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1. 发明申请

US20070203140A1 N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase 审中-公开
标题翻译： N-羟基胍被用作吲哚胺2,3-双加氧酶的调节剂
公开(公告)号：US20070203140A1
公开(公告)日：2007-08-30
申请号：US11703961
申请日：2007-02-08
申请人： Andrew Combs , Brian Glass
发明人： Andrew Combs , Brian Glass
IPC分类号： A61K31/5375 , A61K31/496 , A61K31/4172
CPC分类号： C07C279/18 , C07D213/38 , C07D213/64 , C07D213/74 , C07D231/12 , C07D231/38 , C07D231/40 , C07D263/32 , C07D277/28 , C07D285/06 , C07D295/13 , C07D295/215
摘要： The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions containing the same and methods for the treatment of IDO-associated diseases.
摘要翻译：本发明涉及吲哚胺2,3-双加氧酶（IDO）的调节剂，以及含有其的药物组合物和治疗IDO相关疾病的方法。

2. 发明授权

US08275701B2 Method and system for mortgage exchange 有权
标题翻译：抵押交换的方法和制度
公开(公告)号：US08275701B2
公开(公告)日：2012-09-25
申请号：US13076044
申请日：2011-03-30
申请人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
发明人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q40/025
摘要： A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.
摘要翻译：通过提供借款人有资格接受的贷款的准确表示，这种方法和系统以电子方式促进房地产交易，这些贷款是根据实际数据而不是估计。完成房地产交易所需的所有行动，从借款人信息入门到贷款的结算和融资，均无缝整合。提供自动承保引擎，用于基于用户输入和/或现有数据生成决策矩阵。根据决策矩阵选择适当的贷款，并将其传达给潜在的借款人。选定贷款后，进行履行处理，贷款得到资助和关闭。

3. 发明申请

US20110178921A1 METHOD AND SYSTEM FOR MORTGAGE EXCHANGE 有权
标题翻译：手段交换的方法和系统
公开(公告)号：US20110178921A1
公开(公告)日：2011-07-21
申请号：US13076044
申请日：2011-03-30
申请人： William C. ERBEY , Christopher Kennedy , Bryan Hurley , Andrew Combs
发明人： William C. ERBEY , Christopher Kennedy , Bryan Hurley , Andrew Combs
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q40/025
摘要： A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.
摘要翻译：通过提供借款人有资格接受的贷款的准确表示，这种方法和系统以电子方式促进房地产交易，这些贷款是根据实际数据而不是估计。完成房地产交易所需的所有行动，从借款人信息入门到贷款的结算和融资，均无缝整合。提供自动承保引擎，用于基于用户输入和/或现有数据生成决策矩阵。根据决策矩阵选择适当的贷款，并将其传达给潜在的借款人。选定贷款后，进行履行处理，贷款得到资助和关闭。

4. 发明申请

US20060258719A1 Modulators of indoleamine 2,3-dioxygenase and methods of using the same 有权
标题翻译：吲哚胺2,3-双加氧酶的调节剂及其使用方法
公开(公告)号：US20060258719A1
公开(公告)日：2006-11-16
申请号：US11430441
申请日：2006-05-09
申请人： Andrew Combs , Eddy Yue
发明人： Andrew Combs , Eddy Yue
IPC分类号： C07D285/10 , A61K31/4245 , A61K31/433
CPC分类号： C07D271/08 , A61K31/4245 , A61K31/433 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D285/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
摘要翻译：本发明涉及吲哚胺2,3-双加氧酶（IDO）的调节剂，以及其组合物和药物方法。

5. 发明申请

US20080120227A1 Method and system for mortgage exchange 审中-公开
标题翻译：抵押交换的方法和制度
公开(公告)号：US20080120227A1
公开(公告)日：2008-05-22
申请号：US11802308
申请日：2007-05-22
申请人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
发明人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q40/025
摘要： A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.
摘要翻译：通过提供借款人有资格接受的贷款的准确表示，这种方法和系统以电子方式促进房地产交易，这些贷款是根据实际数据而不是估计。完成房地产交易所需的所有行动，从借款人信息入门到贷款的结算和融资，均无缝整合。提供自动承保引擎，用于基于用户输入和/或现有数据生成决策矩阵。根据决策矩阵选择适当的贷款，并将其传达给潜在的借款人。选定贷款后，进行履行处理，贷款得到资助和关闭。

6. 发明申请

US20070149506A1 Azepine inhibitors of Janus kinases 审中-公开
标题翻译：阿诺地抑制剂Janus激酶
公开(公告)号：US20070149506A1
公开(公告)日：2007-06-28
申请号：US11524641
申请日：2006-09-21
申请人： Argyrios Arvanitis , James Rodgers , Andrew Combs , Richard Sparks , Darius Robinson
发明人： Argyrios Arvanitis , James Rodgers , Andrew Combs , Richard Sparks , Darius Robinson
IPC分类号： A61K31/55 , C07D487/22
CPC分类号： C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译：本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。

7. 发明申请

US20060183906A1 Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-4-yl-amines as janus kinase inhibitors 有权
标题翻译：吡咯并[2,3-b]吡啶-4-基 - 胺和吡咯并[2,3-b]嘧啶-4-基胺
公开(公告)号：US20060183906A1
公开(公告)日：2006-08-17
申请号：US11313394
申请日：2005-12-21
申请人： James Rodgers , Haisheng Wang , Andrew Combs , Richard Sparks
发明人： James Rodgers , Haisheng Wang , Andrew Combs , Richard Sparks
IPC分类号： C07D471/02 , A61K31/44 , C07D491/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
摘要翻译：本发明提供调节Janus激酶活性的吡咯并[2,3-b]吡啶-4-基胺吡咯并[2,3-b]嘧啶-4-基胺，可用于治疗与活性有关的疾病的Janus激酶，包括例如免疫相关疾病和癌症。

8. 发明申请

US20130006846A1 METHOD AND SYSTEM FOR MORTGAGE EXCHANGE 审中-公开
标题翻译：手段交换的方法和系统
公开(公告)号：US20130006846A1
公开(公告)日：2013-01-03
申请号：US13611299
申请日：2012-09-12
申请人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
发明人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
IPC分类号： G06Q40/02
CPC分类号： G06Q40/02 , G06Q40/025
摘要： A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.
摘要翻译：通过提供借款人有资格接受的贷款的准确表示，这种方法和系统以电子方式促进房地产交易，这些贷款是根据实际数据而不是估计。完成房地产交易所需的所有行动，从借款人信息入门到贷款的结算和融资，均无缝整合。提供自动承保引擎，用于基于用户输入和/或现有数据生成决策矩阵。根据决策矩阵选择适当的贷款，并将其传达给潜在的借款人。选定贷款后，进行履行处理，贷款得到资助和关闭。

9. 发明申请

US20060106020A1 Tetracyclic inhibitors of Janus kinases 审中-公开
标题翻译： Janus激酶的四环抑制剂
公开(公告)号：US20060106020A1
公开(公告)日：2006-05-18
申请号：US11115702
申请日：2005-04-27
申请人： James Rodgers , Darius Robinson , Argrios Arvanitis , Thomas Maduskuie , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Jalluri , Andrew Combs , Matthew Crawley
发明人： James Rodgers , Darius Robinson , Argrios Arvanitis , Thomas Maduskuie , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Jalluri , Andrew Combs , Matthew Crawley
IPC分类号： A61K31/503 , A61K31/519 , C07D487/14
CPC分类号： C07D471/22 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
摘要翻译：本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶（例如免疫相关疾病和癌症）的活性相关的疾病。

10. 发明申请

US20050272778A1 Inhibitors of proteins that bind phosphorylated molecules 失效
标题翻译：结合磷酸化分子的蛋白质的抑制剂
公开(公告)号：US20050272778A1
公开(公告)日：2005-12-08
申请号：US10960344
申请日：2004-10-07
申请人： Andrew Combs , Eddy Yue , Michael Bower , Wenyu Zhu , Matthew Crawley , Richard Sparks , James Pruitt , Amy Takvorian
发明人： Andrew Combs , Eddy Yue , Michael Bower , Wenyu Zhu , Matthew Crawley , Richard Sparks , James Pruitt , Amy Takvorian
IPC分类号： A61K31/425 , C07D275/02 , C07D275/03 , C07D417/04 , C07D417/10 , C07K20060101
CPC分类号： C07D275/03 , C07D417/10 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07F9/6539
摘要： The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or disorders, including, for example, diabetes and obesity, that are connected directly or indirectly to the activity of the target protein.
摘要翻译：本发明提供可以调节选择性结合磷酸化肽或蛋白质的靶蛋白（例如磷酸酶）的活性的化合物。本发明化合物可用于治疗与靶蛋白的活性直接或间接连接的疾病或病症，包括例如糖尿病和肥胖症。

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