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1. 发明授权

US10258784B2 Vacuum assisted percutaneous appliance 有权
公开(公告)号：US10258784B2
公开(公告)日：2019-04-16
申请号：US13416546
申请日：2012-03-09
申请人： Allen B. Kantrowitz , Chris Mortin , Daniel C. Wadsworth, Jr.
发明人： Allen B. Kantrowitz , Chris Mortin , Daniel C. Wadsworth, Jr.
IPC分类号： A61M39/02 , A61M25/00
摘要： A device for reducing agent penetration at an insertion site is provided that has a porous inner sleeve fluidly connected to a conduit. A vacuum or hydrodynamic source is fluidly connected to the conduit. The device is stabilized by fibroblast in-growth and inhibits bacterial colonization. A device is also provided that has a conduit having a bore and an outer conduit surface. The outer conduit surface is optionally nanotextured to promote fibroblast adhesion and limit bacterial residency. A sleeve is provided in fluid communication with the bore of the conduit, and is formed from materials characterized by a pore matrix through which vacuum or hydrodynamic draw is achieved in a process to promote stabilization and reducing bacterial colonization by draw fluid from an area around the surrounding the site of the device. The sleeve optionally has a distal nanotextured surface.

2. 发明申请

US20130006186A1 VACUUM ASSISTED PERCUTANEOUS APPLIANCE 审中-公开
标题翻译：真空辅助器具
公开(公告)号：US20130006186A1
公开(公告)日：2013-01-03
申请号：US13416546
申请日：2012-03-09
申请人： Allen B. Kantrowitz , Chris Mortin , Daniel C. Wadsworth, JR.
发明人： Allen B. Kantrowitz , Chris Mortin , Daniel C. Wadsworth, JR.
IPC分类号： A61M25/04
CPC分类号： A61M39/0247 , A61M25/00 , A61M25/0017 , A61M2025/006 , A61M2039/0261 , A61M2039/027 , A61M2039/0282
摘要： A device for reducing agent penetration at an insertion site is provided that has a porous inner sleeve fluidly connected to a conduit. A vacuum or hydrodynamic source is fluidly connected to the conduit. The device is stabilized by fibroblast in-growth and inhibits bacterial colonization.A device is also provided that has a conduit having a bore and an outer conduit surface. The outer conduit surface is optionally nanotextured to promote fibroblast adhesion and limit bacterial residency. A sleeve is provided in fluid communication with the bore of the conduit, and is formed from materials characterized by a pore matrix through which vacuum or hydrodynamic draw is achieved in a process to promote stabilization and reducing bacterial colonization by draw fluid from an area around the surrounding the site of the device. The sleeve optionally has a distal nanotextured surface.
摘要翻译：提供了一种用于在插入位置减少剂渗透的装置，其具有流体连接到导管的多孔内套筒。真空或流体动力源流体连接到导管。该装置通过成纤维细胞生长稳定并抑制细菌定植。还提供了一种具有导管的装置，其具有孔和外导管表面。外导管表面任选地纳米纹理以促进成纤维细胞粘附并限制细菌驻留。提供与导管的孔流体连通的套筒，并且由具有孔基质的材料形成，通过该孔基体实现真空或流体动力学拉伸，以促进稳定化并通过从周围的区域抽取流体来减少细菌定殖围绕设备的站点。套筒任选具有远端纳米纹理表面。

3. 发明授权

US10065030B2 Vacuum assisted percutaneous appliance 有权
公开(公告)号：US10065030B2
公开(公告)日：2018-09-04
申请号：US13394239
申请日：2011-02-23
申请人： Allen B. Kantrowitz , Chris Mortis , Daniel C. Wadsworth, Jr.
发明人： Allen B. Kantrowitz , Chris Mortis , Daniel C. Wadsworth, Jr.
IPC分类号： A61M39/02 , A61M25/00
摘要： A device for reducing agent penetration at an insertion site is provided that has a porous inner sleeve fluidly connected to a conduit. A vacuum or hydrodynamic source is fluidly connected to the conduit. The device is stabilized by fibroblast in-growth and inhibits bacterial colonization. A device is also provided that has a conduit having a bore and an outer conduit surface. The outer conduit surface is optionally nanotextured to promote fibroblast adhesion and limit bacterial residency. A sleeve is provided in fluid communication with the bore of the conduit, and is formed from materials characterized by a pore matrix through which vacuum or hydrodynamic draw is achieved in a process to promote stabilization and reducing bacterial colonization by draw fluid from an area around the surrounding the site of the device. The sleeve optionally has a distal nanotextured surface.

4. 发明申请

US20120310181A1 VACUUM ASSISTED PERCUTANEOUS APPLIANCE 审中-公开
标题翻译：真空辅助器具
公开(公告)号：US20120310181A1
公开(公告)日：2012-12-06
申请号：US13394239
申请日：2011-02-23
申请人： Allen B. Kantrowitz , Chris Mortis , Daniel C. Wadsworth, JR.
发明人： Allen B. Kantrowitz , Chris Mortis , Daniel C. Wadsworth, JR.
IPC分类号： A61M1/00 , A61M25/00
CPC分类号： A61M39/0247 , A61M25/00 , A61M25/0017 , A61M2025/006 , A61M2039/0261 , A61M2039/027 , A61M2039/0282
摘要： A device for reducing agent penetration at an insertion site is provided that has a porous inner sleeve fluidly connected to a conduit. A vacuum or hydrodynamic source is fluidly connected to the conduit. The device is stabilized by fibroblast in-growth and inhibits bacterial colonization. A device is also provided that has a conduit having a bore and an outer conduit surface. The outer conduit surface is optionally nanotextured to promote fibroblast adhesion and limit bacterial residency. A sleeve is provided in fluid communication with the bore of the conduit, and is formed from materials characterized by a pore matrix through which vacuum or hydrodynamic draw is achieved in a process to promote stabilization and reducing bacterial colonization by draw fluid from an area around the surrounding the site of the device. The sleeve optionally has a distal nanotextured surface.
摘要翻译：提供了一种用于在插入位置减少剂渗透的装置，其具有流体连接到导管的多孔内套筒。真空或流体动力源流体连接到导管。该装置通过成纤维细胞生长稳定并抑制细菌定植。还提供了一种具有导管的装置，其具有孔和外导管表面。外导管表面任选地纳米纹理以促进成纤维细胞粘附并限制细菌驻留。提供与导管的孔流体连通的套筒，并且由具有孔基质的材料形成，通过该孔基体实现真空或流体动力学拉伸，以促进稳定化并通过从周围的区域抽取流体来减少细菌定殖围绕设备的站点。套筒任选具有远端纳米纹理表面。

5. 发明申请

US20100143577A1 PERCUTANEOUS ACCESS DEVICE SYSTEM FACILITATING CELL GROWTH THEREON 审中-公开
公开(公告)号：US20100143577A1
公开(公告)日：2010-06-10
申请号：US12701784
申请日：2010-02-08
申请人： Allen B. Kantrowitz
发明人： Allen B. Kantrowitz
IPC分类号： B05D3/10
CPC分类号： A61F2/022
摘要： A biocompatible implantable portal is provided that has a wall defining a communicative passage through an interior bore. The exterior of the portal has a neck region adapted to promote autologous cell growth on the neck region. A series of channels are provided on the exterior neck region to facilitate autologous cell growth while disfavoring fluid pooling and bacterial growth. Typical channel widths are from 20 to 300 microns, with adjacent channels being separated by plateaus having a width of between 0 and 600 microns. Providing the portal exterior neck region with a texture varying on a nanometer length scale facilitates autologous cell growth. Applying a coating such as a tissue scaffolding matrix to the neck region prior to implantation also facilitates cell growth. A coupling or a manifold encompassing the neck region facilitates the draw of vacuum and/or mechanical protection for the growing cells.
摘要翻译：提供了一种生物兼容的可植入入口，其具有限定通过内孔的连通通道的壁。门户的外部具有适于促进颈部区域的自体细胞生长的颈部区域。在外颈部提供一系列通道，以促进自体细胞生长，同时不利于液体汇集和细菌生长。典型的通道宽度为20至300微米，相邻通道由0至600微米之间的宽度隔开。提供具有以纳米长度尺度变化的纹理的门静脉外颈部区域促进自体细胞生长。在植入之前将诸如组织支架基质的涂层施用于颈部区域也有助于细胞生长。包围颈部区域的联接器或歧管有助于生长细胞的抽真空和/或机械保护。

6. 发明申请

US20090131741A1 Methods of making aortic counter pulsation cardiac assist devices with three dimensional tortuous shape 有权
标题翻译：主动脉逆脉搏心脏辅助装置三维曲折形状的方法
公开(公告)号：US20090131741A1
公开(公告)日：2009-05-21
申请号：US12154048
申请日：2008-05-20
申请人： Allen B. Kantrowitz
发明人： Allen B. Kantrowitz
IPC分类号： A61M1/10
CPC分类号： A61M1/1072 , A61M1/1008 , A61M1/106 , A61M1/107 , A61M1/125 , A61M1/127 , A61M2230/04
摘要： Disclosed herein are methods of making aortic counter pulsation cardiac assist devices for assisting cardiac function of a patient. The methods can comprise performing at least one medical imaging procedure on an aorta of the patient, selecting at least one active segment of the aortic counter pulsation cardiac assist device based on anatomic information resulting from the at least one medical imaging procedure, and assembling the at least one active segment to accommodate the anatomic information prior to surgical implantation. The methods can further comprise designing individual custom active segment modules to custom fit a patient, providing a series of different individual, pre-manufactured active segment modules that are assembled to custom fit the patient, or providing a range of stock segment configurations manufactured based on previously determined common configurations and selecting one for a particular patient.
摘要翻译：本文公开了制备用于辅助患者的心脏功能的主动脉旁路脉动心脏辅助装置的方法。所述方法可以包括对患者的主动脉进行至少一个医学成像过程，基于从至少一个医学成像程序得到的解剖信息，选择主动脉旁路脉动心脏辅助装置的至少一个活动段，至少一个活动段以在手术植入之前适应解剖信息。该方法还可以包括设计各个定制活动段模块以定制适合患者，提供一系列不同的单独的，预先制造的活动区段模块，其被组装以定制适合患者，或提供基于先前确定的常见配置并为特定患者选择一种。

7. 发明申请

US20080281412A1 RIGID BODY AORTIC BLOOD PUMP IMPLANT 有权
标题翻译：刚体动物血液泵植入物
公开(公告)号：US20080281412A1
公开(公告)日：2008-11-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

8. 发明申请

US20080281147A1 Long term ambulatory intro-aortic balloon pump with percutaneous access device 有权
标题翻译：具有经皮进入装置的长期动态主动脉内球囊泵
公开(公告)号：US20080281147A1
公开(公告)日：2008-11-13
申请号：US12154091
申请日：2008-05-20
申请人： Allen B. Kantrowitz
发明人： Allen B. Kantrowitz
IPC分类号： A61M1/10
CPC分类号： A61M1/1072 , A61B5/0215 , A61B5/0422 , A61M1/1008 , A61M1/106 , A61M1/107 , A61M1/1086 , A61M1/125 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61M2230/04 , A61N1/056
摘要： Disclosed herein are embodiments of long-term ambulatory intra-aortic balloon pump systems for providing left ventricular cardiac assistance to a patient. The systems can comprise an external drive system for supplying a compressed fluid, the drive system operating in accordance with a control program stored in memory, an intra-luminal balloon pump having an elongate inflatable chamber positionable to be lying completely within a descending aorta of the patient, and a percutaneous access device. The percutaneous access device can be a biocompatible implantable portal comprising a communicative passage through an interior bore and an exterior having a neck region adapted to promote autologous cell growth thereon in an implantable region, the neck region having a plurality of channels extending about the neck region.
摘要翻译：这里公开了用于向患者提供左心室心脏辅助的长期动态主动脉内球囊泵系统的实施例。所述系统可以包括用于供应压缩流体的外部驱动系统，所述驱动系统根据存储在存储器中的控制程序进行操作，腔内球囊泵具有细长的可充气室，其可完全位于下降的主动脉内患者和经皮进入装置。经皮进入装置可以是生物相容的植入式入口，其包括穿过内孔的交通通道和具有适于在可植入区域中促进其自体细胞生长的颈部区域的外部，所述颈部区域具有围绕颈部区域延伸的多个通道。

9. 发明授权

US09498647B2 Fiducial marker system for subject movement compensation during medical treatment 有权
标题翻译：治疗期间受试者运动补偿的基准标记系统
公开(公告)号：US09498647B2
公开(公告)日：2016-11-22
申请号：US11534759
申请日：2006-09-25
申请人： Allen B. Kantrowitz , In K. Mun
发明人： Allen B. Kantrowitz , In K. Mun
IPC分类号： A61N5/10 , A61B17/00
CPC分类号： A61N5/1049 , A61B34/20 , A61B90/36 , A61B90/39 , A61B90/98 , A61B2017/00694 , A61B2017/00699 , A61B2034/2051 , A61B2090/397 , A61N5/1067
摘要： A system is provided for subject movement compensation during a medical procedure. The system uses passive radiofrequency identification tags associated with a subject, and at least one active RFID reader is positioned to interrogate the position of at least three such passive radiofrequency identification tags so as to triangulate the geometric position of a subject body tissue. The reader generates an output signal corresponding to a distance between said reader and a tag. A microprocessor calculates a displacement of a tag relative to the reader from said output signal to yield a value corresponding to subject movement. A medical device operates in synchronicity with the calculation corresponding to subject movement to compensate for subject movement during a treatment process in essentially real time. A process for subject movement compensation during a medical procedure is also provided.
摘要翻译：在医疗过程中提供用于受试者运动补偿的系统。该系统使用与被摄体相关联的无源射频识别标签，并且至少一个有源RFID读取器被定位成询问至少三个这样的被动射频识别标签的位置，以便对被摄体体组织的几何位置进行三角测量。读取器产生对应于所述读取器和标签之间的距离的输出信号。微处理器从所述输出信号计算标签相对于读取器的位移，以产生对应于被摄体移动的值。医疗装置与对应于运动的计算同步运行，以在实质上实时地处理治疗过程中补偿受试者运动。还提供了在医疗过程中的受试者运动补偿的过程。

10. 发明授权

US08721515B2 Rigid body aortic blood pump implant 有权
标题翻译：刚体主动脉血泵植入物
公开(公告)号：US08721515B2
公开(公告)日：2014-05-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed , Jean Kantrowitz
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

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