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1. 发明授权

US4686217A Calcium antagonist 2-fluoroalkyl-1,4-dihydropyridines 失效
标题翻译：钙拮抗剂2-氟烷基-1,4-二氢吡啶
公开(公告)号：US4686217A
公开(公告)日：1987-08-11
申请号：US601309
申请日：1984-04-17
申请人： Andrew J. G. Baxter , John Dixon , Kenneth J. Gould , Alan C. Tinker
发明人： Andrew J. G. Baxter , John Dixon , Kenneth J. Gould , Alan C. Tinker
IPC分类号： C07C17/093 , C07C45/00 , C07C47/55 , C07C205/56 , C07D205/04 , C07D211/78 , C07D211/90 , C07D305/08 , C07D309/12 , C07D401/04 , C07D405/04 , C07D413/04 , C07D521/00 , A61K31/455
CPC分类号： C07D231/12 , C07C17/093 , C07C205/56 , C07C45/00 , C07C47/55 , C07D205/04 , C07D211/78 , C07D211/90 , C07D233/56 , C07D249/08 , C07D305/08 , C07D309/12 , C07D401/04 , C07D405/04 , C07D413/04
摘要： There are described compounds of formula I, ##STR1## in which R.sub.1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted,--COOR.sub.2 and --COOR.sub.3 are various ester groups,one of R.sub.7 and R.sub.8 represents alkyl Cl to 6 and the other represents --CONR.sub.10 R.sub.11 ; --CSNH.sub.2 ; --C(.dbd.NH)SR.sub.9 ; --S(O).sub.m R.sub.9 ; phenyl optionally substituted by one or more of alkyl Cl to 6, halogen, alkoxy Cl to 6 or nitro; alkyl Cl to 6 substituted by halogen; or furanyl;m is 0 or 1R.sub.9 is alkyl Cl to 6, andR.sub.10 and R.sub.11 each independently represent hydrogen or alkyl Cl to 6, or together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring.There are also described processes for making the compounds, and pharmaceutical, e.g. calcium antagonist, formulations containing them.
摘要翻译：描述了式I的化合物，其中R1代表苯并呋喃基，吡啶基或苯基，被取代的吡啶基或苯基，-COOR2和-COOR3是各种酯基，R7和R8之一表示烷基C1至6和另一个代表-CONR10R11; -CSNH2; -C（= NH）SR9; -S（O）m R 9; 任选被一个或多个烷基C1至6，卤素，烷氧基C1至6或硝基取代的苯基; 由卤素取代的C 1-6烷基; 或呋喃基; m为0或1，R 9为C 1-6烷基，R 10和R 11各自独立地表示氢或C 1-6烷基，或与它们所连接的氮原子一起形成5或6元杂环。还描述了制备化合物的方法，以及药物，例如，钙拮抗剂，含有它们的制剂。

2. 发明授权

US4607041A Antihypertensive 2-phenyl Hantzsch dihydropyridines 失效
标题翻译：抗高血压2-苯基汉坦二氢吡啶类
公开(公告)号：US4607041A
公开(公告)日：1986-08-19
申请号：US601389
申请日：1984-04-17
申请人： Andrew J. G. Baxter , John Dixon , Thomas McInally , Alan C. Tinker
发明人： Andrew J. G. Baxter , John Dixon , Thomas McInally , Alan C. Tinker
IPC分类号： C07C17/093 , C07C45/00 , C07C47/55 , C07C205/56 , C07D205/04 , C07D211/78 , C07D211/90 , C07D305/08 , C07D309/12 , C07D401/04 , C07D405/04 , C07D413/04 , C07D521/00 , A61K31/445 , C07D413/14
CPC分类号： C07D231/12 , C07C17/093 , C07C205/56 , C07C45/00 , C07C47/55 , C07D205/04 , C07D211/78 , C07D211/90 , C07D233/56 , C07D249/08 , C07D305/08 , C07D309/12 , C07D401/04 , C07D405/04 , C07D413/04
摘要： There are described compounds of formula I, ##STR1## in which R.sub.1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted by one or more of the groups halogen, nitro, --CN, --OR.sub.9, --S(O).sub.p R.sub.9, or alkyl C1 to 6 optionally substituted by halogen,p is 0, 1 or 2,R.sub.2 and R.sub.3, which may be the same or different, each represent hydrogen; alkyl C1 to 6 optionally substituted by one or more of the groups halogen, cyano, --XR.sub.4, --NR.sub.5 R.sub.6 or phenyl; cycloalkyl C3 to 8 optionally substituted by alkyl C1 to 6; a 4, 5 or 6 membered oxygen or nitrogen containing heterocyclic ring which is optionally substituted by alkyl C1 to 6 the alkyl in turn optionally being substituted by one or more phenyl groups;R.sub.5 and R.sub.6, which may be the same or different, each represent alkyl C1 to 6 optionally substituted by phenyl,Y and Z together form a bond, and additionally, when R.sub.8 is an electron withdrawing group Y may be hydrogen and Z may be hydroxy,one of R.sub.7 and R.sub.8 represents alkyl C1 to 6 and the other represents phenyl,or R.sub.7 and R.sub.8 may be the same or different and each represents phenyl optionally substituted by one or more of alkyl C1 to 6, halogen, alkoxy C1 to 6 or nitro; amino; alkyl C1 to 6 substituted by halogen; --CN; --CH.sub.2 OH; --CHO or --CH(OR.sub.9).sub.2,X is O or S,R.sub.4 is alkyl C1 to 6 or phenyl,R.sub.9 is alkyl C1 to 6, with certain provisons.There are also described processes for making the compounds, and their formulation and use as pharmaceuticals for treatment of hypertension, angina, or congestive heart failure.
摘要翻译：描述式Ⅰ化合物，其中R1代表苯并呋喃基，吡啶基或苯基，吡啶基或苯基被一个或多个卤素，硝基，-CN，-OR9，-S（O） pR9或任选被卤素取代的C 1-6的烷基，p为0,1或2，R 2和R 3可以相同或不同，各自表示氢; 任选被一个或多个卤素，氰基，-XR 4，-NR 5 R 6或苯基基团取代的C 1-6烷基; 任选被C1至6的烷基取代的环烷基C3至8; 任选被烷基C1至6取代的4,5或6元含氧或含氮杂环，所述烷基依次可选地被一个或多个苯基取代; R 5和R 6可以相同或不同，各自表示任选被苯基取代的烷基C1至6，Y和Z一起形成键，另外，当R8是吸电子基团时，Y可以是氢，Z可以是羟基 R 7和R 8中的一个表示烷基C1至6，另一个表示苯基，或者R 7和R 8可以相同或不同，表示任选被一个或多个烷基C1至6，卤素，烷氧基C1至6或硝基氨基; 由卤素取代的C1至6烷基; -CN; -CH 2 OH; -CHO或-CH（OR 9）2，X为O或S，R 4为C 1-6烷基或苯基，R 9为烷基C 1-6，具有一定条件。还描述了制备化合物的方法及其制剂和用作治疗高血压，心绞痛或充血性心力衰竭的药物。

3. 发明授权

US4791216A Para ethyl amino phenol pharmaceutical compounds 失效
标题翻译： Para乙基氨基苯酚药物化合物
公开(公告)号：US4791216A
公开(公告)日：1988-12-13
申请号：US938249
申请日：1986-12-05
申请人： Francis Ince , Alan C. Tinker
发明人： Francis Ince , Alan C. Tinker
IPC分类号： A61K31/135 , A61K31/165 , C07C43/174 , C07C43/23 , C07C45/51 , C07C65/24 , C07C275/28 , C07C311/02 , C07C317/22 , C07C323/25 , C07D215/22 , C07D215/227 , C07D215/26 , C07D263/14 , C07D319/08 , C07C147/06 , C07C87/28 , C07C103/85
CPC分类号： C07D215/227 , C07C255/00 , C07C275/28 , C07C323/00 , C07C323/25 , C07C43/174 , C07C43/23 , C07C45/515 , C07C65/24 , C07D215/26 , C07D263/14 , C07D319/08 , C07C2101/14 , Y10S514/821
摘要： There are provided paraethylamine phenol compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds.
摘要翻译：提供式I的对甲基苯酚酚化合物及其药学上可接受的衍生物。还描述了式I化合物作为药物的用途，制备化合物的方法和药物，例如，心脏，含有化合物的组合物。

4. 发明授权

US4657929A Compounds 失效
标题翻译：化合物
公开(公告)号：US4657929A
公开(公告)日：1987-04-14
申请号：US662348
申请日：1984-10-18
申请人： Francis Ince , Alan C. Tinker
发明人： Francis Ince , Alan C. Tinker
IPC分类号： A61K31/135 , A61K31/165 , C07C43/174 , C07C43/23 , C07C45/51 , C07C65/24 , C07C275/28 , C07C311/02 , C07C317/22 , C07C323/25 , C07D215/22 , C07D215/227 , C07D215/26 , C07D263/14 , C07D319/08 , A61K31/18 , A61K31/25 , C07C87/60 , C07C87/62 , C07C103/50 , C07C103/85 , C07C143/74 , C07C149/273 , C07C157/09
CPC分类号： C07D215/227 , C07C255/00 , C07C275/28 , C07C323/00 , C07C323/25 , C07C43/174 , C07C43/23 , C07C45/515 , C07C65/24 , C07D215/26 , C07D263/14 , C07D319/08 , C07C2101/14 , Y10S514/821
摘要： There are provided pharmaceutical compounds useful in treating hypertension, heart diseases and renal failure. These compounds are 4-hydroxy phenethylamines wherein the 3 position on the phenyl nucleus is occupied by either an amino, amide, carbamyl, urea sulfonamide, substituted alkyl or fluorine atom, and the amine group is further linked to another phenyl radical through an alkylene radical which may contain nitrogen, oxygen, sulfur or cyclic hydrocarbon radicals as intervening groups.
摘要翻译：提供了用于治疗高血压，心脏病和肾衰竭的药物化合物。这些化合物是4-羟基苯乙胺，其中苯基上的3位被氨基，酰胺，氨基甲酰基，脲磺酰胺，取代的烷基或氟原子占据，胺基还通过亚烷基进一步连接到另一个苯基上其可以含有氮，氧，硫或环状烃基作为介入基团。

5. 发明授权

US4868306A Compounds 失效
标题翻译：化合物
公开(公告)号：US4868306A
公开(公告)日：1989-09-19
申请号：US260529
申请日：1988-10-21
申请人： Francis Ince , Alan C. Tinker
发明人： Francis Ince , Alan C. Tinker
IPC分类号： A61K31/135 , A61K31/165 , C07C43/174 , C07C43/23 , C07C45/51 , C07C65/24 , C07C275/28 , C07C311/02 , C07C317/22 , C07C323/25 , C07D215/22 , C07D215/227 , C07D215/26 , C07D263/14 , C07D319/08
CPC分类号： C07D215/227 , C07C255/00 , C07C275/28 , C07C323/00 , C07C323/25 , C07C43/174 , C07C43/23 , C07C45/515 , C07C65/24 , C07D215/26 , C07D263/14 , C07D319/08 , C07C2101/14 , Y10S514/821
摘要： There are provided compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds.
摘要翻译：提供式I化合物，其药学上可接受的衍生物。还描述了式I化合物作为药物的用途，制备化合物的方法和药物，例如，心脏，含有化合物的组合物。

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