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1. 发明申请

US20080281412A1 RIGID BODY AORTIC BLOOD PUMP IMPLANT 有权
标题翻译：刚体动物血液泵植入物
公开(公告)号：US20080281412A1
公开(公告)日：2008-11-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

2. 发明授权

US07513864B2 Synchronization system between aortic valve and cardiac assist device 有权
标题翻译：主动脉瓣与心脏辅助装置之间的同步系统
公开(公告)号：US07513864B2
公开(公告)日：2009-04-07
申请号：US11178969
申请日：2005-07-11
申请人： Allen B. Kantrowitz , Adrian Kantrowitz
发明人： Allen B. Kantrowitz , Adrian Kantrowitz
IPC分类号： A61M1/12
CPC分类号： A61M1/122 , A61M1/106 , A61M1/1067 , A61M1/1072 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303
摘要： A cardiac assist device synchronization system includes a cardiac assist device and an acoustic or accelerometer sensor that provides a signal input to the cardiac assist device indicative of aortic valve closure. The cardiac assist device is coupled to a mammalian aorta and includes an inflatable chamber and a fluid pump. A fluid conduit is in communication between the chamber and the pump to provide for selective inflation of the chamber. A pump controller triggers the pump in counter-pulsation to a mammalian heart upstream from the aorta. A process for synchronizing a cardiac assist device in counter-pulsation with a left ventricle includes locating an acoustic or accelerometer sensor within a thoracic cavity of a mammal having the assist device coupled to the aorta of the mammal. Through the measurement of an acoustic or acceleration property of an aortic valve of the mammal, and the transmission of aortic valve closure measurement through a controller for the cardiac assist device, counter-pulsatile synchronization for the cardiac assist device is achieved.
摘要翻译：心脏辅助装置同步系统包括心脏辅助装置和声学或加速度计传感器，其向心脏辅助装置提供指示主动脉瓣闭合的信号输入。心脏辅助装置耦合到哺乳动物主动脉并且包括可充气室和流体泵。流体导管在腔室和泵之间连通以提供腔室的选择性充气。泵控制器触发泵与主动脉上游的哺乳动物心脏反搏。将逆向脉动中的心脏辅助装置与左心室同步的过程包括将声学或加速度计传感器定位在哺乳动物的胸腔内，该辅助装置与哺乳动物的主动脉联接。通过测量哺乳动物的主动脉瓣的声学或加速特性，以及通过用于心脏辅助装置的控制器传播主动脉瓣闭合测量，实现了心脏辅助装置的反脉动同步。

3. 发明授权

US07846083B2 Left ventricle assist device (LVAD) 有权
标题翻译：左心室辅助装置（LVAD）
公开(公告)号：US07846083B2
公开(公告)日：2010-12-07
申请号：US11679487
申请日：2007-02-27
申请人： Robert M. Smith , Roger W. Snyder , Adrian Kantrowitz , Allen B. Kantrowitz
发明人： Robert M. Smith , Roger W. Snyder , Adrian Kantrowitz , Allen B. Kantrowitz
IPC分类号： A61N1/00
CPC分类号： A61M1/1072 , A61M1/1008 , A61M1/1037 , A61M1/106 , A61M1/122 , A61M1/125
摘要： A pump has an elongated shell with a generally elliptical shape, an outer convex surface and an inner concave surface. A peripheral side edge located between the inner and outer surfaces terminates in a bead edge. A flexible airtight membrane has a membrane edge bonded to the outer shell surface adjacent to the bead edge. Preforming the membrane edge looped with a maximum linear span of curvature that is greater than a maximal transverse linear extent of the bead edge, membrane operational wear during inflation and deflation cycles is reduced in the region around the bead edge. A process of forming a blood pump with a membrane preform is also provided.
摘要翻译：泵具有大致椭圆形的细长壳体，外凸面和内凹面。位于内表面和外表面之间的周边侧边缘终止于边缘。柔性密封膜具有与胎圈边缘相邻的外壳表面结合的膜边缘。预先形成最大线性曲率跨度的膜边缘，其大于胎圈边缘的最大横向线性范围，在充气和放气周期期间的膜操作磨损在珠边缘周围的区域减小。还提供了一种形成具有膜预制件的血液泵的过程。

4. 发明授权

US08721515B2 Rigid body aortic blood pump implant 有权
标题翻译：刚体主动脉血泵植入物
公开(公告)号：US08721515B2
公开(公告)日：2014-05-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed , Jean Kantrowitz
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

5. 发明申请

US20070265490A1 LEFT VENTRICLE ASSIST DEVICE (LVAD) 有权
标题翻译：左侧通气辅助装置（LVAD）
公开(公告)号：US20070265490A1
公开(公告)日：2007-11-15
申请号：US11679487
申请日：2007-02-27
申请人： Robert Smith , Roger Snyder , Adrian Kantrowitz , Allen Kantrowitz
发明人： Robert Smith , Roger Snyder , Adrian Kantrowitz , Allen Kantrowitz
IPC分类号： A61M1/10
CPC分类号： A61M1/1072 , A61M1/1008 , A61M1/1037 , A61M1/106 , A61M1/122 , A61M1/125
摘要： A blood pump for placement in an incision in an aorta is provided that after placement contacts blood passing through the aorta. The pump inflates and deflates in order to provide left ventricular assistance. The pump has an elongated shell with a generally elliptical shape, an outer convex surface and an inner concave surface. A peripheral side edge located between the inner and outer surfaces terminates in a bead edge. A passage is provided through the shell to provide fluid communication between the outer surface and inner surface. A flexible airtight membrane has a membrane edge bonded to the outer shell surface adjacent to the bead edge to form an enclosed internal chamber in fluid communication with the passage. Preforming the membrane edge looped with a maximum linear span of curvature that is greater than a maximal transverse linear extent of the bead edge, membrane operational wear during inflation and deflation cycles is reduced in the region around the bead edge. A process of forming a blood pump with a membrane preform is provided that includes placing an airtight membrane around a platen having a platen edge bead with a curvature of maximal transverse linear extent and a platen footprint substantially identical to a footprint of the blood pump shell. By heat setting the membrane, a looped membrane edge is formed as complementary to the curvature of the platen edge bead to yield a membrane preform. The membrane preform is secured to the outer surface of the shell having a bead edge of maximum linear extent less than the curvature of the looped membrane edge.
摘要翻译：提供用于放置在主动脉切口中的血泵，其在放置后接触通过主动脉的血液。泵充气和放气以提供左心室辅助。泵具有大致椭圆形的细长壳体，外凸面和内凹面。位于内表面和外表面之间的周边侧边缘终止于边缘。通过壳体提供通道以在外表面和内表面之间提供流体连通。柔性密封膜具有与胎圈边缘相邻的外壳表面结合的膜边缘，以形成与通道流体连通的封闭内部室。预先形成最大线性曲率跨度的膜边缘，其大于胎圈边缘的最大横向线性范围，在充气和放气周期期间的膜操作磨损在珠边缘周围的区域减小。提供了一种形成具有膜预制件的血液泵的过程，其包括将气密膜放置在具有最大横向线性范围的曲率的台板边缘珠的压板上，和与血泵壳的占地面积基本相同的压板盖板。通过热定形膜，形成环形膜边缘，以与压板边缘珠的曲率互补以产生膜预制件。膜预制件被固定到外壳的外表面，其具有小于环形膜边缘的曲率的最大线性范围的边缘边缘。

6. 发明授权

US4634422A Percutaneous access device and method for implanting same 失效
标题翻译：经皮进入装置及其植入方法
公开(公告)号：US4634422A
公开(公告)日：1987-01-06
申请号：US615883
申请日：1984-05-31
申请人： Adrian Kantrowitz , Paul S. Freed , Frizell L. Vaughan , Isadore A. Bernstein , Robert H. Gray
发明人： Adrian Kantrowitz , Paul S. Freed , Frizell L. Vaughan , Isadore A. Bernstein , Robert H. Gray
IPC分类号： A61F2/02 , A61M1/00 , A61M31/00 , A61M5/32 , C12N5/02
CPC分类号： A61M39/0247 , A61M2039/0291 , Y10S623/901
摘要： A percutaneous access device (PAD) is provided with a sleeve or separable member which may be detached from the device to enable the culturing of a multilayer fibroblast coating on the member in a stable and undisturbed environment. The member is constructed so that when it is assembled into the device and the device is implanted in a patient, the cultured coating of the member is exposed to the patient's dermis whose fibroblasts will, after a relatively short healing period, merge with the fibroblasts of the coating to form a barrier layer interlocked with the member to prevent epidermal ingrowth or marsupialization of the implanted device.Implantation techniques for further facilitating the formation of the dermal barrier are also disclosed.
摘要翻译：经皮进入装置（PAD）设置有套筒或可分离构件，其可以与装置分离，以便能够在稳定且不受干扰的环境中在构件上培养多层成纤维细胞涂层。构件被构造成使得当其组装到装置中并且将装置植入患者体内时，将该构件的培养包被暴露于患者的真皮，其成纤维细胞在相当短的愈合期后将与成纤维细胞所述涂层形成与所述构件互锁的阻挡层，以防止所述植入装置的表皮向内生长或有囊动作。还公开了用于进一步促进真皮屏障形成的植入技术。

7. 发明授权

US5169379A In-series ventricular assist system and method of controlling same 失效
标题翻译：一系列静态辅助系统及其控制方法
公开(公告)号：US5169379A
公开(公告)日：1992-12-08
申请号：US365817
申请日：1989-06-14
申请人： Paul S. Freed , Kevin P. Gage , Adrian Kantrowitz
发明人： Paul S. Freed , Kevin P. Gage , Adrian Kantrowitz
IPC分类号： A61M1/12 , A61F2/958 , A61M1/10
CPC分类号： A61M1/106 , A61M1/1072 , A61M2025/102 , A61M2025/1022
摘要： An in-series ventricular assist system for assisting the circulation of blood in a patient is disclosed. A pumping bladder is disposed in the thoractic aorta of the patient and selected physiologic events relating to each heart beat are monitored by appropriate sensors. A gas handling subsystem inflates and deflates the pumping bladder in accordance with the detected physiologic events and a predetermined set of assist system parameters. A microprocessor evaluates the effects of inflation and deflation of the pumping bladder and the corresponding assistance on the patient for each heart beat. The microprocessor is operable to alter or adjust the assist system parameters for each subsequent heart beat in accordance with the effects of assistance of the pumping bladder on the patient. In the preferred embodiment, the assist system parameters which are set by the microprocessor for inflating and deflating the pumping bladder during the immediately preceding heart beat are used as the base line for making small adjustments in those parameters for the present heart beat. Alternatively, the microprocessor may be made operable to store the assist system parameters associated within an immediately preceding predetermined number of prior heart beats to compare the detected physiologic events from each of the stored preceding heart beats with those of the current heart beat.

8. 发明申请

US20060030747A1 Synchronization system between aortic valve and cardiac assist device 有权
公开(公告)号：US20060030747A1
公开(公告)日：2006-02-09
申请号：US11178969
申请日：2005-07-11
申请人： Allen Kantrowitz , Adrian Kantrowitz
发明人： Allen Kantrowitz , Adrian Kantrowitz
IPC分类号： A61N1/362
CPC分类号： A61M1/122 , A61M1/106 , A61M1/1067 , A61M1/1072 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303
摘要： A cardiac assist device synchronization system includes a cardiac assist device and an acoustic or accelerometer sensor that provides a signal input to the cardiac assist device indicative of aortic valve closure. The cardiac assist device is coupled to a mammalian aorta and includes an inflatable chamber and a fluid pump. A fluid conduit is in communication between the chamber and the pump to provide for selective inflation of the chamber. A pump controller triggers the pump in counter-pulsation to a mammalian heart upstream from the aorta. A process for synchronizing a cardiac assist device in counter-pulsation with a left ventricle includes locating an acoustic or accelerometer sensor within a thoracic cavity of a mammal having the assist device coupled to the aorta of the mammal. Through the measurement of an acoustic or acceleration property of an aortic valve of the mammal, and the transmission of aortic valve closure measurement through a controller for the cardiac assist device, counter-pulsatile synchronization for the cardiac assist device is achieved.

9. 发明授权

US4913700A Culture and transport assembly for percutaneous access device 失效
标题翻译：用于经皮进入装置的文化和运输组件
公开(公告)号：US4913700A
公开(公告)日：1990-04-03
申请号：US259991
申请日：1988-10-21
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61M1/00 , A61M5/00
CPC分类号： A61M39/0247 , A61M2039/0288 , A61M2039/0291 , A61M2039/0294
摘要： A culture and transport assembly for enclosing a percutaneous access device within a sealed outer container to maintain the device under sterile conditions during transport while accommodating culturing of a coating of dermal cells on a portion of the device while the device is retained within the container. The container has a removable cap to which a culture well body is attached. The percutaneous access device is releasably clamped between the bottom of the body and an underlying platform with a portion of the device projecting into a bore in the body. When the device is so clamped, the bore constituted a sealed culture chamber in which the dermal cell culturing procedure may be performed by introducing cells and culturing solutions into the chamber via fluid passages extending from the chamber to connectors accessible at the exterior of the cap.
摘要翻译：一种培养和运输组件，其用于将经皮进入装置封闭在密封的外部容器内，以在运输过程中将装置维持在无菌条件下，同时在装置保持在容器内的同时容纳在装置的一部分上培养真皮细胞的涂层。容器具有可移除的盖子，文化井体与其相连。经皮进入装置可释放地夹紧在主体的底部和底部平台之间，其中该装置的一部分突出到主体中的孔中。当装置如此夹持时，孔构成密封的培养室，其中可以通过从腔室延伸到在帽外部可接近的连接器的流体通道将细胞和培养溶液引入室中来进行真皮细胞培养程序。

10. 发明授权

US4810246A Disposable cell culture chamber with remote access 失效
标题翻译：一次性细胞培养室与远程访问
公开(公告)号：US4810246A
公开(公告)日：1989-03-07
申请号：US116311
申请日：1987-11-04
申请人： Eldon E. Frisch , Adrian Kantrowitz , Paul S. Freed
发明人： Eldon E. Frisch , Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61M1/00 , A61M5/00
CPC分类号： A61M39/0247 , A61M2039/0261 , A61M2039/0291
摘要： A combination is provided of a percutaneous lead designed for implantation in the human body, which lead has a surface which is adapted to pass through and be exposed to the dermis of a patient when the device is implanted. Said surface is adapted to receive the growth of a cultured autogenous fibroblast coating on an etched, nanoporous surface. A liquid tight sealed removable, disposable chamber encloses said surface, said chamber being provided with openings for introduction therein of finely divided living dermal tissue suspended in a liquid carrier, thus providing a means for formation of the cultured surfaces which can be easily handled. The disposable chamber is removed and discarded at the time of surgery.
摘要翻译：提供设计用于植入人体的经皮引线的组合，该引线具有适于在植入器件时通过并暴露于患者真皮的表面。所述表面适于在蚀刻的纳米多孔表面上接受培养的自体成纤维细胞涂层的生长。液体密封的可移除的一次性腔室包围所述表面，所述腔室设置有用于在其中引入悬浮在液体载体中的细分活性真皮组织的开口，从而提供用于形成可容易处理的培养表面的装置。一次性室在手术时被去除并丢弃。

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