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1. 发明申请

US20070274959A1 In Vitro Method for the Diagnosis of Cardiovascular Functionality of Bone Marrow-Precursor Cells (Bmp) and/or Circulation Precursor Cells Derived from Blood (Bdp) 有权
标题翻译：用于诊断来自血液（Bdp）的骨髓前体细胞（Bmp）和/或循环前体细胞的心血管功能的体外方法
公开(公告)号：US20070274959A1
公开(公告)日：2007-11-29
申请号：US10574380
申请日：2004-10-13
申请人： Andreas Zeiher , Christopher Heeschen , Stefanie Dimmeler
发明人： Andreas Zeiher , Christopher Heeschen , Stefanie Dimmeler
IPC分类号： A61K35/14 , G01N33/567
CPC分类号： G01N33/56966 , A61K2035/124 , G01N33/5005 , G01N2333/70589 , G01N2333/70596 , G01N2333/71 , G01N2333/755
摘要： The present invention relates to an in vitro method for the analysis of a sample from a mammal in connection with cardiovascular diseases, wherein the method comprises the following steps: a) isolating of bone marrow-precursor cells (BMPs) and/or blood-derived circulating precursor cells (BDPs) by means of cell specific surface markers, and b) detecting the cardiovascular functionality of the isolated BMPs and/or BDPs by means of a suitable migration assay. The method according to the invention can be employed as a kit in the context of the diagnosis and/or the prognosis of cardiovascular diseases, for the monitoring of their therapies and/or for a stratification for a prospective cell therapy with stem- and/or precursor cells in order to increase the perfusion of ischemic tissue or for a regeneration of tissue losses (e.g. heart insufficiency), respectively. In a further aspect, the present invention then relates to an in vitro method for isolating specific bone marrow-precursor cells by means of a suitable migration assay. According to the invention, these BMPs and/or BDPs can be used for the treatment of cardiovascular diseases, selected from the group consisting of stable coronary heart disease, acute coronary syndrome, acute myocardial infarction, chronic ischemic cardiomyopathy (ICMP), dilatative cardiomyopathy (DCM) or other causes for a heart insufficiency.
摘要翻译：本发明涉及用于分析哺乳动物与心血管疾病相关的样品的体外方法，其中所述方法包括以下步骤：a）分离骨髓前体细胞（BMP）和/或血液来源的通过细胞特异性表面标志物循环前体细胞（BDP），和b）通过合适的迁移试验检测分离的BMP和/或BDP的心血管功能。根据本发明的方法可以在心血管疾病的诊断和/或预后的背景下用作试剂盒，用于监测其疗法和/或用于具有茎和/或血管的前瞻性细胞治疗的分层，为了增加缺血组织的灌注或组织损失（例如心脏功能不全）的再生，分别为前体细胞。在另一方面，本发明涉及通过合适的迁移试验分离特异性骨髓前体细胞的体外方法。根据本发明，这些BMP和/或BDP可用于治疗心血管疾病，其选自稳定性冠心病，急性冠状动脉综合征，急性心肌梗死，慢性缺血性心肌病（ICMP），扩张性心肌病 DCM）或心脏功能不全的其他原因。

2. 发明申请

US20070042438A1 Scd4ol and placental growth factor (plgf) used as a biochemical marker combination in cardiovascular diseases 有权
标题翻译： Scd4ol和胎盘生长因子（plgf）用作心血管疾病中的生物化学标记物组合
公开(公告)号：US20070042438A1
公开(公告)日：2007-02-22
申请号：US10534985
申请日：2003-11-10
申请人： Andreas Zeiher , Christopher Heeschen , Stefanie Dimmeler , Christian Hamm
发明人： Andreas Zeiher , Christopher Heeschen , Stefanie Dimmeler , Christian Hamm
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , C07K14/70575 , G01N2333/96486 , G01N2800/32
摘要： The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools that facilitate the selection of active ingredients for the treatment of such diseases, and finally act as starting points for the treatment of cardiovascular diseases. Furthermore, the invention relates to the creation of an individual risk profile of negative events that are associated with the progression of arteriosclerosis.
摘要翻译：本发明涉及血管炎症的新型标志物及其组合作为心血管疾病患者的诊断和预后工具。标记物也作为促进活性成分选择用于治疗这些疾病的工具，最终成为治疗心血管疾病的起点。此外，本发明涉及创建与动脉硬化进展相关的阴性事件的个体风险特征。

3. 发明授权

US08309608B2 Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases 有权
标题翻译：在缺血性心脏病的细胞治疗中使用eNOS转录增强子
公开(公告)号：US08309608B2
公开(公告)日：2012-11-13
申请号：US10979399
申请日：2004-11-02
申请人： Andreas Zeiher , Stefanie Dimmeler , Christopher Heeschen , Hartmut Ruetten
发明人： Andreas Zeiher , Stefanie Dimmeler , Christopher Heeschen , Hartmut Ruetten
IPC分类号： A61K31/165
CPC分类号： A61K31/44 , A61K31/00 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/277 , A61K31/401 , A61K31/445 , A61K31/537 , A61K31/54
摘要： The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of patients with ischemic heart diseases such as coronary heart disease or ischemic cardiomyopathy. Treatment of such cells which are isolated from bone marrow, for example, with an eNOS transcription enhancer prior to their administration improves their functional activity and ameliorates neovascularization of the heart and cardiac regeneration.
摘要翻译：本发明涉及增强内皮型一氧化氮合酶（eNOS）在缺血性心脏病如冠状动脉心脏病或缺血性心肌病患者细胞治疗中的干细胞和祖细胞的转录的化合物的用途。在其施用之前，例如用eNOS转录增强子从骨髓中分离的这些细胞的治疗改善了它们的功能活性并改善了心脏新生血管形成和心脏再生。

4. 发明申请

US20050101599A1 Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases 有权
标题翻译：在缺血性心脏病的细胞治疗中使用eNOS转录增强子
公开(公告)号：US20050101599A1
公开(公告)日：2005-05-12
申请号：US10979399
申请日：2004-11-02
申请人： Andreas Zeiher , Stefanie Dimmeler , Christopher Heeschen , Hartmut Ruetten
发明人： Andreas Zeiher , Stefanie Dimmeler , Christopher Heeschen , Hartmut Ruetten
IPC分类号： A61K31/00 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/277 , A61K31/401 , A61K31/44 , A61K31/445 , A61K31/537 , A61K31/54
CPC分类号： A61K31/44 , A61K31/00 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/277 , A61K31/401 , A61K31/445 , A61K31/537 , A61K31/54
摘要： The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of patients with ischemic heart diseases such as coronary heart disease or ischemic cardiomyopathy. Treatment of such cells which are isolated from bone marrow, for example, with an eNOS transcription enhancer prior to their administration improves their functional activity and ameliorates neovascularization of the heart and cardiac regeneration.
摘要翻译：本发明涉及增强内皮型一氧化氮合酶（eNOS）在缺血性心脏病如冠状动脉心脏病或缺血性心肌病患者细胞治疗中的干细胞和祖细胞的转录的化合物的用途。在其施用之前，例如用eNOS转录增强子从骨髓中分离的这些细胞的治疗改善了它们的功能活性并改善了心脏新生血管形成和心脏再生。

5. 发明申请

US20060246044A1 Methods for improving cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases by means of shockwaves 审中-公开
标题翻译：通过冲击波改善心血管和神经系统疾病患者的细胞治疗和组织再生的方法
公开(公告)号：US20060246044A1
公开(公告)日：2006-11-02
申请号：US11304865
申请日：2005-12-15
申请人： Andreas Lutz , Harald Eizenhofer , Andreas Zeiher , Stefanie Dimmeler , Christopher Heeschen , Alexandra Aicher
发明人： Andreas Lutz , Harald Eizenhofer , Andreas Zeiher , Stefanie Dimmeler , Christopher Heeschen , Alexandra Aicher
IPC分类号： A61K48/00 , A61H1/00 , C12N15/09
CPC分类号： A61H23/008 , A61B17/22004 , A61B2017/00247 , A61B2018/00392 , A61K35/44 , A61K38/1866 , A61K38/195 , A61K2300/00
摘要： Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and/or applying to the patient a therapeutically effective amount of stem cells and/or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient's heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.
摘要翻译：通过用冲击波治疗患者的组织和/或向患者施用治疗有效量的干细胞和/或祖细胞来改善患有心血管或神经疾病的患者的细胞治疗和组织再生。这种治疗增加化学引诱物的表达，促血管生成因子和促生存因子。化学引诱物可以是例如血管内皮生长因子（VEGF）或基质细胞衍生因子1（SDF-1）。例如，经处理的组织可以位于患者的心脏或患者的骨骼肌中，冲击波可以是体外冲击波（ESW）或体内冲击波。心血管疾病可能有缺血性或非缺血性病因。例如，心血管疾病可以是心肌梗塞，缺血性心肌病或扩张型心肌病。例如，神经系统疾病可以是周围神经病变或神经性疼痛。

6. 发明授权

US09062307B2 Antagonists of miRNA-29 expression and their use in the prevention and treatment of aneurysm 有权
标题翻译： miRNA-29表达的拮抗剂及其在预防和治疗动脉瘤中的应用
公开(公告)号：US09062307B2
公开(公告)日：2015-06-23
申请号：US13637924
申请日：2011-04-01
申请人： Andreas Zeiher , Stefanie Dimmeler , Reinier Boon
发明人： Andreas Zeiher , Stefanie Dimmeler , Reinier Boon
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/113 , A61K31/7088 , C12Q1/02
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/113 , C12Q1/025
摘要： The present invention relates to antagonists of the expression and/or the function of the micro RNA miRNA-29 for use in the prevention and/or treatment of aortic aneurysms. Further disclosed is a method for the identification of miRNA-29 antagonists, a pharmaceutical composition comprising said miRNA-29 antagonists and a method for preventing and treating age-related aortic aneurysm formation in a subject in need of such a treatment.
摘要翻译：本发明涉及用于预防和/或治疗主动脉瘤的微RNA miRNA-29的表达和/或功能的拮抗剂。进一步公开的是鉴定miRNA-29拮抗剂的方法，包含所述miRNA-29拮抗剂的药物组合物以及预防和治疗需要这种治疗的受试者中与年龄有关的主动脉瘤形成的方法。

7. 发明申请

US20130116303A1 Antagonists of miRNA-29 Expression and Their Use in the Prevention and Treatment of Aneurysm 有权
标题翻译： miRNA-29表达的拮抗剂及其在预防和治疗动脉瘤中的应用
公开(公告)号：US20130116303A1
公开(公告)日：2013-05-09
申请号：US13637924
申请日：2011-04-01
申请人： Andreas Zeiher , Stefanie Dimmeler , Reinier Boon
发明人： Andreas Zeiher , Stefanie Dimmeler , Reinier Boon
IPC分类号： C12N15/113 , C12Q1/02
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/113 , C12Q1/025
摘要： The present invention relates to antagonists of the expression and/or the function of the micro RNA miRNA-29 for use in the prevention and/or treatment of aortic aneurysms. Further disclosed is a method for the identification of miRNA-29 antagonists, a pharmaceutical composition comprising said miRNA-29 antagonists and a method for preventing and treating age-related aortic aneurysm formation in a subject in need of such a treatment.
摘要翻译：本发明涉及用于预防和/或治疗主动脉瘤的微RNA miRNA-29的表达和/或功能的拮抗剂。进一步公开的是鉴定miRNA-29拮抗剂的方法，包含所述miRNA-29拮抗剂的药物组合物以及预防和治疗需要这种治疗的受试者中与年龄有关的主动脉瘤形成的方法。

8. 发明申请

US20100068190A1 MESOANGIOBLAST-LIKE CELL AS WELL AS METHODS AND USES RELATING THERETO 审中-公开
标题翻译： MESOANGIOBLAST-LIKE CELL作为方法和使用相关的THERETO
公开(公告)号：US20100068190A1
公开(公告)日：2010-03-18
申请号：US12491844
申请日：2009-06-25
申请人： Stefanie Dimmeler , Andreas Zeiher , Masamichi Koyanagi
发明人： Stefanie Dimmeler , Andreas Zeiher , Masamichi Koyanagi
IPC分类号： A61K35/12 , C12N5/00 , A61P9/00 , C12N15/00
CPC分类号： A61K35/545 , A61K38/1833 , C12N5/0665 , C12N5/0692
摘要： The present invention relates to a medicament comprising a mesoangioblast-like cell obtained from a subject, a method of isolating a mesoangioblast-like cell, a method of producing a mesoderm-derived cell using a mesoangioblast-like cell, the use of a mesoangioblast-like cell for the preparation of a medicament for treating a cardiovascular disease and/or an ischemic disease and a method of converting the mesoangioblast-like cell into a pluripotent stem cell.
摘要翻译：本发明涉及一种药物，其包含从受试者获得的成细胞样细胞样细胞，分离中膜成血管细胞样细胞的方法，使用中胚细胞样细胞产生中胚层衍生细胞的方法，使用中胚性成纤维细胞样细胞，用于制备用于治疗心血管疾病和/或缺血性疾病的药物的细胞样细胞，以及将成mesromanot母细胞转化为多能干细胞的方法。

9. 发明申请

US20050244897A1 Endothelial cells as diagnostic instrument in cardiovascular diseases 审中-公开
标题翻译：内皮细胞作为心血管疾病的诊断仪器
公开(公告)号：US20050244897A1
公开(公告)日：2005-11-03
申请号：US10534150
申请日：2003-11-17
申请人： Andreas Zeiher , Stefanie Dimmeler , Lothar Rossig
发明人： Andreas Zeiher , Stefanie Dimmeler , Lothar Rossig
IPC分类号： G01N33/569 , G01N33/68 , G01N33/53 , G01N33/567
CPC分类号： G01N33/6893 , G01N33/56966 , G01N2800/32
摘要： The invention relates to a method for the immunocytological determination of apoptotic endothelial cells and/or endothelial precursor cells in samples such as, for example, peripheral blood, by means of, for example, throughflow cytometry or by means of a solid-phase immunoassay, as a diagnostic instrument in patients in whom a cardiovascular disease is either manifest or who carry the risk for the same and as an instrument by means of which the prevention and the therapeutic management of such a disease can be improved.
摘要翻译：本发明涉及通过例如流式细胞术或借助于固相免疫测定来免疫细胞测定样品例如外周血中的凋亡内皮细胞和/或内皮前体细胞的方法，作为心血管疾病明显或具有相同风险的患者的诊断仪器，以及可以改善这种疾病的预防和治疗管理的仪器。

10. 发明授权

US5105819A Ultrasound endoscope device 失效
标题翻译：超声内窥镜装置
公开(公告)号：US5105819A
公开(公告)日：1992-04-21
申请号：US663903
申请日：1991-04-16
申请人： Helmut Wollschlager , Susanna Wollschlager , Andreas Zeiher , Hans-Peter Klein
发明人： Helmut Wollschlager , Susanna Wollschlager , Andreas Zeiher , Hans-Peter Klein
IPC分类号： A61B1/00 , A61B1/005 , A61B8/12 , A61B8/14
CPC分类号： A61B8/12 , A61B8/14 , A61B8/445 , A61B8/4466 , A61B8/4488 , A61M25/09033 , A61B8/543
摘要： An ultrasonic endoscope device for scanning a patient's organ is constructed using a mobile ultrasonic transducer probe on a carriage housed in a distal and section of the device, within a guide channel formed by a plurality of axially aligned rigid guide links having hollow spaces opened to one side and pivotable by means of a tension wire running through the links. A flexible hose in conjunction with a balloon envelope surround the end section and serves as a water supply path. The device is especially useful for transeophaged echocardiographic scanning.
摘要翻译： PCT No.PCT / DE89 / 00551 Sec。 371日期：1991年4月16日 102（e）1991年4月16日PCT PCT 1989年8月23日PCT公布。出版物WO90 / 02520 1990年3月22日。用于扫描患者器官的超声波内窥镜装置使用移动式超声波换能器探针在容纳在装置的远端和部分中的托架上，在由多个轴向对准的刚性导轨连杆具有向一侧敞开的中空空间，并且可通过穿过连杆的张力线枢转。柔性软管与气囊信封一起围绕端部并用作供水路径。该装置对于经狭窄超声心动图扫描特别有用。

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