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1. 发明授权

US09551026B2 Method for nucleic acid detection using voltage enhancement 有权
标题翻译：使用电压增强的核酸检测方法
公开(公告)号：US09551026B2
公开(公告)日：2017-01-24
申请号：US13337968
申请日：2011-12-27
申请人： Andres Fernandez , Bryan Staker , Radoje Drmanac
发明人： Andres Fernandez , Bryan Staker , Radoje Drmanac
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6825 , C12Q2523/307 , C12Q2565/501 , C12Q2565/607
摘要： Methods are provided for carrying out DNA sequencing on a device having upper and lower conductive layers separated by an insulative layer. Holes in the upper conductive layer create discrete attachment sites for DNA fragments. Voltage is applied to the surface to control affinity between the attachment sites and the DNA fragments, and to compact the DNA fragments for discrete optical detection.
摘要翻译：提供了用于在具有由绝缘层隔开的上导电层和下导电层的器件上进行DNA测序的方法。上导电层中的孔为DNA片段产生离散的附着位点。将电压施加到表面以控制附着位点和DNA片段之间的亲和力，并压缩DNA片段以进行离散的光学检测。

2. 发明申请

US20120122721A1 METHOD FOR NUCLEIC ACID DETECTION USING VOLTAGE ENHANCEMENT 有权
标题翻译：使用电压增强的核酸检测方法
公开(公告)号：US20120122721A1
公开(公告)日：2012-05-17
申请号：US13337968
申请日：2011-12-27
申请人： Andres Fernandez , Bryan Staker , Radoje Drmanac
发明人： Andres Fernandez , Bryan Staker , Radoje Drmanac
IPC分类号： C40B30/04
CPC分类号： C12Q1/6832 , C12Q1/6825 , C12Q2523/307 , C12Q2565/501 , C12Q2565/607
摘要： Methods are provided for carrying out nucleic acid analysis, including sequence identification, employing voltage and/or controlled electric charge to enhance operation. A device comprises substrates for nucleic acid analysis, a first electrically conductive layer, a first electrically insulative layer of dielectric material on the first conductive layer, a second electrically conductive layer disposed upon the first insulative layer in a pattern to define discrete attachment sites for macromolecules on the first insulative layer, the second conductive layer provided with means for resisting affinity for the macromolecules to impede their attachment to sites on the second conductive layer, and terminals for the first and second conductive layers for applying a voltage pattern between the first and the second conductive layers to control affinity between the macromolecules and the discrete attachment sites.
摘要翻译：提供用于进行核酸分析的方法，包括序列鉴定，采用电压和/或受控电荷以增强操作。一种器件包括用于核酸分析的衬底，第一导电层，第一导电层上的介电材料的第一电绝缘层，第二导电层，以图案形式设置在第一绝缘层上，以限定大分子的离散附着位点在第一绝缘层上，第二导电层设置有用于抵抗大分子阻挡其附着于第二导电层上的部位的亲和力的装置，以及用于在第一和第二绝缘层之间施加电压图案的第一和第二导电层的端子第二导电层以控制大分子和离散附着位点之间的亲和力。

3. 发明授权

US07177081B2 High contrast grating light valve type device 有权
标题翻译：高对比度光栅光阀型装置
公开(公告)号：US07177081B2
公开(公告)日：2007-02-13
申请号：US09802619
申请日：2001-03-08
申请人： Akira Tomita , David Thomas Amm , Michael J. Daneman , James Hunter , Bryan Staker
发明人： Akira Tomita , David Thomas Amm , Michael J. Daneman , James Hunter , Bryan Staker
IPC分类号： G02B5/18
CPC分类号： G02B26/0808 , G02B5/1828
摘要： A grating light valve has with a plurality of spaced reflective ribbons are spatially arranged over a substrate with reflective surfaces. The grating light valve is configured to optimized the conditions for constructive and destructive interference with an incident light source having a wavelength λ. The grating light valve preferably has a set of movable active ribbons alternating between the set of stationary bias ribbons. The active ribbons and the bias ribbons are spatially separated over the substrate surface such that reflective regions of the substrate surface correspond to the spaces between the ribbons. The ribbons and reflective regions of the substrate optically and geometrically optimized for to generate the conditions for constrictive and destructive interference with the incident light source. Accordingly, ribbons of the active ribbons are configured with reflective cross sections that are is approximately equal to the sum of the diffraction cross sections of the bias ribbons and the reflective regions of the substrate. In operation, active ribbons are moved by a multiple of λ/4 to switch between the conditions for constructive and destructive interference.
摘要翻译：光栅光阀具有多个间隔开的反射带，其空间上布置在具有反射表面的基板上。光栅光阀被配置为优化与具有波长λ的入射光源的建构性和相消干涉的条件。光栅光阀优选地具有在一组固定偏置带之间交替的一组可移动有源带。有源带和偏置带在衬底表面上在空间上分开，使得衬底表面的反射区域对应于带之间的空间。光学和几何优化的基板的带和反射区域以产生用于对入射光源的收缩和相消干涉的条件。因此，有源带的带被构造成具有近似等于偏置带的衍射横截面和基板的反射区域之和的反射横截面。在操作中，活动色带移动λ/ 4的倍数，以在建构性和相消干涉的条件之间切换。

4. 发明授权

US06813059B2 Reduced formation of asperities in contact micro-structures 有权
标题翻译：减少接触微结构中粗糙的形成
公开(公告)号：US06813059B2
公开(公告)日：2004-11-02
申请号：US10187159
申请日：2002-06-28
申请人： James Hunter , Bryan Staker
发明人： James Hunter , Bryan Staker
IPC分类号： G02B2600
CPC分类号： G02B26/0841 , G02B26/0808
摘要： A device comprising movable micro-structures configured to contact a substrate is disclosed. The substrate has a metal-insulator-metal construction with an upper metal layer and an insulator being patterned to provide substrate contact regions to a lower metal layer. The micro-structures have metal under layers for providing ribbon contact regions and non-contact regions. In use, a bias voltage is applied across the micro-structures and the top metal layer of the substrate causing the micro-structures and the substrate to contact through the contact regions. During contact, the contact regions are maintained at a potential that is substantially less than the applied bias voltage, thereby reducing the formation of asperities and/or sticking between contacting parts. The micro-structures are preferably ribbon structures in an optical MEM device configured to modulate light.
摘要翻译：公开了一种包括被配置为接触衬底的可移动微结构的器件。衬底具有金属 - 绝缘体 - 金属结构，其具有上金属层，并且绝缘体被图案化以向下金属层提供衬底接触区域。微结构具有用于提供带状接触区域和非接触区域的金属层。在使用中，跨越微结构和衬底的顶部金属层施加偏置电压，导致微结构和衬底通过接触区域接触。在接触期间，接触区域保持在基本上小于所施加的偏置电压的电位，从而减少接触部件之间的粗糙和/或粘附的形成。微结构优选是配置成调制光的光学MEM器件中的带状结构。

5. 发明授权

US06898377B1 Method and apparatus for calibration of light-modulating array 有权
标题翻译：光调制阵列校准方法和装置
公开(公告)号：US06898377B1
公开(公告)日：2005-05-24
申请号：US10183254
申请日：2002-06-26
申请人： David A. LeHoty , Bryan Staker
发明人： David A. LeHoty , Bryan Staker
IPC分类号： G02B6/35 , G02B26/08 , H04J14/00 , H04J14/02 , H04J14/08
CPC分类号： G02B26/0808 , G02B6/3586 , H04J14/005
摘要： One embodiment disclosed relates to a method for calibrating an array of light-modulating elements. The method includes illuminating the array of elements, modulating an intensity of light diffracted by the elements over a modulation range, and measuring the modulated light intensity from each element of the array using a linear detector. Other embodiments disclosed relate to an apparatus and system for calibrating an array of light-modulating elements. The apparatus includes a light source for illuminating the array of elements and a linear detector for measuring light intensities at points along a line segment. The apparatus is configured so that modulated light from each of the elements impinges upon a different point of the line segment. The system includes means for modulating an intensity of light diffracted by the elements over a modulation range and a detector for measuring the modulated light intensity from each element of the array.
摘要翻译：公开的一个实施例涉及用于校准光调制元件阵列的方法。该方法包括照亮元件阵列，调制在调制范围内由元件衍射的光的强度，以及使用线性检测器测量来自阵列的每个元件的调制光强度。所公开的其它实施例涉及用于校准光调制元件阵列的装置和系统。该装置包括用于照射元件阵列的光源和用于测量沿着线段的点处的光强度的线性检测器。该装置被配置成使得来自每个元件的调制光照射在线段的不同点上。该系统包括用于调制由调制范围上的元件衍射的光的强度的装置和用于从阵列的每个元件测量调制光强度的检测器。

6. 发明授权

US06804038B1 Bipolar operation of light-modulating array 有权
标题翻译：双调光调制阵列的操作
公开(公告)号：US06804038B1
公开(公告)日：2004-10-12
申请号：US10183579
申请日：2002-06-26
申请人： David A. LeHoty , Bryan Staker
发明人： David A. LeHoty , Bryan Staker
IPC分类号： G02B2600
CPC分类号： H04N9/3132 , G02B26/00 , G02B26/0808 , G02B27/0012 , G02B27/28 , H04N5/202 , H04N5/57 , H04N5/7416 , H04N5/7458
摘要： One embodiment disclosed comprises a method for bipolar operation of a light-modulating array. The method includes driving light-modulating elements of the array in a first polarity, switching polarities from the first polarity to a second polarity, driving the light-modulating elements of the array in a second polarity, switching polarities from the second polarity to the first polarity, and repeating the steps. Another embodiment disclosed comprises an apparatus utilizing a light-modulating array. The apparatus includes a first look-up table storing data for operating elements the light-modulating array in a first polarity mode, and a second look-up table storing data for operating the elements of the light-modulating array in a second polarity mode. The apparatus also includes a drive system for driving the elements of the light-modulating array. The drive system is coupled to both the first and second look-up tables.
摘要翻译：所公开的一个实施例包括用于光调制阵列的双极性操作的方法。该方法包括以第一极性驱动阵列的光调制元件，将极性从第一极性切换到第二极性，驱动阵列的光调制元件为第二极性，将极性从第二极性切换到第一极性极性，并重复这些步骤。所公开的另一实施例包括利用光调制阵列的装置。该装置包括第一查找表，其以第一极性模式存储用于操作元件的光调制阵列的数据;以及第二查找表，其存储用于以第二极性模式操作光调制阵列的元件的数据。该装置还包括用于驱动光调制阵列的元件的驱动系统。驱动系统耦合到第一和第二查找表。

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