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1. 发明授权

US5892092A Preparation of aliphatic, unsaturated nitriles 失效
标题翻译：脂肪族不饱和腈的制备
公开(公告)号：US5892092A
公开(公告)日：1999-04-06
申请号：US144478
申请日：1998-08-31
申请人： Andreas Kramer , Wolfgang Siegel , Michael Henningsen , Georg Heinrich Grosch
发明人： Andreas Kramer , Wolfgang Siegel , Michael Henningsen , Georg Heinrich Grosch
IPC分类号： B01J23/02 , C07B61/00 , C07C253/00 , C07C255/06 , C07C255/07 , C07C255/31
CPC分类号： C07C253/00
摘要： A process for preparing unsaturated nitriles of the formula I ##STR1## where R, R.sup.1 and R.sup.2 are each independently of one another alkyl or alkenyl each having 1-20 carbon atoms or cycloalkyl or cycloalkenyl each having 3-12 carbon atoms and any two of the radicals R, R.sup.1 and R.sup.2 may be part of a saturated or unsaturated ring and R.sup.1 and R.sup.2 may also be hydrogen and n is 0 or 1-20, by dehydration of oximes of the formula II ##STR2## where R, R.sup.1, R.sup.2 and n are as defined above, comprises dehydrating in the gas or liquid phase at from 150.degree. to 300.degree. C. over a heterogeneous catalyst consisting of an oxidic, carbidic or nitridic support doped with basic oxides and/or hydroxides or compounds which are converted into said oxides or hydroxides under the reaction conditions, or of said basic oxides.
摘要翻译：制备式I的不饱和腈的方法，其中R，R 1和R 2各自独立地为各自具有1-20个碳原子的烷基或链烯基或各自具有3-12个碳原子的环烷基或环烯基，任何两个的基团R 1，R 2和R 2可以是饱和或不饱和环的一部分，R 1和R 2也可以是氢，n是0或1-20，通过式II的肟脱水，其中R，R 1 R2和n如上定义，包括在气相或液相中在150-300℃下脱水，所述非均相催化剂由掺有碱性氧化物和/或氢氧化物或化合物的氧化，碳化或氮化载体组成，在反应条件下或所述碱性氧化物中转化为所述氧化物或氢氧化物。

2. 发明授权

US06906223B2 Method for the production of trioxime derivatives 失效
标题翻译：生产三肟衍生物的方法
公开(公告)号：US06906223B2
公开(公告)日：2005-06-14
申请号：US10332046
申请日：2001-07-04
申请人： Andreas Kramer , Matthias Kiefer , Michael Henningsen , Wolfgang Siegel , Jochen Schröder
发明人： Andreas Kramer , Matthias Kiefer , Michael Henningsen , Wolfgang Siegel , Jochen Schröder
IPC分类号： C07B61/00 , C07C249/06 , C07C249/08 , C07C251/40 , C07C251/58 , C07C49/12 , C07C251/60
CPC分类号： C07C249/06 , C07C249/08 , C07C251/40
摘要： The present invention relates to a process for preparing trioxime derivatives of the formula I in which the substituents R1 and R2 are identical or different and each is cyano, alkyl, haloalkyl or cycloalkyl, and R3 and R4 are identical or different and each is alkyl, haloalkyl, cycloalkyl, alkylcarbonyl or arylalkyl, by the following reaction steps in water without isolation of the intermediates: A) nitrosation of 1,3-diketones of the formula II to give monooximes of the formula III, B) oximation of III with hydroxylamine derivatives of the formula IV H2N—OR3′ IV in which R3′ is hydrogen or a group R3 to give bisoximes of the formula V, C) alkylation of V with alkylating agents or acylation of V with acylating agents to give compounds of the formula VI and D) subsequent oximation of VI with hydroxylamine to give compounds of the formula I.
摘要翻译：本发明涉及一种制备式I的三肟衍生物的方法，其中取代基R 1和R 2是相同或不同的，并且各自为氰基，烷基，卤代烷基或环烷基，R 3和R 4相同或不同，并且各自为烷基，卤代烷基，环烷基，烷基羰基或芳烷基，通过以下反应步骤在水中不分离中间体：A）式II的1,3-二酮的亚硝化，得到式III的单肟，B）III式与Ⅳ的羟胺衍生物的肟化，其中式Ⅳ的线性公式描述=“在线式 “end =”lead“？> H 2 N-OR 3”在线公式描述=“在线公式”end =“tail” 其中R 3'是氢或基团R 3'，得到式V的双肟，C）用烷基化剂烷基化V或用酰化酰化V 试剂得到式VI化合物和D）随后的肟基 VI与羟胺的离子，得到式I的化合物。

3. 发明授权

US06207864B1 Process for preparing cyclopropylacetylene 失效
标题翻译：环丙基乙炔的制备方法
公开(公告)号：US06207864B1
公开(公告)日：2001-03-27
申请号：US09380382
申请日：1999-09-01
申请人： Michael Henningsen , Armin Stamm , Martin Fischer , Wolfgang Siegel
发明人： Michael Henningsen , Armin Stamm , Martin Fischer , Wolfgang Siegel
IPC分类号： C07C4530
CPC分类号： C07F9/535 , C07C1/30 , C07C17/00 , C07C17/18 , C07C2601/02 , C07C13/04 , C07C22/00
摘要： The invention relates to a process for the halogenation of cyclopropylmethyl ketone with at least one dihalo-triorganophosphorane of the general formula I R3PHal2 (I), in which the radicals R can be the same or different and denote a saturated or unsaturated aliphatic C1-C20 hydrocarbon radical, a phenyl or (C1-C4 alkyl)phenyl radical, which may be optionally substituted by one or two fluorine, chlorine and/or nitro groups, P stands for phosphorus and Hal denotes chlorine, bromine, or iodine, at a temperature of from 800° to 130° C., where the dihalo-triorganophosphane of the general formula (I) is synthesized in situ from triorganophosphane oxide or triorganophosphane sulfide of the general formula II R3PA (II), in which R is as defined above with respect to formula I and A denotes oxygen or sulfur, using a halogenating agent, wherein the triorganophosphane oxide or triorganophosphane sulfide is used in catalytic amounts, to the halogenation product of cyclopropylmethyl ketone obtained in said process, and to a process for the conversion of said halogenation product to cyclopropylacetytene.
摘要翻译：本发明涉及用至少一种通式Iin的二卤代三有机基磷烷卤化环丙基甲基酮的方法，其中基团R可以相同或不同，表示饱和或不饱和的脂族C 1 -C 20烃基，苯基或（C 1 -C 4烷基）苯基，其可任选被一个或两个氟，氯和/或硝基取代，P代表磷，Hal代表氯，溴或碘，温度为800°至130° ℃，其中通式（I）的二卤代三有机膦原位由通式IIin的三有机膦氧化物或三有机磷烷硫化物原位合成，其中R如对于式I所定义，A表示氧或硫，使用一种卤化剂，其中三有机膦氧化物或三有机基硫化物以催化量使用于在所述方法中获得的环丙基甲基酮的卤化产物，t o将所述卤化产物转化为环丙基乙烯基的方法。

4. 发明授权

US06417353B1 Preparing amines 失效
标题翻译：制备胺
公开(公告)号：US06417353B1
公开(公告)日：2002-07-09
申请号：US09520908
申请日：2000-03-07
申请人： Frank Funke , Joachim Wulff-Döring , Gerhard Schulz , Wolfgang Siegel , Andreas Kramer , Johann-Peter Melder , Arthur Höhn , Philipp Buskens , Wolfgang Reif , Jan Nouwen
发明人： Frank Funke , Joachim Wulff-Döring , Gerhard Schulz , Wolfgang Siegel , Andreas Kramer , Johann-Peter Melder , Arthur Höhn , Philipp Buskens , Wolfgang Reif , Jan Nouwen
IPC分类号： C07B4304
CPC分类号： C07C209/26 , B01J23/885 , B01J37/03 , C07C213/02 , C07C2601/08 , C07C2602/10 , C07C211/06 , C07C211/07 , C07C211/17 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/38 , C07C217/58
摘要： Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing copper, wherein the catalytically active mass of the catalyst contains, before the reduction with hydrogen, 20 to 85% by weight of oxygen-containing compounds of zirconium, calculated as ZrO2, 1 to 30% by weight of oxygen-containing compounds of copper, calculated as CuO, 14 to 70% by weight of oxygen-containing compounds of nickel, calculated as NiO, 0 to 5% by weight of oxygen-containing compounds of molybdenum, calculated as MoO3, and 0 to 10% by weight of oxygen-containing compounds of aluminum, calculated as Al2O3.
摘要翻译：胺在升高的温度下在升高的温度下与选自氨，伯胺和仲胺的氮化合物和氢气在含催化剂的聚合物的存在下反应制备，其中催化剂活性物质含有，在用氢还原之前，以ZrO 2计为20〜85重量％的含氧化合物，以30重量％计，氧化铝为14〜70重量％，氧化铝为100重量％以NiO表示的镍化合物，以MoO 3计为0〜5重量％的含氧化合物的钼和0〜10重量％的按Al 2 O 3计算的含氧化合物的铝。

5. 发明授权

US6160178A Racemization of optically active amines 有权
标题翻译：光学活性胺的外消旋化
公开(公告)号：US6160178A
公开(公告)日：2000-12-12
申请号：US303599
申请日：1999-05-03
申请人： Hartmut Riechers , Joachim Simon , Arthur Hohn , Andreas Kramer , Frank Funke , Wolfgang Siegel , Christoph Nubling
发明人： Hartmut Riechers , Joachim Simon , Arthur Hohn , Andreas Kramer , Frank Funke , Wolfgang Siegel , Christoph Nubling
IPC分类号： B01J23/72 , B01J23/755 , B01J37/18 , C07B55/00 , C07B61/00 , C07C209/00 , C07C209/68 , C07C211/07 , C07C213/08 , C07C217/08
CPC分类号： C07C213/08 , C07B2200/07 , C07C209/68 , C07C217/08 , C07C211/07
摘要： Optically active amines are racemized by reaction of the optically active amine in the gas phase at elevated temperature in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst.
摘要翻译：光学活性胺通过在氢气和氢化或脱氢催化剂存在下在高温下在气相中的光学活性胺的反应进行外消旋化。

6. 发明授权

US6153797A Racemizing of optically active amines 有权
标题翻译：光学活性胺的外消旋化
公开(公告)号：US6153797A
公开(公告)日：2000-11-28
申请号：US259043
申请日：1999-03-01
申请人： Hartmut Riechers , Joachim Simon , Arthur Hohn , Andreas Kramer , Frank Funke , Wolfgang Siegel , Christoph Nubling
发明人： Hartmut Riechers , Joachim Simon , Arthur Hohn , Andreas Kramer , Frank Funke , Wolfgang Siegel , Christoph Nubling
IPC分类号： B01J23/755 , C07B55/00 , C07B57/00 , C07B61/00 , C07C209/68 , C07C211/03 , C07C213/02 , C07C213/08 , C07C217/08 , C07C204/00
CPC分类号： C07C213/08 , C07C209/68
摘要： In a process for racemizing optically active amines by reacting the optically active amine in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst at elevated temperature, the reaction is carried out in liquid phase and the catalyst comprises the catalytically active constituents copper, silver, iron, cobalt, nickel, ruthenium, rhodium, palladium, osmium, iridium and/or platinum and a support material selected from the group consisting of aluminum oxide, zirconium dioxide, titanium dioxide, carbon and/or oxygen compounds of silicon.
摘要翻译：在通过使光学活性胺在氢气和氢化或脱氢催化剂的存在下在升高的温度下使光学活性胺反应的方法中，反应在液相中进行，催化剂包含催化活性成分铜，银，铁钴，镍，钌，铑，钯，锇，铱和/或铂，以及选自氧化铝，二氧化锆，二氧化钛，碳和/或氧化合物的硅的载体材料。

7. 发明授权

US6127580A Process for the preparation of substituted anthraquinones 失效
标题翻译：制备取代蒽醌的方法
公开(公告)号：US6127580A
公开(公告)日：2000-10-03
申请号：US200936
申请日：1998-11-30
申请人： Wolfgang Siegel , Andreas Kramer
发明人： Wolfgang Siegel , Andreas Kramer
IPC分类号： C07C46/02 , C07C45/00
CPC分类号： C07C46/02
摘要： Process for the preparation of anthraquinones of the general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which can be identical or different, are hydrogen, a C.sub.1 -C.sub.8 -alkyl or C.sub.2 -C.sub.8 -alkenyl radical, in which 1,4-naphthoquinone is reacted with a 1,3-diene of the general formula II ##STR2## in a cycloaddition step to give the corresponding tetrahydroanthraquinone and the tetrahydroanthraquinone is oxidized with oxygen in the presence of a basic catalyst to give the anthraquinone, in which both the cycloaddition step and the oxidation step are carried out in the presence of an aqueous diluent.Preferably, the cycloaddition step and oxidation step are carried out at a reaction temperature between 90 and 110.degree. C. and at atmospheric pressure.
摘要翻译：用于制备通式I的蒽醌的方法，其中可以相同或不同的R 1，R 2，R 3和R 4是氢，C 1 -C 8 - 烷基或C 2 -C 8 - 烯基，其中1,4 萘醌在环加成步骤中与通式II的1,3-二烯反应，得到相应的四氢蒽醌，四氢蒽醌在碱性催化剂存在下用氧氧化得到蒽醌，其中环加成步骤并且氧化步骤在水性稀释剂的存在下进行。优选环加成步骤和氧化步骤在90-110℃的反应温度和大气压下进行。

8. 发明授权

US6049007A Racemization of optically active amines 有权
标题翻译：光学活性胺的外消旋化
公开(公告)号：US6049007A
公开(公告)日：2000-04-11
申请号：US259042
申请日：1999-03-01
申请人： Hartmut Riechers , Joachim Simon , Arthur Hohn , Andreas Kramer , Frank Funke , Wolfgang Siegel , Christoph Nubling
发明人： Hartmut Riechers , Joachim Simon , Arthur Hohn , Andreas Kramer , Frank Funke , Wolfgang Siegel , Christoph Nubling
IPC分类号： B01J23/755 , C07B55/00 , C07B57/00 , C07B61/00 , C07C209/68 , C07C211/03 , C07C213/02 , C07C213/08 , C07C217/08 , C07C209/00
CPC分类号： C07C213/08 , C07C209/68
摘要： A process for the preparation of racemic amines of the formula I ##STR1## where R.sup.1 and R.sup.2 are different and R.sup.1, R.sup.2, R.sup.3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R.sup.3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III ##STR2## and the amine of the formula R.sup.3 NH.sub.2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.
摘要翻译：制备式I的外消旋胺的方法，其中R 1和R 2不同，R 1，R 2，R 3是烷基，环烷基，芳烷基，芳基，杂芳基和杂环基，R 3也可以是氢，其中基团可以带有取代基选自烷基，环烷基，烷氧基，芳氧基，氨基，烷基氨基和二烷基氨基，其包括同时使相应的光学活性胺I和式II的仲醇和/或式III的不对称酮和式R 3 NH 2的胺在氢气和氢化催化剂或脱氢催化剂的存在下在升高的温度下进行。

9. 发明授权

US06554966B1 Process for preparing essentially formic acid-free N-alkyl-N′-methylalkyleneureas 有权
标题翻译：基本上不含无甲酸的N-烷基-N'-甲基亚烷基脲的方法
公开(公告)号：US06554966B1
公开(公告)日：2003-04-29
申请号：US09603195
申请日：2000-06-26
申请人： Andreas Kramer , Johann-Peter Melder , Heinz Rütter , Günter Riewe , Wolfgang Siegel , Hans-Jürgen Weyer
发明人： Andreas Kramer , Johann-Peter Melder , Heinz Rütter , Günter Riewe , Wolfgang Siegel , Hans-Jürgen Weyer
IPC分类号： B01D300
CPC分类号： C07D239/10
摘要： The invention relates to a process for preparing essentially formic acid-free N-alkyl-N′-methylalkyleneureas of the formula with R1=H or CH3, R2=CnH2n+1 with n=1-4 and x=0 or 1, from the corresponding alkyleneureas by reaction with monomeric or polymerized formaldehyde in the presence of formic acid. This entails feeding the mixture, obtained in the reaction, of N-alkyl-N′-methylalkyleneurea and formic acid to the upper region of a distillation column, distilling without further additions and removing essentially formic acid-free N-alkyl-N′-methylalkyleneurea in the lower region of the column. The process parameters are set so that the pressure in the upper region of the column is at a higher level than in the lower region of the column, and the difference in pressure between the upper and lower regions of the column is from 10 to 100 mbar, and the temperature in the lower region of the column is higher than in the upper region of the column, with the difference in temperature between the upper and lower regions of the column being from 40° C. to 210° C.
摘要翻译：本发明涉及一种制备基本上无甲酸的N-烷基-N'-甲基亚烷基脲的方法，其中R1 = H或CH3，R2 = CnH2n + 1，其中n = 1-4和x = 0或1，通过在甲酸存在下与单体或聚合的甲醛反应来制备相应的亚烷基脲。这需要将N-烷基-N'-甲基亚烷基脲和甲酸的反应混合物加入到蒸馏塔的上部区域，无需进一步添加即可蒸馏除去基本上不含甲酸的N-烷基-N'- 甲基亚烷基脲在柱的下部区域。设定工艺参数使得塔的上部区域中的压力处于比塔的下部区域更高的水平，并且塔的上部和下部区域之间的压力差为10至100mbar ，塔的下部区域的温度高于塔的上部区域，塔的上部和下部区域之间的温度差为40℃〜210℃。

10. 发明授权

US06303823B2 Process for preparing ketones, in particular 6-methylheptan-2-one 失效
标题翻译：制备酮的方法，特别是6-甲基庚-2-酮
公开(公告)号：US06303823B2
公开(公告)日：2001-10-16
申请号：US09729459
申请日：2000-12-05
申请人： Andreas Kramer , Christian Knoll , Johann-Peter Melder , Wolfgang Siegel , Gerd Kaibel
发明人： Andreas Kramer , Christian Knoll , Johann-Peter Melder , Wolfgang Siegel , Gerd Kaibel
IPC分类号： C07C4573
CPC分类号： C07C45/74 , C07C45/62 , C07C45/73 , C07C49/04 , C07C49/203
摘要： A process for preparing ketones by so-called “crossed aldol condensation” of a ketone with an aldehyde in the presence of a catalyst system consisting of approximately equimolar amounts of a secondary amine and of a carboxylic acid containing at least 2 C atoms, to form an &agr;,&bgr;-unsaturated ketone, and, where appropriate, subsequent catalytic hydrogenation. The process is used in particular for preparing 6-methyl-3-hepten-2-one by reacting acetone with isovaleraldehyde, and for preparing its hydrogenation product, 6-methylheptan-2-one, which is an important precursor for numerous active substances, in particular for preparing lipid-soluble vitamins such as vitamin E.
摘要翻译：在由大约等摩尔量的仲胺和含有至少2个C原子的羧酸组成的催化剂体系的存在下，通过所谓的“交叉醛醇缩合”酮与醛制备酮的方法，以形成 α，β-不饱和酮，以及适当的后续催化氢化。该方法特别用于通过丙酮与异戊醛反应制备6-甲基-3-庚烯-2-酮，并用于制备其氢化产物6 - 甲基庚-2-酮，其是许多活性物质的重要前体，特别是用于制备脂溶性维生素如维生素E.

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