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    • 3. 发明授权
    • Method and device for measuring systolic and diastolic blood pressure and heart rate in an environment with extreme levels of noise and vibrations
    • 在具有极高噪声和振动水平的环境中测量收缩压和舒张压和心率的方法和装置
    • US06705998B2
    • 2004-03-16
    • US10133575
    • 2002-04-29
    • Stergios StergiopoulosAmar DhanantwariLisa PintoRonald Zachariah
    • Stergios StergiopoulosAmar DhanantwariLisa PintoRonald Zachariah
    • A61B502
    • A61B5/02208A61B5/022A61B5/025A61B7/045
    • A method and a device for measuring systolic and diastolic blood pressure and heart rate in an environment comprising extreme levels of noise and vibrations is disclosed. Blood pressure signals corresponding to the Korotkoff sounds are detected using a first acoustic sensor, or array of sensors, placed on the patient's skin over the brachial artery. A second acoustic transducer is placed on the outside of a pressure cuff the patient away for detecting noise and vibrations. Pressure is applied to the artery using the pressure cuff forcing the artery to close. The pressure is then reduced and while reducing the pressure the acoustic signals detected by the first and second acoustic sensor as well as a signal indicative of the pressure applied to the artery are provided to a processor. The signal of the first acoustic sensor is then processed using an adaptive interferer canceller algorithm with the signal of the second acoustic sensor as interferer. From the processed signal heart beat pulses are determined and relating the heart beat pulses to the pressure signal provides the systolic and diastolic blood pressure. Use of the adaptive interferer canceller provides good results for measurements performed under extreme levels of noise and vibrations such as aboard a helicopter, naval vessels, ambulances and noisy emergency rooms.
    • 公开了一种用于在包括极端噪声和振动的环境中测量收缩和舒张压和心率的方法和装置。 使用放置在肱动脉上的患者皮肤上的第一声传感器或传感器阵列检测对应于Korotkoff声音的血压信号。 将第二声换能器放置在患者远离的压力袖带的外侧以检测噪声和振动。 使用压力袖带迫使动脉闭合,向动脉施加压力。 然后降低压力并且在降低压力的同时,将由第一和第二声学传感器检测的声学信号以及指示施加到动脉的压力的信号提供给处理器。 然后使用具有第二声传感器的信号作为干扰源的自适应干扰消除器算法来处理第一声传感器的信号。 从经处理的信号中,确定心搏脉冲并将心跳脉搏与压力信号相关联,提供收缩压和舒张压。 自适应干扰消除器的使用对于在诸如直升机,海军舰艇,救护车和嘈杂的急诊室之间的极端噪音和振动水平下进行的测量提供了良好的结果。
    • 4. 发明授权
    • Method and device for measuring systolic and diastolic blood pressure and heart rate in an environment with extreme levels of noise and vibrations
    • 在具有极高噪声和振动水平的环境中测量收缩压和舒张压和心率的方法和装置
    • US06805671B2
    • 2004-10-19
    • US10342277
    • 2003-01-15
    • Stergios StergiopoulosAmar DhanantwariLisa PintoRonald ZachariahMan Yee Winnie Wong
    • Stergios StergiopoulosAmar DhanantwariLisa PintoRonald ZachariahMan Yee Winnie Wong
    • A61B502
    • A61B5/02208A61B5/025A61B7/045
    • A method and a device for measuring blood pressure and heart rate in an environment comprising extreme levels of noise and vibrations is disclosed. Blood pressure signals corresponding to the Korotkoff sounds are detected using an array of primary acoustic sensors, placed on the patient's skin over the brachial artery. A secondary acoustic transducer is placed on the outside of a pressure cuff the patient away for detecting noise and vibrations. Pressure is applied to the artery using the pressure cuff forcing the artery to close. The pressure is then reduced and while reducing the pressure the acoustic signals detected by the first and second acoustic sensor as well as a signal indicative of the pressure applied to the artery are provided to a processor. The signals provided by the primary acoustic sensors are then processed using a combination of focused beamforming and planar wave beamforming. The final beam time series is then processed using an adaptive interferer canceller algorithm with the signal provided by the secondary acoustic sensor as interferer. Use of an array of acoustic sensors in combination with beamforming substantially enhances signal detection as well as accurate isolation of the signal source which is highly beneficial for blood pressure measurements measurements performed under extreme levels of noise and vibrations.
    • 公开了一种用于在包括极高水平的噪声和振动的环境中测量血压和心率的方法和装置。 使用放置在肱动脉上的患者皮肤上的主要声学传感器阵列来检测对应于Korotkoff声音的血压信号。 辅助声换能器放置在患者远离的压力袖带的外侧,用于检测噪声和振动。 使用压力袖带迫使动脉闭合,向动脉施加压力。 然后降低压力并且在降低压力的同时,将由第一和第二声学传感器检测的声学信号以及指示施加到动脉的压力的信号提供给处理器。 然后,使用聚焦波束形成和平面波束形成的组合来处理由主声传感器提供的信号。 然后使用自适应干扰消除器算法来处理最终光束时间序列,其中由第二声传感器提供的信号作为干扰源。 使用声波传感器阵列与波束成形技术相结合,可显着增强信号检测以及信号源的准确隔离,这对于在极高噪声和振动水平下进行的血压测量测量非常有益。
    • 5. 发明授权
    • Method and device for correcting organ motion artifacts in MRI systems
    • 用于校正MRI系统中器官运动伪像的方法和装置
    • US06894494B2
    • 2005-05-17
    • US10608141
    • 2003-06-30
    • Stergios StergiopoulosMiroslaw WrobelAndreas FreibertWaheed YounisAmar Dhanantwari
    • Stergios StergiopoulosMiroslaw WrobelAndreas FreibertWaheed YounisAmar Dhanantwari
    • G01R33/567G01V3/00
    • G01R33/5673G01R33/56325
    • The present invention relates to a signal processing method and system for correcting organ motion artifacts for cardiac and brain imaging. A plurality of sets of MRI measurement data indicative of at least an image of an object is received. Each set corresponds to one row kx of a k-space matrix of at least a k-space matrix. For each set a k-space matrix of the at least a k-space matrix is determined for allocation thereto based on motion information of the object occurring during acquisition of the plurality of sets of the MRI measurement data. In a following step a location within the allocated k-space matrix corresponding to a row of the k-space matrix allocated thereto is determined for each set. At least a k-space matrix is then generated by re-arranging the plurality of sets. Each of the at least a k-space matrix comprises the sets of the plurality of sets of the MRI measurement data allocated thereto. Inverse Fourier transforming of the plurality of k-space matrices provides at least a reconstructed image. Through careful selection of the phases of the cardiac and respiratory cycles and corresponding ranges MRI data acquisition periods are of the order of seconds or a few minutes. Furthermore, integration of motion artifact free MRI images of different phases of organ motion using the coherent k-space synthesis according to the invention allows provision of an animation showing different phases of a cardiac or lung cycle. In an embodiment for correcting motion artifacts for brain imaging a motion vector describing translational and rotational motion of a patient's head is tracked during the MRI data acquisition process. The motion artifacts are then corrected based on coherent k-space synthesis using the motion vector data.
    • 本发明涉及用于校正心脏和脑成像的器官运动假象的信号处理方法和系统。 接收指示对象的至少一个图像的多组MRI测量数据。 每个集合对应于至少一个k空间矩阵的k空间矩阵的一行k×××。 对于每个集合,基于在获取多组MRI测量数据的采集期间发生的对象的运动信息,确定至少k空间矩阵的k空间矩阵用于分配。 在随后的步骤中,针对每个集合确定与分配给其的k空间矩阵的行相对应的所分配的k空间矩阵内的位置。 然后,通过重新排列多个集合来生成至少一个k空间矩阵。 所述至少k空间矩阵中的每一个包括分配给其的所述多个MRI测量数据的集合。 多个k空间矩阵的逆傅立叶变换提供至少一个重构图像。 通过仔细选择心脏和呼吸周期的相位和相应范围,MRI数据采集周期大约为数秒或数分钟。 此外,使用根据本发明的相干k空间合成的器官运动的不同阶段的运动伪像自由MRI图像的集成允许提供显示心脏或肺循环的不同阶段的动画。 在用于校正脑成像的运动伪像的实施例中,描述了在MRI数据采集过程期间描述患者头部的平移和旋转运动的运动矢量。 然后基于使用运动矢量数据的相干k空间合成校正运动假象。