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1. 发明授权

US5254563A Beta-carbolines, process for their production and their use in pharmaceutical agents 失效
标题翻译： β-咔啉，其制备方法及其在药剂中的应用
公开(公告)号：US5254563A
公开(公告)日：1993-10-19
申请号：US773659
申请日：1991-10-23
申请人： Andreas Huth , Martin Kruger , Dieter Rahtz , Dieter Seidelmann , Ralph Schmiechen , Lechoslaw Turski , John S. Andrews , Herbert H. Schneider
发明人： Andreas Huth , Martin Kruger , Dieter Rahtz , Dieter Seidelmann , Ralph Schmiechen , Lechoslaw Turski , John S. Andrews , Herbert H. Schneider
IPC分类号： A61K31/435 , A61K31/505 , A61P25/08 , A61P25/20 , A61P25/28 , C07D471/04 , C07D487/04 , C07F7/18
CPC分类号： C07D471/04 , C07D487/04 , C07F7/1856
摘要： Compounds of formula I ##STR1## in which R.sup.A, B (which is CR.sup.4) and R.sup.3 and have the meaning indicated in the application, as well as their production and their use in pharmaceutical agents, are described.
摘要翻译： PCT No.PCT / DE90 / 00982 Sec。 371日期1991年10月23日 102（e）日期1991年10月23日PCT 1990年12月19日PCT PCT。出版物WO91 / 09858 日期：1991年7月11日。描述了其中RA，B（其是CR4）和R3并具有本申请中指出的含义的式I I的化合物及其制备及其在药剂中的用途。

2. 发明授权

US4987146A N-hetaryl imidazole derivatives 失效
标题翻译： N-芳基咪唑衍生物
公开(公告)号：US4987146A
公开(公告)日：1991-01-22
申请号：US379844
申请日：1989-07-14
申请人： Ralph Rohde , Helmut Biere , Ralph Schmiechen , John S. Andrews , David N. Stephens
发明人： Ralph Rohde , Helmut Biere , Ralph Schmiechen , John S. Andrews , David N. Stephens
IPC分类号： A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/495 , A61K31/53 , A61P25/00 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： N-hetaryl imidazole derivatives of general Formula I ##STR1##are disclosed in whichHet represents an optionally substituted monocyclic or bicyclic heteroaromate,R.sup.3 represents hydrogen, a straight or branched C.sub.1-6 -alkyl group, or a C.sub.1-6 -alkoxy-alkyl group, andR.sup.4 represents --COOR.sup.5 --CONR.sup.6 R.sup.7 --CN, ##STR2##with R.sup.5 meaning hydrogen, a straight or branched C.sub.1-6 -alkyl group, R.sup.6 and R.sup.7 are the same of different and represent hydrogen or a straight, branched, or cyclic alkyl group with up to 7 carbon atoms or, together with the nitrogen atom, form a saturated five or six ring optionally containing another heteroatom and R.sup.8 means hydrogen or a straight, branched or cyclic alkyl group with up to 7 carbon atoms.
摘要翻译：公开了通式I的N-芳基咪唑衍生物（I），其中Het表示任选取代的单环或双环杂芳族化合物，R 3表示氢，直链或支链C 1-6 - 烷基或C 1-6 - 烷氧基 - 烷基，R 4表示-COOR 5 + L，-CONR 6 R 7 + L，-CN，R 5表示氢，直链或支链C 1-6 - 烷基，R 6和R 7相同，表示氢或具有至多7个碳原子的直链，支链或环状烷基，或者与氮原子一起形成任选地含有另外的杂原子的饱和五或六个环，并且R 8表示氢或直链，支链或环状烷基，最多7个碳原子。

3. 发明授权

US4806076A Radial upblast exhaust fan apparatus 失效
标题翻译：径向升华排风机
公开(公告)号：US4806076A
公开(公告)日：1989-02-21
申请号：US158552
申请日：1988-02-22
申请人： John S. Andrews
发明人： John S. Andrews
IPC分类号： F04D29/42 , F23L17/00 , F04D29/44
CPC分类号： F23L17/005 , F04D29/4253
摘要： A radial upblast exhaust fan apparatus including a main housing having a fan housing in the lower portion thereof and an upper housing thereabove. A passive zone is defined between two lateral sections of the upper housing such as to divide the air flow path into two sections. The passive zone section defines a first inner wall and a second inner wall which cooperate with a first outer wall and a second outer wall defined by the upper housing to provide a first exhaust flow path and a second exhaust flow path. These walls are shaped as sectors of conical sections preferably and include end walls to isolate the first exhaust flow path from fluid flow communication with respect to the second exhaust flow path. A fan means is positionable within the fan housing to urge exhaust gases to flow upwardly through the exhaust paths. The walls of the exhaust flow paths are generally arcuate to facilitate exhaust flow. A wind band may be secured to the upper end of the exhaust housing adjacent the exhaust openings therein in spaced relation to the outer wall of the upper housing by usage of a wind band bracket. In this manner mixing of exhaust gases with ambient air is greatly facilitated. The drive for the fan may be positioned pg,2 within the passive zone or externally with a belt drive device positioned within the band zone and connected operationally to the dirve being externally located.
摘要翻译：一种径向上升排气风扇装置，包括主壳体，该主壳体的下部具有风扇壳体和在其上方的上壳体。被动区被限定在上壳体的两个横向部分之间，以将空气流动路径分成两部分。被动区段限定第一内壁和第二内壁，其与由上壳体限定的第一外壁和第二外壁配合，以提供第一排气流路和第二排气流路。这些壁优选成形为圆锥形部分，并且包括端壁，以将第一排气流路与相对于第二排气流动路径的流体流动连通隔离。风扇装置可定位在风扇壳体内以促使废气向上流过排气路径。废气流路的壁通常是弧形的，以便于排气流动。通过使用风带支架，风带可以通过与上壳体的外壁隔开的关系固定到排气口的靠近排气开口的上端。以这种方式，排气与环境空气的混合极大地促进了。风扇的驱动器可以位于被动区域内，或者外部具有位于带区内的皮带驱动装置，并且可操作地连接到位于外部的前端。

4. 发明授权

US4034826A Silencer for ventilation ducts 失效
标题翻译：消音器用于通风管道
公开(公告)号：US4034826A
公开(公告)日：1977-07-12
申请号：US597259
申请日：1975-07-18
申请人： John S. Andrews
发明人： John S. Andrews
IPC分类号： F01N1/24 , F24F13/24 , G10K11/16
CPC分类号： F24F13/24 , F01N1/24 , G10K11/16 , Y10S454/906 , Y10T24/1418
摘要： A silencer having a tubular configuration which can be interposed in a duct and form a part of the duct walls. The silencer has an inner perforate wall and an outer imperforate wall. The annular space between the two walls is filled with acoustical sound absorbing materials. The outer imperforate wall is adapted for quick opening to permit easy replacement of the sound absorbing materials.
摘要翻译：一种具有管状构造的消音器，其可插入管道中并形成管道壁的一部分。消声器有一个内孔和一个外无孔壁。两个墙壁之间的环形空间充满了声学吸声材料。外无孔壁适于快速打开，以便于更容易地更换吸音材料。

5. 发明申请

US20090131503A1 3,5 - SUBSTITUTED INDOLE COMPOUNDS HAVING NOS AND NOREPINEPHRINE REUPTAKE INHIBITORY ACTIVITY 审中-公开
标题翻译： 3,5 - 具有NOS和NOREPINEPHRINE REUPTAKE抑制活性的取代的吲哚化合物
公开(公告)号：US20090131503A1
公开(公告)日：2009-05-21
申请号：US12272656
申请日：2008-11-17
申请人： Subhash C. Annedi , Shawn Maddaford , Jailall Ramnauth , Paul Renton , Suman Rakhit , John S. Andrews , Gabriela Mladenova
发明人： Subhash C. Annedi , Shawn Maddaford , Jailall Ramnauth , Paul Renton , Suman Rakhit , John S. Andrews , Gabriela Mladenova
IPC分类号： A61K31/403 , C07D409/12
CPC分类号： C07D409/12
摘要： The present invention relates to novel 3,5-substituted indole compounds of Formula (I) having nitric oxide synthase (NOS) inhibitory activity together with inhibitory activity at the norepinephrine transporter (NET), to pharmaceutical and diagnostic compositions containing them, and to their medical use.
摘要翻译：本发明涉及具有一氧化氮合酶（NOS）抑制活性和去甲肾上腺素转运蛋白（NET）的抑制活性）的新型3,5-取代吲哚化合物，含有它们的药物和诊断组合物，以及它们医疗用途

6. 发明授权

US4747857A U-loop air handling apparatus 失效
标题翻译： U型空气处理设备
公开(公告)号：US4747857A
公开(公告)日：1988-05-31
申请号：US079077
申请日：1987-07-29
申请人： John S. Andrews
发明人： John S. Andrews
IPC分类号： F24F3/16 , F24F13/24 , B01D53/00
CPC分类号： F24F13/24 , F24F3/1603
摘要： A U-loop air handling apparatus adapted to receive air from a surrounding environment for conditioning and channeling thereof to return ducts. The conditioning includes cooling and filtration thereof such as to be specifically usable in high technology areas requiring extremely clean working conditions. The apparatus includes a fan operatively positioned between an intake section and an output section. The intake section includes a reducing section for receiving air and passing this air through a pre-filter and a cooling coil. Condensation is removed at the cooling coil and a cross sectional area of the channel of air travel is narrowed to a smaller diameter by the reducing section. A fan box receives the conditioned air from the reducing section where it is carried through an inlet box and bell member into the fan. The fan powers the air outwardly into an acoustical box which channels the air parallel and in an opposite direction with respect to the direction of movement of the air within the intake section. The acoustical box carries the air through a damper box to prevent back flow and outwardly through a transition box to return to the environment. The various air carrying members are internally lined with acoustical insulation to minimize transmission of sound and vibration outwardly into the environment resulting from air movement or from the operation of the fan. Also the fan itself is separated vibrationally and acoustically from a portion of the intake section and a portion of the output section by flexible connecting means of rubber-like material, preferably neoprene. Further isolation is provided by independent support means being provided for the fan box and for the reducing section and for the acoustical box.
摘要翻译： U形环空气处理装置，适于从周围环境接收空气，用于调节并将其引导至返回管道。调理装置包括冷却和过滤，以便特别可用于需要极其清洁的工作条件的高技术领域。该装置包括可操作地定位在进气部分和输出部分之间的风扇。进气部分包括用于接收空气并使空气通过预过滤器和冷却盘管的还原部分。在冷却盘管处除去冷凝物，通过还原段将空气行进通道的横截面积缩小至较小的直径。风扇箱从减压部接收调节后的空气，通过入口箱和钟形部件将其送入风扇。风扇将空气向外驱动到声箱中，该声箱相对于进气部分内的空气的运动方向平行地并且沿相反方向引导空气。声箱通过阻尼箱运送空气，以防止回流，并通过过渡箱向外流回环境。各种空气承载构件内部衬有隔音材料，以最小化由空气流动或风扇的操作引起的声音和振动向外进入环境的传播。此外，风扇本身通过橡胶状材料（优选氯丁橡胶）的柔性连接装置从入口部分的一部分和输出部分的一部分振动和声学地分离。另外通过独立的支撑装置提供进一步的隔离，该支撑装置被设置用于风扇箱和减小部分以及声箱。

7. 发明授权

US08673909B2 Indole compounds and methods for treating visceral pain 有权
标题翻译：吲哚化合物和治疗内脏痛的方法
公开(公告)号：US08673909B2
公开(公告)日：2014-03-18
申请号：US12272775
申请日：2008-11-17
申请人： Shawn Maddaford , Jailall Ramnauth , Suman Rakhit , Joanne Patman , Paul Renton , Subhash C. Annedi , John S. Andrews , Gabriela Mladenova
发明人： Shawn Maddaford , Jailall Ramnauth , Suman Rakhit , Joanne Patman , Paul Renton , Subhash C. Annedi , John S. Andrews , Gabriela Mladenova
IPC分类号： A61K31/535 , A61K31/44 , A61K31/445 , A61K31/40 , C07D401/00 , C07D411/00 , C07D209/04
CPC分类号： A61K31/404 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/5377 , C07D403/04 , C07D409/14
摘要： The invention features methods of treating visceral pain or a condition in a mammal caused by the action of nitric oxide synthase (NOS) or by the action of serotonin 5HT1D/1B receptors, by administering to a patient in need thereof a therapeutically effective amount of an indole compound of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof. The methods of the invention may further comprise the administration of additional therapeutic agent. The invention also features new compounds of Formula (I), pharmaceutical compositions thereof, and methods of resolving enantiomeric mixtures.
摘要翻译：本发明的特征在于，通过向有需要的患者施用治疗有效量的治疗有效量的治疗由一氧化氮合酶（NOS）的作用或通过5-羟色胺5HT1D / 1B受体的作用而引起的内脏疼痛或哺乳动物状况的方法式（I）的吲哚化合物或其药学上可接受的盐或前药。本发明的方法还可以包括施用另外的治疗剂。本发明还具有式（I）的新化合物，其药物组合物和拆分对映体混合物的方法。

8. 发明申请

US20090192157A1 INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN 有权
标题翻译：吲哚化合物和治疗粘膜疼痛的方法
公开(公告)号：US20090192157A1
公开(公告)日：2009-07-30
申请号：US12272775
申请日：2008-11-17
申请人： Shawn Maddaford , Jailall Ramnauth , Suman Rakhit , Joanne Patman , Paul Renton , Subhash C. Annedi , John S. Andrews , Gabriela Mladenova
发明人： Shawn Maddaford , Jailall Ramnauth , Suman Rakhit , Joanne Patman , Paul Renton , Subhash C. Annedi , John S. Andrews , Gabriela Mladenova
IPC分类号： A61K31/404 , C07D409/14 , C07D403/04 , C07D409/12 , A61K31/454 , A61K31/4439 , A61K31/5377 , A61K31/439 , A61P25/00
CPC分类号： A61K31/404 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/5377 , C07D403/04 , C07D409/14
摘要： The invention features methods of treating visceral pain or a condition in a mammal caused by the action of nitric oxide synthase (NOS) or by the action of serotonin 5HT1D/1B receptors, by administering to a patient in need thereof a therapeutically effective amount of an indole compound of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof. The methods of the invention may further comprise the administration of additional therapeutic agent. The invention also features new compounds of Formula (I), pharmaceutical compositions thereof, and methods of resolving enantiomeric mixtures.
摘要翻译：本发明的特征在于，通过向有需要的患者施用治疗有效量的治疗有效量的治疗由一氧化氮合酶（NOS）的作用或通过5-羟色胺5HT1D / 1B受体的作用而引起的内脏疼痛或哺乳动物状况的方法式（I）的吲哚化合物或其药学上可接受的盐或前药。本发明的方法还可以包括施用另外的治疗剂。本发明还具有式（I）的新化合物，其药物组合物和拆分对映体混合物的方法。

9. 发明授权

US3960526A Particle separating apparatus 失效
标题翻译：颗粒分离装置
公开(公告)号：US3960526A
公开(公告)日：1976-06-01
申请号：US534821
申请日：1974-12-20
申请人： John S. Andrews
发明人： John S. Andrews
IPC分类号： B01D50/00
CPC分类号： B01D50/00
摘要： A gaseous stream is freed of its particulate material in apparatus which includes a casing having an inlet opening, an outlet opening, and an impingement screen disposed across the inlet opening and comprising single or multiple, preferably staggered rows of impingement elements of V-shaped transverse profile positioned with the apex thereof facing the inlet opening. As the gaseous stream flows through the impingement screen, vortices are formed at the trailing edge of each element whereby droplets in the gaseous stream are entrained into the vortices, spin into a low pressure region which exists inside the open rear of the impingement element, and drain by gravity to collecting means. A series of radially extending vanes positioned downstream of the impingement screen impart swirl to the gaseous stream. A series of coaxial frustoconical rings are provided downstream of the vanes. Support means maintain the coaxial frustoconical rings in overlapping arrangement. The action of the vanes, of the coaxial rings and of the support means on the gaseous stream enhances particle removal.
摘要翻译：一种气体流在设备中不含其颗粒物质，其中包括具有入口开口，出口开口和穿过入口开口设置的冲击筛的壳体，其包括V形横向的单个或多个优选交错的冲击元件排其顶点位于入口开口处。当气流流过冲击筛时，涡流形成在每个元件的后缘，由此气流中的液滴被夹带到涡流中，旋转到存在于冲击元件开口后部的低压区域，以及通过重力排放到收集装置。位于冲击屏幕下游的一系列径向延伸的叶片对气流产生漩涡。在叶片的下游提供一系列同轴的截头圆锥形环。支撑装置维持重叠布置的同轴截头圆锥环。叶片，同轴环和支撑装置在气流上的作用增强了颗粒的去除。

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