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1. 发明授权

US08718737B2 Method and apparatus for demodulating signals in a pulse oximetry system 有权
标题翻译：用于在脉搏血氧测定系统中解调信号的方法和装置
公开(公告)号：US08718737B2
公开(公告)日：2014-05-06
申请号：US13437800
申请日：2012-04-02
申请人： Mohamed K. Diab , Walter M. Weber , Ammar Al-Ali
发明人： Mohamed K. Diab , Walter M. Weber , Ammar Al-Ali
IPC分类号： A61B5/1455
CPC分类号： A61B5/7228 , A61B5/14551 , A61B5/14552 , A61B5/1495 , A61B5/7203 , A61B5/7217 , A61B5/7232 , A61B2560/0242 , A61B2562/0238 , H04J3/10 , H04J14/08
摘要： A method and an apparatus measure blood oxygenation in a subject. A light source is activated to cause a first emission at a first wavelength and a second emission at a second wavelength. A detector detects a composite signal indicative of an attenuation of the first and second wavelengths by tissue of a patient. The composite signal is demodulated into a first intensity signal and a second intensity signal. Blood oxygenation in the subject is determined from the first and second intensity signals.
摘要翻译：一种测量受试者血液氧合的方法和装置。光源被激活以引起第一波长的第一发射和第二波长的第二发射。检测器通过患者的组织检测指示第一和第二波长的衰减的复合信号。复合信号被解调为第一强度信号和第二强度信号。从第一和第二强度信号确定受试者的血氧。

2. 发明授权

US08255028B2 Physiological monitor 有权
标题翻译：生理监护仪
公开(公告)号：US08255028B2
公开(公告)日：2012-08-28
申请号：US11429471
申请日：2006-05-05
申请人： Ammar Al-Ali , Mohamed K. Diab , Massi E. Kiani , Robert James Kopotic , David Tobler
发明人： Ammar Al-Ali , Mohamed K. Diab , Massi E. Kiani , Robert James Kopotic , David Tobler
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/02416 , A61B5/1459 , A61B5/6814 , A61B5/6815 , A61B5/6819 , A61B5/6825 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/742 , A61B5/746 , A61M16/00 , A61M16/021 , A61M2230/205
摘要： A patient monitor has multiple sensors adapted to attach to tissue sites of a living subject. The sensors generate sensor signals that are responsive to at least two wavelengths of optical radiation after attenuation by pulsatile blood within the tissue sites. A patient monitor uses the plurality of signals to reduce the effects of noise.
摘要翻译：患者监护仪具有适于附着于活体的组织部位的多个传感器。传感器产生响应于在组织部位内的脉动血液衰减之后的至少两个波长的光辐射的传感器信号。患者监视器使用多个信号来减少噪声的影响。

3. 发明授权

US07530949B2 Dual-mode pulse oximeter 有权
标题翻译：双模脉搏血氧仪
公开(公告)号：US07530949B2
公开(公告)日：2009-05-12
申请号：US10911391
申请日：2004-08-03
申请人： Ammar Al Ali , Don Carothers , David Dalke , Mohamed K. Diab , Julian Goldman , Massi E. Kiani , Michael Lee , Jerome Novak , Robert Smith , Val E. Vaden
发明人： Ammar Al Ali , Don Carothers , David Dalke , Mohamed K. Diab , Julian Goldman , Massi E. Kiani , Michael Lee , Jerome Novak , Robert Smith , Val E. Vaden
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0002 , A61B5/1495 , A61B5/742 , A61B2560/0271 , A61B2560/0456 , A61B2562/085 , G06F19/00
摘要： A pulse oximeter has an integrated mode in which it operates as a plug-in module for a multiparameter patient monitoring system (MPMS). The pulse oximeter also has a portable mode in which operates separately from the MPMS as a battery-powered handheld or standalone instrument. The pulse oximeter has a sensor port that receives a photo-plethysmographic signal as input to an internal processor. The pulse oximeter processes this sensor signal to derive oxygen saturation and pulse rate measurements. In the portable mode, this information is provided on its display, and stored in memory for trend capability. In the integrated mode, the pulse oximeter provides oxygen saturation and pulse rate measurements to the MPMS through a docking station to be displayed on a MPMS monitor. In the integrated mode, the portable pulse oximeter docks to the docking station, which in turn is inserted in one or more MPMS slots. The docking station can function as a simple electrical pass-through device between the docked portable pulse oximeter and the MPMS or it can provide a MPMS communications interface.
摘要翻译：脉搏血氧计具有集成模式，其作为用于多参数病人监测系统（MPMS）的插件模块。脉搏血氧计还具有便携式模式，其中与MPMS分开操作，作为电池供电的手持或独立仪器。脉搏血氧计具有传感器端口，其接收作为对内部处理器的输入的光学体积描记信号。脉冲血氧计处理该传感器信号以导出氧饱和度和脉搏率测量。在便携式模式中，该信息在其显示器上提供，并存储在存储器中用于趋势能力。在集成模式中，脉搏血氧计通过对接站向MPMS提供氧饱和度和脉搏率测量，以在MPMS监视器上显示。在集成模式中，便携式脉搏血氧仪停靠在对接站，对接站又插入一个或多个MPMS槽中。对接站可以作为对接便携式脉搏血氧计与MPMS之间的简单电气穿越装置，或者可以提供MPMS通信接口。

4. 发明授权

US07471969B2 Pulse oximeter probe-off detector 有权
标题翻译：脉搏式血氧计探测器
公开(公告)号：US07471969B2
公开(公告)日：2008-12-30
申请号：US10721607
申请日：2003-11-25
申请人： Mohamed K. Diab , Ammar Al Ali
发明人： Mohamed K. Diab , Ammar Al Ali
IPC分类号： A61B5/1455
CPC分类号： A61B5/7221 , A61B5/14551 , A61B5/6843 , A61B2560/0276
摘要： A processor provides signal quality based limits to a signal strength operating region of a pulse oximeter. These limits are superimposed on the typical gain dependent signal strength limits. If a sensor signal appears physiologically generated, the pulse oximeter is allowed to operate with minimal signal strength, maximizing low perfusion performance. If a sensor signal is potentially due to a signal induced by a dislodged sensor, signal strength requirements are raised. Thus, signal quality limitations enhance probe off detection without significantly impacting low perfusion performance. One signal quality measure used is pulse rate density, which defines the percentage of time physiologically acceptable pulses are occurring. If the detected signal contains a significant percentage of unacceptable pulses, the minimum required signal strength is raised proportionately. Another signal quality measure used in conjunction with pulse rate density is energy ratio, computed as the percentage of total energy contained in the pulse rate fundamental and associated harmonics.
摘要翻译：处理器为脉冲血氧计的信号强度操作区域提供基于信号质量的限制。这些极限叠加在典型的增益相关信号强度极限上。如果传感器信号出现生理生成，脉搏血氧计允许以最小的信号强度进行操作，最大限度地降低灌注性能。如果传感器信号潜在地由于由移动的传感器引起的信号，则会提高信号强度要求。因此，信号质量限制增强了探针检测，而不会显着影响低灌注性能。使用的一种信号质量测量是脉率密度，其定义了生理上可接受的脉冲发生的时间的百分比。如果检测到的信号含有显着百分比的不可接受的脉冲，则所需的最小信号强度成比例地提高。与脉搏密度结合使用的另一个信号质量测量是能量比，计算为脉冲速率基波和相关谐波中包含的总能量的百分比。

5. 发明授权

US07003339B2 Method and apparatus for demodulating signals in a pulse oximetry system 有权
公开(公告)号：US07003339B2
公开(公告)日：2006-02-21
申请号：US10700324
申请日：2003-11-03
申请人： Mohamed K. Diab , Walter M. Weber , Ammar Al-Ali
发明人： Mohamed K. Diab , Walter M. Weber , Ammar Al-Ali
IPC分类号： A61B5/00
CPC分类号： A61B5/7228 , A61B5/14551 , A61B5/14552 , A61B5/1495 , A61B5/7203 , A61B5/7217 , A61B5/7232 , A61B2560/0242 , A61B2562/0238 , H04J3/10 , H04J14/08
摘要： A method and an apparatus measure blood oxygenation in a subject. A first signal source applies a first input signal during a first time interval. A second signal source applies a second input signal during a second time interval. A detector detects a first parametric signal responsive to the first input signal passing through a portion of the subject having blood therein. The detector also detects a second parametric signal responsive to the second input signal passing through the portion of the subject. The detector generates a detector output signal responsive to the first and second parametric signals. A signal processor receives the detector output signal and demodulates the detector output signal by applying a first demodulation signal to a signal responsive to the detector output signal to generate a first output signal responsive to the first parametric signal. The signal processor applies a second demodulation signal to the signal responsive to the detector output signal to generate a second output signal responsive to the second parametric signal. The first demodulation signal and the second demodulation signal both include at least a first component having a first frequency and a first amplitude and a second component having a second frequency and a second amplitude. The second frequency is a harmonic of the first frequency. The second amplitude is related to the first amplitude to minimize crosstalk from the first parametric signal to the second output signal and to minimize crosstalk from the second parametric signal to the first output signal.

6. 发明授权

US06654624B2 Pulse oximeter probe-off detector 有权
公开(公告)号：US06654624B2
公开(公告)日：2003-11-25
申请号：US10027574
申请日：2001-12-19
申请人： Mohamed K. Diab , Ammar Al Ali
发明人： Mohamed K. Diab , Ammar Al Ali
IPC分类号： A61B500
CPC分类号： A61B5/7221 , A61B5/14551 , A61B5/6843 , A61B2560/0276
摘要： An intelligent, rule-based processor provides signal quality based limits to the signal strength operating region of a pulse oximeter. These limits are superimposed on the typical gain dependent signal strength limits. If a sensor signal appears physiologically generated, the pulse oximeter is allowed to operate with minimal signal strength, maximizing low perfusion performance. If a sensor signal is potentially due to a signal induced by a dislodged sensor, signal strength requirements are raised. Thus, signal quality limitations enhance probe off detection without significantly impacting low perfusion performance. One signal quality measure used is pulse rate density, which defines the percentage of time physiologically acceptable pulses are occurring. If the detected signal contains a significant percentage of unacceptable pulses, the minimum required signal strength is raised proportionately. Another signal quality measure used in conjunction with pulse rate density is energy ratio, computed as the percentage of total energy contained in the pulse rate fundamental and associated harmonics.

7. 发明授权

US08626255B2 Noninvasive multi-parameter patient monitor 有权
标题翻译：无创多参数患者监护仪
公开(公告)号：US08626255B2
公开(公告)日：2014-01-07
申请号：US13477979
申请日：2012-05-22
申请人： Ammar Al-Ali , Joe E. Kiani , Mohamed K. Diab , Greg A. Olsen , Roger C. Wu , Rick Fishel
发明人： Ammar Al-Ali , Joe E. Kiani , Mohamed K. Diab , Greg A. Olsen , Roger C. Wu , Rick Fishel
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B1/00 , A61B5/0022 , A61B5/0205 , A61B5/02416 , A61B5/02427 , A61B5/0261 , A61B5/0295 , A61B5/14532 , A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/1495 , A61B5/6815 , A61B5/6826 , A61B5/6829 , A61B5/6832 , A61B5/6838 , A61B5/7221 , A61B5/7246 , A61B5/7275 , A61B5/7278 , A61B5/7405 , A61B5/742 , A61B5/746 , A61B5/7475 , A61B2562/08 , A61B2562/085 , A61B2562/222 , G06F19/00 , G06F19/3418 , Y10S439/909
摘要： Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO2”), fractional arterial oxygen saturation (“SpaO2”), or the like. In an embodiment, the monitor advantageously includes a plurality of display modes enabling more parameter data to be displayed than the available physical display real estate.
摘要翻译：本公开的实施例包括手持多参数患者监视器，其能够从能够检测由身体组织衰减的光的光敏检测器的输出确定多个生理参数。例如，在一个实施例中，监视器能够有利地和准确地显示脉搏率，体积描记器数据，灌注质量，信号置信度和身体组织中血液成分的值中的一个或多个，包括例如动脉一氧化碳饱和度 “HbCO”），高铁血红蛋白饱和度（“HbMet”），总血红蛋白（“Hbt”），动脉血氧饱和度（“SpO2”），分数动脉血氧饱和度（“SpaO2”）等。在一个实施例中，监视器有利地包括多个显示模式，使得能够显示比可用的物理显示空间更多的参数数据。

8. 发明授权

US08185180B2 Method and apparatus for demodulating signals in a pulse oximetry system 有权
标题翻译：用于在脉搏血氧测定系统中解调信号的方法和装置
公开(公告)号：US08185180B2
公开(公告)日：2012-05-22
申请号：US11842106
申请日：2007-08-20
申请人： Mohamed K. Diab , Walter M. Weber , Ammar Al-Ali
发明人： Mohamed K. Diab , Walter M. Weber , Ammar Al-Ali
IPC分类号： A61B5/1455
CPC分类号： A61B5/7228 , A61B5/14551 , A61B5/14552 , A61B5/1495 , A61B5/7203 , A61B5/7217 , A61B5/7232 , A61B2560/0242 , A61B2562/0238 , H04J3/10 , H04J14/08
摘要： A method and an apparatus measure blood oxygenation in a subject. A light source is activated to cause a first emission at a first wavelength and a second emission at a second wavelength. A detector detects a composite signal indicative of an attenuation of the first and second wavelengths by tissue of a patient. The composite signal is demodulated into a first intensity signal and a second intensity signal. Blood oxygenation in the subject is determined from the first and second intensity signals. In one embodiment, demodulation is based at least in part on a period when at least one of the wavelengths is not activated. In one embodiment, a modulation of the first and second wavelengths is determined in order to avoid frequencies of ambient noise. In one embodiment, the composite signal's sampling rate is reduced before and/or after demodulation.
摘要翻译：一种测量受试者血液氧合的方法和装置。光源被激活以引起第一波长的第一发射和第二波长的第二发射。检测器通过患者的组织检测指示第一和第二波长的衰减的复合信号。复合信号被解调为第一强度信号和第二强度信号。从第一和第二强度信号确定受试者的血氧。在一个实施例中，解调至少部分地基于至少一个波长未被激活的周期。在一个实施例中，确定第一和第二波长的调制以避免环境噪声的频率。在一个实施例中，复合信号的采样率在解调之前和/或之后被减小。

9. 发明授权

US08028701B2 Respiratory monitoring 有权
标题翻译：呼吸监测
公开(公告)号：US08028701B2
公开(公告)日：2011-10-04
申请号：US11756501
申请日：2007-05-31
申请人： Ammar Al-Ali , Mohamed K. Diab
发明人： Ammar Al-Ali , Mohamed K. Diab
IPC分类号： A61M11/00
CPC分类号： A61B5/0836 , A61B5/0004 , A61B5/0816 , A61B5/097 , A61B5/6819 , A61B5/682 , A61B5/6822 , A61M16/0666 , A61M16/0672 , A61M16/085 , A61M16/10 , A61M16/1065 , A61M2202/0208 , A61M2205/18 , A61M2205/3561 , A61M2205/581 , A61M2205/583 , A61M2230/42 , A61M2230/432 , A61M2230/435
摘要： A patient interface in accordance with one embodiment of the present invention is configured to be at least partially carried by a patient and to receive gas exhaled by the patient. The patient interface includes first and second cannula tubes each having a first end and a second end, the first ends are configured to be inserted into the nostrils of a patient, the first and second cannula tubes are configured to direct exhaled gas from the patient from the first ends to said second ends. The patient interface also includes first and second sensors positioned near the second ends, and the first and second sensors are configured to provide first and second signals based upon the gas, wherein the first and second signals are indicative of a physiological parameter of the patient. The patient interface also includes a communications link configured to provide the signal to a physiological monitor.
摘要翻译：根据本发明的一个实施例的患者接口被配置为至少部分地由患者携带并且接收由患者呼出的气体。所述患者界面包括第一和第二插管管，每个具有第一端和第二端，所述第一端构造成插入患者的鼻孔中，所述第一和第二插管管被构造成将来自患者的呼出气体从第一端到所述第二端。患者接口还包括位于第二端附近的第一和第二传感器，并且第一和第二传感器被配置为基于气体提供第一和第二信号，其中第一和第二信号指示患者的生理参数。患者接口还包括被配置为向生理监视器提供信号的通信链路。

10. 发明授权

US07991446B2 Systems and methods for acquiring calibration data usable in a pulse oximeter 有权
标题翻译：用于获取可用于脉搏血氧计的校准数据的系统和方法
公开(公告)号：US07991446B2
公开(公告)日：2011-08-02
申请号：US11431151
申请日：2006-05-08
申请人： Ammar Al Ali , Don Carothers , David Dalke , Mohamed K. Diab , Julian M. Goldman , Massi E. Kiani , Michael Lee , Jerome Novak , Robert Smith , Val E. Vaden
发明人： Ammar Al Ali , Don Carothers , David Dalke , Mohamed K. Diab , Julian M. Goldman , Massi E. Kiani , Michael Lee , Jerome Novak , Robert Smith , Val E. Vaden
IPC分类号： A61B5/1455
CPC分类号： A61B5/7278 , A61B5/0002 , A61B5/0205 , A61B5/0402 , A61B5/14551 , A61B5/1495 , A61B5/742 , A61B5/743 , A61B2560/0271 , A61B2560/0456 , A61B2562/085 , G06F19/00
摘要： The present disclosure includes a pulse oximeter attachment having an accessible memory. In one embodiment, the pulse oximeter attachment stores calibration data, such as, for example, calibration data associated with a type of a sensor, a calibration curve, or the like. The calibration data is used to calculate physiological parameters of pulsing blood.
摘要翻译：本公开包括具有可访问存储器的脉搏血氧计附件。在一个实施例中，脉搏血氧计附件存储校准数据，例如与传感器类型相关联的校准数据，校准曲线等。校准数据用于计算脉冲血液的生理参数。

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