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1. 发明授权

US08275701B2 Method and system for mortgage exchange 有权
标题翻译：抵押交换的方法和制度
公开(公告)号：US08275701B2
公开(公告)日：2012-09-25
申请号：US13076044
申请日：2011-03-30
申请人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
发明人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02 , G06Q40/025
摘要： A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.
摘要翻译：通过提供借款人有资格接受的贷款的准确表示，这种方法和系统以电子方式促进房地产交易，这些贷款是根据实际数据而不是估计。完成房地产交易所需的所有行动，从借款人信息入门到贷款的结算和融资，均无缝整合。提供自动承保引擎，用于基于用户输入和/或现有数据生成决策矩阵。根据决策矩阵选择适当的贷款，并将其传达给潜在的借款人。选定贷款后，进行履行处理，贷款得到资助和关闭。

2. 发明授权

US6138129A Method and apparatus for providing automated searching and linking of electronic documents 失效
标题翻译：用于提供电子文档的自动搜索和链接的方法和装置
公开(公告)号：US6138129A
公开(公告)日：2000-10-24
申请号：US991451
申请日：1997-12-16
申请人： J. Andrew Combs
发明人： J. Andrew Combs
IPC分类号： G06F17/30 , G06F17/00
CPC分类号： G06F17/30985 , G06F17/30882 , Y10S707/99933 , Y10S707/99936
摘要： A method and apparatus for a relatively meaningful search and/or link operation to be performed within and/or between one or more electronic documents. According to one aspect of the invention, a method and apparatus is provided for extracting and storing text, image and/or location information of an electronic document. According to another aspect of the invention, a tag may be specified as label for a set of search and/or link (e.g., source and target) parameters, each having a set of "rules" associated therewith, for searching the stored text, image, and/or location information. According to yet another aspect of the invention, the set of parameters may include context (e.g., specified character/text patterns that may occur within and/or adjacent to one or more specified patterns) and/or location (e.g., a page number/range, a box on a page, a filename, tag, character/line offset, etc.) information/rules.
摘要翻译：一种用于在一个或多个电子文档之内和/或之间执行相对有意义的搜索和/或链接操作的方法和装置。根据本发明的一个方面，提供一种用于提取和存储电子文档的文本，图像和/或位置信息的方法和装置。根据本发明的另一方面，可以将标签指定为一组搜索和/或链接（例如，源和目标）参数的标签，每个参数具有与其相关联的一组“规则”，用于搜索所存储的文本，图像和/或位置信息。根据本发明的另一方面，该组参数可以包括上下文（例如，可能在一个或多个指定模式内和/或与一个或多个指定模式相邻的特定字符/文本模式）和/或位置（例如，页码/ 范围，页面上的框，文件名，标签，字符/行偏移量等）信息/规则。

3. 发明申请

US20130006846A1 METHOD AND SYSTEM FOR MORTGAGE EXCHANGE 审中-公开
标题翻译：手段交换的方法和系统
公开(公告)号：US20130006846A1
公开(公告)日：2013-01-03
申请号：US13611299
申请日：2012-09-12
申请人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
发明人： William C. Erbey , Christopher Kennedy , Bryan Hurley , Andrew Combs
IPC分类号： G06Q40/02
CPC分类号： G06Q40/02 , G06Q40/025
摘要： A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.
摘要翻译：通过提供借款人有资格接受的贷款的准确表示，这种方法和系统以电子方式促进房地产交易，这些贷款是根据实际数据而不是估计。完成房地产交易所需的所有行动，从借款人信息入门到贷款的结算和融资，均无缝整合。提供自动承保引擎，用于基于用户输入和/或现有数据生成决策矩阵。根据决策矩阵选择适当的贷款，并将其传达给潜在的借款人。选定贷款后，进行履行处理，贷款得到资助和关闭。

4. 发明申请

US20070203140A1 N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase 审中-公开
标题翻译： N-羟基胍被用作吲哚胺2,3-双加氧酶的调节剂
公开(公告)号：US20070203140A1
公开(公告)日：2007-08-30
申请号：US11703961
申请日：2007-02-08
申请人： Andrew Combs , Brian Glass
发明人： Andrew Combs , Brian Glass
IPC分类号： A61K31/5375 , A61K31/496 , A61K31/4172
CPC分类号： C07C279/18 , C07D213/38 , C07D213/64 , C07D213/74 , C07D231/12 , C07D231/38 , C07D231/40 , C07D263/32 , C07D277/28 , C07D285/06 , C07D295/13 , C07D295/215
摘要： The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions containing the same and methods for the treatment of IDO-associated diseases.
摘要翻译：本发明涉及吲哚胺2,3-双加氧酶（IDO）的调节剂，以及含有其的药物组合物和治疗IDO相关疾病的方法。

5. 发明申请

US20060106020A1 Tetracyclic inhibitors of Janus kinases 审中-公开
标题翻译： Janus激酶的四环抑制剂
公开(公告)号：US20060106020A1
公开(公告)日：2006-05-18
申请号：US11115702
申请日：2005-04-27
申请人： James Rodgers , Darius Robinson , Argrios Arvanitis , Thomas Maduskuie , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Jalluri , Andrew Combs , Matthew Crawley
发明人： James Rodgers , Darius Robinson , Argrios Arvanitis , Thomas Maduskuie , Stacey Shepard , Louis Storace , Haisheng Wang , Maria Rafalski , Ravi Jalluri , Andrew Combs , Matthew Crawley
IPC分类号： A61K31/503 , A61K31/519 , C07D487/14
CPC分类号： C07D471/22 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
摘要翻译：本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶（例如免疫相关疾病和癌症）的活性相关的疾病。

6. 发明申请

US20050272778A1 Inhibitors of proteins that bind phosphorylated molecules 失效
标题翻译：结合磷酸化分子的蛋白质的抑制剂
公开(公告)号：US20050272778A1
公开(公告)日：2005-12-08
申请号：US10960344
申请日：2004-10-07
申请人： Andrew Combs , Eddy Yue , Michael Bower , Wenyu Zhu , Matthew Crawley , Richard Sparks , James Pruitt , Amy Takvorian
发明人： Andrew Combs , Eddy Yue , Michael Bower , Wenyu Zhu , Matthew Crawley , Richard Sparks , James Pruitt , Amy Takvorian
IPC分类号： A61K31/425 , C07D275/02 , C07D275/03 , C07D417/04 , C07D417/10 , C07K20060101
CPC分类号： C07D275/03 , C07D417/10 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07F9/6539
摘要： The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds can be useful in treating diseases or disorders, including, for example, diabetes and obesity, that are connected directly or indirectly to the activity of the target protein.
摘要翻译：本发明提供可以调节选择性结合磷酸化肽或蛋白质的靶蛋白（例如磷酸酶）的活性的化合物。本发明化合物可用于治疗与靶蛋白的活性直接或间接连接的疾病或病症，包括例如糖尿病和肥胖症。

7. 发明授权

US09436925B2 Inventory management 有权
标题翻译：库存管理
公开(公告)号：US09436925B2
公开(公告)日：2016-09-06
申请号：US14504030
申请日：2014-10-01
申请人： James Andrew Combs
发明人： James Andrew Combs
IPC分类号： G06K7/00 , G06Q10/08 , G06K19/06
CPC分类号： G06Q10/087 , G06K19/06028 , G06K19/06037 , G06K19/0614
摘要： A device includes a code that is interpretable to identify a three-dimensional (3D) design specification by which a replacement for the device can be printed on a 3D printer.
摘要翻译：设备包括可解释以识别三维（3D）设计规范的代码，通过该代码可以在3D打印机上打印设备的替换。

8. 发明申请

US20070265331A1 Novel gamma-lactams as beta-secretase inhibitors 有权
标题翻译：新型γ-内酰胺酶作为β-分泌酶抑制剂
公开(公告)号：US20070265331A1
公开(公告)日：2007-11-15
申请号：US10634078
申请日：2003-08-04
申请人： Carl Decicco , Andrew Tebben , Lorin Thompson , Andrew Combs
发明人： Carl Decicco , Andrew Tebben , Lorin Thompson , Andrew Combs
IPC分类号： A61K31/4015 , A61P25/28 , A61P43/00 , A61P7/00 , C07D207/46
CPC分类号： C07D207/273 , A61K38/00 , C07D403/12 , C07D405/06 , C07K5/06139
摘要： There is provided a series of novel substituted gamma-lactams of Formula (I) wherein R1, R2, R3, R4 and R5 are defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present invention is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
摘要翻译：提供了一系列新颖的式（I）的取代的γ-内酰胺，其中R 1，R 2，R 3，R 2， > 4和R 5在本文中定义，其药物组合物和使用方法。这些新型化合物通过β-分泌酶抑制淀粉样前体蛋白（APP）的加工，更具体地，抑制Aβ-肽的产生。本发明涉及可用于治疗与β-淀粉样蛋白产生相关的神经系统疾病的化合物，例如阿尔茨海默病和受抗淀粉样蛋白活性影响的其它病症。

9. 发明申请

US20070185165A1 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase 有权
标题翻译： N-羟基脒基杂环作为吲哚胺2,3-双加氧酶的调节剂
公开(公告)号：US20070185165A1
公开(公告)日：2007-08-09
申请号：US11641284
申请日：2006-12-19
申请人： Andrew Combs , Amy Takvorian , Wenyu Zhu , Richard Sparks
发明人： Andrew Combs , Amy Takvorian , Wenyu Zhu , Richard Sparks
IPC分类号： A61K31/454 , A61K31/433 , A61K31/4245 , C07D417/02 , C07D413/02
CPC分类号： A61K31/541 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D271/08 , C07D285/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions thereof and methods of use thereof relating to the treatment of cancer and other diseases.
摘要翻译：本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的N-羟基脒基化合物及其药物组合物及其与治疗癌症和其它疾病有关的使用方法。

10. 发明授权

US06536582B1 Reversible shelf vertical conveyor 失效
标题翻译：可逆架立式输送机
公开(公告)号：US06536582B1
公开(公告)日：2003-03-25
申请号：US09950505
申请日：2001-09-13
申请人： John Andrew Combs
发明人： John Andrew Combs
IPC分类号： B65G1718
CPC分类号： B65G17/123 , B65G17/18 , B65G2201/02
摘要： A reversible shelf type vertical conveyor wherein a plurality of shelves are pivotally mounted between two endless chains that are driven by pairs of upper and lower sprockets, the shelves pivoted to a space saving vertical orientation during the return run and to a horizontal orientation during the working run. Positive control of the orientation of shelves is provided by pairs of rollers attached to the shelves which straddle a guide bars during the return run and ride within guide channels during the working run. During the transition between return and working runs at the top and bottom, shelves are held tight against bosses adjacent the sprockets. Each successive cycle pivots the shelves 180 degrees, and the shelves are symmetrical about their pivot axis.
摘要翻译：一种可逆的搁板型立式输送机，其中多个搁架枢转地安装在由成对的上链轮和下链轮驱动的两个环形链之间，搁架在返回运行期间枢转到节省空间的垂直定向并且在工作期间处于水平取向跑。货架方向的正确控制由连接在货架上的成对的滚筒提供，货架在返回运行期间跨越导杆，并在工作运行期间乘坐引导通道。在顶部和底部的返回和工作运行之间的过渡期间，搁板紧紧地抵靠链轮附近的凸台。每个连续的循环使架子旋转180度，并且搁架围绕其枢转轴线对称。

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