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1. 发明授权

US08153725B2 Supports for oligomer synthesis 有权
标题翻译：支持低聚物合成
公开(公告)号：US08153725B2
公开(公告)日：2012-04-10
申请号：US12728083
申请日：2010-03-19
申请人： Vasulinga Ravikumar , Muthiah Manoharan , Andrei P. Guzaev , Zhiwei Wang , Raju K. Kumar
发明人： Vasulinga Ravikumar , Muthiah Manoharan , Andrei P. Guzaev , Zhiwei Wang , Raju K. Kumar
IPC分类号： C08F289/00 , C07H21/04 , C07D491/18
CPC分类号： C07D491/18 , C07B2200/11 , C07D491/08 , C07D493/18
摘要： Universal linkers, their facile processes of manufacture and methods of using the same are provided.
摘要翻译：提供了通用接头，其简便的制造过程及其使用方法。

2. 发明授权

US07038037B2 Method for sequential support-bound synthesis of conjugated oligomeric compounds 失效
标题翻译：顺序支持结合合成低聚化合物的方法
公开(公告)号：US07038037B2
公开(公告)日：2006-05-02
申请号：US10176419
申请日：2002-06-20
申请人： Martin A. Maier , Andrei P. Guzaev , Muthiah Manoharan
发明人： Martin A. Maier , Andrei P. Guzaev , Muthiah Manoharan
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C40B50/14 , A61K47/60 , A61K47/61 , A61K47/62 , C07H21/00 , C07K1/006 , C07K7/06 , C07K7/08 , C40B40/04
摘要： A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.
摘要翻译：公开了使用具有至少两个N-保护性氨基的桥连分子来制备共轭寡聚化合物，优选PNA-肽缀合物或寡核苷酸 - 肽缀合物的顺序支持结合合成方法。还公开了用于治疗或预防递送的共轭寡聚化合物。

3. 发明授权

US06121437A Phosphate and thiophosphate protecting groups 失效
标题翻译：磷酸盐和硫代磷酸盐保护基团
公开(公告)号：US06121437A
公开(公告)日：2000-09-19
申请号：US268797
申请日：1999-03-16
申请人： Andrei P. Guzaev , Muthiah Manoharan
发明人： Andrei P. Guzaev , Muthiah Manoharan
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C07H19/04 , C07H1/00
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , Y02P20/55
摘要： Novel phosphorus protecting groups, intermediates thereof, and synthetic processes for making the same are disclosed. Oligomeric compounds are prepared through the protection of one or more internucleosidic phosphorus functionalities, preferably followed by oxidation and cleavage of the protecting groups to provide oligonucleotides.
摘要翻译：公开了新的磷保护基团，其中间体及其制备方法。通过保护一个或多个核苷间磷官能团制备低聚化合物，优选随后氧化和切割保护基以提供寡核苷酸。

4. 发明授权

US07576119B2 Supports for oligomer synthesis 有权
标题翻译：支持低聚物合成
公开(公告)号：US07576119B2
公开(公告)日：2009-08-18
申请号：US11622325
申请日：2007-01-11
申请人： Vasulinga Ravikumar , Muthiah Manoharan , Andrei P. Guzaev , Zhiwei Wang , Raju K. Kumar
发明人： Vasulinga Ravikumar , Muthiah Manoharan , Andrei P. Guzaev , Zhiwei Wang , Raju K. Kumar
IPC分类号： A61K31/407 , C07D491/48
CPC分类号： C07D491/18 , C07B2200/11 , C07D491/08 , C07D493/18
摘要： Universal linkers, their facile processes of manufacture and methods of using the same are provided.
摘要翻译：提供了通用接头，其简便的制造过程及其使用方法。

5. 发明授权

US06825338B2 Labeled oligonucleotides, methods for making same, and compounds useful therefor 失效
标题翻译：标记的寡核苷酸，其制备方法以及对其有用的化合物
公开(公告)号：US06825338B2
公开(公告)日：2004-11-30
申请号：US09823031
申请日：2001-03-30
申请人： Muthiah Manoharan , Andrei P. Guzaev
发明人： Muthiah Manoharan , Andrei P. Guzaev
IPC分类号： C07H2100
CPC分类号： C07H21/00
摘要： Selectively functionalized oligonucleotides, methods for making same, and compounds useful therefor are disclosed. The oligonucleotides can be selectively functionalized with a first conjugate group at the 3′-terminial position and optionally functionalized with a second conjugate group at the 5′-terminal position and/or one or more internucleotides. Alternatively, the oligonucleotides can be selectively functionalized with a first conjugate group at the 5′-terminal position and optionally functionalized with a second conjugate group at one or more internucleotides. In yet another embodiment, the oligonucleotides can be functionalized with a first conjugate group at one or more internucleotides and with a second conjugate group at one or more different internucleotides.
摘要翻译：公开了选择性官能化的寡核苷酸，其制备方法及其有用的化合物。寡核苷酸可以在3'-末端位置用第一个共轭基团选择性地官能化，并且任选地在5'-末端位置用第二个共轭基团官能化和/或一个或多个核苷酸。或者，寡核苷酸可以在5'-末端位置用第一缀合基团选择性官能化，并且任选地在一个或多个核苷酸上用第二缀合物官能化。在另一个实施方案中，寡核苷酸可以用一个或多个核苷酸上的第一缀合基团和在一个或多个不同核苷酸处的第二缀合基团进行官能化。

6. 发明授权

US08957038B2 Treatment of neurological disorders 有权
标题翻译：治疗神经系统疾病
公开(公告)号：US08957038B2
公开(公告)日：2015-02-17
申请号：US13383560
申请日：2010-07-15
申请人： Dinah W. Y. Sah , Andrei P. Guzaev , Matthew H. Adams , Pei Ge , Muthiah Manoharan , Douglas Ulen Gwost , Gregory Robert Stewart , David Kent Stiles , Brian Dale Nelson , William Frederick Kaemmerer , Don Marshall Gash
发明人： Dinah W. Y. Sah , Andrei P. Guzaev , Matthew H. Adams , Pei Ge , Muthiah Manoharan , Douglas Ulen Gwost , Gregory Robert Stewart , David Kent Stiles , Brian Dale Nelson , William Frederick Kaemmerer , Don Marshall Gash
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： A61K51/0491 , A61K49/04 , A61K49/06 , A61M5/007 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3517 , C12N2320/10 , C12N2320/35 , C12N2310/3521
摘要： This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.
摘要翻译：本发明提供治疗组合物以及确定和施用有效量的神经障碍治疗的系统和方法。治疗组合物可以含有能够降低与神经障碍相关的靶RNA表达的标记的干扰RNA（iRNA）试剂。本发明的方法包括通过将含有示踪剂的溶液引入哺乳动物的脑中来确定治疗组合物的有效量。监测追踪溶液，直到基本上达到稳定状态分布的目标体积分布，并确定治疗组合物的递送速率。然后可以以通过使用追踪溶液确定的速率施用治疗组合物。

7. 发明申请

US20120116360A1 TREATMENT OF NEUROLOGICAL DISORDERS 有权
标题翻译：治疗神经病变
公开(公告)号：US20120116360A1
公开(公告)日：2012-05-10
申请号：US13383560
申请日：2010-07-15
申请人： Dinah W. Y. Sah , Andrei P. Guzaev , Matthew H. Adams , Pei Ge , Muthiah Manoharan , Douglas Ulen Gwost , Gregory Robert Stewart , David Kent Stiles , Brian Dale Nelson , William Frederick Kaemmerer , Don Marshall Gash
发明人： Dinah W. Y. Sah , Andrei P. Guzaev , Matthew H. Adams , Pei Ge , Muthiah Manoharan , Douglas Ulen Gwost , Gregory Robert Stewart , David Kent Stiles , Brian Dale Nelson , William Frederick Kaemmerer , Don Marshall Gash
IPC分类号： A61M5/168 , A61K49/00 , A61M5/142 , A61K31/7088
CPC分类号： A61K51/0491 , A61K49/04 , A61K49/06 , A61M5/007 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3517 , C12N2320/10 , C12N2320/35 , C12N2310/3521
摘要： This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution.
摘要翻译：本发明提供治疗组合物以及确定和施用有效量的神经障碍治疗的系统和方法。治疗组合物可以含有能够降低与神经障碍相关的靶RNA表达的标记的干扰RNA（iRNA）试剂。本发明的方法包括通过将含有示踪剂的溶液引入哺乳动物的脑中来确定治疗组合物的有效量。监测追踪溶液，直到基本上达到稳定状态分布的目标体积分布，并确定治疗组合物的递送速率。然后可以以通过使用追踪溶液确定的速率施用治疗组合物。

8. 发明申请

US20100234528A1 SUPPORTS FOR OLIGOMER SYNTHESIS 有权
标题翻译：支持低分子合成
公开(公告)号：US20100234528A1
公开(公告)日：2010-09-16
申请号：US12728083
申请日：2010-03-19
申请人： Vasulinga Ravikumar , Muthiah Manoharan , Andrei P. Guzaev , Zhiwei Wang , Raju Krishna Kumar
发明人： Vasulinga Ravikumar , Muthiah Manoharan , Andrei P. Guzaev , Zhiwei Wang , Raju Krishna Kumar
IPC分类号： C08F289/00 , C07H21/04 , C07D491/18 , C07F7/02 , C08F212/08 , C08F220/56
CPC分类号： C07D491/18 , C07B2200/11 , C07D491/08 , C07D493/18
摘要： Universal linkers, their facile processes of manufacture and methods of using the same are provided.
摘要翻译：提供了通用接头，其简便的制造过程及其使用方法。

9. 发明授权

US06335434B1 Nucleosidic and non-nucleosidic folate conjugates 有权
标题翻译：核苷和非核苷酸叶酸偶联物
公开(公告)号：US06335434B1
公开(公告)日：2002-01-01
申请号：US09275505
申请日：1999-03-24
申请人： Andrei P. Guzaev , Phillip Dan Cook , Muthiah Manoharan , Balkrishen Bhat
发明人： Andrei P. Guzaev , Phillip Dan Cook , Muthiah Manoharan , Balkrishen Bhat
IPC分类号： C12Q168
CPC分类号： C07H15/26 , C07D475/04
摘要： Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage sites. The folate can be attached via the &agr;- or &ggr;-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are diclosed. Also disclosed are nucleosidic and non-nucleosidic linkers conjugated to folic acid and related folates.
摘要翻译：描述了寡核苷酸 - 叶酸盐缀合物，其中叶酸酯与包含2'，3'，5'，核碱基和核苷酸间位点的寡核苷酸上的一个或多个位点缀合。叶酸可以通过α-或γ-羧酸盐，任选地通过连接基团连接。缀合物区域特异性合成的方法是分开的。还公开了与叶酸和相关叶酸缀合的核苷和非核苷酸接头。

10. 发明授权

US08541599B2 Supports for oligomer synthesis 有权
公开(公告)号：US08541599B2
公开(公告)日：2013-09-24
申请号：US13414516
申请日：2012-03-07
申请人： Vasulinga Ravikumar , Muthiah Manoharan , Andrei P. Guzaev , Zhiwei Wang , Raju K. Kumar
发明人： Vasulinga Ravikumar , Muthiah Manoharan , Andrei P. Guzaev , Zhiwei Wang , Raju K. Kumar
IPC分类号： C07D491/08 , C07D498/18
CPC分类号： C07D491/08 , C07B2200/11
摘要： Universal linkers, their facile processes of manufacture and methods of using the same are provided.

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