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1. 发明申请

US20050250185A1 OGH fusion polypeptides and therapeutic uses thereof 审中-公开
标题翻译： OGH融合多肽及其治疗用途
公开(公告)号：US20050250185A1
公开(公告)日：2005-11-10
申请号：US11008727
申请日：2004-12-09
申请人： Andrew Murphy , Lynn Macdonald , Mark Sleeman
发明人： Andrew Murphy , Lynn Macdonald , Mark Sleeman
IPC分类号： A61K48/00 , C07H21/04 , C07K14/575 , C07K14/59 , C07K16/46
CPC分类号： A61K48/005 , A01K2267/0362 , A61K38/00 , C07K14/575 , C07K14/59 , C07K2319/30
摘要： A fusion polypeptide comprising an orphan glyprotein hormone (OGH), OGH-family member, or a fragment thereof; a glycoprotein hormone subunit α1 or α2, or a fragment thereof, and optionally a peptide (P), and a fusion component (F). In one embodiment, the fusion protein comprises hOGH-hFc-hα2 or hTSH-hFc-hα1.
摘要翻译：包含孤儿糖蛋白激素（OGH），OGH家族成员或其片段的融合多肽; 糖蛋白激素亚基α1或α2或其片段，以及任选的肽（P）和融合成分（F）。在一个实施方案中，融合蛋白包含hOGH-hFc-halpha2或hTSH-hFc-halpha1。

2. 发明授权

US08871996B2 Mice expressing human voltage-gated sodium channels 有权
标题翻译：表达人电压门控钠通道的小鼠
公开(公告)号：US08871996B2
公开(公告)日：2014-10-28
申请号：US13155491
申请日：2011-06-08
申请人： Lynn Macdonald , Andrew J. Murphy , Michael L. LaCroix-Fralish , Nicole M. Alessandri Haber
发明人： Lynn Macdonald , Andrew J. Murphy , Michael L. LaCroix-Fralish , Nicole M. Alessandri Haber
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/0356
摘要： Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a humanization of an extracellular loop of an endogenous NaV channel gene, in particular a humanization of the one or more extracellular pore loops of a NaV1.7 channel protein. Genetically modified non-human animals are also provided, wherein the genetic modification comprises replacement of an endogenous NaV channel gene, in particular a replacement of the endogenous NaV1.7 gene with a human NaV1.7 gene, and wherein the genetically modified non-human animals are capable of generating action potentials and communicating through the excitable cells of the genetically modified non-human animals via the expressed human or humanized NaV1.7 protein the surface of the excitable cells. Genetically modified mice are described, including mice that express the human or humanized NaV1.7 gene from the endogenous NaV1.7 locus, and wherein the mice comprise functional β-subunits.
摘要翻译：提供了遗传修饰的非人动物以及用于制备和使用它们的方法和组合物，其中所述遗传修饰包括内源性NaV通道基因的细胞外环的人源化，特别是一种或多种细胞外孔环的人源化 NaV1.7通道蛋白。还提供了遗传修饰的非人动物，其中遗传修饰包括内源性NaV通道基因的替换，特别是用人NaV1.7基因替代内源性NaV1.7基因，并且其中所述遗传修饰的非人动物动物能够通过表达的人或人源化NaV1.7蛋白质产生动力电位并通过基因修饰的非人动物的可兴奋细胞进行通信，所述可激活细胞的表面。描述了转基因小鼠，包括从内源性NaV1.7基因座表达人或人源化NaV1.7基因的小鼠，其中小鼠包含功能性和亚基。

3. 发明申请

US20140017781A1 Methods of Modifying Eukaryotic Cells 审中-公开
公开(公告)号：US20140017781A1
公开(公告)日：2014-01-16
申请号：US14036774
申请日：2013-09-25
申请人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens
发明人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens
IPC分类号： C12N15/85
CPC分类号： C12P21/00 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K16/462 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C12N15/67 , C12N15/85 , C12N15/8509 , C12N15/902 , C12N15/907 , C12N2800/204
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

4. 发明申请

US20140017238A1 Methods of Modifying Eukaryotic Cells 有权
公开(公告)号：US20140017238A1
公开(公告)日：2014-01-16
申请号：US14036514
申请日：2013-09-25
申请人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens
发明人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens
IPC分类号： C07K16/46
CPC分类号： C12P21/00 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K16/462 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C12N15/67 , C12N15/85 , C12N15/8509 , C12N15/902 , C12N15/907 , C12N2800/204
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

5. 发明申请

US20120322108A1 Adam6 Mice 有权
标题翻译： Adam6小鼠
公开(公告)号：US20120322108A1
公开(公告)日：2012-12-20
申请号：US13404075
申请日：2012-02-24
申请人： Lynn Macdonald , Sean Stevens , Andrew J. Murphy
发明人： Lynn Macdonald , Sean Stevens , Andrew J. Murphy
IPC分类号： A01K67/027 , C12P21/00 , C12N5/10
CPC分类号： C07K16/40 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/22 , C07K16/28 , C07K16/2866 , C07K16/461 , C07K16/462 , C07K2317/21 , C07K2317/92 , C12N9/6489 , C12N15/8509 , C12N2800/204 , C12N2800/30
摘要： Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.
摘要翻译：提供了包含来自内源性ADAM6基因座的ADAM6活性的减少或缺失或缺少编码小鼠ADAM6蛋白的内源性基因座的小鼠，其中所述小鼠包含编码ADAM6或直系同源物或其同源物或其片段的序列，其功能在一只雄性老鼠在一个实施方案中，序列是异位ADAM6序列或赋予雄性小鼠通过交配产生后代的能力的序列。还提供了具有遗传修饰的免疫球蛋白重链基因座的小鼠和细胞，其包含编码小鼠ADAM6或其功能片段或同源物或直系同源物的异位核苷酸序列。

6. 发明授权

US10143186B2 Common light chain mouse 有权
公开(公告)号：US10143186B2
公开(公告)日：2018-12-04
申请号：US13022759
申请日：2011-02-08
申请人： John McWhirter , Lynn Macdonald , Sean Stevens , David R. Buckler , Andrew J. Murphy
发明人： John McWhirter , Lynn Macdonald , Sean Stevens , David R. Buckler , Andrew J. Murphy
IPC分类号： A01K67/027 , C07K16/46 , C07K16/00 , C07K16/28 , C12N15/85 , C12N15/90 , C07K16/22
摘要： A genetically modified mouse is provided, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable sequence, wherein the mouse expresses only one or two human light chain variable domains encoded by human immunoglobulin sequences operably linked to the mouse kappa (κ) constant gene at the endogenous mouse κ locus, wherein the mouse expresses a reverse chimeric antibody having a light chain variable domain derived from one of only two human light chain variable region gene segments and a mouse κ constant domain, and a human heavy chain variable domain and a mouse heavy chain constant domain, from an endogenous mouse heavy chain locus. Bispecific epitope-binding proteins that are fully human are provided, comprising two different heavy chains that associate with an identical light chain that comprises a variable domain derived from one of two different human light chain variable region gene segments.

7. 发明申请

US20140013457A1 Methods of Modifying Eukaryotic Cells 审中-公开
公开(公告)号：US20140013457A1
公开(公告)日：2014-01-09
申请号：US14036518
申请日：2013-09-25
申请人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens
发明人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens
IPC分类号： C12N15/85
CPC分类号： C12P21/00 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K16/462 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C12N15/67 , C12N15/85 , C12N15/8509 , C12N15/902 , C12N15/907 , C12N2800/204
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

8. 发明申请

US20120260357A1 Low Affinity FcgR Deficient Mice 有权
标题翻译：低亲和力FcgR缺陷小鼠
公开(公告)号：US20120260357A1
公开(公告)日：2012-10-11
申请号：US13466225
申请日：2012-05-08
申请人： Lynn Macdonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J. Murphy
发明人： Lynn Macdonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J. Murphy
IPC分类号： A01K67/027 , C12N5/10
CPC分类号： A61K49/0008 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/03 , A01K2267/0387 , C07K14/70535 , G01N33/5014
摘要： Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
摘要翻译：提供了遗传修饰的非人动物以及用于制备和使用它们的方法和组合物，其中所述遗传修饰包括内源性低亲和力FcγR基因座的缺失，并且其中所述小鼠能够表达功能性FcRγ-链。描述了转基因小鼠，包括从内源性FcγR基因座表达低亲和性人FcγR基因的小鼠，其中小鼠包含功能性FcRγ-链。提供了在宿主免疫系统的辅助细胞上表达多达五个低亲和力的人FcγR基因的转基因小鼠。

9. 发明申请

US20210368751A1 HUMANIZED RODENTS THAT EXPRESS HEAVY CHAIN CONTAINING VL DOMAINS 有权
公开(公告)号：US20210368751A1
公开(公告)日：2021-12-02
申请号：US17224524
申请日：2021-04-07
申请人： Lynn Macdonald , Cagan Gurer , Karolina A. Meagher , Sean Stevens , Andrew J. Murphy
发明人： Lynn Macdonald , Cagan Gurer , Karolina A. Meagher , Sean Stevens , Andrew J. Murphy
IPC分类号： A01K67/027 , C07K16/46 , C12N9/64
摘要： Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a rodent (e.g., a mouse), wherein the non-human animals rearrange human immunoglobulin light chain gene segments in the context of heavy chain constant regions and express immunoglobulin-like molecules comprising human immunoglobulin light chain variable domains fused to heavy chain constant domains that are cognate with human immunoglobulin light chain variable domains fused to light chain constant domains.

10. 发明授权

US08658853B2 Low affinity FcγR deficient mice 有权
标题翻译：低亲和力FcgammaR缺陷小鼠
公开(公告)号：US08658853B2
公开(公告)日：2014-02-25
申请号：US13466225
申请日：2012-05-08
申请人： Lynn Macdonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J Murphy
发明人： Lynn Macdonald , Naxin Tu , Cagan Gurer , Sean Stevens , Andrew J Murphy
IPC分类号： A01K67/027 , C12N5/00 , C12N5/02
CPC分类号： A61K49/0008 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/03 , A01K2267/0387 , C07K14/70535 , G01N33/5014
摘要： Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
摘要翻译：提供了遗传修饰的非人动物，以及用于制备和使用它们的方法和组合物，其中所述遗传修饰包括内源性低亲和力FcγAMR基因座的缺失，并且其中所述小鼠能够表达功能性Fcγγ链。描述了转基因小鼠，包括从内源性FcgammaR基因座表达低亲和力的人FcγRR基因的小鼠，其中所述小鼠包含功能性Fcγγ链。提供了在宿主免疫系统的辅助细胞上表达多达五个低亲和力的人FcgammaR基因的转基因小鼠。

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