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1. 发明申请

US20060246044A1 Methods for improving cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases by means of shockwaves 审中-公开
标题翻译：通过冲击波改善心血管和神经系统疾病患者的细胞治疗和组织再生的方法
公开(公告)号：US20060246044A1
公开(公告)日：2006-11-02
申请号：US11304865
申请日：2005-12-15
申请人： Andreas Lutz , Harald Eizenhofer , Andreas Zeiher , Stefanie Dimmeler , Christopher Heeschen , Alexandra Aicher
发明人： Andreas Lutz , Harald Eizenhofer , Andreas Zeiher , Stefanie Dimmeler , Christopher Heeschen , Alexandra Aicher
IPC分类号： A61K48/00 , A61H1/00 , C12N15/09
CPC分类号： A61H23/008 , A61B17/22004 , A61B2017/00247 , A61B2018/00392 , A61K35/44 , A61K38/1866 , A61K38/195 , A61K2300/00
摘要： Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and/or applying to the patient a therapeutically effective amount of stem cells and/or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient's heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.
摘要翻译：通过用冲击波治疗患者的组织和/或向患者施用治疗有效量的干细胞和/或祖细胞来改善患有心血管或神经疾病的患者的细胞治疗和组织再生。这种治疗增加化学引诱物的表达，促血管生成因子和促生存因子。化学引诱物可以是例如血管内皮生长因子（VEGF）或基质细胞衍生因子1（SDF-1）。例如，经处理的组织可以位于患者的心脏或患者的骨骼肌中，冲击波可以是体外冲击波（ESW）或体内冲击波。心血管疾病可能有缺血性或非缺血性病因。例如，心血管疾病可以是心肌梗塞，缺血性心肌病或扩张型心肌病。例如，神经系统疾病可以是周围神经病变或神经性疼痛。

2. 发明授权

US5941838A Shock wave source based on the electromagnetic principle 有权
标题翻译：基于电磁原理的冲击波源
公开(公告)号：US5941838A
公开(公告)日：1999-08-24
申请号：US153200
申请日：1998-09-15
申请人： Harald Eizenhofer
发明人： Harald Eizenhofer
IPC分类号： A61B17/22 , A61B17/225 , G10K9/12
CPC分类号： A61B17/2251 , G10K9/12
摘要： Shock wave source based on the electromagnetic principle with defined focusing, with an electrically conductive, three-dimensionally curved membrane, with a coil, which is located adjacent thereto and to which current pulses can be admitted. A switchable electric connection is provided between the coil and a power supply unit. A housing is provided accommodating the membrane and the coil embedded in a coil form, between which housing and the membrane the coil form is located. A transmission medium is provided adjacent to the membrane and exerts pressure on the membrane. The coil form is made deformable and elastically compressible and is installed in the compressed state. The installed amount of the transmission medium remains unaffected during the operating state after the assembly.
摘要翻译：基于具有限定聚焦的电磁原理的冲击波源，具有导电的三维弯曲的膜，其具有与其相邻的线圈，并且可以允许电流脉冲。在线圈和电源单元之间提供可切换的电连接。设置有容纳膜和嵌入线圈形式的线圈的壳体，壳体和线圈形式所在的膜之间。在膜附近设置传输介质，并对膜施加压力。线圈形状可变形并且可弹性压缩并且被安装在压缩状态。在组装之后的运行状态下，传输介质的安装量不受影响。

3. 发明授权

US5195508A Spark gap unit for lithotripsy 失效
标题翻译：用于石灰石的SPARK GAP单元
公开(公告)号：US5195508A
公开(公告)日：1993-03-23
申请号：US701817
申请日：1991-05-17
申请人： Michael Muller , Peter Buchbauer , Harald Eizenhofer , Friedrich Ueberle , Herbert Weiler , Reiner Schultheiss
发明人： Michael Muller , Peter Buchbauer , Harald Eizenhofer , Friedrich Ueberle , Herbert Weiler , Reiner Schultheiss
IPC分类号： A61B17/22 , G10K15/06
CPC分类号： G10K15/06
摘要： A spark gap unit that is easy to manufacture and significantly lighter than previously used spark gap units for generating underwater shock waves, particularly for non-invasive lithotrispy, has an internal conductor with an inner electrode, an insulation which at least partially envelops the internal conductor, and an external conductor with a bow and an outer electrode. The internal conductor is significantly shorter than the external conductor, and the external conductor at the rearward end of the spark gap unit projects beyond the internal conductor. The internal conductor, the insulation, and the external conductor are coaxially arranged. An outside diameter of the internal conductor is relatively small in comparison to an inside diameter of the external conductor. The spark gap unit has a hollow space inside the insulation, this hollow space being open in the direction of a rearward end of the spark gap unit. In the opposite direction from the rearward end, the hollow space is bounded by the internal conductor itself and the envelopment of the internal conductor by the insulation.
摘要翻译：易于制造和比以前使用的用于产生水下冲击波的火花隙单元明显更轻的火花隙单元，特别是用于非侵入性碎石的火花隙单元具有内部导体，其具有内部电极，至少部分地包围内部导体的绝缘体，以及具有弓形和外部电极的外部导体。内部导体明显短于外部导体，并且火花隙单元后端的外部导体超出内部导体。内部导体，绝缘体和外部导体同轴布置。与外部导体的内径相比，内部导体的外径相对较小。火花隙单元在绝缘体内部具有中空空间，该中空空间在火花隙单元的后端方向上敞开。在与后端相反的方向上，中空空间由内部导体本身和内部导体的绝缘体包围。

4. 发明申请

US20080267927A1 Methods for improving cell therapy and tissue regeneration in patients with cardiovascular diseases by means of shockwaves 有权
标题翻译：通过冲击波改善心血管疾病患者的细胞治疗和组织再生的方法
公开(公告)号：US20080267927A1
公开(公告)日：2008-10-30
申请号：US12214660
申请日：2008-06-20
申请人： Andreas Lutz , Harald Eizenhofer , Andreas Michael Zeiher , Stefanie Drimmeler , Christopher Heeschen , Alexandra Aicher
发明人： Andreas Lutz , Harald Eizenhofer , Andreas Michael Zeiher , Stefanie Drimmeler , Christopher Heeschen , Alexandra Aicher
IPC分类号： A61K35/12 , A61P9/10
CPC分类号： A61H23/008 , A61B17/22004 , A61B2017/00247 , A61B2018/00392 , A61K35/44 , A61K38/1866 , A61K38/195 , A61K2300/00
摘要： Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and/or applying to the patient a therapeutically effective amount of stem cells and/or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient's heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.
摘要翻译：通过用冲击波治疗患者的组织和/或向患者施用治疗有效量的干细胞和/或祖细胞来改善患有心血管或神经疾病的患者的细胞治疗和组织再生。这种治疗增加化学引诱物的表达，促血管生成因子和促生存因子。化学引诱物可以是例如血管内皮生长因子（VEGF）或基质细胞衍生因子1（SDF-1）。例如，经处理的组织可以位于患者的心脏或患者的骨骼肌中，冲击波可以是体外冲击波（ESW）或体内冲击波。心血管疾病可能有缺血性或非缺血性病因。例如，心血管疾病可以是心肌梗塞，缺血性心肌病或扩张型心肌病。例如，神经系统疾病可以是周围神经病变或神经性疼痛。

5. 发明申请

US20050016285A1 Testing and monitoring of a shock wave or pressure wave source 有权
标题翻译：冲击波或压力波源的测试和监测
公开(公告)号：US20050016285A1
公开(公告)日：2005-01-27
申请号：US10872140
申请日：2004-06-18
申请人： Harald Eizenhofer
发明人： Harald Eizenhofer
IPC分类号： A61B17/22 , G01H3/10 , G01M9/00
CPC分类号： G01H3/10 , A61B17/22029
摘要： A device for the testing and monitoring of the function of a shock wave or pressure wave source is provided. The testing and monitoring device is characterized in that a passive non-linear transmission element transforms very short shock wave pulses received by it, the shock wave pulses typically having pulse durations lasting a few microseconds, into a considerably lower frequency range, whose oscillations are then sensed and evaluated.
摘要翻译：提供了用于测试和监测冲击波或压力波源的功能的装置。测试和监测装置的特征在于，被动非线性传输元件将由其接收的非常短的冲击波脉冲（通常具有持续几微秒的脉冲持续时间）转换成相当低的频率范围，其振荡是感觉和评估。

6. 发明授权

US5224468A Combination shock wave source 失效
标题翻译：组合冲击波源
公开(公告)号：US5224468A
公开(公告)日：1993-07-06
申请号：US680072
申请日：1991-04-03
申请人： Michael Grunewald , Hans Lobentanzer , Harald Eizenhofer , Friedrich Ueberle , Heribert Koch
发明人： Michael Grunewald , Hans Lobentanzer , Harald Eizenhofer , Friedrich Ueberle , Heribert Koch
IPC分类号： A61B17/22 , A61B17/225 , A61B18/00 , G10K9/12 , G10K15/04
CPC分类号： G10K9/12 , G10K15/043
摘要： An arrangement for generating focussed shock waves having two two-dimensional shock wave sources. The sources are of different types. In particular, an electromagnetic shock wave source is used in combination with a piezoelectric shock wave source. The arrangement has applications in no-contact lithotrity.
摘要翻译：用于产生具有两个二维冲击波源的聚焦冲击波的装置。来源是不同的类型。特别地，电磁冲击波源与压电冲击波源组合使用。该安排具有无接触式的应用。

7. 发明授权

US09060915B2 Methods for improving cell therapy and tissue regeneration in patients with cardiovascular diseases by means of shockwaves 有权
标题翻译：通过冲击波改善心血管疾病患者的细胞治疗和组织再生的方法
公开(公告)号：US09060915B2
公开(公告)日：2015-06-23
申请号：US12214660
申请日：2008-06-20
申请人： Andreas Lutz , Harald Eizenhofer , Andreas Michael Zeiher , Stefanie Dimmeler , Christopher Heeschen , Alexandra Aicher
发明人： Andreas Lutz , Harald Eizenhofer , Andreas Michael Zeiher , Stefanie Dimmeler , Christopher Heeschen , Alexandra Aicher
IPC分类号： A61K48/00 , A61H23/00 , A61B17/22 , A61K38/18 , A61K38/19 , A61K35/44 , A61B17/00 , A61B18/00
CPC分类号： A61H23/008 , A61B17/22004 , A61B2017/00247 , A61B2018/00392 , A61K35/44 , A61K38/1866 , A61K38/195 , A61K2300/00
摘要： Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and/or applying to the patient a therapeutically effective amount of stem cells and/or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient's heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.
摘要翻译：通过用冲击波治疗患者的组织和/或向患者施用治疗有效量的干细胞和/或祖细胞来改善患有心血管或神经疾病的患者的细胞治疗和组织再生。这种治疗增加化学引诱物的表达，促血管生成因子和促生存因子。化学引诱物可以是例如血管内皮生长因子（VEGF）或基质细胞衍生因子1（SDF-1）。例如，经处理的组织可以位于患者的心脏或患者的骨骼肌中，冲击波可以是体外冲击波（ESW）或体内冲击波。心血管疾病可能有缺血性或非缺血性病因。例如，心血管疾病可以是心肌梗塞，缺血性心肌病或扩张型心肌病。例如，神经系统疾病可以是周围神经病变或神经性疼痛。

8. 发明授权

US06146340A Electromagnetic shock wave source having a mechanically prestressed electrically conductive membrane 失效
标题翻译：具有机械预应力导电膜的电磁冲击波源
公开(公告)号：US06146340A
公开(公告)日：2000-11-14
申请号：US824964
申请日：1997-03-27
申请人： Harald Eizenhofer
发明人： Harald Eizenhofer
IPC分类号： G01N29/24 , A61B17/22 , A61B18/00 , B06B1/04 , G10K15/04
CPC分类号： B06B1/045 , G10K15/043 , A61B17/22
摘要： The shock wave source according to the invention has a membrane of an electrically conductive material which is connected on one side with a propagation medium and, on the other side, with a flat coil. The membrane is subjected to a mechanical prestress which acts radially on it by virtue of the clamping of its edge area by at least one member which has a projection which extends in a direction normal to the plane of the membrane.
摘要翻译：根据本发明的冲击波源具有导电材料的膜，其在一侧与传播介质连接，另一侧连接有扁平线圈。该薄膜经受机械预应力，其通过至少一个具有沿垂直于膜平面的方向延伸的突起的构件夹紧其边缘区域而使其径向地作用在其上。

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