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    • 3. 发明申请
    • REMOVAL OF FUSARIUM INFECTED KERNELS FOR GRAIN
    • 去除粮食感染的食物
    • US20110094946A1
    • 2011-04-28
    • US12997923
    • 2009-06-25
    • David A. PrystupaJennifer PowellMatthew AllenChris Vogt
    • David A. PrystupaJennifer PowellMatthew AllenChris Vogt
    • B07C5/342
    • B07C5/3425G01N21/314G01N21/85G01N2021/8592G01N2021/8838G01N2201/0627G01N2201/0833G01N2201/1293Y10S209/938
    • Fusarium infected grain is separated by comparing reflected and transmitted light at two wavelengths, one at which the light is substantially reflected and scattered the same by healthy and infected kernels, the other at which the light is reflected and scattered to a significantly greater degree by infected than healthy kernels. An apparatus having a rotating apertured cylinder, with a low internal vacuum, allows comparison of individual kernels. When comparison indicates that a kernel is infected, a lever dislodges it from the cylinder allowing it to fall into a receptacle for infected kernels. Kernels remaining on the cylinder are scraped off to fall into a receptacle for healthy kernels. Although results vary, to some extent depending on the degree of infection, approximately 90% of healthy kernels and 5% of infected kernels are deemed “healthy”, while approximately 10% of healthy kernels and 95% of infected kernels are deemed “infected,” reducing the level of infected kernels.
    • 通过比较两个波长的反射和透射光来分离镰刀菌感染的谷粒,其中光被健康和感染的核重要地反射和散射,另一个在光被反射和散射的情况下被显着更大程度地被感染 比健康的内核。 具有低内部真空的旋转有孔圆筒的装置允许比较各个内核。 当比较表明内核受到感染时,杠杆将其从气缸中移出,使其能够落入受感染的内核的容器中。 残留在圆筒上的颗粒被刮掉以落入健康的内核的容器中。 虽然结果有所不同,但在一定程度上取决于感染程度,约90%的健康粒子和5%的感染粒子被认为是“健康的”,而大约10%的健康粒子和95%的感染核心被认为是感染的, “降低受感染的内核的水平。
    • 10. 发明申请
    • Magnetic Resonance Imaging Contrast Agents Synthesized Using Ring-Opening Metathesis Polymerization
    • 使用开环复分解聚合合成的磁共振成像对比剂
    • US20080063602A1
    • 2008-03-13
    • US11743740
    • 2007-05-03
    • Laura KiesslingRonald RainesMatthew Allen
    • Laura KiesslingRonald RainesMatthew Allen
    • A61K49/06A61B5/055C08G73/00
    • A61K49/128
    • Polymeric chelating agents and metal chelates, particularly those of lanthanide metals and more specifically those of Gd(III), useful as contrast agents in magnetic resonance imaging (MRI) for therapeutic and diagnostic applications as well as clinical and biomedical research applications. The polymeric chelates are generated using ring-opening metathesis polymerization (ROMP). Polymers can have multiple sites for functionalization allowing for the synthesis of multimodal and targeted contrast agents. Hydroxypyridonate (HOPO)-based chelating moieties are integrated into a ROMP-derived polymer. More specifically, the HOPO-based chelating moiety is integrated into a benzonorbornadiene unit that constitutes the backbone of the polymer. The ROMP-derived polymer chelators can comprise multiple metal ions, particularly Gd(III) ions, in polymers of varying lengths to provide a series of agents with controlled relaxivites. Polymer chelates include those that are water-soluble.
    • 聚合螯合剂和金属螯合物,特别是镧系元素金属螯合剂,更具体地,可用作Gd(III)的螯合剂,用作治疗和诊断应用以及临床和生物医学研究应用的磁共振成像(MRI)中的造影剂。 使用开环易位聚合(ROMP)产生聚合物螯合物。 聚合物可以具有多个用于官能化的位点,允许合成多峰和靶向造影剂。 将羟基吡啶酮(HOPO)基螯合部分整合到ROMP衍生的聚合物中。 更具体地,基于HOPO的螯合部分整合成构成聚合物主链的苯并降二烯单元。 ROMP衍生的聚合物螯合剂可以在不同长度的聚合物中包含多种金属离子,特别是Gd(III)离子,以提供具有受控弛豫物质的一系列试剂。 聚合物螯合物包括那些水溶性螯合物。