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    • 10. 发明授权
    • Mice expressing human voltage-gated sodium channels
    • 表达人电压门控钠通道的小鼠
    • US08871996B2
    • 2014-10-28
    • US13155491
    • 2011-06-08
    • Lynn MacdonaldAndrew J. MurphyMichael L. LaCroix-FralishNicole M. Alessandri Haber
    • Lynn MacdonaldAndrew J. MurphyMichael L. LaCroix-FralishNicole M. Alessandri Haber
    • A01K67/027
    • A01K67/0278A01K2217/072A01K2227/105A01K2267/0356
    • Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a humanization of an extracellular loop of an endogenous NaV channel gene, in particular a humanization of the one or more extracellular pore loops of a NaV1.7 channel protein. Genetically modified non-human animals are also provided, wherein the genetic modification comprises replacement of an endogenous NaV channel gene, in particular a replacement of the endogenous NaV1.7 gene with a human NaV1.7 gene, and wherein the genetically modified non-human animals are capable of generating action potentials and communicating through the excitable cells of the genetically modified non-human animals via the expressed human or humanized NaV1.7 protein the surface of the excitable cells. Genetically modified mice are described, including mice that express the human or humanized NaV1.7 gene from the endogenous NaV1.7 locus, and wherein the mice comprise functional β-subunits.
    • 提供了遗传修饰的非人动物以及用于制备和使用它们的方法和组合物,其中所述遗传修饰包括内源性NaV通道基因的细胞外环的人源化,特别是一种或多种细胞外孔环的人源化 NaV1.7通道蛋白。 还提供了遗传修饰的非人动物,其中遗传修饰包括内源性NaV通道基因的替换,特别是用人NaV1.7基因替代内源性NaV1.7基因,并且其中所述遗传修饰的非人动物 动物能够通过表达的人或人源化NaV1.7蛋白质产生动力电位并通过基因修饰的非人动物的可兴奋细胞进行通信,所述可激活细胞的表面。 描述了转基因小鼠,包括从内源性NaV1.7基因座表达人或人源化NaV1.7基因的小鼠,其中小鼠包含功能性和亚基。