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1. 发明申请

US20100151560A1 Compact disk based platform for separating and detecting immunomagnetic bead labeled cells 有权
标题翻译：用于分离和检测免疫磁珠标记细胞的基于光盘的平台
公开(公告)号：US20100151560A1
公开(公告)日：2010-06-17
申请号：US12382844
申请日：2009-03-25
申请人： Andrew M. Wo , Chen-Lin Chen , Ken-Chao Chen , Yu-Cheng Pan
发明人： Andrew M. Wo , Chen-Lin Chen , Ken-Chao Chen , Yu-Cheng Pan
IPC分类号： C12M1/34
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0668 , B01L2200/12 , B01L2300/0803 , B01L2400/0409 , B01L2400/043
摘要： Disclosed is a disk based platform for separating and detecting cells that are labeled with immunomagnetic beads. A disk-like carrier board forms therein at least one flow channel structure, which includes an inner reservoir for receiving a sample fluid, an outer reservoir, and a plurality of micro flow channels arranged between and in fluid communication with the inner and outer reservoirs. When the disk-like carrier board spins, cells labeled with immunomagnetic beads are attracted by a magnetic attraction unit that is arranged above the disk-like carrier board and adjacent to the inner reservoir to thereby remain in the inner reservoir, and cells that are not so labeled are acted upon by a centrifugal force induced by the spinning of the disk-like carrier board to flow with the sample fluid from the inner reservoir through the micro flow channels into the outer reservoir.
摘要翻译：公开了一种用于分离和检测用免疫磁珠标记的细胞的基于盘的平台。盘形载体板在其中形成至少一个流动通道结构，其包括用于接收样品流体的内部储存器，外部储存器和布置在内部和外部储存器之间并与其流体连通的多个微流体通道。当盘状载体板旋转时，用免疫磁性珠子标记的细胞被磁性吸引单元吸引，磁吸引单元布置在盘状载体板的上方并与内部储存器相邻，从而保留在内部储存器中，而不是细胞如此标记的作用是通过由盘状载体板的纺丝引起的离心力而使样品流体从内部储存器通过微流动通道流入外部储存器。

2. 发明申请

US20100227379A1 Compact disk based system for separating immunomagnetic bead labeled particulates and method thereof 有权
标题翻译：用于分离免疫磁珠标记的微粒的基于光盘的系统及其方法
公开(公告)号：US20100227379A1
公开(公告)日：2010-09-09
申请号：US12457918
申请日：2009-06-25
申请人： Andrew M. Wo , Chen-Lin Chen , Ken-Chao Chen , Yu-Cheng Pan
发明人： Andrew M. Wo , Chen-Lin Chen , Ken-Chao Chen , Yu-Cheng Pan
IPC分类号： C12N1/02 , C12M1/42
CPC分类号： C12N1/02 , C12M47/04 , G01N35/00069 , G01N2035/00495 , Y10T436/111666 , Y10T436/25375
摘要： Disclosed is a disk based system for separating at least two types of particulates contained in a sample fluid. The system includes a disk-like carrier board and a magnetic attraction unit. The disk-like carrier board forms at least one flow channel structure, which includes an inner reservoir, at least one separation chamber, and at least one outer reservoir arranged in sequence from a geometric center of the disk-like carrier board to an outer circumferential rim of the disk-like carrier board. A method of separation carried out with the system includes introducing the sample fluid into the inner reservoir and then rotating the disk-like carrier board to induce a centrifugal force. The sample fluid contains particulates that are labeled with immunomagnetic beads and the labeled particulates are attracted by the magnetic force generated by the magnetic attraction unit to retain in the inner reservoir or the separation chamber. Particulates not labeled with the immunomagnetic beads and contained in the sample fluid move with the sample fluid to the outer reservoir.
摘要翻译：公开了一种用于分离包含在样品流体中的至少两种类型的微粒的基于盘的系统。该系统包括盘状载体板和磁性吸引单元。盘形载体板形成至少一个流动通道结构，其包括内部储存器，至少一个分离室和至少一个外部储存器，其依次从盘状载体板的几何中心排列到外部圆周盘状载板的边缘。用系统进行的分离方法包括将样品流体引入内部储存器中，然后旋转盘状载体板以引起离心力。样品流体包含用免疫磁珠标记的微粒，并且标记的微粒被磁吸引单元产生的磁力吸引，以保持在内储存器或分离室中。未标记有免疫磁珠并且包含在样品流体中的颗粒与样品流体一起移动到外部储存器。

3. 发明授权

US08226826B2 Compact disk based system for separating immunomagnetic bead labeled particulates and method thereof 有权
标题翻译：用于分离免疫磁珠标记的微粒的基于光盘的系统及其方法
公开(公告)号：US08226826B2
公开(公告)日：2012-07-24
申请号：US12457918
申请日：2009-06-25
申请人： Andrew M. Wo , Chen-Lin Chen , Ken-Chao Chen , Yu-Cheng Pan
发明人： Andrew M. Wo , Chen-Lin Chen , Ken-Chao Chen , Yu-Cheng Pan
IPC分类号： B01D35/06 , C12M1/34
CPC分类号： C12N1/02 , C12M47/04 , G01N35/00069 , G01N2035/00495 , Y10T436/111666 , Y10T436/25375
摘要： Disclosed is a disk based system for separating at least two types of particulates contained in a sample fluid. The system includes a disk-like carrier board and a magnetic attraction unit. The disk-like carrier board forms at least one flow channel structure, which includes an inner reservoir, at least one separation chamber, and at least one outer reservoir arranged in sequence from a geometric center of the disk-like carrier board to an outer circumferential rim of the disk-like carrier board. A method of separation carried out with the system includes introducing the sample fluid into the inner reservoir and then rotating the disk-like carrier board to induce a centrifugal force. The sample fluid contains particulates that are labeled with immunomagnetic beads and the labeled particulates are attracted by the magnetic force generated by the magnetic attraction unit to retain in the inner reservoir or the separation chamber. Particulates not labeled with the immunomagnetic beads and contained in the sample fluid move with the sample fluid to the outer reservoir.
摘要翻译：公开了一种用于分离包含在样品流体中的至少两种类型的微粒的基于盘的系统。该系统包括盘状载体板和磁性吸引单元。盘形载体板形成至少一个流动通道结构，其包括内部储存器，至少一个分离室和至少一个外部储存器，其依次从盘状载体板的几何中心排列到外部圆周盘状载板的边缘。用系统进行的分离方法包括将样品流体引入内部储存器中，然后旋转盘状载体板以引起离心力。样品流体包含用免疫磁珠标记的微粒，并且标记的微粒被磁吸引单元产生的磁力吸引，以保持在内储存器或分离室中。未标记有免疫磁珠并且包含在样品流体中的颗粒与样品流体一起移动到外部储存器。

4. 发明授权

US08039249B2 Compact disk based platform for separating and detecting immunomagnetic bead labeled cells 有权
标题翻译：用于分离和检测免疫磁珠标记细胞的基于光盘的平台
公开(公告)号：US08039249B2
公开(公告)日：2011-10-18
申请号：US12382844
申请日：2009-03-25
申请人： Andrew M. Wo , Chen-Lin Chen , Ken-Chao Chen , Yu-Cheng Pan
发明人： Andrew M. Wo , Chen-Lin Chen , Ken-Chao Chen , Yu-Cheng Pan
IPC分类号： C12M1/34
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0668 , B01L2200/12 , B01L2300/0803 , B01L2400/0409 , B01L2400/043
摘要： Disclosed is a disk based platform for separating and detecting cells that are labeled with immunomagnetic beads. A disk-like carrier board forms therein at least one flow channel structure, which includes an inner reservoir for receiving a sample fluid, an outer reservoir, and a plurality of micro flow channels arranged between and in fluid communication with the inner and outer reservoirs. When the disk-like carrier board spins, cells labeled with immunomagnetic beads are attracted by a magnetic attraction unit that is arranged above the disk-like carrier board and adjacent to the inner reservoir to thereby remain in the inner reservoir, and cells that are not so labeled are acted upon by a centrifugal force induced by the spinning of the disk-like carrier board to flow with the sample fluid from the inner reservoir through the micro flow channels into the outer reservoir.
摘要翻译：公开了一种用于分离和检测用免疫磁珠标记的细胞的基于盘的平台。盘形载体板在其中形成至少一个流动通道结构，其包括用于接收样品流体的内部储存器，外部储存器和布置在内部和外部储存器之间并与其流体连通的多个微流体通道。当盘状载体板旋转时，用免疫磁性珠子标记的细胞被磁性吸引单元吸引，磁吸引单元布置在盘状载体板的上方并与内部储存器相邻，从而保留在内部储存器中，而不是细胞如此标记的作用是通过由盘状载体板的纺丝引起的离心力而使样品流体从内部储存器通过微流动通道流入外部储存器。

5. 发明申请

US20110061472A1 BIOCHIP SYSTEM, METHOD FOR DETERMINING SPERM QUALITY AND METHOD FOR SEPARATING SPERM 审中-公开
标题翻译： BIOCHIP系统，用于确定SPERM质量的方法和用于分离SPERM的方法
公开(公告)号：US20110061472A1
公开(公告)日：2011-03-17
申请号：US12763217
申请日：2010-04-20
申请人： Andrew M. Wo , Yu-An Chen , Fang-Sheng Tsai , Zi-Wei Huang
发明人： Andrew M. Wo , Yu-An Chen , Fang-Sheng Tsai , Zi-Wei Huang
IPC分类号： G01N1/10
CPC分类号： G01N35/00
摘要： A method for determining sperm quality is provided. At least one first microfluidic region and at least one second microfluidic region are provided, which meet at a junction. The second microfluidic region includes a shrunk portion with a width sized to substantially allow only one sperm to pass therethrough. A detector is disposed at the shrunk portion. First and second flow fields are formed in the first and second microfluidic regions, respectively. The first and second flow fields have different directions at the junction. A semen sample is loaded at a semen sample loading end. At least one sperm moves in the first microfluidic region against the direction of the first flow field and at least one sperm moves in the second microfluidic region along the direction of the second flow field. The detector generates a signal upon one sperm in the semen sample passing through the shrunk portion.
摘要翻译：提供了一种测定精子质量的方法。提供至少一个第一微流体区域和至少一个第二微流体区域，其在结处相遇。第二微流体区域包括缩小部分，其宽度尺寸确定为仅允许一个精子通过。检测器设置在收缩部分。第一和第二流场分别形成在第一和第二微流体区域中。第一和第二流场在连接处具有不同的方向。精液样本加载在精液样品加载端。至少一个精子在第一微流体区域中相对于第一流场的方向移动，并且至少一个精子沿着第二流场的方向在第二微流体区域中移动。检测器在精液样本中的一个精子上产生通过收缩部分的信号。

6. 发明授权

US07919048B2 Cellular microarray and its microfabrication method 有权
标题翻译：细胞微阵列及其微细加工方法
公开(公告)号：US07919048B2
公开(公告)日：2011-04-05
申请号：US12149030
申请日：2008-04-25
申请人： Andrew M. Wo , Lo-Chang Hsiung , Chun-Hui Yang , Hsin-Yu Lee
发明人： Andrew M. Wo , Lo-Chang Hsiung , Chun-Hui Yang , Hsin-Yu Lee
IPC分类号： C40B60/02
CPC分类号： B03C5/026 , Y10T436/25375
摘要： A cellular microarray is disclosed, which has a substrate, multiple first conductive lines, multiple second conductive lines, and multiple PIREs arranged on the surface of the substrate in an array. Each PIRE includes multiple first ring-shaped electrodes, and multiple second ring-shaped electrodes. The first ring-shaped electrodes, and the second ring-shaped electrodes are located on the surface of the substrate alternately in each PIRE. Moreover, the outermost ring-shaped electrodes of any two adjacent feather-shaped electrodes are different. The disclosed cellular microarray can adhere the cells rapidly and uniformly, increase the output of manufacturing, and reduce the cost for manufacturing and application.
摘要翻译：公开了一种细胞微阵列，其具有衬底，多个第一导电线，多个第二导电线和布置在阵列的衬底的表面上的多个PIRE。每个PIRE包括多个第一环形电极和多个第二环形电极。第一环形电极和第二环形电极在每个PIRE中交替地位于基板的表面上。此外，任何两个相邻的羽状电极的最外环形电极是不同的。所公开的细胞微阵列可以快速且均匀地粘附细胞，增加制造的输出，并降低制造和应用的成本。

7. 发明申请

US20100062214A1 Method for drilling micro-hole and structure thereof 审中-公开
标题翻译：微孔钻孔方法及其结构
公开(公告)号：US20100062214A1
公开(公告)日：2010-03-11
申请号：US12230819
申请日：2008-09-05
申请人： Andrew M. Wo , De-Shien Jong , Chang-Yu Chen , Kuan-Ting Liu , Lo-Chang Hsiung
发明人： Andrew M. Wo , De-Shien Jong , Chang-Yu Chen , Kuan-Ting Liu , Lo-Chang Hsiung
IPC分类号： B32B3/10 , B23K26/38
CPC分类号： B23K26/0619 , B23K26/384 , Y10T428/24273
摘要： Disclosed is a micro-hole structure and a method for forming the micro-hole. A working energy source is projected onto a predetermined drilling site on a first surface of a substrate for a given period of time so as to melt a portion of the substrate to form a working energy entering section until the working energy source penetrates through a second surface of the substrate to form a micro-hole. A melt formed by melting a portion of the substrate in the micro-hole next to the second surface is allowed to reflow in a direction opposite to the projection of the working energy source to thereby form a reflow section in the substrate. Further, a two or more stages emission of laser pulses is used to form the micro-hole to control the bore diameter of the micro-hole.
摘要翻译：公开了微孔结构和形成微孔的方法。将工作能量源投影到基板的第一表面上的预定钻孔位置一段给定的时间段，以便熔化基板的一部分以形成工作能量进入部分，直到工作能量源穿过第二表面的基底以形成微孔。允许通过在第二表面旁边的微孔中熔化基底的一部分而形成的熔体在与工作能量源的突起相反的方向上回流，从而在衬底中形成回流部。此外，使用激光脉冲的两级或更多级发射来形成微孔以控制微孔的孔直径。

8. 发明申请

US20090093376A1 Cellular microarray and its microfabrication method 有权
标题翻译：细胞微阵列及其微细加工方法
公开(公告)号：US20090093376A1
公开(公告)日：2009-04-09
申请号：US12149030
申请日：2008-04-25
申请人： Andrew M. Wo , Lo-Chang Hsiung , Chun-Hui Yang , Hsin-Yu Lee
发明人： Andrew M. Wo , Lo-Chang Hsiung , Chun-Hui Yang , Hsin-Yu Lee
IPC分类号： C40B40/02
CPC分类号： B03C5/026 , Y10T436/25375
摘要： A cellular microarray is disclosed, which has a substrate, multiple first conductive lines, multiple second conductive lines, and multiple PIREs arranged on the surface of the substrate in an array. Each PIRE includes multiple first ring-shaped electrodes, and multiple second ring-shaped electrodes. The first ring-shaped electrodes, and the second ring-shaped electrodes are located on the surface of the substrate alternately in each PIRE. Moreover, the outermost ring-shaped electrodes of any two adjacent feather-shaped electrodes are different. The disclosed cellular microarray can adhere the cells rapidly and uniformly, increase the output of manufacturing, and reduce the cost for manufacturing and application.
摘要翻译：公开了一种细胞微阵列，其具有衬底，多个第一导电线，多个第二导电线和布置在阵列的衬底的表面上的多个PIRE。每个PIRE包括多个第一环形电极和多个第二环形电极。第一环形电极和第二环形电极在每个PIRE中交替地位于基板的表面上。此外，任何两个相邻的羽状电极的最外环形电极是不同的。所公开的细胞微阵列可以快速且均匀地粘附细胞，增加制造的输出，并降低制造和应用的成本。

9. 发明申请

US20090025810A1 MICRO-VORTEX GENERATOR 审中-公开
标题翻译：微型VORTEX发电机
公开(公告)号：US20090025810A1
公开(公告)日：2009-01-29
申请号：US11867163
申请日：2007-10-04
申请人： Andrew M. Wo , Cheng-Ming Lin , Yu-Shiang Lai
发明人： Andrew M. Wo , Cheng-Ming Lin , Yu-Shiang Lai
IPC分类号： F15C3/00
CPC分类号： B01F11/0258 , B01F13/0059 , B01L3/5027 , H02K33/18 , Y10T137/2087
摘要： The present invention relates to a MEMS-based micro-oscillator which can generate specific vortical pattern in a micro-channel. The micro-vortex generator is composed of a suspended bridge with a gold-plated, rectangular flat-plate as the primary structure. When an AC current passed through the gold leads under an external magnetic field, the plate will oscillate due to Lorenz force, thereby generating micro-vortices.
摘要翻译：本发明涉及一种可在微通道中产生特定涡旋图案的基于MEMS的微振荡器。微涡流发生器由具有镀金，矩形平板作为主要结构的悬挂桥组成。当交流电流在外部磁场下通过金引线时，板将由于洛伦兹力而振荡，从而产生微旋涡。

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