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1. 发明申请

US20050153874A1 Method of reducing serum proinsulin levels in type 2 diabetics 审中-公开
标题翻译：降低2型糖尿病患者血清胰岛素原水平的方法
公开(公告)号：US20050153874A1
公开(公告)日：2005-07-14
申请号：US11032278
申请日：2005-01-10
申请人： Wayman Cheatham , Anders Boss , Andreas Pfuetzner
发明人： Wayman Cheatham , Anders Boss , Andreas Pfuetzner
IPC分类号： A61K38/28
CPC分类号： A61K38/28
摘要： Methods are provided for reducing serum proinsulin levels, lessening post-prandial pancreatic stress, and reducing risk factors for atherosclerosis in subjects with diabetes mellitus, type 2. The method includes administration of insulin in a manner that mimics the meal-related first phase insulin response, using a dose sufficient to reduce serum levels of proinsulin. In some embodiments of the method insulin administration is commenced early in the course of the disease. Mimicking first phase kinetics, peak serum insulin levels can be reached within about 18 minutes of administration. In increasingly preferred embodiments peak serum insulin levels can be reached within about 15, 12, or 10 minutes of administration. Serum insulin levels return to baseline within about two hours of administration.
摘要翻译：提供了用于降低血清胰岛素原水平，减轻餐后胰腺压力并降低患有糖尿病2型的受试者的动脉粥样硬化的危险因素的方法。该方法包括以模拟与膳食相关的第一阶段胰岛素反应的方式施用胰岛素，使用足以降低胰岛素原血清水平的剂量。在该方法的一些实施方案中，胰岛素给药在疾病过程的早期开始。模拟第一相动力学，可在约18分钟内达到峰值血清胰岛素水平。在越来越优选的实施方案中，可以在施用的约15,12或10分钟内达到峰值血清胰岛素水平。血清胰岛素水平在约2小时内恢复至基线。

2. 发明授权

US5779477A Method and appliance using one or more wire-feeding tracks for production of artificial supporting members for the human body 失效
标题翻译：用于生产人体的人造支撑构件的一个或多个送丝轨道的方法和装置
公开(公告)号：US5779477A
公开(公告)日：1998-07-14
申请号：US602775
申请日：1996-04-23
申请人： Anders Boss
发明人： Anders Boss
IPC分类号： A61C8/00 , A61C13/003 , A61C13/225
CPC分类号： A61C8/0048 , A61C13/26
摘要： A method for producing artificial supporting members in the human body is provided. In a first manufacturing stage, at least two support part members are matched together by machining contact surfaces on the supporting part members via which the supporting members are joined. Also during this stage, positional information regarding the relative positions of the contact surfaces and the supporting part members is identified. In a second manufacturing stage, the supporting part members are joined together using the positional information and are applied on a bearing member in relation to a plane. The plane extends at right angles with respect to a selected direction of the supporting member parts when they are in their matched positions. At least one of a wire feeding track and the bearing member are moved whereby the position of the wire feeding track is altered with respect to the plane. The wire feeding track is moved to cross connection portions of the supporting part members. As the wire feeding track crosses the connection portions, the supporting part member is machined to create a contact surface which can cooperate with another contact surface on another supporting part member. The positional information obtained during the first manufacturing stage is based on the positional relationship of the wire feeding track and the bearing member in the plane.
摘要翻译： PCT No.PCT / SE95 / 00809 Sec。 371日期：1996年4月23日 102（e）日期1996年4月23日PCT提交1995年6月30日PCT公布。公开号WO96 / 01082 日本1996年1月18日提供了人体中生产人造支撑构件的方法。在第一制造阶段中，至少两个支撑部件通过加工支撑部件连接的支撑部件上的接触表面而相互配合。此外，在该阶段中，识别关于接触表面和支撑部件的相对位置的位置信息。在第二制造阶段，使用位置信息将支撑部件接合在一起，并相对于平面施加在轴承部件上。当它们处于其匹配位置时，平面相对于支撑构件部件的选定方向成直角延伸。导线馈送轨道和支承构件中的至少一个被移动，由此导线馈送轨道的位置相对于平面改变。送丝轨道移动到支撑部件的交叉连接部分。当送丝轨道穿过连接部分时，对支撑部件进行加工，以形成可与另一个支撑部件上的另一个接触表面配合的接触表面。在第一制造阶段中获得的位置信息基于导线馈送轨道和轴承部件在平面中的位置关系。

3. 发明申请

US20060239934A1 SUPERIOR CONTROL OF BLOOD GLUCOSE IN DIABETES TREATMENT 有权
标题翻译：血糖控制在糖尿病治疗中的优势
公开(公告)号：US20060239934A1
公开(公告)日：2006-10-26
申请号：US11278381
申请日：2006-03-31
申请人： Wayman Cheatham , Anders Boss
发明人： Wayman Cheatham , Anders Boss
IPC分类号： A61K38/28 , A61K9/14 , A61K31/495 , A61L9/04
CPC分类号： A61K38/28 , A61K9/007 , A61K9/0073 , A61K9/0075 , A61K31/495 , A61K47/545 , Y10S514/866
摘要： Methods related to the treatment of diabetes and improving the control of blood glucose levels are provided. In particular, methods are provided for effectively reducing postprandial glucose excursions while reducing the incidence of clinically significant late postprandial hypoglycemia by administered an insulin composition in a form suitable for pulmonary administration. Additionally, methods for effectively reducing post-prandial glucose excursions while reducing the incidence of clinically significant late postprandial hypoglycemia by administered an insulin composition in a form suitable for pulmonary administration along with a long-acting basal insulin.
摘要翻译：提供了与治疗糖尿病和改善血糖水平控制有关的方法。特别地，提供了通过以适合于肺部给药的形式施用胰岛素组合物来有效减少餐后葡萄糖偏移同时降低临床上晚期餐后低血糖发生率的方法。另外，通过以与长效基础胰岛素一起施用适于肺部给药的形式的胰岛素组合物，有效降低餐后葡萄糖偏差的方法同时降低临床上显着晚期餐后低血糖的发生率。

4. 发明授权

US5662474A Spacing member for tooth implant 失效
标题翻译：牙植入物的间距构件
公开(公告)号：US5662474A
公开(公告)日：1997-09-02
申请号：US530121
申请日：1995-12-05
申请人： Lars Jorneus , Anders Boss , Halvar Hanssen
发明人： Lars Jorneus , Anders Boss , Halvar Hanssen
IPC分类号： A61C8/00 , A61C13/12 , A61C13/225
CPC分类号： A61C8/0066 , A61C8/005 , A61C8/0068 , A61C8/0054 , A61C8/006
摘要： The invention relates to a spacing member for a tooth implant, comprising a base portion for attachment to a fixture implanted in the jawbone, and an upper part with an essentially conical outer limit surface for attachment to a tooth prosthesis. The base portion comprises a through hole for a spacing screw which is intended to engage with an internally threaded bore in the upper portion of the fixture and thereby form a first screw connection for locking the spacing member securely in a defined direction of deflection in relation to the fixture. The upper part comprises a second screw connection for attachment of the tooth prosthesis, which screw connection forms a fixed angle .delta. in relation to the first screw connection. The upper part of the inlet opening for the through hole which is formed in the conical outer limit surface in the upper part of the spacing member, and through which opening the spacing screw is intended to be introduced during assembly, is offset towards the line of symmetry of the through hole. In this way, the height of the spacer can be kept low, even in those cases where the fixed angle .delta. between the two screw connections is comparatively small, preferably within the range of 15.degree.-25.degree..
摘要翻译： PCT No.PCT / SE95 / 00131 Sec。 371 1995年12月5日第 102（e）日期1995年12月5日PCT 1995年2月9日提交PCT公布。公开号WO95 / 21589 日期1995年8月17日本发明涉及一种用于牙齿植入物的间隔构件，其包括用于附接到植入颚骨中的夹具的基部，以及具有用于附接到牙齿假体的基本上圆锥形的外限制表面的上部。基座部分包括用于间隔螺钉的通孔，其用于与夹具上部的内螺纹孔接合，从而形成第一螺纹连接件，用于将间隔构件牢固地锁定在相对于夹具。上部包括用于附接牙齿假体的第二螺钉连接件，该螺钉连接件相对于第一螺钉连接形成固定角度的三角形。用于通孔的入口开口的上部，其形成在间隔构件的上部中的锥形外极限表面中，并且组装期间打算引入间隔螺钉的开口偏移朝向通孔的对称性。以这种方式，即使在两个螺钉连接件之间的固定角度差相对较小的情况下，优选在15°-25°的范围内，间隔件的高度也可以保持较低。

5. 发明授权

US5269685A Anchoring member 失效
标题翻译：锚定成员
公开(公告)号：US5269685A
公开(公告)日：1993-12-14
申请号：US935993
申请日：1992-08-27
申请人： Lars Jorneus , Anders Boss
发明人： Lars Jorneus , Anders Boss
IPC分类号： A61C8/00 , F16B25/00
CPC分类号： A61C8/0022
摘要： A screw-shaped titanium anchoring member for permanent anchorage in bone tissue, specifically permanent anchorage of artificial teeth or tooth bridges in the jaw-bone, comprises at least one cavity located at the forward tip of the screw, the edges of the at least one cavity on the outer threaded cylindrical surface forming cutting tooth with cutting edge to provide self-tapping when the anchoring member is screwed into a bored hole in the bone tissue and the total volume of the at least one cavity being adapted to contain the scraped-off bone tissue material. The anchoring member on the outer cylindrical surface of the cutting tooth, a short distance behind its cutting edge, is provided with a clearance surface defined on the outer surface of the anchoring member, which when seen in a cross-section through the cutting part of the anchoring member, is slightly bevelled a short distance behind the threaded cutting edge.

6. 发明申请

US20070027063A1 METHOD OF PRESERVING THE FUNCTION OF INSULIN-PRODUCING CELLS 审中-公开
标题翻译：保留胰岛素生产细胞功能的方法
公开(公告)号：US20070027063A1
公开(公告)日：2007-02-01
申请号：US11461746
申请日：2006-08-01
申请人： Anders Boss , Wayman Cheatham , David Diamond
发明人： Anders Boss , Wayman Cheatham , David Diamond
IPC分类号： A61K38/28
CPC分类号： A61K38/28 , A61K9/0075
摘要： Methods and compositions for preserving the function of insulin-producing cells and to furthering the lifespan of insulin-producing cells in non-insulin dependent patients with insulin-related disorders are provided.
摘要翻译：提供了用于保持胰岛素产生细胞的功能和促进胰岛素相关疾病的非胰岛素依赖性患者中产生胰岛素的细胞的寿命的方法和组合物。

7. 发明申请

US20070020191A1 Potentiation of glucose elimination 有权
标题翻译：增加葡萄糖消除
公开(公告)号：US20070020191A1
公开(公告)日：2007-01-25
申请号：US11329686
申请日：2006-01-10
申请人： Anders Boss , Solomon Steiner , Rodney Woods , Joseph Sulner
发明人： Anders Boss , Solomon Steiner , Rodney Woods , Joseph Sulner
IPC分类号： A61K38/28 , A61L9/04
CPC分类号： A61K38/28 , A61K9/007 , A61K9/0073 , A61K9/0075 , A61K31/495 , A61K47/545 , Y10S514/866
摘要： Methods related to the treatment of diabetes and improving the efficiency of insulin utilization are provided. The method enables effective control of prandial glucose levels while reducing the risk of postprandial hypoglycemia. In particular, methods of potentiating the activity of endogenous insulin in type 2 diabetics and exogenous long-acting insulin in diabetics requiring basal insulin replacement are provided.
摘要翻译：提供了与治疗糖尿病和提高胰岛素利用效率相关的方法。该方法可有效控制餐前葡萄糖水平，同时降低餐后低血糖风险。特别地，提供了在需要基础胰岛素替代物的糖尿病患者中增强2型糖尿病患者和外源性长效胰岛素内源性胰岛素活性的方法。

8. 发明申请

US20060153778A1 Methods and compositions for minimizing accrual of inhalable insulin in the lungs 审中-公开
标题翻译：减少肺中可吸入胰岛素应力的方法和组合物
公开(公告)号：US20060153778A1
公开(公告)日：2006-07-13
申请号：US11330427
申请日：2006-01-10
申请人： Cohava Gelber , Anders Boss
发明人： Cohava Gelber , Anders Boss
IPC分类号： A61K38/28 , A61K9/14 , A61K31/495 , A61L9/04
CPC分类号： A61K9/0075 , A61K31/495 , A61K38/28 , A61K2300/00
摘要： Inhalable insulin compositions are provided that rapidly clear from the lungs of patients. Additionally, methods of minimizing insulin accrual after administration of an inhaled insulin composition are disclosed.
摘要翻译：提供可从患者肺部快速清除的可吸入胰岛素组合物。此外，公开了在施用吸入性胰岛素组合物之后使胰岛素应计最小化的方法。

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