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1. 发明授权

US5851772A Microchip method for the enrichment of specific DNA sequences 失效
标题翻译： Microchip的富集特定DNA序列的方法
公开(公告)号：US5851772A
公开(公告)日：1998-12-22
申请号：US593345
申请日：1996-01-29
申请人： Andrei Darievich Mirzabekov , Yuri Petrovich Lysov , Valentine Vladimirovich Shick , Svetlana Alekseevna Dubiley
发明人： Andrei Darievich Mirzabekov , Yuri Petrovich Lysov , Valentine Vladimirovich Shick , Svetlana Alekseevna Dubiley
IPC分类号： C12Q1/68 , C40B40/06 , C07H21/04
CPC分类号： C12Q1/6811 , C12Q1/6837 , B01J2219/00529 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00722 , C40B40/06
摘要： A method for enriching specific genetic material sequences is provided, whereby oligonucleotide molecules complementary to the desired genetic material is first used to isolate the genetic material from a first source of genomic material. Then the genetic material is used as a label to isolate similar genetic sequences from other sources.
摘要翻译：提供了丰富特定遗传物质序列的方法，其中与所需遗传物质互补的寡核苷酸分子首先用于从基因组材料的第一来源分离遗传物质。然后将遗传物质用作标记，以从其他来源分离相似的遗传序列。

2. 发明授权

US6090549A Use of continuous/contiguous stacking hybridization as a diagnostic tool 失效
公开(公告)号：US6090549A
公开(公告)日：2000-07-18
申请号：US855372
申请日：1997-05-13
申请人： Andrei Darievich Mirzabekov , Eugene Vladislavovich Kirillov , Sergei Valeryevich Parinov , Victor Evgenievich Barski , Svetlana Alekseevna Dubiley
发明人： Andrei Darievich Mirzabekov , Eugene Vladislavovich Kirillov , Sergei Valeryevich Parinov , Victor Evgenievich Barski , Svetlana Alekseevna Dubiley
IPC分类号： C12Q1/68 , C07H19/04 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6827 , C12Q1/682 , C12Q1/6834 , C12Q1/6874 , Y10T436/143333
摘要： A method for detecting disease-associated alleles in patient genetic material is provided whereby a first group of oligonucleotide molecules, synthesized to compliment base sequences of the disease associated alleles is immobilized on a predetermined position on a substrate, and then contacted with patient genetic material to form duplexes. The duplexes are then contacted with a second group of oligonucleotide molecules which are synthesized to extend the predetermined length of the oligonucleotide molecules of the first group, and where each of the oligonucleotide molecules of the second group are tagged and either incorporate universal bases or a mixture of guanine, cytosine, thymine, and adenine, or complementary nucleotide strands that are tagged with a different fluorochrome which radiates light at a predetermined wavelength. The treated substrate is then washed and the light patterns radiating therefrom are compared with predetermined light patterns of various diseases that were prepared on identical substrates. A method is also provided for determining the length of a repeat sequence in DNA or RNA, and also for determining the base sequence of unknown DNA or RNA.

3. 发明授权

US06440671B1 Use of continuous/contiguous stacking hybridization as a diagnostic tool 有权
标题翻译：使用连续/连续堆叠杂交作为诊断工具
公开(公告)号：US06440671B1
公开(公告)日：2002-08-27
申请号：US09498851
申请日：2000-02-07
申请人： Andrei Darievich Mirzabekov , Eugene Vladislavovich Kirillov , Sergei Valeryevich Parinov , Victor Evgenievich Barski , Svetlana Alekseevna Dubiley
发明人： Andrei Darievich Mirzabekov , Eugene Vladislavovich Kirillov , Sergei Valeryevich Parinov , Victor Evgenievich Barski , Svetlana Alekseevna Dubiley
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C12Q1/682 , C12Q1/6834 , C12Q1/6874 , Y10T436/143333 , C12Q2565/501 , C12Q2565/102 , C12Q2525/117 , C12Q2565/543 , C12Q2549/113 , C12Q2533/107 , C12Q2563/107 , C12Q2521/501 , C12Q2521/101 , C12Q2525/197 , C12Q2525/151
摘要： A method for detecting disease-associated alleles in patient genetic material is provided whereby a first group of oligonucleotide molecules, synthesized to compliment base sequences of the disease associated alleles is immobilized on a predetermined position on a substrate, and then contacted with patient genetic material to form duplexes. The duplexes are then contacted with a second group of oligonucleotide molecules which are synthesized to extend the predetermined length of the oligonucleotide molecules of the first group, and where each of the oligonucleotide molecules of the second group are tagged and either incorporate universal bases or a mixture of guanine, cytosine, thymine, and adenine, or complementary nucleotide strands that are tagged with a different fluorochrome which radiates light at a predetermined wavelength. The treated substrate is then washed and the light patterns radiating therefrom are compared with predetermined light patterns of various diseases that were prepared on identical substrates. A method is also provided for determining the length of a repeat sequence in DNA or RNA, and also for determining the base sequence of unknown DNA or RNA.
摘要翻译：提供了一种用于检测患者遗传物质中疾病相关等位基因的方法，由此将合成以补充疾病相关等位基因的碱基序列的第一组寡核苷酸分子固定在底物上的预定位置上，然后与患者遗传物质接触形成双工。然后将双链体与第二组寡核苷酸分子接触，所述第二组寡核苷酸分子被合成以延长第一组的寡核苷酸分子的预定长度，并且其中第二组的每个寡核苷酸分子被标记并且掺入通用碱基或混合物鸟嘌呤，胞嘧啶，胸腺嘧啶和腺嘌呤，或用不同荧光染料标记的互补核苷酸链，其以预定波长辐射光。然后洗涤经处理的基底，并将从其辐射的光图案与在相同基底上制备的各种疾病的预定光图案进行比较。还提供了用于确定DNA或RNA中的重复序列的长度以及用于确定未知DNA或RNA的碱基序列的方法。

4. 发明授权

US5908745A Use of continuous/contiguous stacking hybridization as a diagnostic tool 失效
标题翻译：使用连续/连续堆叠杂交作为诊断工具
公开(公告)号：US5908745A
公开(公告)日：1999-06-01
申请号：US587332
申请日：1996-01-16
申请人： Andrei Darievich Mirzabekov , Gennadiy Moseyevich Yershov , Eugene Vladislavovich Kirillov , Sergei Valeryevich Parinov , Victor Evgenievich Barski , Yuri Petrovich Lysov
发明人： Andrei Darievich Mirzabekov , Gennadiy Moseyevich Yershov , Eugene Vladislavovich Kirillov , Sergei Valeryevich Parinov , Victor Evgenievich Barski , Yuri Petrovich Lysov
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6834 , C12Q1/6874 , Y10T436/143333
摘要： A method for detecting disease-associated alleles in patient genetic material is provided whereby a first group of oligonucleotide molecules, synthesized to compliment base sequences of the disease associated alleles is immobilized on a predetermined position on a substrate, and then contacted with patient genetic material to form duplexes. The duplexes are then contacted with a second group of oligonucleotide molecules which are synthesized to extend the predetermined length of the oligonucleotide molecules of the first group, and where each of the oligonucleotide molecules of the second group are tagged and either incorporate universal bases or a mixture of guanine, cytosine, thymine, and adenine, or complementary nucleotide strands that are tagged with a different fluorochrome which radiates light at a predetermined wavelength. The treated substrate is then washed and the light patterns radiating therefrom are compared with predetermined light patterns of various diseases that were prepared on identical substrates.
摘要翻译：提供了一种用于检测患者遗传物质中疾病相关等位基因的方法，由此将合成以补充疾病相关等位基因的碱基序列的第一组寡核苷酸分子固定在基底上的预定位置上，然后与患者遗传物质接触形成双工。然后将双链体与第二组寡核苷酸分子接触，所述第二组寡核苷酸分子被合成以延长第一组的寡核苷酸分子的预定长度，并且其中第二组的每个寡核苷酸分子被标记并且掺入通用碱基或混合物鸟嘌呤，胞嘧啶，胸腺嘧啶和腺嘌呤，或用不同荧光染料标记的互补核苷酸链，其以预定波长辐射光。然后洗涤经处理的基底，并将从其辐射的光图案与在相同基底上制备的各种疾病的预定光图案进行比较。

5. 发明授权

US5905024A Method for performing site-specific affinity fractionation for use in DNA sequencing 失效
$Method for performing site-specific affinity fractionation for use in DNA sequencing$
标题翻译：用于DNA测序的用于进行位点特异性亲和分离的方法
公开(公告)号：US5905024A
公开(公告)日：1999-05-18
申请号：US768893
申请日：1996-12-17
申请人： Andrei Darievich Mirzabekov , Yuri Petrovich Lysov , Svetlana A. Dubley
发明人： Andrei Darievich Mirzabekov , Yuri Petrovich Lysov , Svetlana A. Dubley
IPC分类号： B01L3/00 , B01L3/02 , C12Q1/68 , C40B40/06 , C40B60/14 , C07H21/02 , C12P19/34 , G01N33/52
CPC分类号： B01L3/0255 , B01L3/0244 , B01L3/5085 , B82Y30/00 , B01J2219/00387 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B01L2200/12 , B01L2300/069 , B01L2300/0893 , B01L2300/0896 , B01L2300/1822 , B01L2300/1888 , C40B40/06 , C40B60/14 , Y10S436/80 , Y10S436/807 , Y10S436/809 , Y10T436/143333
摘要： A method for fractionating and sequencing DNA via affinity interaction is provided comprising contacting cleaved DNA to a first array of oligonucleotide molecules to facilitate hybridization between said cleaved DNA and the molecules; extracting the hybridized DNA from the molecules; contacting said extracted hybridized DNA with a second array of oligonucleotide molecules, wherein the oligonucleotide molecules in the second array have specified base sequences that are complementary to said extracted hybridized DNA; and attaching labeled DNA to the second array of oligonucleotide molecules, wherein the labeled re-hybridized DNA have sequences that are complementary to the oligomers. The invention further provides a method for performing multi-step conversions of the chemical structure of compounds comprising supplying an array of polyacrylamide vessels separated by hydrophobic surfaces; immobilizing a plurality of reactants, such as enzymes, in the vessels so that each vessel contains one reactant; contacting the compounds to each of the vessels in a predetermined sequence and for a sufficient time to convert the compounds to a desired state; and isolating the converted compounds from said array.
摘要翻译：提供了通过亲和相互作用对DNA进行分级和测序的方法，包括将切割的DNA与第一阵列的寡核苷酸分子接触以促进所述切割的DNA与分子之间的杂交; 从分子中提取杂交的DNA; 使所述提取的杂交DNA与第二阵列的寡核苷酸分子接触，其中所述第二阵列中的寡核苷酸分子具有与所述提取的杂交DNA互补的特定碱基序列; 并将标记的DNA附着到第二寡核苷酸分子阵列上，其中标记的再杂交DNA具有与寡聚物互补的序列。本发明还提供了一种用于进行化合物化学结构的多步转化的方法，包括提供由疏水性表面分离的聚丙烯酰胺容器阵列; 将诸如酶的多种反应物固定在容器中，使得每个容器含有一种反应物; 以预定顺序将化合物与每个容器接触并持续足够的时间将化合物转化为所需状态; 并从所述阵列中分离转化的化合物。

6. 发明授权

US06143499A Miniaturized reaction vessel system, method for performing site-specific biochemical reactions and affinity fractionation for use in DNA sequencing 失效
$Miniaturized reaction vessel system, method for performing site-specific biochemical reactions and affinity fractionation for use in DNA sequencing$
标题翻译：小型化反应容器系统，用于进行位点特异性生化反应的方法和用于DNA测序的亲和分离
公开(公告)号：US06143499A
公开(公告)日：2000-11-07
申请号：US99959
申请日：1998-06-19
申请人： Andrei Darievich Mirzabekov , Yuri Petrovich Lysov , Svetlana A. Dubley
发明人： Andrei Darievich Mirzabekov , Yuri Petrovich Lysov , Svetlana A. Dubley
IPC分类号： B01L3/00 , B01L3/02 , C12Q1/68 , C40B40/06 , C40B60/14 , C12P19/34 , C07M21/02 , C07M21/04
CPC分类号： B01L3/0255 , B01L3/0244 , B01L3/5085 , B82Y30/00 , B01J2219/00387 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B01L2200/12 , B01L2300/069 , B01L2300/0893 , B01L2300/0896 , B01L2300/1822 , B01L2300/1888 , C40B40/06 , C40B60/14 , Y10S436/80 , Y10S436/807 , Y10S436/809 , Y10T436/143333
摘要： A method for fractionating and sequencing DNA via affinity interaction is provided comprising contacting cleaved DNA to a first array of oligonucleotide molecules to facilitate hybridization between said cleaved DNA and the molecules; extracting the hybridized DNA from the molecules; contacting said extracted hybridized DNA with a second array of oligonucleotide molecules, wherein the oligonucleotide molecules in the second array have specified base sequences that are complementary to said extracted hybridized DNA; and attaching labeled DNA to the second array of oligonucleotide molecules, wherein the labeled re-hybridized DNA have sequences that are complementary to the oligomers. The invention further provides a method for performing multi-step conversions of the chemical structure of compounds comprising supplying an array of polyacrylamide vessels separated by hydrophobic surfaces; immobilizing a plurality of reactants, such as enzymes, in the vessels so that each vessel contains one reactant; contacting the compounds to each of the vessels in a predetermined sequence and for a sufficient time to convert the compounds to a desired state; and isolating the converted compounds from said array.
摘要翻译：提供了通过亲和相互作用对DNA进行分级和测序的方法，包括将切割的DNA与第一阵列的寡核苷酸分子接触以促进所述切割的DNA与分子之间的杂交; 从分子中提取杂交的DNA; 使所述提取的杂交DNA与第二阵列的寡核苷酸分子接触，其中所述第二阵列中的寡核苷酸分子具有与所述提取的杂交DNA互补的特定碱基序列; 并将标记的DNA附着到第二寡核苷酸分子阵列上，其中标记的再杂交DNA具有与寡聚物互补的序列。本发明还提供了一种用于进行化合物化学结构的多步转化的方法，包括提供由疏水性表面分离的聚丙烯酰胺容器阵列; 将诸如酶的多种反应物固定在容器中，使得每个容器含有一种反应物; 以预定顺序将化合物与每个容器接触并持续足够的时间将化合物转化为所需状态; 并从所述阵列中分离转化的化合物。

7. 发明授权

US06465174B1 Rapid method to detect duplex formation in sequencing by hybridization methods, a method for constructing containment structures for reagent interaction 失效
标题翻译：用于通过杂交方法检测测序中的双链体形成的快速方法，用于构建用于试剂相互作用的包封结构的方法
公开(公告)号：US06465174B1
公开(公告)日：2002-10-15
申请号：US09127313
申请日：1998-07-31
申请人： Andrei Darievich Mirzabekov , Gennadiy Moiseyevich Yershov , Dmitry Yuryevich Guschin , Margaret Anne Gemmell , Valentine V. Shick , Dmitri Y. Proudnikov , Edward N. Timofeev
发明人： Andrei Darievich Mirzabekov , Gennadiy Moiseyevich Yershov , Dmitry Yuryevich Guschin , Margaret Anne Gemmell , Valentine V. Shick , Dmitri Y. Proudnikov , Edward N. Timofeev
IPC分类号： C12Q168
CPC分类号： B82Y30/00 , B01J19/0046 , B01J19/0093 , B01J2219/00387 , B01J2219/00432 , B01J2219/00495 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/0065 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , C12Q1/6874 , C40B40/06 , C40B60/14 , C12Q2545/101
摘要： A method for determining the existence of duplexes of oligonucleotide complementary molecules is provided whereby a plurality of immobilized oligonucleotide molecules, each of a specific length and each having a specific base sequence, is contacted with complementary, single stranded oligonucleotide molecules to form a duplex so as to facilitate intercalation of a fluorescent dye between the base planes of the duplex. The invention also provides for a method for constructing oligonucleotide matrices comprising confining light sensitive fluid to a surface, exposing said light-sensitive fluid to a light pattern so as to cause the fluid exposed to the light to polymerize into discrete units and adhere to the surface; and contacting each of the units with a set of different oligonucleotide molecules so as to allow the molecules to disperse into the units.
摘要翻译：提供了确定寡核苷酸互补分子的双链体存在的方法，其中将多个固定的寡核苷酸分子（每个具有特定碱基序列的每一个）与互补的单链寡核苷酸分子接触以形成双链体，以便以促进荧光染料在双面体的基面之间插入。本发明还提供了一种构建寡核苷酸基质的方法，其包括将光敏流体限定在表面上，将所述光敏流体暴露于光图案，以使暴露于光的流体聚合成离散的单元并附着在表面上 ; 并使每个单元与一组不同的寡核苷酸分子接触，以使分子分散到单元中。

8. 发明授权

US07846656B2 Composition for polymerizing immobilization of biological molecules and method for producing said composition 有权
标题翻译：用于聚合固定生物分子的组合物和用于制备所述组合物的方法
公开(公告)号：US07846656B2
公开(公告)日：2010-12-07
申请号：US10450641
申请日：2001-10-16
申请人： Andrei Darievich Mirzabekov , Alla Jurievna Rubina , Sergei Vasilievich Pankov
发明人： Andrei Darievich Mirzabekov , Alla Jurievna Rubina , Sergei Vasilievich Pankov
IPC分类号： C12Q1/68
CPC分类号： G01N33/545 , C07H21/04 , C07K17/08 , C08F220/00
摘要： The invention refers to the field of molecular biology and bio-organic chemistry and deals with a composition for immobilization in polymer carriers of oligonucleotides, proteins, nucleic acids or any other molecules, which structure comprises active groups, including amino- or sulfhydryl groups, as well as a method for immobilization of various molecules including oligonucleotides, proteins, nucleic acids or any other molecules which structure comprises active groups, including amino- or sulfhydryl groups, consisting of a porous polymer being obtained on the basis of the composition claimed under conditions of addition or substitution reaction (radical, nucleophilic, or electrophilic nature, etc.) during synthesis of polymer by photo- and chemical initiated polymerization.The composition claimed, as well as the method of immobilization of molecules in a polymer carrier using these compositions, may be used in various applications including microchips manufacturing that use is made of molecular biology on DNA sequencing and mapping, on detection of mutations and a whole range of medical applications.
摘要翻译：本发明涉及分子生物学和生物有机化学领域，涉及在寡核苷酸，蛋白质，核酸或任何其它分子的聚合物载体中固定的组合物，该结构包含活性基团，包括氨基或巯基，如以及用于固定各种分子的方法，包括寡核苷酸，蛋白质，核酸或任何其它分子，其结构包含活性基团，包括氨基或巯基，其由多孔聚合物组成，所述多孔聚合物是根据在通过光化学引发聚合合成聚合物期间的添加或取代反应（自由基，亲核或亲电性质等）。使用这些组合物所要求保护的组合物以及分子在聚合物载体中的固定方法可用于各种应用，包括使用分子生物学对DNA测序和测序，突变检测和整体检测使用的微芯片制造范围广泛的医疗应用。

9. 发明授权

US5861247A Rapid method to detect duplex formation in sequencing by hybridization methods 失效
标题翻译：通过杂交方法检测测序中双链体形成的快速方法
公开(公告)号：US5861247A
公开(公告)日：1999-01-19
申请号：US592120
申请日：1996-01-26
申请人： Andrei Darievich Mirzabekov , Edward Nikolaevich Timofeev , Vladimer Leonidovich Florentiev , Eugene Vladislavovich Kirillov
发明人： Andrei Darievich Mirzabekov , Edward Nikolaevich Timofeev , Vladimer Leonidovich Florentiev , Eugene Vladislavovich Kirillov
IPC分类号： B01J19/00 , C12Q1/68 , C40B40/06 , C40B60/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J19/0093 , C12Q1/6837 , C12Q1/6874 , B01J2219/00387 , B01J2219/00432 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： A method for determining the existence of duplexes of oligonucleotide complementary molecules is provided whereby a plurality of immobilized oligonucleotide molecules, each of a specific length and each having a specific base sequence, is contacted with complementary, single stranded oligonucleotide molecules to form a duplex so as to facilitate intercalation of a fluorescent dye between the base planes of the duplex. The invention also provides for a method for constructing oligonucleotide matrices comprising confining light sensitive fluid to a surface, exposing said light-sensitive fluid to a light pattern so as to cause the fluid exposed to the light to coalesce into discrete units and adhere to the surface; and contacting each of the units with a set of different oligonucleotide molecules so as to allow the molecules to disperse into the units.
摘要翻译：提供了确定寡核苷酸互补分子的双链体存在的方法，其中将多个固定的寡核苷酸分子（每个具有特定碱基序列的每一个）与互补的单链寡核苷酸分子接触以形成双链体，以便以促进荧光染料在双面体的基面之间插入。本发明还提供了一种用于构建寡核苷酸基质的方法，其包括将光敏流体限制在表面上，将所述光敏流体暴露于光图案，以使暴露于光的流体聚结成离散的单元并附着在表面上 ; 并使每个单元与一组不同的寡核苷酸分子接触，以使分子分散到单元中。

10. 发明授权

US5962329A Method of dispensing microdoses of aqueous solutions of substances onto a carrier and a device for carrying out said method 失效
标题翻译：将物质水溶液的微剂量分配到载体上的方法和用于实施所述方法的装置
公开(公告)号：US5962329A
公开(公告)日：1999-10-05
申请号：US61308
申请日：1998-04-16
申请人： Gennady Moiseevich Ershov , Eugenii Vladislavovich Kirillov , Andrei Darievich Mirzabekov
发明人： Gennady Moiseevich Ershov , Eugenii Vladislavovich Kirillov , Andrei Darievich Mirzabekov
IPC分类号： C12Q1/68 , B01J4/02 , B01J19/00 , B01L3/02 , C40B60/14 , G01N1/00 , G01N35/10 , G01N1/12 , G01N1/02
CPC分类号： B01L3/0244 , B01J19/0046 , B01J19/0093 , B01J4/02 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/0072 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00873 , B01J2219/00891 , B01J2219/00961 , B01J2219/00995 , C40B60/14 , G01N1/10 , G01N2035/1037 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/143333 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A method and a device for dispensing microdoses of aqueous solutions are provided, whereby the substance is transferred by the free surface end of a rodlike transferring element; the temperature of the transferring element is maintained at essentially the dew point of the ambient air during the transfer. The device may comprise a plate-like base to which are affixed a plurality of rods; the unfixed butt ends of the rods are coplanar. The device further comprises a means for maintaining the temperature of the unfixed butt ends of the rods essentially equal to the dew point of the ambient air during transfer of the aqueous substance.
摘要翻译：提供了一种用于分配水溶液的微剂量的方法和装置，由此该物质通过棒状转移元件的自由表面端转移; 转移元件的温度在转移期间基本上保持在环境空气的露点。该装置可以包括板状基座，多个杆被固定到该基板上; 杆的未固定的对接端是共面的。该装置还包括用于在转移水性物质期间将棒的未固定的对接端的温度基本上等于环境空气的露点的装置。

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