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1. 发明授权

US10113196B2 Prenatal paternity testing using maternal blood, free floating fetal DNA and SNP genotyping 有权
公开(公告)号：US10113196B2
公开(公告)日：2018-10-30
申请号：US13335043
申请日：2011-12-22
申请人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
发明人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
IPC分类号： C12Q1/6869 , C12Q1/6876 , G06F19/14
摘要： Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.

2. 发明申请

US20130261004A1 METHODS FOR NON-INVASIVE PRENATAL PATERNITY TESTING 审中-公开
标题翻译：非侵入性预防性试验方法
公开(公告)号：US20130261004A1
公开(公告)日：2013-10-03
申请号：US13846160
申请日：2013-03-18
申请人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
发明人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6876 , C12Q2600/156 , G16B10/00
摘要： Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
摘要翻译：本文公开了非侵入性产前亲子鉴定的方法。该方法使用从怀孕母亲获得的血浆进行的遗传测量，以及所称父亲的遗传测量以及母亲的遗传测量，以确定所称父亲是否是胎儿的生物之父。这通过基于信息学的方法来实现，该方法可以将母体血浆中发现的胎儿DNA的遗传指纹与所称父亲的遗传指纹进行比较。

3. 发明申请

US20120122701A1 Methods for Non-Invasive Prenatal Paternity Testing 审中-公开
标题翻译：非侵入性产前亲子鉴定方法
公开(公告)号：US20120122701A1
公开(公告)日：2012-05-17
申请号：US13335043
申请日：2011-12-22
申请人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
发明人： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko
IPC分类号： C12Q1/68 , G01N33/53 , G01N21/64 , C40B20/00
CPC分类号： C12Q1/6869 , C12Q1/6876 , C12Q2600/156 , G06F19/14
摘要： Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
摘要翻译：本文公开了非侵入性产前亲子鉴定的方法。该方法使用从怀孕母亲获得的血浆进行的遗传测量，以及所称父亲的遗传测量以及母亲的遗传测量，以确定所称父亲是否是胎儿的生物之父。这通过基于信息学的方法来实现，该方法可以将母体血浆中发现的胎儿DNA的遗传指纹与所称父亲的遗传指纹进行比较。

4. 发明申请

US20110288780A1 Methods for Non-Invasive Prenatal Ploidy Calling 有权
标题翻译：非侵入性产前倍性调用方法
公开(公告)号：US20110288780A1
公开(公告)日：2011-11-24
申请号：US13110685
申请日：2011-05-18
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： G06F19/00 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/6869 , C12Q2537/161 , C12Q2537/165 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172 , G06F19/00 , G06F19/12 , G06F19/18 , G06F19/22 , G06F19/34 , G16H50/30
摘要： Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.
摘要翻译：本文公开了非侵入性产前倍性呼叫的方法。本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态，并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

5. 发明授权

US10017812B2 Methods for non-invasive prenatal ploidy calling 有权
公开(公告)号：US10017812B2
公开(公告)日：2018-07-10
申请号：US13300235
申请日：2011-11-18
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58 , C12Q1/6869 , C12Q1/6827 , G06F19/18 , C12Q1/6883 , C12Q1/6862 , G06F19/24
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6827 , C12Q1/686 , C12Q1/6862 , C12Q1/6874 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G06F19/34 , G16B20/00 , G16B40/00 , C12Q2537/161 , C12Q2537/165 , C12Q2537/143
摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

6. 发明授权

US08825412B2 Methods for non-invasive prenatal ploidy calling 有权
标题翻译：非侵入性产前倍性调用方法
公开(公告)号：US08825412B2
公开(公告)日：2014-09-02
申请号：US13110685
申请日：2011-05-18
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： G01N33/48 , G06F19/00 , G01N31/00 , G06G7/48 , G06G7/58 , G06F19/12 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/6869 , C12Q2537/161 , C12Q2537/165 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172 , G06F19/00 , G06F19/12 , G06F19/18 , G06F19/22 , G06F19/34 , G16H50/30
摘要： Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.
摘要翻译：本文公开了非侵入性产前倍性呼叫的方法。本文公开了从胎儿母体和胎儿的DNA样本以及来自母亲和任选也来自父亲的基因型数据测量的基因型数据中确定妊娠胎儿染色体倍性状态的方法。通过使用联合分布模型来确定给定父母基因型数据的不同可能胎儿倍性状态的一组预期等位基因分布，并将预期等位基因分布与在混合样品中测量的测量等位基因分布的模式进行比较来确定倍性状态，并选择其预期等位基因分布模式与观察到的等位基因分布模式最接近的倍性状态。在一个实施方案中，DNA的混合样品可以以使等位基因偏倚最小化的方式优先富集在多个多态位点。

7. 发明申请

US20130178373A1 METHODS FOR NON-INVASIVE PRENATAL PLOIDY CALLING 有权
公开(公告)号：US20130178373A1
公开(公告)日：2013-07-11
申请号：US13791397
申请日：2013-03-08
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6827 , C12Q1/6862 , C12Q1/6874 , C12Q1/6883 , C12Q2600/156 , G06F19/18 , G06F19/24 , C12Q2537/161 , C12Q2537/165
摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

8. 发明申请

US20140065621A1 METHODS FOR INCREASING FETAL FRACTION IN MATERNAL BLOOD 审中-公开
标题翻译：用于增加母体中的胎儿分数的方法
公开(公告)号：US20140065621A1
公开(公告)日：2014-03-06
申请号：US13793316
申请日：2013-03-11
申请人： Ravi Mhatre , Johan Baner , Bernhard Zimmermann , Matthew Hill , Zachary Demko
发明人： Ravi Mhatre , Johan Baner , Bernhard Zimmermann , Matthew Hill , Zachary Demko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A23D9/00 , C12Q2600/118 , C12Q2600/156
摘要： The invention provides methods of increasing the fetal fraction in maternal blood and plasma. This increase in fetal fraction improves the accuracy and decreases the “no call” rate for prenatal testing that measures fetal DNA in maternal blood.
摘要翻译：本发明提供了增加母体血液和血浆中胎儿分数的方法。胎儿分数的这种增加提高了准确性，降低了测量母体血液胎儿DNA的产前测试的“无呼叫”率。

9. 发明授权

US09182789B2 Transparent electronic device components with opaque edge coverings 有权
标题翻译：具有不透明边缘覆盖层的透明电子设备部件
公开(公告)号：US09182789B2
公开(公告)日：2015-11-10
申请号：US13037722
申请日：2011-03-01
申请人： Matthew Hill , Richard Hung Minh Dinh , Lucy E. Browning , Lee Hua Tan , Tang Yew Tan
发明人： Matthew Hill , Richard Hung Minh Dinh , Lucy E. Browning , Lee Hua Tan , Tang Yew Tan
IPC分类号： B32B3/02 , G06F1/16
CPC分类号： G06F1/1656 , B32B3/02 , Y10T428/24777
摘要： An electronic device may have components such as button members, display cover glass layers, structures associated with connector ports, and other components. The components may have transparent and opaque structures. The transparent structures may be formed on top of the opaque structures. The transparent structures may have peripheral edges through which light may pass. To help prevent the appearance of the components from becoming degraded by the presence of dirt, at least some of the edge portions of the transparent structures may be covered with an opaque covering material. The opaque covering material may be formed from paint or sidewall structures that are formed as an integral part of the opaque structures.
摘要翻译：电子设备可以具有诸如按钮构件，显示器盖玻璃层，与连接器端口相关联的结构以及其它部件的部件。这些部件可以具有透明和不透明的结构。透明结构可以形成在不透明结构的顶部上。透明结构可以具有光可以通过的外围边缘。为了防止由于存在污垢而使部件的外观变得劣化，透明结构的至少一些边缘部分可以用不透明的覆盖材料覆盖。不透明覆盖材料可以由形成为不透明结构的整体部分的油漆或侧壁结构形成。

10. 发明授权

US08925467B2 Railroad car seal for railroad hopper cars 有权
标题翻译：铁路货车的铁路车密封
公开(公告)号：US08925467B2
公开(公告)日：2015-01-06
申请号：US13045704
申请日：2011-03-11
申请人： James S. Kennedy , Jon M. Kaufman , Victoria V. Bowermaster , James Hill , Matthew Hill
发明人： James S. Kennedy , Jon M. Kaufman , Victoria V. Bowermaster , James Hill , Matthew Hill
IPC分类号： B61D3/00 , B61D7/22
CPC分类号： B61D7/22
摘要： A seal is disclosed for retrofitting to an existing railroad hopper car having opposing sidewalls and at least one trough extending between the opposing sidewalls. The seal includes a first member configured to mate against a surface of a trough adjacent a sidewall, the first member including a first edge having angled sections corresponding to angled sections of where the sidewall meets the trough, and a second member integral with the first member and extending substantially upright from the first edge of the first member, the second member configured to mate against a surface of the sidewall adjacent the trough, wherein the second member is angled relative to the first member at each of the angled sections corresponding to angled sections of the sidewall adjacent the trough.
摘要翻译：公开了一种用于改装到具有相对侧壁的现有铁路料斗车厢和在相对侧壁之间延伸的至少一个槽的密封件。所述密封件包括构造成与靠近侧壁相邻的槽的表面配合的第一构件，所述第一构件包括第一边缘，所述第一边缘具有对应于所述侧壁与所述槽对齐的成角度部分的成角度的部分，以及与所述第一构件并且从第一构件的第一边缘基本上直立地延伸，第二构件构造成与靠近槽的侧壁的表面配合，其中第二构件相对于第一构件成角度，每个成角度部分对应于成角度的部分靠近槽的侧壁。

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