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1. 发明授权

US5254563A Beta-carbolines, process for their production and their use in pharmaceutical agents 失效
标题翻译： β-咔啉，其制备方法及其在药剂中的应用
公开(公告)号：US5254563A
公开(公告)日：1993-10-19
申请号：US773659
申请日：1991-10-23
申请人： Andreas Huth , Martin Kruger , Dieter Rahtz , Dieter Seidelmann , Ralph Schmiechen , Lechoslaw Turski , John S. Andrews , Herbert H. Schneider
发明人： Andreas Huth , Martin Kruger , Dieter Rahtz , Dieter Seidelmann , Ralph Schmiechen , Lechoslaw Turski , John S. Andrews , Herbert H. Schneider
IPC分类号： A61K31/435 , A61K31/505 , A61P25/08 , A61P25/20 , A61P25/28 , C07D471/04 , C07D487/04 , C07F7/18
CPC分类号： C07D471/04 , C07D487/04 , C07F7/1856
摘要： Compounds of formula I ##STR1## in which R.sup.A, B (which is CR.sup.4) and R.sup.3 and have the meaning indicated in the application, as well as their production and their use in pharmaceutical agents, are described.
摘要翻译： PCT No.PCT / DE90 / 00982 Sec。 371日期1991年10月23日 102（e）日期1991年10月23日PCT 1990年12月19日PCT PCT。出版物WO91 / 09858 日期：1991年7月11日。描述了其中RA，B（其是CR4）和R3并具有本申请中指出的含义的式I I的化合物及其制备及其在药剂中的用途。

2. 发明授权

US4952698A Imidazole derivatives 失效
标题翻译：咪唑衍生物
公开(公告)号：US4952698A
公开(公告)日：1990-08-28
申请号：US189511
申请日：1988-04-11
申请人： Helmut Biere , Andreas Huth , Dieter Rahtz , Ralph Schmiechen , Dieter Seidelmann , Herbert H. Schneider , David N. Stephens
发明人： Helmut Biere , Andreas Huth , Dieter Rahtz , Ralph Schmiechen , Dieter Seidelmann , Herbert H. Schneider , David N. Stephens
IPC分类号： A61K31/415 , A61P21/02 , A61P25/04 , A61P25/08 , A61P25/20 , C07D233/90 , C07D413/00 , C07D413/04
CPC分类号： C07D413/04 , C07D233/90
摘要： Imidazole derivatives of general formula I ##STR1## wherein R.sup.1 represents hydrogen or halogen in the o-, m- or p-position, and the halogen can occur once or repeatedly in the phenyl radical,R.sup.4 represents ##STR2## with R.sup.6 and R.sup.9 representing hydrogen or a straight or branched alkyl group with 1 to 6 carbon atoms, R.sup.7 and R.sup.8 are the same or different and represent hydrogen or a straight or branched alkyl group with 1 to 6 carbon atoms or R.sup.7 and R.sup.8 together with the nitrogen atom represent a saturated heterocyclic five-membered or six-membered ring optionally containing another heteroatom, andR.sup.5 represents hydrogen, an alkyl group with 1 to 6 carbon atoms or an alkoxyalkyl group with 1 to 6 carbon atoms, which are suitable as psychopharmaceuticals, are described.
摘要翻译： PCT No.PCT / DE87 / 00342 Sec。 371日期：1988年4月11日 102（e）日期1988年4月11日PCT提交1987年7月30日PCT公布。公开号WO88 / 01268 PCT 日期：1988年2月25日。通式I的咪唑衍生物其中R 1表示氢或卤素在邻 - ，间或对 - 位和卤素可以在苯基中一次或重复出现， R 4表示，其中R 6和R 9表示氢或具有1至6个碳原子的直链或支链烷基，R 7和R 8相同或不同，表示氢或具有1至6个碳原子的直链或支链烷基碳原子或R 7和R 8与氮原子一起表示任选含有其它杂原子的饱和杂环五元或六元环，R 5表示氢，具有1至6个碳原子的烷基或具有1至6个碳原子的烷氧基烷基描述了适合作为心理药物的碳原子。

3. 发明授权

US5414002A 5- or 6-substituted .beta.-carboline-3-carboxylic acid esters 失效
标题翻译： 5-或6-取代的β-咔啉-3-羧酸酯
公开(公告)号：US5414002A
公开(公告)日：1995-05-09
申请号：US416629
申请日：1989-10-03
申请人： Helmut Biere , Andreas Huth , Dieter Rahtz , Ralph Schmiechen , Dieter Seidelmann , Wolfgang Kehr , Herbert H. Schneider , Mogens Engelstoft , Bondo J. Hansen , Frank Waetjen , Tage Honore
发明人： Helmut Biere , Andreas Huth , Dieter Rahtz , Ralph Schmiechen , Dieter Seidelmann , Wolfgang Kehr , Herbert H. Schneider , Mogens Engelstoft , Bondo J. Hansen , Frank Waetjen , Tage Honore
IPC分类号： C07D487/04 , A61K31/435 , A61K31/437 , A61P25/18 , C07D471/04
CPC分类号： C07D471/04
摘要： 5- or 6-substituted .beta.-carboline-3-carboxylic acid esters of Formula I ##STR1## wherein R.sup.1 is hydrogen, nitrilo, halogen, lower alkyl or lower alkoxy, andR.sup.3 is a branched C.sub.3-6 alkyl group which is optionally substituted by halogen, or a C.sub.3-6 cycloalkyl group which is optionally methyl-substituted, are valuable pharmaceuticals.
摘要翻译：式I的5-或6-取代的β-咔啉-3-羧酸酯其中R1是氢，次氮基，卤素，低级烷基或低级烷氧基，R3是支链C 3-6烷基，其任选地被卤素或任选被甲基取代的C 3-6环烷基是有价值的药物。

4. 发明授权

US4564610A Substituted 5H-pyrimido[5,4-b]indoles 失效
标题翻译：取代的5H-嘧啶并[5,4-b]吲哚
公开(公告)号：US4564610A
公开(公告)日：1986-01-14
申请号：US562248
申请日：1983-12-16
申请人： Dieter Rahtz , Andreas Huth , Ralph Schmiechen , Dieter Seidelmann , Wolfgang Kehr , Herbert H. Schneider , Claus T. Braestrup
发明人： Dieter Rahtz , Andreas Huth , Ralph Schmiechen , Dieter Seidelmann , Wolfgang Kehr , Herbert H. Schneider , Claus T. Braestrup
IPC分类号： A61K31/505 , A61P25/00 , C07D209/42 , C07D487/04 , C07F9/6561
CPC分类号： C07D487/04 , C07D209/42 , C07F9/6561
摘要： Substituted 5H-pyrimido[5,4-b]indoles of Formula I ##STR1## wherein R.sup.2 is halogen; the oxadiazolyl group ##STR2## wherein R" is lower alkyl with up to 3 carbon atoms; C.sub.1-5 -alkyl, cycloalkyl, aralkyl, or aryl; OR.sup.I, SO.sub.n R.sup.I with n being 0, 1, or 2, or ##STR3## wherein R.sup.I is hydrogen, C.sub.1-5 -alkyl, cycloalkyl, aralkyl, or aryl; ##STR4## wherein R.sup.II and R.sup.III are hydrogen, C.sub.1-5 -alkyl, C.sub.3-5 -alkenyl, cycloalkyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; andR.sup.A is hydrogen; the oxadiazolyl group ##STR5## wherein R" is lower alkyl with up to 3 carbon atoms; halogen, nitro, OR.sup.I, SO.sub.n R.sup.I with n being 0, 1, or 2, ##STR6## wherein R.sup.I is hydrogen, C.sub.1-5 -alkyl, cycloalkyl, aralkyl, or aryl; ##STR7## wherein R.sup.II and R.sup.III are hydrogen, C.sub.1-5 -alkyl, cycloalkyl, C.sub.3-5 -alkenyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; orPO(OR).sub.2 wherein R is C.sub.1-5 -alkyl, exhibit strong affinity for binding to benzodiazepine receptors.The novel compounds are suitable for use in psychopharmaceutical preparations.
摘要翻译：取代的式I的5H-嘧啶并[5,4-b]吲哚其中R 2是卤素; 恶二唑基其中R“是具有至多3个碳原子的低级烷基; C 1-5 - 烷基，环烷基，芳烷基或芳基; ORI，nn为0,1或2，或其中R 1为氢，C 1-5 - 烷基，环烷基，芳烷基或芳基的SO nRI; 其中RII和RIII是氢，C1-5-烷基，C3-5-烯基，环烷基，芳烷基，芳基，或具有连接的N-原子的5-或6-元杂环; RA为氢; 恶二唑基其中R“是具有至多3个碳原子的低级烷基; 卤素，硝基，ORI，nn为0,1或2的SO nRI，其中R 1为氢，C 1-5 - 烷基，环烷基，芳烷基或芳基; 其中RII和RIII是氢，C1-5烷基，环烷基，C3-5-烯基，芳烷基，芳基，或具有连接的N-原子的5或6元杂环; 或其中R为C 1-5 - 烷基的PO（OR）2表现出对苯并二氮杂受体结合的强亲合力。新型化合物适用于精神药物制剂。

5. 发明授权

US4945090A Phenoxy-substituted beta-carboline derivatives, their production and their use as drugs 失效
标题翻译：苯氧基取代的β-咔啉衍生物，其生产和用作药物
公开(公告)号：US4945090A
公开(公告)日：1990-07-31
申请号：US929861
申请日：1986-11-13
申请人： Ralph Schmiechen , Dieter Seidelmann , Andreas Huth , Herbert H. Schneider , David N. Stephens , Mogens Engelstoft , John B. Hansen , Erling Petersen
发明人： Ralph Schmiechen , Dieter Seidelmann , Andreas Huth , Herbert H. Schneider , David N. Stephens , Mogens Engelstoft , John B. Hansen , Erling Petersen
IPC分类号： A61K31/435 , A61P25/08 , A61P25/20 , C07D471/04
CPC分类号： C07D471/04
摘要： Phenoxy-substituted beta-carbolines of the formula I ##STR1## X is COOR.sup.3, CONHC.sub.1-3 -alkyl or oxadiazolyl of the formula ##STR2## R.sup.2 is H, lower alkyl or cycloalkyl, R.sup.3 is lower alkyl,R.sup.4 is hydrogen, lower alkyl or lower alkoxyalkyl,R.sup.1 is hydrogen, halogen, lower alkyl, lower alkoxy, acyl, phenyl, C.sub.2-5 alkylenedioxy, trifluoromethyl, nitrilo, nitro, lower alkoxycarbonyl, azido, SO.sub.2 R.sup.6, SO.sub.2 NR.sup.7 R.sup.8, or NR.sup.9 R.sup.10,R.sup.6 is lower alkyl,R.sup.7 and R.sup.8 independently are lower alkyl or together with the nitrogen atom form a hetero ring,R.sup.9 and R.sup.10 independently are hydrogen, lower alkyl, acyl or together with the nitrogen atom form a hetero ring system,with the proviso that X is not COOEt, if ##STR3## is 5-phenoxy and R.sup.4 is methyl or ##STR4## is 6-(4-methoxyphenoxy) and R.sup.4 is methoxymethyl have valuable pharmacological properties.
摘要翻译：式I的苯氧基取代的β-咔啉（I）X是下式的COOR3，CONHC1-3-烷基或恶二唑基，R 2是H，低级烷基或环烷基，R 3是低级烷基，R 4是氢低级烷基或低级烷氧基烷基，R1为氢，卤素，低级烷基，低级烷氧基，酰基，苯基，C2-5亚烷基二氧基，三氟甲基，次氮基，硝基，低级烷氧基羰基，叠氮基，SO2R6，SO2NR7R8或NR9R10，R6为低级烷基，R7和R8独立地是低级烷基或与氮原子一起形成杂环，R9和R10独立地是氢，低级烷基，酰基或与氮原子一起形成杂环体系，条件是X不是COOEt （a）为5-苯氧基，R4为甲基或（b）为6-（4-甲氧基苯氧基），R4为甲氧基甲基具有有价值的药理学性质。

6. 发明授权

US5064854A 3,4-disubstituted phenyl heterocycles and their use 失效
标题翻译： 3,4-取代苯基杂环化合物及其用途
公开(公告)号：US5064854A
公开(公告)日：1991-11-12
申请号：US376489
申请日：1989-07-07
申请人： Andreas Huth , Ralph Schmiechen , Helmut Wachtel , Herbert H. Schneider
发明人： Andreas Huth , Ralph Schmiechen , Helmut Wachtel , Herbert H. Schneider
IPC分类号： C07D233/34 , A61K31/415 , A61K31/4166 , A61K31/42 , A61K31/421 , A61P25/18 , C07D207/26 , C07D207/27 , C07D233/38 , C07D263/24 , C07D263/26 , C07D277/14 , C07D405/10 , C07D409/10 , C07F7/10
CPC分类号： C07D207/26 , C07D263/24 , C07D277/14 , C07D405/10 , C07D409/10
摘要： Compounds of general Formula I are disclosed ##STR1## wherein R.sup.1 is C.sub.1-4 -alkyl,R.sup.3 is hydrogen, C.sub.1-4 -alkyl, acyl, aryl,R.sup.5 is hydrogen, C.sub.1-4 -alkyl,X is oxygen, CH.sub.2 or NR.sup.4 with R.sup.4 =hydrogen, C.sub.1-4 -alkyl andY is an aromatic or nonaromatic ring system which can optionally contain one to two hetero atoms and can be substituted, and the stereoisomers and their mixtures,as well as their preparation and use as medicinal agents.
摘要翻译：公开了通式I的化合物，其中R 1是C 1-4 - 烷基，R 3是氢，C 1-4 - 烷基，酰基，芳基，R 5是氢，C 1-4 - 烷基，X是氧， CH2或NR4，其中R4 =氢，C1-4 - 烷基，Y是可任选地含有一至两个杂原子并且可以被取代的芳族或非芳族环系，以及其立体异构体及其混合物，以及它们的制备和用途作为药剂。

7. 发明授权

US4186129A 5-(Substituted phenyl)-oxazolidinones and their sulfur analogs 失效
标题翻译： 5-（取代的苯基）恶唑烷酮及其硫类似物
公开(公告)号：US4186129A
公开(公告)日：1980-01-29
申请号：US855867
申请日：1977-11-30
申请人： Andreas Huth , Ralph Schmiechen , Wolfgang Kehr , Gert Paschelke , Helmut Wachtel , Herbert H. Schneider , Dieter Palenschat
发明人： Andreas Huth , Ralph Schmiechen , Wolfgang Kehr , Gert Paschelke , Helmut Wachtel , Herbert H. Schneider , Dieter Palenschat
IPC分类号： C07D263/16 , C07D263/24 , C07D277/14 , C07D277/16 , C07D263/38 , A61K31/42 , C07D263/46 , C07D277/34
CPC分类号： C07D263/16 , C07D263/24 , C07D277/14 , C07D277/16
摘要： Novel 5-(substituted phenyl)-oxazolidinones and their sulfur analogs of Formula I ##STR1## wherein R.sub.1 is optionally substituted lower alkyl, cycloalkyl or cycloalkylalkyl;R.sub.2 is hydrogen, optionally substituted lower alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, alkenyl or a heterocyclic group;R.sub.3 is hydrogen, optionally substituted lower alkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, or optionally substituted acyl;R.sub.4 is hydrogen or optionally substituted lower alkyl;R.sub.5 is hydrogen or optionally substituted lower alkyl or optionally substituted lower alkoxycarbonyl; andX is oxygen or sulfur, have valuable pharmacological effects.
摘要翻译：式（I）的新型5-（取代苯基）恶唑烷酮及其硫类似物，其中R 1为任选取代的低级烷基，环烷基或环烷基烷基; R 2是氢，任选取代的低级烷基，环烷基，环烷基烷基，任选取代的芳基，任选取代的芳烷基，烯基或杂环基; R 3是氢，任选取代的低级烷基，烯基，炔基，任选取代的芳基，任选取代的芳烷基或任选取代的酰基; R4是氢或任选取代的低级烷基; R5是氢或任选取代的低级烷基或任选取代的低级烷氧基羰基; X为氧或硫，具有宝贵的药理作用。

8. 发明授权

US5179111A Imidazole derivatives 失效
标题翻译：咪唑衍生物
公开(公告)号：US5179111A
公开(公告)日：1993-01-12
申请号：US284223
申请日：1988-12-14
申请人： Helmut Biere , Ralph Rohde , Herbert H. Schneider , Lechoslaw Turski
发明人： Helmut Biere , Ralph Rohde , Herbert H. Schneider , Lechoslaw Turski
IPC分类号： A61K31/41 , A61K31/415 , A61P25/18 , C07D233/90 , C07D401/12 , C07D413/00 , C07D413/04 , C07D413/14
CPC分类号： C07D401/12 , C07D233/90 , C07D413/04 , C07D413/14
摘要： Imidazole derivatives of general Formula I ##STR1## wherein R.sup.1 means hydrogen, an optionally substituted C.sub.1-10 hydrocarbon or hetaryl residue, or a cyclic ether residue,R.sup.2 means hydrogen, halogen, an optionally substituted amino, nitro, azide, thiocyanate or cyano group, a linear or branched C.sub.1-10 -alkyl residue optionally substituted with halogen, or -OR.sup.1 wherein R.sup.1 has the above-mentioned meanings, andR.sup.1 and R.sup.2 jointly with the oxygen atom form a saturated or unsaturated 5- to 7-membered ring which can contain still another hetero atom,R.sup.3 means hydrogen, a linear or branched C.sub.1-6 -alkyl group, or a C.sub.1-6 -alkoxyalkyl group,R.sup.4 means -COOR.sup.5, -CONR.sup.6 R.sup.7, -CN, ##STR2## and their use as medicinal agents are disclosed.
摘要翻译：通式I的咪唑衍生物其中R 1表示氢，任选取代的C 1-10烃或杂芳基残基或环醚残基，R 2表示氢，卤素，任选取代的氨基，硝基，叠氮基，硫氰酸酯或氰基，任选被卤素取代的直链或支链C 1-10 - 烷基或-OR 1，其中R 1具有上述含义，并且R 1和R 2与氧原子一起形成饱和或不饱和的5-至7- 可以含有另外的杂原子的三元环，R 3表示氢，直链或支链C 1-6 - 烷基或C 1-6 - 烷氧基烷基，R 4表示-COOR 5，-CONR 6 R 7，-CN，作为药剂使用。

9. 发明授权

US4847262A 2-substituted ergolines having neuroleptic and antidepressant activities 失效
标题翻译：具有抗精神病药和抗抑郁药活性的2-取代麦角肽
公开(公告)号：US4847262A
公开(公告)日：1989-07-11
申请号：US136311
申请日：1987-12-22
申请人： Gerhard Sauer , Andreas Huth , Helmut Wachtel , Herbert H. Schneider
发明人： Gerhard Sauer , Andreas Huth , Helmut Wachtel , Herbert H. Schneider
IPC分类号： A61K31/475 , A61K31/48 , A61P25/18 , A61P25/24 , A61P25/26 , C07D457/02 , C07D457/12 , C07F7/08 , C07F7/10
CPC分类号： C07D457/02 , C07D457/12 , C07F7/0812 , C07F7/0814 , C07F7/10
摘要： Novel ergoline derivatives, substituted in the 2-position, of the formula ##STR1## wherein C.sub.8 ---C.sub.9 and C.sub.9 ---C.sub.10 each independently is a CC-single or a C.dbd.C-double bond, but not together a cumulated double bond, and the substituent in the 8-position is in the .alpha.- or .beta.-configuration where C.sub.8 ---C.sub.9 is a CC-single bond,R.sup.2 is a CN, SR, SOR, ##STR2## wherein n is 2 or 3, ##STR3## and --CH(OR)R whereinR has the meaning of H or C.sub.1-4 -alkyl,the grouping COR' and CSR'wherein R'=OH, OC.sub.1-4 -alkyl, benzyl, NH.sub.2 or NHR",the grouping CH.dbd.CH--CO.sub.2 R" and CH.sub.2 --CH.sub.2 --CO.sub.2 R'wherein R"=C.sub.1-4 -alkyl,the grouping C.tbd.C--R'" and HC.dbd.CH--R'"wherein R'"=hydrogen, C.sub.1-4 -alkyl, phenyl, CH.sub.2 OH, CR".sub.2 OH, ##STR4## CO.sub.2 R", CH.sub.2 NR".sub.2 or SiMe.sub.2 R"; C.sub.1-3 -alkyl, or C.sub.1-3 -alkyl substituted by OH or phenyl; or ##STR5## wherein R" is C.sub.1-4 alkyl, R.sup.6 is C.sub.1-4 -alkyl andR.sup.8 is methyl, NH--CO--NEt.sub.2 or NH--CS--NEt.sub.2, and the physiologically acceptable acid addition salt thereof, possess biological efficacy in the region of the central nervous system,, e.g., as neuroleptics and antidepressants.
摘要翻译：式中，C 8 -C 9和C 9 -C 10各自独立地为C 1 -C 6双键，但未被取代的式（Ⅰ）的2-位麦角灵衍生物，一起是累积的双键，并且8位的取代基是α-或β-构型，其中C 8 -C 9是CC-单键，R 2是CN，SR，SOR，其中n 是2或3，和-CH（OR）R，其中R具有H或C 1-4 - 烷基的意义，分组COR'和CSR'，其中R'= OH，OC1-4-烷基，苄基， NH 2或NHR“，分组CH = CH-CO 2 R”和CH 2 -CH 2 -CO 2 R'，其中R“= C 1-4 - 烷基，C 3 B C-R”'和HC = CH-R' “其中R”“=氢，C 1-4 - 烷基，苯基，CH 2 OH，CR''OH，CO 2 R”，CH 2 NR“2或SiMe 2 R” C 3-烷基或被OH或苯基取代的C 1-3 - 烷基; 或其中R“为C 1-4烷基，R 6为C 1-4 - 烷基且R 8为甲基，NH-CO-NEt 2或NH-CS-NEt 2及其生理学上可接受的酸加成盐具有生物功效在中枢神经系统的区域，例如，作为神经安定药和抗抑郁药。

10. 发明授权

US4731367A 2-substituted ergolines useful as neuroleptics and antidepressants 失效
标题翻译：用作精神安定药和抗抑郁药的2-取代麦角蛋白
公开(公告)号：US4731367A
公开(公告)日：1988-03-15
申请号：US721522
申请日：1985-04-09
申请人： Gerhard Sauer , Andreas Huth , Helmut Wachtel , Herbert H. Schneider
发明人： Gerhard Sauer , Andreas Huth , Helmut Wachtel , Herbert H. Schneider
IPC分类号： A61K31/475 , A61K31/48 , A61P25/18 , A61P25/24 , A61P25/26 , C07D457/02 , C07D457/12 , C07F7/08 , C07F7/10 , C07D457/04 , C07F7/02
CPC分类号： C07D457/02 , C07D457/12 , C07F7/0812 , C07F7/0814 , C07F7/10
摘要： Novel ergoline derivatives, substituted in the 2-position, of the formula ##STR1## wherein C.sub.8 -C.sub.9 and C.sub.9 -C.sub.10 each independently is a CC-single or a C.dbd.C-double bond, but not together a cumulated double bond, and the substituent in the 8-position is in the .alpha.- or .beta.-configuration where C.sub.8 -C.sub.9 is a CC-single bond,R.sup.2 isCN, SR, SOR, ##STR2## wherein n is 2 or 3, ##STR3## and --CH(OH)R, wherein R has the meaning of H or C.sub.1-4 -alkyl, the grouping COR' and CSR' wherein R'.dbd.OH, OC.sub.1-4 -alkyl, benzyl, NH.sub.2 or NHR",the grouping CH.dbd.CH--CO.sub.2 R" and CH.sub.2 --CH.sub.2 --CO.sub.2 R" wherein R".dbd.C.sub.1-4 -alkyl,the grouping C.vertline.C-R'" and HC.dbd.CH--R'" wherein R'".dbd. hydrogen, C.sub.1-4 -alkyl, phenyl, CH.sub.2 OH, CR".sub.2 OH, ##STR4## CO.sub.2 R", CH.sub.2 NR".sub.2 or SiMe.sub.2 R"; C.sub.1-3 -alkyl, or C.sub.1-3 -alkyl substituted by OH or phenyl; or ##STR5## wherein R" is C.sub.1-4 alkyl, R.sup.6 is C.sub.1-4 -alkyl andR.sup.8 is methyl, NH--CO--NEt.sub.2 or NH--CS--NEt.sub.2,and the physiologically acceptable acid addition salt thereof, possess biological efficacy in the region of the central nervous system, e.g., as neuroleptics and anti-depressants.
摘要翻译：在2-位上取代的式（I）的新的麦角灵衍生物，其中C8-C9和C9-C10各自独立地是CC-单或C = C-双键，但不是一起是累积的双并且8-位中的取代基是α-或β-构型，其中C 8 -C 9是CC-单键，R 2是CN，SR，SOR，其中n是2或3，和-CH（OH）R，其中R具有H或C 1-4 - 烷基的意义，分组COR'和CSR'，其中R'= OH，OC1-4-烷基，苄基，NH2或NHR“ 分组CH = CH-CO 2 R“和CH 2 -CH 2 -CO 2 R”其中R“= C 1-4 - 烷基，分组C≡C-R”'和HC = CH-R“'，其中R' “=氢，C 1-4 - 烷基，苯基，CH 2 OH，CR''OH，CO 2 R”，CH 2 NR“2或SiMe 2 R” C 3-烷基或被OH或苯基取代的C 1-3 - 烷基; 或其中R“为C 1-4烷基，R 6为C 1-4 - 烷基且R 8为甲基，NH-CO-NEt 2或NH-CS-NEt 2及其生理学上可接受的酸加成盐具有生物功效在中枢神经系统的区域，例如，作为精神安定药和抗抑郁药。

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