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1. 发明授权

US08114431B2 Biomolecular coating for implants 有权
标题翻译：植入物的生物分子涂层
公开(公告)号：US08114431B2
公开(公告)日：2012-02-14
申请号：US11857819
申请日：2007-09-19
申请人： Andres J. Garcia , Catherine D. Reyes , Timothy Petrie , Zvi Schwartz , Barbara D. Boyan , Jenny E. Raynor , David M. Collard , Abigail M. Wojtowicz , Robert E. Guldberg
发明人： Andres J. Garcia , Catherine D. Reyes , Timothy Petrie , Zvi Schwartz , Barbara D. Boyan , Jenny E. Raynor , David M. Collard , Abigail M. Wojtowicz , Robert E. Guldberg
IPC分类号： A61F2/00 , A61K38/00 , A61K51/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K9/00 , C07K16/00 , C07K17/00
CPC分类号： A61K38/39 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2300/412
摘要： Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α2β1 or α5β1 integrin-specific ligand are provided. The substrates and devices coated with an α2β1 or α5β1 integrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.
摘要翻译：提供了用于改善体内组织生长和器官整合的方法和组合物。提供了涂有α2和bgr1或α5和bgr1整联蛋白特异性配体的底物和装置。显示出涂有α2和bgr1或α5和bgr1整联蛋白特异性配体的底物和装置在表面上相对于对照具有更大的组织形成，特别是更大的骨形成。

2. 发明申请

US20120142597A1 BIOMOLECULAR COATING FOR IMPLANTS 有权
标题翻译：植物生物分子涂料
公开(公告)号：US20120142597A1
公开(公告)日：2012-06-07
申请号：US13372234
申请日：2012-02-13
申请人： Andres J. Garcia , Catherine D. Reyes , Timothy Petrie , Zvi Schwartz , Barbara D. Boyan , Jenny E. Raynor , David M. Collard , Abigail M. Wojtowicz , Robert E. Guldberg
发明人： Andres J. Garcia , Catherine D. Reyes , Timothy Petrie , Zvi Schwartz , Barbara D. Boyan , Jenny E. Raynor , David M. Collard , Abigail M. Wojtowicz , Robert E. Guldberg
IPC分类号： A61K38/16 , A61P19/08 , A61K38/39 , C07K14/00 , C07K14/78
CPC分类号： A61K38/39 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2300/412
摘要： Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α2β1 or α5β1 integrin-specific ligand are provided. The substrates and devices coated with an α2β1 or α5β1 integrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.
摘要翻译：提供了用于改善体内组织生长和器官整合的方法和组合物。提供了涂有α2和bgr1或α5和bgr1整联蛋白特异性配体的底物和装置。显示出涂有α2和bgr1或α5和bgr1整联蛋白特异性配体的底物和装置在表面上相对于对照具有更大的组织形成，特别是更大的骨形成。

3. 发明申请

US20080131425A1 BIOMOLECULAR COATING FOR IMPLANTS 有权
标题翻译：植物生物分子涂料
公开(公告)号：US20080131425A1
公开(公告)日：2008-06-05
申请号：US11857819
申请日：2007-09-19
申请人： Andres J. Garcia , Catherine D. Reyes , Timothy Petrie , Zvi Schwartz , Barbara D. Boyan , Jenny E. Raynor , David M. Collard , Abigail M. Wojtowicz , Robert E. Guldberg
发明人： Andres J. Garcia , Catherine D. Reyes , Timothy Petrie , Zvi Schwartz , Barbara D. Boyan , Jenny E. Raynor , David M. Collard , Abigail M. Wojtowicz , Robert E. Guldberg
IPC分类号： A61K47/48 , A61K38/00 , A61P19/00 , A61K39/395
CPC分类号： A61K38/39 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2300/412
摘要： Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α2β1 or α5β1 integrin-specific ligand are provided. The substrates and devices coated with an α2β1 or α5β1 integrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.
摘要翻译：提供了用于改善体内组织生长和器官整合的方法和组合物。提供了涂有α2β1或α5β1整联蛋白特异性配体的底物和装置。显示了涂有α2β1α或α5β1整联蛋白特异性配体的底物和装置在表面上相对于对照具有更大的组织形成，特别是更大的骨形成。

4. 发明授权

US09457132B2 Controlled covalent attachment of bioactive bacteriophage for regulating biofilm development 有权
标题翻译：用于调节生物膜发育的生物活性噬菌体的受控共价附着
公开(公告)号：US09457132B2
公开(公告)日：2016-10-04
申请号：US14119716
申请日：2012-06-28
申请人： Rodney Martin Donlan , Susan Marie Lehman , Andres J. Garcia
发明人： Rodney Martin Donlan , Susan Marie Lehman , Andres J. Garcia
IPC分类号： A61L29/10 , A01N63/00 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , A61L31/16 , A61L15/60 , A61L15/36 , A61L27/36 , A61L29/16 , A61L15/44 , A61K35/76 , A61M25/00
CPC分类号： A61L29/106 , A01N63/00 , A61K35/76 , A61L15/36 , A61L15/44 , A61L15/60 , A61L27/34 , A61L27/3637 , A61L27/52 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/606 , A61M2025/0056 , C12N2795/10132 , C12N2795/10232 , C12N2795/10332 , A01N25/10 , A01N25/34
摘要： Medical devices that are resistant to biofilm development and methods of the manufacture of biofilm resistant medical devices are provided. One or more bacteriophages are tethered to the surface of a medical device or a hydrogei-type coating on the surface of the device by covalent bonding while maintaining bacteriophage infective or lytic activity. The presence of the bacteriophages on a medical device, such as an indwelling medical device, prevents biofilm formation or reduces existing biofilm formation on the surface of the device when in use. These devices address the long felt need for biofilm resistant devices that increase safety and reduce complications normally associated with prior indwelling or other medical devices.
摘要翻译：提供了抗生物膜发展的医疗装置和制造生物膜抗性医疗装置的方法。一个或多个噬菌体通过共价键连接到医疗装置的表面或器件表面上的水i型涂层，同时保持噬菌体感染或溶解活性。在医疗装置（例如留置医疗装置）上的噬菌体的存在防止生物膜形成或在使用时减少在装置表面上的现有生物膜形成。这些装置解决了对生物膜抗性装置的长期需求，其增加安全性并减少通常与先前留置的其他医疗装置相关联的并发症。

5. 发明申请

US20140199360A1 CONTROLLED COVALENT ATTACHMENT OF BIOACTIVE BACTERIOPHAGE FOR REGULATING BIOFILM DEVELOPMENT 有权
标题翻译：用于调节生物膜发育的生物活性炭的控制共价连接
公开(公告)号：US20140199360A1
公开(公告)日：2014-07-17
申请号：US14119716
申请日：2012-06-28
申请人： Rodney Martin Donlan , Susan Marie Lehman , Andres J. Garcia
发明人： Rodney Martin Donlan , Susan Marie Lehman , Andres J. Garcia
IPC分类号： A61L29/16 , A61L29/10 , A61L15/44 , A61L29/08 , A61L15/36
CPC分类号： A61L29/106 , A01N63/00 , A61K35/76 , A61L15/36 , A61L15/44 , A61L15/60 , A61L27/34 , A61L27/3637 , A61L27/52 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/606 , A61M2025/0056 , C12N2795/10132 , C12N2795/10232 , C12N2795/10332 , A01N25/10 , A01N25/34
摘要： Medical devices that are resistant to biofilm development and methods of the manufacture of biofilm resistant medical devices are provided. One or more bacteriophages are tethered to the surface of a medical device or a hydrogen-type coating on the surface of the device by covalent bonding while maintaining bacteriophage infective or lytic activity. The presence of the bacteriophages on a medical device, such as an indwelling medical device, prevents biofilm formation or reduces existing biofilm formation on the surface of the device when in use. These devices address the long felt need for biofilm resistant devices that increase safety and reduce complications normally associated with prior indwelling or other medical devices.
摘要翻译：提供了抗生物膜发展的医疗装置和制造生物膜抗性医疗装置的方法。一个或多个噬菌体通过共价键连接到医疗装置的表面或装置表面上的氢型涂层，同时保持噬菌体感染或溶解活性。在医疗装置（例如留置医疗装置）上的噬菌体的存在防止生物膜形成或在使用时减少在装置表面上的现有生物膜形成。这些装置解决了对生物膜抗性装置的长期需求，其增加安全性并减少通常与先前留置的其他医疗装置相关联的并发症。

6. 发明申请

US20110008404A1 Modification Of Biomaterials With Microgel Films 审中-公开
标题翻译：用微胶粒膜改性生物材料
公开(公告)号：US20110008404A1
公开(公告)日：2011-01-13
申请号：US12809433
申请日：2008-12-19
申请人： Louis Andrew Lyon , Andres J. Garcia , Julia E. Babensee
发明人： Louis Andrew Lyon , Andres J. Garcia , Julia E. Babensee
IPC分类号： A61K9/00 , A61K47/30 , A61P29/00 , A61P17/02 , H05H1/00
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/41 , A61L2300/412 , A61L2300/426 , A61L2300/602 , A61L2300/606
摘要： The various embodiments of the present disclosure relate generally to the modification of biomaterials with microgel films. More particularly, the various embodiments of the present invention are directed to the modification of biomaterials and medical devices with microgel thin films to alter a host's response to an implanted biomaterial or medical device. An embodiment of the present invention comprises a coated biomaterial comprising a non-fouling polymer film attached to at least a portion of a surface of the biomaterial, the non-fouling polymer film comprising a plurality of a cross-linked polymer microparticles, wherein at least a portion of the cross-linked polymer microparticles are covalently bonded to at least a portion of the surface of the biomaterial.
摘要翻译：本公开的各种实施方案一般涉及用微凝胶膜修饰生物材料。更具体地，本发明的各种实施方案涉及用微凝胶薄膜修饰生物材料和医疗装置，以改变宿主对植入的生物材料或医疗装置的反应。本发明的一个实施方案包括涂覆的生物材料，其包含附着在生物材料表面的至少一部分上的非结垢聚合物膜，所述非结垢聚合物膜包含多个交联聚合物微粒，其中至少交联聚合物微粒的一部分共价键合到生物材料表面的至少一部分上。

7. 发明授权

US06413538B1 Bioactive glass or ceramic substrates having bound cell adhesion molecules 失效
标题翻译：具有结合细胞粘附分子的生物活性玻璃或陶瓷基质
公开(公告)号：US06413538B1
公开(公告)日：2002-07-02
申请号：US09648098
申请日：2000-08-25
申请人： Andres J. Garcia , Paul Ducheyne , David Boettiger
发明人： Andres J. Garcia , Paul Ducheyne , David Boettiger
IPC分类号： A61F200
CPC分类号： A61L27/3895 , A61F2/28 , A61F2/30767 , A61F2/3094 , A61F2/30965 , A61F2310/00179 , A61L27/025 , A61L27/10 , A61L27/306 , A61L27/34 , A61L27/3608 , A61L27/38 , A61L27/3847 , A61L27/56 , C12N5/0068 , C12N5/0654 , C12N2533/12 , C08L89/00
摘要： Non-crystalline, porous bioactive glass and ceramic materials are prepared that permit in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells. The bioactive glass and ceramic materials are treated such that when used in contact with anchorage-dependent cells, there is enhanced cell attachment and cell function to provide expeditious tissue growth in vitro or in vivo. Treatment involves immersing the glass or ceramic material in an aqueous solution containing ions in a concentration typical of interstitial fluid followed by immersion in an aqueous solution containing at least one cell adhesion molecule. Immersion may also be in an additional aqueous solution containing an additional cell adhesion molecule before or after immersing in the solution containing ions. The glass material is preferably formed from SiO2, CaO, Na2O and P2O5. The glass material is preferably prepared by melting constituents, cooling and pulverizing the resultant glass to obtain a powder, and then forming and hot pressing the powder. The glass may be formed to produce templates, a swell as to produce granules that may be formed into a paste. An implant may be formed by coating an implant material with the treated bioactive glass or ceramic material.
摘要翻译：制备非结晶多孔生物活性玻璃和陶瓷材料，其允许当暴露于组织培养基时体外形成骨组织并接种细胞。处理生物活性玻璃和陶瓷材料使得当与锚定依赖性细胞接触使用时，增强细胞附着和细胞功能以在体外或体内提供快速的组织生长。处理包括将玻璃或陶瓷材料浸入含有典型的间质液浓度的离子的水溶液中，随后浸入含有至少一种细胞粘附分子的水溶液中。在浸入含有离子的溶液之前或之后，浸渍也可以是含有另外的细胞粘附分子的另外的水溶液。玻璃材料优选由SiO 2，CaO，Na 2 O和P 2 O 5形成。玻璃材料优选通过熔融成分，冷却和粉碎所得玻璃以获得粉末，然后形成和热压该粉末来制备。可以形成玻璃以产生模板，膨胀以产生可形成糊状物的颗粒。可以通过用经处理的生物活性玻璃或陶瓷材料涂覆植入材料来形成植入物。

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