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    • 2. 发明申请
    • VACUUM ASSISTED PERCUTANEOUS APPLIANCE
    • 真空辅助器具
    • US20130006186A1
    • 2013-01-03
    • US13416546
    • 2012-03-09
    • Allen B. KantrowitzChris MortinDaniel C. Wadsworth, JR.
    • Allen B. KantrowitzChris MortinDaniel C. Wadsworth, JR.
    • A61M25/04
    • A61M39/0247A61M25/00A61M25/0017A61M2025/006A61M2039/0261A61M2039/027A61M2039/0282
    • A device for reducing agent penetration at an insertion site is provided that has a porous inner sleeve fluidly connected to a conduit. A vacuum or hydrodynamic source is fluidly connected to the conduit. The device is stabilized by fibroblast in-growth and inhibits bacterial colonization.A device is also provided that has a conduit having a bore and an outer conduit surface. The outer conduit surface is optionally nanotextured to promote fibroblast adhesion and limit bacterial residency. A sleeve is provided in fluid communication with the bore of the conduit, and is formed from materials characterized by a pore matrix through which vacuum or hydrodynamic draw is achieved in a process to promote stabilization and reducing bacterial colonization by draw fluid from an area around the surrounding the site of the device. The sleeve optionally has a distal nanotextured surface.
    • 提供了一种用于在插入位置减少剂渗透的装置,其具有流体连接到导管的多孔内套筒。 真空或流体动力源流体连接到导管。 该装置通过成纤维细胞生长稳定并抑制细菌定植。 还提供了一种具有导管的装置,其具有孔和外导管表面。 外导管表面任选地纳米纹理以促进成纤维细胞粘附并限制细菌驻留。 提供与导管的孔流体连通的套筒,并且由具有孔基质的材料形成,通过该孔基体实现真空或流体动力学拉伸,以促进稳定化并通过从周围的区域抽取流体来减少细菌定殖 围绕设备的站点。 套筒任选具有远端纳米纹理表面。
    • 4. 发明申请
    • VACUUM ASSISTED PERCUTANEOUS APPLIANCE
    • 真空辅助器具
    • US20120310181A1
    • 2012-12-06
    • US13394239
    • 2011-02-23
    • Allen B. KantrowitzChris MortisDaniel C. Wadsworth, JR.
    • Allen B. KantrowitzChris MortisDaniel C. Wadsworth, JR.
    • A61M1/00A61M25/00
    • A61M39/0247A61M25/00A61M25/0017A61M2025/006A61M2039/0261A61M2039/027A61M2039/0282
    • A device for reducing agent penetration at an insertion site is provided that has a porous inner sleeve fluidly connected to a conduit. A vacuum or hydrodynamic source is fluidly connected to the conduit. The device is stabilized by fibroblast in-growth and inhibits bacterial colonization. A device is also provided that has a conduit having a bore and an outer conduit surface. The outer conduit surface is optionally nanotextured to promote fibroblast adhesion and limit bacterial residency. A sleeve is provided in fluid communication with the bore of the conduit, and is formed from materials characterized by a pore matrix through which vacuum or hydrodynamic draw is achieved in a process to promote stabilization and reducing bacterial colonization by draw fluid from an area around the surrounding the site of the device. The sleeve optionally has a distal nanotextured surface.
    • 提供了一种用于在插入位置减少剂渗透的装置,其具有流体连接到导管的多孔内套筒。 真空或流体动力源流体连接到导管。 该装置通过成纤维细胞生长稳定并抑制细菌定植。 还提供了一种具有导管的装置,其具有孔和外导管表面。 外导管表面任选地纳米纹理以促进成纤维细胞粘附并限制细菌驻留。 提供与导管的孔流体连通的套筒,并且由具有孔基质的材料形成,通过该孔基体实现真空或流体动力学拉伸,以促进稳定化并通过从周围的区域抽取流体来减少细菌定殖 围绕设备的站点。 套筒任选具有远端纳米纹理表面。
    • 5. 发明申请
    • PERCUTANEOUS ACCESS DEVICE SYSTEM FACILITATING CELL GROWTH THEREON
    • US20100143577A1
    • 2010-06-10
    • US12701784
    • 2010-02-08
    • Allen B. Kantrowitz
    • Allen B. Kantrowitz
    • B05D3/10
    • A61F2/022
    • A biocompatible implantable portal is provided that has a wall defining a communicative passage through an interior bore. The exterior of the portal has a neck region adapted to promote autologous cell growth on the neck region. A series of channels are provided on the exterior neck region to facilitate autologous cell growth while disfavoring fluid pooling and bacterial growth. Typical channel widths are from 20 to 300 microns, with adjacent channels being separated by plateaus having a width of between 0 and 600 microns. Providing the portal exterior neck region with a texture varying on a nanometer length scale facilitates autologous cell growth. Applying a coating such as a tissue scaffolding matrix to the neck region prior to implantation also facilitates cell growth. A coupling or a manifold encompassing the neck region facilitates the draw of vacuum and/or mechanical protection for the growing cells.
    • 提供了一种生物兼容的可植入入口,其具有限定通过内孔的连通通道的壁。 门户的外部具有适于促进颈部区域的自体细胞生长的颈部区域。 在外颈部提供一系列通道,以促进自体细胞生长,同时不利于液体汇集和细菌生长。 典型的通道宽度为20至300微米,相邻通道由0至600微米之间的宽度隔开。 提供具有以纳米长度尺度变化的纹理的门静脉外颈部区域促进自体细胞生长。 在植入之前将诸如组织支架基质的涂层施用于颈部区域也有助于细胞生长。 包围颈部区域的联接器或歧管有助于生长细胞的抽真空和/或机械保护。
    • 6. 发明申请
    • Methods of making aortic counter pulsation cardiac assist devices with three dimensional tortuous shape
    • 主动脉逆脉搏心脏辅助装置三维曲折形状的方法
    • US20090131741A1
    • 2009-05-21
    • US12154048
    • 2008-05-20
    • Allen B. Kantrowitz
    • Allen B. Kantrowitz
    • A61M1/10
    • A61M1/1072A61M1/1008A61M1/106A61M1/107A61M1/125A61M1/127A61M2230/04
    • Disclosed herein are methods of making aortic counter pulsation cardiac assist devices for assisting cardiac function of a patient. The methods can comprise performing at least one medical imaging procedure on an aorta of the patient, selecting at least one active segment of the aortic counter pulsation cardiac assist device based on anatomic information resulting from the at least one medical imaging procedure, and assembling the at least one active segment to accommodate the anatomic information prior to surgical implantation. The methods can further comprise designing individual custom active segment modules to custom fit a patient, providing a series of different individual, pre-manufactured active segment modules that are assembled to custom fit the patient, or providing a range of stock segment configurations manufactured based on previously determined common configurations and selecting one for a particular patient.
    • 本文公开了制备用于辅助患者的心脏功能的主动脉旁路脉动心脏辅助装置的方法。 所述方法可以包括对患者的主动脉进行至少一个医学成像过程,基于从至少一个医学成像程序得到的解剖信息,选择主动脉旁路脉动心脏辅助装置的至少一个活动段, 至少一个活动段以在手术植入之前适应解剖信息。 该方法还可以包括设计各个定制活动段模块以定制适合患者,提供一系列不同的单独的,预先制造的活动区段模块,其被组装以定制适合患者,或提供基于 先前确定的常见配置并为特定患者选择一种。
    • 9. 发明授权
    • Fiducial marker system for subject movement compensation during medical treatment
    • 治疗期间受试者运动补偿的基准标记系统
    • US09498647B2
    • 2016-11-22
    • US11534759
    • 2006-09-25
    • Allen B. KantrowitzIn K. Mun
    • Allen B. KantrowitzIn K. Mun
    • A61N5/10A61B17/00
    • A61N5/1049A61B34/20A61B90/36A61B90/39A61B90/98A61B2017/00694A61B2017/00699A61B2034/2051A61B2090/397A61N5/1067
    • A system is provided for subject movement compensation during a medical procedure. The system uses passive radiofrequency identification tags associated with a subject, and at least one active RFID reader is positioned to interrogate the position of at least three such passive radiofrequency identification tags so as to triangulate the geometric position of a subject body tissue. The reader generates an output signal corresponding to a distance between said reader and a tag. A microprocessor calculates a displacement of a tag relative to the reader from said output signal to yield a value corresponding to subject movement. A medical device operates in synchronicity with the calculation corresponding to subject movement to compensate for subject movement during a treatment process in essentially real time. A process for subject movement compensation during a medical procedure is also provided.
    • 在医疗过程中提供用于受试者运动补偿的系统。 该系统使用与被摄体相关联的无源射频识别标签,并且至少一个有源RFID读取器被定位成询问至少三个这样的被动射频识别标签的位置,以便对被摄体体组织的几何位置进行三角测量。 读取器产生对应于所述读取器和标签之间的距离的输出信号。 微处理器从所述输出信号计算标签相对于读取器的位移,以产生对应于被摄体移动的值。 医疗装置与对应于运动的计算同步运行,以在实质上实时地处理治疗过程中补偿受试者运动。 还提供了在医疗过程中的受试者运动补偿的过程。