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1. 发明申请

US20070010846A1 Method of manufacturing an expandable member with substantially uniform profile 审中-公开
标题翻译：制造具有基本均匀轮廓的可扩张部件的方法
公开(公告)号：US20070010846A1
公开(公告)日：2007-01-11
申请号：US11250618
申请日：2005-10-17
申请人： Andrea Leung , Hugues Malandain , Erika Palmer , Paul Sand
发明人： Andrea Leung , Hugues Malandain , Erika Palmer , Paul Sand
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61B17/3421 , A61B17/3478 , A61B90/02 , A61B2017/00261 , A61B2017/00526 , A61B2017/320048 , A61M25/1029 , A61M29/00
摘要： A method includes heating a first portion of a tubular member to a first temperature greater than a temperature of a second portion of the tubular member. The first portion of the tubular member is different from the second portion of the tubular member. The tubular member is stretched after the heating such that a length of the first portion of the tubular member is associated with a width of an anulus of an intervertebral disc. After the heating and the stretching, the tubular member is disposed within a mold cavity at least until the first portion of the tubular member has a second temperature less than the first temperature and such that an outer diameter of the tubular member in a collapsed configuration is substantially constant along a longitudinal length of the tubular member.
摘要翻译：一种方法包括将管状构件的第一部分加热到大于管状构件的第二部分的温度的第一温度。管状构件的第一部分不同于管状构件的第二部分。管状构件在加热之后被拉伸，使得管状构件的第一部分的长度与椎间盘的环的宽度相关联。在加热和拉伸之后，管状构件至少直到管状构件的第一部分具有小于第一温度的第二温度并且使得处于折叠构型的管状构件的外径为沿管状构件的纵向长度基本上恒定。

2. 发明申请

US20070078436A1 Balloon assisted apparatus and method for accessing an intervertebral disc 审中-公开
标题翻译：用于进入椎间盘的气囊辅助装置和方法
公开(公告)号：US20070078436A1
公开(公告)日：2007-04-05
申请号：US11250617
申请日：2005-10-17
申请人： Andrea Leung , Hugues Malandain , Erika Palmer , Paul Sand
发明人： Andrea Leung , Hugues Malandain , Erika Palmer , Paul Sand
IPC分类号： A61M31/00
CPC分类号： A61M29/02 , A61B17/3421 , A61B17/3478 , A61B90/02 , A61B2017/00261 , A61B2017/00526 , A61B2017/320048 , A61M25/1029 , A61M29/00
摘要： An apparatus includes a projection having a sharpened end portion configured to be inserted through an annulus of an intervertebral disc to define a distracted volume in the annulus. An expandable member is coupled to the projection and defines a longitudinal axis. The expandable member is configured to be expanded from a collapsed configuration to an expanded configuration in a direction substantially perpendicular to the longitudinal axis when at least a portion of the expandable member is disposed within the distracted volume of the annulus of the intervertebral disc. When the expandable member expands, it defines an expanded volume and defines a cross-sectional perimeter while in the expanded configuration. A cannula is configured to be at least partially inserted into the expanded volume. The cannula defines a cross-sectional outer perimeter having no portion extending outside of the cross-sectional perimeter of the expandable member while in its expanded configuration.
摘要翻译：一种装置包括具有尖锐端部的突起，其被构造成插入通过椎间盘的环状物以限定在环空中的分散的体积。可膨胀构件联接到突起并且限定纵向轴线。可膨胀构件被构造成当至少一部分可扩张构件设置在椎间盘的环的分散体积内时，在基本上垂直于纵向轴线的方向上从折叠构型扩张到扩张构型。当可膨胀构件膨胀时，其限定膨胀的体积并且在膨胀构型中限定横截面周长。套管被构造成至少部分地插入到膨胀的容积中。插管限定了横截面的外周边，在其扩展构型中没有部分延伸到可扩张构件的横截面周边的外侧。

3. 发明申请

US20220143082A1 CELL TREATMENTS AND THERAPEUTIC REINFUSION METHODS 有权
公开(公告)号：US20220143082A1
公开(公告)日：2022-05-12
申请号：US17580419
申请日：2022-01-20
申请人： Todd Alamin , Avram Allan Edidin , Hugues Malandain , Healey Montague-Alamin
发明人： Todd Alamin , Avram Allan Edidin , Hugues Malandain , Healey Montague-Alamin
IPC分类号： A61K35/13 , C12M1/00 , C12N5/09
摘要： Tumor tissue, including soft and/or bony tissue, are harvested from a subject and morcellated. The morcellated tissue is placed in a cartridge which is placed in a containment chamber of a tumor tissue processing device. Cancer cells in the morcellated tumor tissue are destroyed without destroying tumor antigens therein. These cells are destroyed cryogenically by exposing the cartridge to a cooling fluid such as liquid nitrogen, optionally with a warming cycle, and optionally with more than one freezing/thawing cycle. The treated tissue and/or cells are then extracted from the cartridge and reintroduced to the subject after they have reached a threshold condition. The treated tissue and/or cells can be reintroduced via a containment sleeve or a reimplantation bag.

4. 发明授权

US08641769B2 Plastically deformable inter-osseous device 有权
标题翻译：塑性变形骨间装置
公开(公告)号：US08641769B2
公开(公告)日：2014-02-04
申请号：US13809329
申请日：2011-06-27
申请人： Hugues Malandain
发明人： Hugues Malandain
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61B17/8852 , A61F2/442 , A61F2/4611 , A61F2002/30014 , A61F2002/30016 , A61F2002/30018 , A61F2002/30377 , A61F2002/30579 , A61F2002/4475 , A61F2002/4627 , A61F2002/4631 , A61F2220/0016 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00137 , A61F2310/00161 , A61F2310/00167 , A61F2310/00203
摘要： Described here are deformable, monolithic, stabilization devices, or implants, suitable for use within bone and between bones, for instance, to fuse vertebral bodies, to repair herniated discs, or to repair spinal compression fractures. The implants are introduced into a chosen site at a first, smaller height and then plastically deformed to achieve a second, but unique, pre-selected, larger height. Variations of the device provide one or more specific larger heights. The devices are particularly suitable as intervertebral spinal fusion implants for the immobilization of adjacent vertebral bodies. Methods of deploying the implants are also described as are instruments for such deployment.Also described are variations of the device particularly suitable as sizing instruments. These versions are elastic, i.e., not plastically deformable, and may be restored to their original size. Many of the described variations include deformable regions serving as hinges. Other variations are non-monolithic or may have one or more classical hinges substituted for the deformable regions.
摘要翻译：这里描述的是可变形的，整体的，稳定的装置或植入物，适用于骨骼内和骨骼之间，例如使椎体融合，修复突出的椎间盘或修复脊柱压迫性骨折。将植入物以第一较小的高度引入选定的位置，然后塑性变形以实现第二但唯一的预先选择的较大的高度。设备的变化提供一个或多个特定的更大的高度。该装置特别适用于固定相邻椎体的椎间融合植入物。植入物的部署方法也被描述为这种部署的工具。还描述了特别适合作为尺寸调节装置的装置的变型。这些版本是弹性的，即不是塑性变形的，并且可以恢复到它们的原始尺寸。许多描述的变型包括用作铰链的可变形区域。其它变化是非整体的或者可以具有代替可变形区域的一个或多个经典铰链。

5. 发明申请

US20080177327A1 Central rod connector and T-rod 审中-公开
标题翻译：中央杆连接器和T型杆
公开(公告)号：US20080177327A1
公开(公告)日：2008-07-24
申请号：US11581831
申请日：2006-10-17
申请人： Hugues Malandain , David L. Brumfield
发明人： Hugues Malandain , David L. Brumfield
IPC分类号： A61B17/56
CPC分类号： A61B17/7043 , A61B17/701 , A61B17/7011 , A61B17/7035 , A61B2017/7073
摘要： Connecting devices and elongated members for orthopedic medical use are disclosed. In certain embodiments, a connecting device may include a central portion that can accommodate part of an elongated member and wings for connecting to anchor members. Such central portions can be open or closed, and such wings can be solid, e.g. rod-type structures, or can be slotted. A T-shaped elongated member is also disclosed.
摘要翻译：公开了用于矫形医疗用途的连接装置和细长构件。在某些实施例中，连接装置可以包括中心部分，该中心部分可以容纳细长构件的一部分和用于连接到锚定构件的翼。这样的中心部分可以是敞开的或闭合的，并且这样的翼可以是固体的，例如。杆型结构，或可以开槽。还公开了一种T形细长构件。

6. 发明申请

US20080051892A1 PERCUTANEOUS SPINAL IMPLANTS AND METHODS 有权
公开(公告)号：US20080051892A1
公开(公告)日：2008-02-28
申请号：US11927831
申请日：2007-10-30
申请人： Hugues Malandain , Avram Edidin , Robert Vandervelde
发明人： Hugues Malandain , Avram Edidin , Robert Vandervelde
IPC分类号： A61F2/44 , A61B17/58
CPC分类号： A61B17/7065 , A61B2017/00557 , A61F2/44
摘要： A method includes positioning a medical device within a body between adjacent spinous processes, moving the medical device from a collapsed configuration to an expanded configuration within the body using an actuator removably coupled to the medical device, and removing the actuator from the body while the medical device remains between the adjacent spinous processes.

7. 发明申请

US20070276372A1 Percutaneous Spinal Implants and Methods 审中-公开
标题翻译：经皮脊髓植入物及方法
公开(公告)号：US20070276372A1
公开(公告)日：2007-11-29
申请号：US11625624
申请日：2007-01-22
申请人： Hugues Malandain , Avram Edidin , Robert Vandervelde
发明人： Hugues Malandain , Avram Edidin , Robert Vandervelde
IPC分类号： A61B17/58
CPC分类号： A61B17/7065 , A61B2017/00557
摘要： A method includes inserting percutaneously an implant in a first configuration between adjacent spinous processes, the implant having a first end and a second end opposite the first end, moving the first end of the implant in a first axial direction, and moving the second end of the implant in a second axial direction, opposite from the first axial direction, such that the implant is in a second configuration.
摘要翻译：一种方法包括经皮插入植入物在相邻棘突之间的第一构型中，所述植入物具有第一端和与第一端相对的第二端，沿着第一轴向方向移动植入物的第一端，并移动植入物的第二端所述植入物在与所述第一轴向方向相反的第二轴向方向上，使得所述植入物处于第二构型。

8. 发明申请

US20070123889A1 Mechanical cavity-creation surgical device and methods and kits for using such devices 审中-公开
标题翻译：机械腔创建手术装置以及使用这种装置的方法和套件
公开(公告)号：US20070123889A1
公开(公告)日：2007-05-31
申请号：US11454525
申请日：2006-06-16
申请人： Hugues Malandain , Lex Jansen
发明人： Hugues Malandain , Lex Jansen
IPC分类号： A61B17/00
CPC分类号： A61B17/1617 , A61B17/1659 , A61B17/1671 , A61B17/320016 , A61B17/320036 , A61B17/320708 , A61B17/320783 , A61B2017/00539 , A61B2017/00544
摘要： A mechanical cavity-creation surgical device and methods and kits for using such devices is described. In one variation, the mechanical cavity-creation surgical device contains a side window at the distal end of a shaft that allows the articulation of a blade, pick, or tip from a position that is inside the shaft to a position that protrudes at least partially from the side window.
摘要翻译：描述了一种用于使用这种装置的机械腔创建手术装置和方法和套件。在一个实施例中，机械腔创建手术装置包括在轴的远端处的侧窗，其允许从轴内部的位置将刀片，拾取头或尖端铰接到至少部分地突出的位置从侧窗。

9. 发明申请

US20070055237A1 Percutaneous spinal implants and methods 审中-公开
标题翻译：经皮脊髓植入物和方法
公开(公告)号：US20070055237A1
公开(公告)日：2007-03-08
申请号：US11356294
申请日：2006-02-17
申请人： Avram Edidin , Andrew Kohm , Hugues Malandain
发明人： Avram Edidin , Andrew Kohm , Hugues Malandain
IPC分类号： A61F2/30
CPC分类号： A61B17/025 , A61B17/7065 , A61B2017/00557 , A61B2017/0256
摘要： Apparatuses and methods for performing minimally-invasive medical procedures are described. In one embodiment, for example, an apparatus includes an elongate member having a proximal portion and a distal portion are each configured to move from a first configuration to a second configuration and from the second configuration to the first configuration. At least a section of each of the proximal portion and the distal portion is collapsed in the first configuration and is expanded in the second configuration. A central portion is positioned between the proximal portion and the distal portion. The non-expanding central portion is configured to be disposed between adjacent spinous processes upon spinal extension. A material of the non-expanding central portion is different than a material of the proximal portion and the distal portion.
摘要翻译：描述了用于执行微创医疗程序的装置和方法。在一个实施例中，例如，一种装置包括具有近侧部分的细长构件，并且远侧部分各自被配置为从第一构型移动到第二构型，并且从第二构型移动到第一构型。近端部分和远端部分中的每一个的至少一部分在第一构造中折叠并且在第二构造中扩张。中心部分位于近端部分和远端部分之间。非扩张中心部分构造成在脊柱延伸时设置在相邻棘突之间。不扩张中心部分的材料不同于近端部分和远端部分的材料。

10. 发明申请

US20130123927A1 PLASTICALLY DEFORMABLE INTER-OSSEOUS DEVICE 有权
标题翻译：塑性可变的互操作设备
公开(公告)号：US20130123927A1
公开(公告)日：2013-05-16
申请号：US13809329
申请日：2011-06-27
申请人： Hugues Malandain
发明人： Hugues Malandain
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61B17/8852 , A61F2/442 , A61F2/4611 , A61F2002/30014 , A61F2002/30016 , A61F2002/30018 , A61F2002/30377 , A61F2002/30579 , A61F2002/4475 , A61F2002/4627 , A61F2002/4631 , A61F2220/0016 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00137 , A61F2310/00161 , A61F2310/00167 , A61F2310/00203
摘要： Described here are deformable, monolithic, stabilization devices, or implants, suitable for use within bone and between bones, for instance, to fuse vertebral bodies, to repair herniated discs, or to repair spinal compression fractures. The implants are introduced into a chosen site at a first, smaller height and then plastically deformed to achieve a second, but unique, pre-selected, larger height. Variations of the device provide one or more specific larger heights. The devices are particularly suitable as intervertebral spinal fusion implants for the immobilization of adjacent vertebral bodies. Methods of deploying the implants are also described as are instruments for such deployment.Also described are variations of the device particularly suitable as sizing instruments. These versions are elastic, i.e., not plastically deformable, and may be restored to their original size. Many of the described variations include deformable regions serving as hinges. Other variations are non-monolithic or may have one or more classical hinges substituted for the deformable regions.
摘要翻译：这里描述的是可变形的，整体的，稳定的装置或植入物，适用于骨骼内和骨骼之间，例如使椎体融合，修复突出的椎间盘或修复脊柱压迫性骨折。将植入物以第一较小的高度引入选定的位置，然后塑性变形以实现第二但唯一的预先选择的较大的高度。设备的变化提供一个或多个特定的更大的高度。该装置特别适用于固定相邻椎体的椎间融合植入物。植入物的部署方法也被描述为这种部署的工具。还描述了特别适合作为尺寸调节装置的装置的变型。这些版本是弹性的，即不是塑性变形的，并且可以恢复到它们的原始尺寸。许多描述的变型包括用作铰链的可变形区域。其它变化是非整体的或者可以具有代替可变形区域的一个或多个经典铰链。

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