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1. 发明授权

US6063338A Low background multi-well plates and platforms for spectroscopic measurements 失效
标题翻译：低背景多孔板和光谱测量平台
公开(公告)号：US6063338A
公开(公告)日：2000-05-16
申请号：US867567
申请日：1997-06-02
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , John D. Mendlein , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , John D. Mendlein , Roger Y. Tsien
IPC分类号： B01L3/00 , B01L9/00 , C40B60/14
CPC分类号： B01L3/5085 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L2200/12 , B01L2300/0829 , B01L2300/12 , B01L9/523 , C40B60/14
摘要： The invention provides for multi-well plates and platforms that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates and platforms are particularly well suited for fluorescent measurements.
摘要翻译：本发明提供了包含具有低荧光和高透射率的环烯烃层的多孔板和平台。这些多孔板和平台特别适用于荧光测量。

2. 发明授权

US07854898B2 Multi-well platforms, caddies, lids and combinations thereof 有权
标题翻译：多井平台，球场，盖子及其组合
公开(公告)号：US07854898B2
公开(公告)日：2010-12-21
申请号：US12271762
申请日：2008-11-14
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L3/50855 , B01L9/523 , B01L2300/0654 , B01L2300/0829 , C12M23/12 , C40B60/14
摘要： The present invention relates to multi-well platforms, lids, caddies and any combination thereof. The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.
摘要翻译：本发明涉及多孔平台，盖子，球童及其任何组合。多井平台包括可以是任何形状的多个井，并且可以以任何装饰图案排列。盖子包括对应于井场的区域。球罐的尺寸大约是标准96孔微孔板的面积。当多孔平台与球童接合时，当从组合的底部观察时，多孔平台的井场的井优选地不被球童遮蔽。

3. 发明授权

US06730520B2 Low fluorescence assay platforms and related methods for drug discovery 有权
标题翻译：低荧光测定平台及药物发现的相关方法
公开(公告)号：US06730520B2
公开(公告)日：2004-05-04
申请号：US10120644
申请日：2002-04-09
申请人： Peter J. Coassin , Alec Tate Harootunian , Andrew A. Pham , Harry Stylli , Roger Y. Tsien
发明人： Peter J. Coassin , Alec Tate Harootunian , Andrew A. Pham , Harry Stylli , Roger Y. Tsien
IPC分类号： G01N2176
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L9/523 , B01L2300/021 , B01L2300/0829 , B01L2300/12 , C12M23/12 , C12Q1/00 , C40B60/14 , G01N1/30 , G01N21/03 , G01N21/6428 , G01N21/6452 , G01N33/5308 , G01N33/542 , G01N2021/0346
摘要： One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.
摘要翻译：本发明的一个方面是用于荧光测量的多孔平台，其包括框架内的多个孔，其中所述多孔平台具有低荧光背景。本发明的另一方面是用于光谱测量的系统，其包括用于测定的试剂和用于荧光测量的多孔平台。本发明的另一方面是通过检测从样品发射的光来检测多孔平台中包含的样品中分析物的存在的方法。本发明的另一方面是通过检测从样品发射的光来识别多孔平台中包含的样品中生物过程或靶的调节剂的方法。本发明的另一方面是通过该方法鉴定的组合物。本发明的另一方面是鉴定治疗剂的方法。本发明的另一方面是通过使用本发明的方法鉴定治疗剂并监测治疗剂在体内模型中的毒理学和功效来测试治疗活性和毒理学治疗剂的方法。

4. 发明授权

US07459130B2 Multi-well platforms, caddies, lids and combinations thereof 有权
标题翻译：多井平台，球场，盖子及其组合
公开(公告)号：US07459130B2
公开(公告)日：2008-12-02
申请号：US11067322
申请日：2005-02-25
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L3/50855 , B01L9/523 , B01L2300/0654 , B01L2300/0829 , C12M23/12 , C40B60/14
摘要： The present invention relates to multi-well platforms, lids, caddies and any combination thereof. The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.
摘要翻译：本发明涉及多孔平台，盖子，球童及其任何组合。多井平台包括可以是任何形状的多个井，并且可以以任何装饰图案排列。盖子包括对应于井场的区域。球罐的尺寸大约是标准96孔微孔板的面积。当多孔平台与球童接合时，当从组合的底部观察时，多孔平台的井场的井优选地不被球童遮蔽。

5. 发明授权

US07142290B2 Detector and screening device for ion channels 有权
公开(公告)号：US07142290B2
公开(公告)日：2006-11-28
申请号：US11355396
申请日：2006-02-15
申请人： Roger Y. Tsien , Peter J. Coassin , Andrew A. Pham , Alec Tate Harootunian , Minh Vuong
发明人： Roger Y. Tsien , Peter J. Coassin , Andrew A. Pham , Alec Tate Harootunian , Minh Vuong
IPC分类号： G01N21/00
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/48728 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2021/6484 , G01N2201/0639
摘要： The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.

6. 发明授权

US06861035B2 Multi-well platforms, caddies, lids and combinations thereof 有权
公开(公告)号：US06861035B2
公开(公告)日：2005-03-01
申请号：US10209315
申请日：2002-07-30
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
IPC分类号： B01L3/00 , B01L9/00 , C40B60/14
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L3/50855 , B01L9/523 , B01L2300/0654 , B01L2300/0829 , C12M23/12 , C40B60/14
摘要： The present invention relates to multi-well platforms, lids, caddies and any combination thereof. The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.

7. 发明授权

US06171780B2 Low fluorescence assay platforms and related methods for drug discovery 失效
标题翻译：低荧光测定平台及药物发现的相关方法
公开(公告)号：US06171780B2
公开(公告)日：2001-01-09
申请号：US09030578
申请日：1998-02-24
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Harry Stylli , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Harry Stylli , Roger Y. Tsien
IPC分类号： C12Q100
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L9/523 , B01L2300/0829 , C40B60/14 , G01N2021/0346 , Y10S435/968 , Y10S435/975
摘要： One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.
摘要翻译：本发明的一个方面是用于荧光测量的多孔平台，其包括框架内的多个孔，其中所述多孔平台具有低荧光背景。本发明的另一方面是用于光谱测量的系统，其包括用于测定的试剂和用于荧光测量的多孔平台。本发明的另一方面是通过检测从样品发射的光来检测多孔平台中包含的样品中分析物的存在的方法。本发明的另一方面是通过检测从样品发射的光来识别多孔平台中包含的样品中生物过程或靶的调节剂的方法。本发明的另一方面是通过该方法鉴定的组合物。本发明的另一方面是鉴定治疗剂的方法。本发明的另一方面是通过使用本发明的方法鉴定治疗剂并监测治疗剂在体内模型中的毒理学和功效来测试治疗活性和毒理学治疗剂的方法。

8. 发明申请

US20090148350A1 Multi-Well Platforms, Caddies, Lids and Combinations Thereof 有权
标题翻译：多井平台，球童，盖子及其组合
公开(公告)号：US20090148350A1
公开(公告)日：2009-06-11
申请号：US12271762
申请日：2008-11-14
申请人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
发明人： Andrew A. Pham , Peter J. Coassin , Alec Tate Harootunian , Peter N. Pham , Harry Stylli , Roger Y. Tsien
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01L3/50855 , B01L9/523 , B01L2300/0654 , B01L2300/0829 , C12M23/12 , C40B60/14
摘要： The present invention relates to multi-well platforms, lids, caddies and any combination thereof. The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.
摘要翻译：本发明涉及多孔平台，盖子，球童及其任何组合。多井平台包括可以是任何形状的多个井，并且可以以任何装饰图案排列。盖子包括对应于井场的区域。球罐的尺寸大约是标准96孔微孔板的面积。当多孔平台与球童接合时，当从组合的底部观察时，多孔平台的井场的井优选地不被球童遮蔽。

9. 发明授权

US06608671B2 Detector and screening device for ion channels 失效
标题翻译：用于离子通道的检测器和筛选装置
公开(公告)号：US06608671B2
公开(公告)日：2003-08-19
申请号：US09118728
申请日：1998-07-17
申请人： Roger Y. Tsien , Peter J. Coassin , Andrew A. Pham , Alec Tate Harootunian , Minh Vuong
发明人： Roger Y. Tsien , Peter J. Coassin , Andrew A. Pham , Alec Tate Harootunian , Minh Vuong
IPC分类号： G01N2100
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/48728 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2021/6484 , G01N2201/0639
摘要： The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.
摘要翻译：本发明提供了用于光学测量的检测器组件，光纤组件和屏蔽系统。

10. 发明授权

US07002671B2 Detector and screening device for ion channels 有权
公开(公告)号：US07002671B2
公开(公告)日：2006-02-21
申请号：US10643304
申请日：2003-08-18
申请人： Roger Y. Tsien , Peter J. Coassin , Andrew A. Pham , Alec Tate Harootunian , Minh Vuong
发明人： Roger Y. Tsien , Peter J. Coassin , Andrew A. Pham , Alec Tate Harootunian , Minh Vuong
IPC分类号： G01N21/00
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/48728 , G01N2021/6421 , G01N2021/6471 , G01N2021/6478 , G01N2021/6484 , G01N2201/0639
摘要： The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.

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