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1. 发明授权

US07795040B2 Methods, particles, and kits for determining activity of a kinase 失效
标题翻译：测定激酶活性的方法，粒子和试剂盒
公开(公告)号：US07795040B2
公开(公告)日：2010-09-14
申请号：US11736254
申请日：2007-04-17
申请人： James W. Jacobson , Ananda G. Lugade , Michaela R. Hoffmeyer
发明人： James W. Jacobson , Ananda G. Lugade , Michaela R. Hoffmeyer
IPC分类号： G01N33/543
CPC分类号： C12Q1/485
摘要： Methods, particles and kits for determining kinase activity within a sample are provided. An embodiment of a method includes exposing a fluorescent particle to an assay, wherein the fluorescent particle includes a support substrate having one or more fluorescent materials and a peptide substrate coupled to the support substrate via a functional group of the support substrate. The method further includes phosphorylating the peptide substrate during exposure of the fluorescent particle to the assay and processing the fluorescent particle such that the peptide substrate is dephosphorylated and a polarized double bond is generated at a dephosphorylated site. In addition, the method includes coupling a fluorescent reporter having a nucleophilic terminal group to the fluorescent particle via the polarized double bond.
摘要翻译：提供了用于确定样品中激酶活性的方法，颗粒和试剂盒。一种方法的实施方案包括将荧光颗粒暴露于测定中，其中荧光颗粒包括具有一种或多种荧光材料的支撑衬底和通过支撑衬底的官能团与支撑衬底耦合的肽底物。该方法还包括在将荧光颗粒暴露于测定期间磷酸化底物，并处理荧光颗粒，使得肽底物脱磷酸化，并在去磷酸化位点产生偏振双键。此外，该方法包括通过偏振双键将具有亲核末端基团的荧光报告物偶联到荧光颗粒上。

2. 发明申请

US20100317544A1 Methods, Particles, and Kits for Determining Activity of a Kinase 审中-公开
标题翻译：用于确定激酶活性的方法，粒子和试剂盒
公开(公告)号：US20100317544A1
公开(公告)日：2010-12-16
申请号：US12861521
申请日：2010-08-23
申请人： James W. Jacobson , Ananda G. Lugade , Michaela R. Hoffmeyer
发明人： James W. Jacobson , Ananda G. Lugade , Michaela R. Hoffmeyer
IPC分类号： C12Q1/48 , C40B30/08 , C40B40/10
CPC分类号： C12Q1/485
摘要： Methods, particles and kits for determining kinase activity within a sample are provided. An embodiment of a method includes exposing a fluorescent particle to an assay, wherein the fluorescent particle includes a support substrate having one or more fluorescent materials and a peptide substrate coupled to the support substrate via a functional group of the support substrate. The method further includes phosphorylating the peptide substrate during exposure of the fluorescent particle to the assay and processing the fluorescent particle such that the peptide substrate is dephosphorylated and a polarized double bond is generated at a dephosphorylated site. In addition, the method includes coupling a fluorescent reporter having a nucleophilic terminal group to the fluorescent particle via the polarized double bond.
摘要翻译：提供了用于确定样品中激酶活性的方法，颗粒和试剂盒。一种方法的实施方案包括将荧光颗粒暴露于测定中，其中荧光颗粒包括具有一种或多种荧光材料的支撑衬底和通过支撑衬底的官能团与支撑衬底耦合的肽底物。该方法还包括在将荧光颗粒暴露于测定期间磷酸化底物，并处理荧光颗粒，使得肽底物脱磷酸化，并在去磷酸化位点产生偏振双键。此外，该方法包括通过偏振双键将具有亲核末端基团的荧光报告物偶联到荧光颗粒上。

3. 发明授权

US08324359B1 Oxocarbonamide peptide nucleic acids and methods of using same 有权
标题翻译：氧碳酰胺肽核酸及其使用方法
公开(公告)号：US08324359B1
公开(公告)日：2012-12-04
申请号：US11947705
申请日：2007-11-29
申请人： Ananda G. Lugade , James W. Jacobson
发明人： Ananda G. Lugade , James W. Jacobson
IPC分类号： C07H21/00 , C12Q1/68
CPC分类号： C07K14/003
摘要： The present invention concerns oxocarbonamide peptide nucleic acids (OxoPNAs). OxoPNAs provide increased stability, sensitivity, and specificity as compared to their natural DNA and RNA counterparts. The OxoPNA molecules of the present invention may be employed in a wide range of applications, particularly in applications involving hybridization. For example, OxoPNA probes may be employed for the detection and functional analysis of nucleic acid molecules, including miRNAs and other non-coding RNAs.
摘要翻译：本发明涉及氧羰酰胺肽核酸（OxoPNA）。与其天然DNA和RNA对应物相比，OxoPNAs提供了更高的稳定性，灵敏度和特异性。本发明的OxoPNA分子可以用于广泛的应用，特别是在涉及杂交的应用中。例如，OxoPNA探针可用于检测和功能分析核酸分子，包括miRNA和其他非编码RNA。

4. 发明申请

US20120302453A1 OXOCARBONAMIDE PEPTIDE NUCLEIC ACIDS AND METHODS OF USING SAME 有权
标题翻译：亚硫酰胺肽核酸及其使用方法
公开(公告)号：US20120302453A1
公开(公告)日：2012-11-29
申请号：US11947705
申请日：2007-11-29
申请人： Ananda G. LUGADE , James W. Jacobson
发明人： Ananda G. LUGADE , James W. Jacobson
IPC分类号： C07K2/00 , C40B30/04 , C12Q1/68 , G01N21/64
CPC分类号： C07K14/003
摘要： The present invention concerns oxocarbonamide peptide nucleic acids (OxoPNAs). OxoPNAs provide increased stability, sensitivity, and specificity as compared to their natural DNA and RNA counterparts. The OxoPNA molecules of the present invention may be employed in a wide range of applications, particularly in applications involving hybridization. For example, OxoPNA probes may be employed for the detection and functional analysis of nucleic acid molecules, including miRNAs and other non-coding RNAs.
摘要翻译：本发明涉及氧羰酰胺肽核酸（OxoPNA）。与其天然DNA和RNA对应物相比，OxoPNAs提供了更高的稳定性，灵敏度和特异性。本发明的OxoPNA分子可以用于广泛的应用，特别是在涉及杂交的应用中。例如，OxoPNA探针可用于检测和功能分析核酸分子，包括miRNA和其他非编码RNA。

5. 发明申请

US20090068680A1 Method for Characterizing Immune Disorders 审中-公开
标题翻译：表征免疫功能障碍的方法
公开(公告)号：US20090068680A1
公开(公告)日：2009-03-12
申请号：US12273292
申请日：2008-11-18
申请人： James P. Mapes , James W. Jacobson , Harold N. Baker , Michael D. Spain
发明人： James P. Mapes , James W. Jacobson , Harold N. Baker , Michael D. Spain
IPC分类号： G01N33/53
CPC分类号： G01N33/54313 , G01N33/564 , G01N2800/24 , Y10S435/973 , Y10S436/811
摘要： Methods for characterizing immune diseases are provided which include exposing a sample of biological fluid from a patient to a pooled population of particles, wherein a first subset of particles is bound to a reactant that binds an antibody and a second subset of particles is bound to a reactant that binds an antigen. The methods further include determining a ratio of measured amounts of the antibody and the antigen in the sample. In some cases, the ratio is compared to one or more standard ratios representing differing states of the disease to determine a state of the disease within the patient. In other embodiments, the steps of exposing and determining a ratio of antibody to antigen are repeated for one or more additional samples of biological fluid taken from the patient. In such cases, at least two ratios are compared to analyze a progression of the disease.
摘要翻译：提供了表征免疫疾病的方法，其包括将患者的生物流体样品暴露于汇集的颗粒群体，其中颗粒的第一子集与结合抗体的反应物结合，并且第二子粒子与结合抗原的反应物。所述方法还包括确定样品中抗体和抗原的测量量的比例。在一些情况下，将该比率与表示疾病状态不同的一个或多个标准比例进行比较，以确定患者内疾病的状态。在其它实施方案中，对从患者取得的生物流体的一个或多个另外的样本重复暴露和确定抗体与抗原的比例的步骤。在这种情况下，比较至少两个比率来分析疾病的进展。

6. 发明授权

US07189516B2 Method for characterizing autoimmune disorders 有权
标题翻译：表征自身免疫性疾病的方法
公开(公告)号：US07189516B2
公开(公告)日：2007-03-13
申请号：US10222867
申请日：2002-08-19
申请人： James P. Mapes , James W. Jacobson , Harold N. Baker , Michael D. Spain
发明人： James P. Mapes , James W. Jacobson , Harold N. Baker , Michael D. Spain
IPC分类号： G01N33/53
CPC分类号： G01N33/54313 , G01N33/564 , G01N2800/24 , Y10S435/973 , Y10S436/811
摘要： The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is detected and measured by different bead sets having different reactants. According to another approach the ratio of self-antigen to autoantibody is measured by exposing a sample suspected of containing self-antigen and autoantibody to a bead set associated with monoclonal antibody specific for the self-antigen and a bead set associated with the self-antigen.
摘要翻译：本发明涉及通过使用多重测定系统检测和测量至少一种分析物来表征自身免疫性疾病的方法。根据一个实施例，通过具有不同反应物的不同珠组检测和测量靶。根据另一种方法，通过将怀疑含有自身抗原和自身抗体的样品暴露于与自身抗原特异性的单克隆抗体相关联的珠粒组和与自身抗原相关的珠粒组来测量自身抗原与自身抗体的比例。

7. 发明授权

US5597571A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
标题翻译：引起针对禽类球虫病抗体的艾美球虫抗原组合物
公开(公告)号：US5597571A
公开(公告)日：1997-01-28
申请号：US484387
申请日：1995-06-07
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

8. 发明授权

US4540506A Composition for cleaning drains clogged with deposits containing hair 失效
标题翻译：用于清洁含有头发的沉积物堵塞的排水管的组合物
公开(公告)号：US4540506A
公开(公告)日：1985-09-10
申请号：US485473
申请日：1983-04-15
申请人： James W. Jacobson , J. Leslie Glick , Kenneth L. Madello
发明人： James W. Jacobson , J. Leslie Glick , Kenneth L. Madello
IPC分类号： C11D7/24 , C11D3/34 , C11D3/386 , C11D7/42
CPC分类号： C11D3/386 , C11D3/3472 , C11D3/3427
摘要： A composition for disintegrating hair which comprises a hair-disintegrating amount of a mixture of a proteolytic enzyme and a disulfide reducing agent, and maintained at a pH that enhances hair denaturation, and a method for clearing pipe clogged with a hair-containing deposit are disclosed.
摘要翻译：公开了一种用于分解毛发的组合物，其包含分解量的蛋白水解酶和二硫化物还原剂的混合物，并且保持在增强毛发变性的pH值，以及用于清除含有毛发沉积物堵塞的管道的方法。

9. 发明授权

US5656485A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
公开(公告)号：US5656485A
公开(公告)日：1997-08-12
申请号：US691454
申请日：1996-08-02
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan Lee Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan Lee Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

10. 发明申请

US20100267059A1 IMMUNODEFICIENCY SCREENING AT POINT OF CARE 审中-公开
标题翻译：保健点免疫屏蔽
公开(公告)号：US20100267059A1
公开(公告)日：2010-10-21
申请号：US12763865
申请日：2010-04-20
申请人： James W. Jacobson
发明人： James W. Jacobson
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/70514 , G01N2333/70517 , G01N2333/70596 , G01N2800/24 , G01N2800/38
摘要： Embodiments of the invention utilizes advanced detection methodologies as a cost-effective, efficient, ultra-sensitive rapid method for diagnosing severe combined immunodeficiency (SCID) in infants. In certain aspects, multiple markers of SCID are concurrently detected and measured to provide a more efficient, sensitive and accurate diagnosis of SCID.
摘要翻译：本发明的实施例利用先进的检测方法作为诊断婴儿严重联合免疫缺陷（SCID）的成本效益高，超灵敏的快速方法。在某些方面，SCID的多个标记物被同时检测和测量，以提供对SCID的更有效，灵敏和准确的诊断。

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