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1. 发明申请

US20100185252A1 DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART 审中-公开
标题翻译：用于监测人心脏心脏衰竭进展的医用植入物的装置和方法
公开(公告)号：US20100185252A1
公开(公告)日：2010-07-22
申请号：US12528496
申请日：2007-09-27
申请人： Anders Björling , Malin Öhlander , Tom Eriksson , Johan Eckerdal , Urban Lönn , Kenth Nilsson , Cecilia Tuvstedt , Johan Svahn , Anna-Karin Johansson , Kjell Norén , Michael Broomé
发明人： Anders Björling , Malin Öhlander , Tom Eriksson , Johan Eckerdal , Urban Lönn , Kenth Nilsson , Cecilia Tuvstedt , Johan Svahn , Anna-Karin Johansson , Kjell Norén , Michael Broomé
IPC分类号： A61N1/365 , A61B5/1455 , A61B5/1468 , A61B5/103
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/076 , A61B5/1459 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/36557 , A61N1/36585
摘要： In a device and method for a medical implant for monitoring progression of heart failure in a human heart, an activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.
摘要翻译：在用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法中，活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。在确定的活性水平获得确定水平的静脉氧含量，并将该水平的静脉氧含量与在相应活动水平的储存值进行比较。将比较结果用作确定心力衰竭程度的基础。

2. 发明申请

US20100121398A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MONITORING VALVE MOVEMENTS OF A HEART 审中-公开
标题翻译：用于监测心脏瓣膜运动的可植入医疗装置和方法
公开(公告)号：US20100121398A1
公开(公告)日：2010-05-13
申请号：US12597227
申请日：2007-04-27
申请人： Anders Björling , Cecilia Tuvstedt , Kenth Nilsson , Kjell Norén
发明人： Anders Björling , Cecilia Tuvstedt , Kenth Nilsson , Kjell Norén
IPC分类号： A61N1/368
CPC分类号： A61N1/36521 , A61N1/36578 , A61N1/3682
摘要： An implantable medical device for monitoring the movements of the valve planes of the heart to determine at least one hemodynamic measure reflecting a mechanical functioning of a heart of a patient, includes an impedance measuring circuit that measures impedance between at least electrode pairs including at least one electrode placed substantially at the level of the valve plane. The measured impedances reflect valve plane movements. A hemodynamic parameter determining circuit determines at least one hemodynamic parameter based on the impedances reflecting the mechanical functioning of the heart.
摘要翻译：一种可植入医疗装置，用于监测心脏的瓣膜平面的移动以确定反映患者心脏的机械功能的至少一个血流动力学量度，包括阻抗测量电路，其测量至少包括至少一个电极基本上位于阀平面的水平面上。测量的阻抗反映了阀平面运动。血液动力学参数确定电路基于反映心脏的机械功能的阻抗来确定至少一个血液动力学参数。

3. 发明授权

US07215996B2 Bi-ventricular heart stimulating device, system and method 有权
标题翻译：双心室心脏刺激装置，系统及方法
公开(公告)号：US07215996B2
公开(公告)日：2007-05-08
申请号：US10499253
申请日：2002-10-04
申请人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
发明人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.
摘要翻译：在可植入心脏刺激装置，系统和方法中，将电刺激脉冲以其间具有可变时间间隔输送到心脏的第一和第二心室，并且在心脏中的两个不同位置处感测信号，从其中导出阻抗值。在心脏周期期间确定阻抗值的最小值和最大值，并且还确定最小值与最大值之间的关系。时间间隔变化，并且在许多心脏周期上监测关系。设定时间间隔使得该关系满足预定的要求。

4. 发明授权

US08073540B2 Implantable heart stimulating device with stimulation rate optimization 有权
标题翻译：具有刺激速率优化的植入式心脏刺激装置
公开(公告)号：US08073540B2
公开(公告)日：2011-12-06
申请号：US12305552
申请日：2006-06-21
申请人： Kjell Norén , Kenth Nilsson
发明人： Kjell Norén , Kenth Nilsson
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36564 , A61N1/36578
摘要： An implantable heart stimulating device has a stimulation pulse generator that emits stimulation pulses at an adjustable stimulation rate, an activity sensor that emits an activity signal in response to detected activity of the patient, and a physiological parameter sensor that generates a physiological sensor signal in response to a detected physiological parameter. The activity and physiological sensor signals are supplied to a control arrangement that sets the stimulation rate for the stimulation pulse generator by executing a stimulation rate algorithm dependent on those signals. In the stimulation rate algorithm, if the physiological signal indicates an emotional stress on the part of the patient, the stimulation rate is increased to an adjustable emotional stress rate level, and if no increase in the activity signal occurs during a predetermined time period following the stimulation rate increase, the stimulation rate is decreased.
摘要翻译：可植入心脏刺激装置具有以可调节刺激速率发出刺激脉冲的刺激脉冲发生器，响应于患者的检测到的活动而发出活动信号的活动传感器，以及响应于生成生理传感器信号的生理参数传感器到检测到的生理参数。活动和生理传感器信号被提供给控制装置，其通过执行依赖于那些信号的刺激速率算法来设定刺激脉冲发生器的刺激速率。在刺激速率算法中，如果生理信号表示患者的情绪应激，则刺激率增加到可调节的情绪应激率水平，并且如果活动信号的增加在后面的预定时间段内不发生刺激率增加，刺激率降低。

5. 发明申请

US20130060118A1 IMPLANTABLE MEDICAL DEVICE AND METHOD COMPRISING MEANS FOR DETECTING AND CLASSIFYING AN ARRHYTHMIA 有权
标题翻译：可植入医疗装置和方法，包括用于检测和分类ARRHYTHMIA的手段
公开(公告)号：US20130060118A1
公开(公告)日：2013-03-07
申请号：US13696261
申请日：2010-05-12
申请人： Anders Björling , Malin Hollmark , Tomas Svensson , Stefan Hjelm , Kjell Norén , Karin Järverud
发明人： Anders Björling , Malin Hollmark , Tomas Svensson , Stefan Hjelm , Kjell Norén , Karin Järverud
IPC分类号： A61N1/39 , A61B5/0245 , A61B5/053
CPC分类号： A61N1/3621 , A61N1/3622 , A61N1/36521 , A61N1/3704 , A61N1/3962
摘要： An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during at least a portion of cardiac cycle. A moment processor (132) calculates a moment parameter value based on the cardiogenic impedance signal. The moment parameter is representative of a weighted sum of impedance amplitudes within a time window centered at defined time instance within the cardiac cycle. The weights of the impedance amplitudes are further dependent on the length in time between the defined time instance and the point of time of the associated impedance amplitude. The moment parameter is of high diagnostic value and is employed by an arrhythmia classifier (132) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.
摘要翻译：可植入医疗装置（100）被配置为在心脏周期的至少一部分期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源性阻抗信号。时刻处理器（132）基于心源阻抗信号计算力矩参数值。力矩参数代表以心动周期内规定时间范围为中心的时间窗内的阻抗振幅加权和。阻抗幅度的权重进一步取决于所定义的时间实例和相关联的阻抗幅度的时间点之间的时间长度。时刻参数具有很高的诊断价值，并被心律失常分类器（132）采用，以便将检测到的心脏（10）的心律失常进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

6. 发明申请

US20110313302A1 BLOOD PRESSURE MEASUREMENT WITH IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：血压测量与可植入医疗器械
公开(公告)号：US20110313302A1
公开(公告)日：2011-12-22
申请号：US13162872
申请日：2011-06-17
申请人： Anders Björling , Kjell Norén , Karin Järverud
发明人： Anders Björling , Kjell Norén , Karin Järverud
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02 , A61B5/1107 , A61B5/686 , A61B5/7203 , A61B5/7239 , A61N1/36564 , A61N1/36578
摘要： An implantable medical device is connected to a cardiomechanic sensor implanted in or in connection with a cardiac ventricle. The sensor generates a deformation signal representative of the myocardial deformation. The implantable medical device processes the deformation signal by calculating the derivative thereof to generate a deformation rate signal representative of the rate of myocardial deformation. The deformation rate signal is filtered and respective maximum deformation rate values are identified for multiple cardiac cycles in the filtered deformation rate signal. A value representative of the systemic blood pressure is calculated based on a combination of the respective maximum deformation rate values.
摘要翻译：植入式医疗装置连接到植入在心室或与心室连接的心脏机械传感器。传感器产生代表心肌变形的变形信号。可植入医疗装置通过计算其变形来产生变形信号，以产生代表心肌变形速率的变形速率信号。对变形率信号进行滤波，并在滤波的变形率信号中针对多个心动周期识别各自的最大变形速率值。基于相应的最大变形率值的组合来计算代表全身血压的值。

7. 发明授权

US07778697B2 Detection of ischemia 有权
标题翻译：检测缺血
公开(公告)号：US07778697B2
公开(公告)日：2010-08-17
申请号：US11667505
申请日：2004-10-11
申请人： Anders Björling , Kjell Norén
发明人： Anders Björling , Kjell Norén
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/02028 , A61B5/053 , A61B5/0538 , A61N1/36521 , A61N1/36557 , A61N1/3684
摘要： In an ischemia detection method, and in an ischemia detector and a cardiac stimulator embodying an ischemia detector, a workload of a patient is measured, as is an ejection fraction (EF) associated with the heart of the patient is determined. A predetermined reference relation between EF and workload for the patient is stored, and an analysis unit detects a state of ischemia of the patient from deviation in the determined EF for various workloads from the stored reference relation.
摘要翻译：在局部缺血检测方法中，在局部缺血检测器和体内缺血检测器的心脏刺激器中，测量患者的工作量，并确定与患者心脏相关联的射血分数（EF）。存储EF和患者的工作负荷之间的预定参考关系，并且分析单元从所存储的参考关系中检测出针对各种工作负载的所确定的EF中的患者的局部缺血状态。

8. 发明授权

US06860857B2 Implantable intravascular pressure determining device and method 失效
标题翻译：植入式血管内压力测定装置及方法
公开(公告)号：US06860857B2
公开(公告)日：2005-03-01
申请号：US10078210
申请日：2002-02-19
申请人： Kjell Norén , Seven-Erik Hedberg , Kenth Nilsson
发明人： Kjell Norén , Seven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61B5/0215 , A61B5/00
CPC分类号： A61B5/02158 , A61B5/721
摘要： In an implantable intravascular pressure determining device and method, a pressure sensor generates a raw pressure signal and an acceleration sensor measures acceleration in a patient. Time intervals are identified wherein the raw pressure signal accurately represents the intravascular pressure, these intervals being identified as the time intervals wherein the measured acceleration is below a predetermined threshold. The raw pressure signal is processed, to generate a processed signal which is used as an intravascular pressure signal, only in the aforementioned time intervals.
摘要翻译：在可植入的血管内压力测定装置和方法中，压力传感器产生原始压力信号，加速度传感器测量患者的加速度。识别时间间隔，其中原始压力信号准确地表示血管内压力，这些间隔被识别为测量的加速度低于预定阈值的时间间隔。原始压力信号被处理，以产生用作血管内压力信号的处理信号，仅在上述时间间隔内。

9. 发明授权

US06589184B2 Implantable intravascular pressure determining device and method 失效
标题翻译：植入式血管内压力测定装置及方法
公开(公告)号：US06589184B2
公开(公告)日：2003-07-08
申请号：US10078208
申请日：2002-02-19
申请人： Kjell Norén , Seven-Erik Hedberg , Kenth Nilsson
发明人： Kjell Norén , Seven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61B502
CPC分类号： A61B5/0215
摘要： In an implantable intravascular pressure determining device and method, a pressure sensor generates a raw pressure signal, an acceleration sensor generates an acceleration signal, and an evaluation unit determines a disturbance pressure signal from the acceleration signal. A processed signal is generated as the difference between the raw pressure signal and the disturbance pressure signal. The processed signal corresponds to intravascular pressure.
摘要翻译：在可植入血管内压力测定装置和方法中，压力传感器产生原始压力信号，加速度传感器产生加速度信号，评价部根据加速度信号来决定干扰压力信号。产生经处理的信号作为原始压力信号和干扰压力信号之间的差。经处理的信号对应于血管内压。

10. 发明授权

US08738120B2 Implantable medical device and method comprising means for detecting and classifying an arrhythmia 有权
标题翻译：可植入医疗装置和方法包括用于检测和分类心律失常的装置
公开(公告)号：US08738120B2
公开(公告)日：2014-05-27
申请号：US13696261
申请日：2010-05-12
申请人： Anders Björling , Malin Hollmark , Tomas Svensson , Stefan Hjelm , Kjell Norén , Karin Järverud
发明人： Anders Björling , Malin Hollmark , Tomas Svensson , Stefan Hjelm , Kjell Norén , Karin Järverud
IPC分类号： A61B5/0468
CPC分类号： A61N1/3621 , A61N1/3622 , A61N1/36521 , A61N1/3704 , A61N1/3962
摘要： An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during at least a portion of cardiac cycle. A moment processor (132) calculates a moment parameter value based on the cardiogenic impedance signal. The moment parameter is representative of a weighted sum of impedance amplitudes within a time window centered at defined time instance within the cardiac cycle. The weights of the impedance amplitudes are further dependent on the length in time between the defined time instance and the point of time of the associated impedance amplitude. The moment parameter is of high diagnostic value and is employed by an arrhythmia classifier (132) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.
摘要翻译：可植入医疗装置（100）被配置为在心脏周期的至少一部分期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源性阻抗信号。时刻处理器（132）基于心源阻抗信号计算力矩参数值。力矩参数代表以心动周期内规定时间范围为中心的时间窗内的阻抗振幅加权和。阻抗幅度的权重进一步取决于所定义的时间实例和相关联的阻抗幅度的时间点之间的时间长度。时刻参数具有很高的诊断价值，并被心律失常分类器（132）采用，以便将检测到的心脏（10）的心律失常进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

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