interfacial polymerisation on a support membrane. The support membrane is further impregnated with a conditioning agent and is stable in polar aprotic solvents. The composite membrane is optionally treated in a quenching medium, where the interfacial polymerisation reaction can be quenched and, in certain embodiments, membrane chemistry can be modified. Finally the composite membrane is treated with an activating solvent prior to nanofiltration.
摘要翻译：本发明涉及包含溶剂和溶解的溶质并且显示优先排斥溶质的进料流溶液的纳滤的复合膜。复合膜包括通过支撑膜上的界面聚合形成的薄聚合物膜。支持膜进一步用调理剂浸渍，并且在极性非质子溶剂中是稳定的。任选地在淬灭介质中处理复合膜，其中界面聚合反应可被淬灭，并且在某些实施方案中，可以修饰膜化学。最后，复合膜在纳滤之前用活化溶剂处理。

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