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1. 发明授权

US4810246A Disposable cell culture chamber with remote access 失效
标题翻译：一次性细胞培养室与远程访问
公开(公告)号：US4810246A
公开(公告)日：1989-03-07
申请号：US116311
申请日：1987-11-04
申请人： Eldon E. Frisch , Adrian Kantrowitz , Paul S. Freed
发明人： Eldon E. Frisch , Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61M1/00 , A61M5/00
CPC分类号： A61M39/0247 , A61M2039/0261 , A61M2039/0291
摘要： A combination is provided of a percutaneous lead designed for implantation in the human body, which lead has a surface which is adapted to pass through and be exposed to the dermis of a patient when the device is implanted. Said surface is adapted to receive the growth of a cultured autogenous fibroblast coating on an etched, nanoporous surface. A liquid tight sealed removable, disposable chamber encloses said surface, said chamber being provided with openings for introduction therein of finely divided living dermal tissue suspended in a liquid carrier, thus providing a means for formation of the cultured surfaces which can be easily handled. The disposable chamber is removed and discarded at the time of surgery.
摘要翻译：提供设计用于植入人体的经皮引线的组合，该引线具有适于在植入器件时通过并暴露于患者真皮的表面。所述表面适于在蚀刻的纳米多孔表面上接受培养的自体成纤维细胞涂层的生长。液体密封的可移除的一次性腔室包围所述表面，所述腔室设置有用于在其中引入悬浮在液体载体中的细分活性真皮组织的开口，从而提供用于形成可容易处理的培养表面的装置。一次性室在手术时被去除并丢弃。

2. 发明授权

US4892544A Methods for forming hollow, porous-surfaced elastomeric bodies 失效
标题翻译：用于形成中空多孔表面弹性体的方法
公开(公告)号：US4892544A
公开(公告)日：1990-01-09
申请号：US164700
申请日：1988-03-07
申请人： Eldon E. Frisch
发明人： Eldon E. Frisch
IPC分类号： A61F2/06 , A61F2/12 , A61J1/00 , A61J1/05 , B29C67/20 , C08J9/26
CPC分类号： C08J9/26 , A61F2/06 , B29C67/202 , A61F2/12 , A61J1/10 , B29L2031/7532 , C08J2383/04 , Y10S623/901
摘要： A method of forming hollow, porous elastomeric bodies and hollow, duo-layered elastomeric bodies wherein one layer is porous and contiguous with the other layer which is solid by (a) coating a surface of a mandrel with a coating liquid, (b) adhering a layer of water-elutable particles onto the coated mandrel surface, (c) applying a layer of fluid elastomer composition to the particle-coated mandrel surface wherein the elastomeric composition is capable of forming a water-insoluble elastomer, (d) causing said elastomeric composition to form a cohesive mass while in contact with the particle-coated mandrel surface, (e) dissolving said elutable particles from the cohesvie mass with a water-based solvent, and (f) removing the cohesive mass from the mandrel. The coating liquid comprises water and may also further comprise a wetting agent and/or a sugar. The invention also relates to the method wherein the water-elutable particles are adhered to the mandrel surface by heating the mandrel surface. The method is useful for making prostheses, e.g., mammary prostheses and vascular prostheses.

3. 发明授权

US4615704A Shape retention tissue expander and method of using 失效
标题翻译：形状保留组织扩张器及使用方法
公开(公告)号：US4615704A
公开(公告)日：1986-10-07
申请号：US674457
申请日：1984-11-26
申请人： Eldon E. Frisch
发明人： Eldon E. Frisch
IPC分类号： A61B19/00 , A61F2/00 , A61F2/12
CPC分类号： A61F2/12 , A61B90/02 , A61F2/0004
摘要： This invention relates to an implantable, inflatable dual chamber shape retention tissue expander having a resilient annular base and a generally hemispherical shape after inflation which is used to form a generally hemispherical pocket beneath the tissue to be expanded to, for example, provide an appropriately shaped pocket for the receipt of an implantable mammary prosthesis and to a method of using such a tissue expander.
摘要翻译：本发明涉及一种可植入的，可充气的双室形状保持组织扩张器，其具有弹性环形基部，并且在充气之后具有大致半球形形状，该膨胀器用于在组织下方形成将被扩张的大致半球形凹穴，例如提供适当形状用于接收植入式乳房假体的口袋以及使用这种组织扩张器的方法。

4. 发明授权

US4906423A Methods for forming porous-surfaced polymeric bodies 失效
标题翻译：形成多孔表面聚合体的方法
公开(公告)号：US4906423A
公开(公告)日：1990-03-06
申请号：US111889
申请日：1987-10-23
申请人： Eldon E. Frisch
发明人： Eldon E. Frisch
IPC分类号： A61L27/00 , A61F2/06 , A61L27/16 , A61L27/18 , A61L27/56 , B29C33/52 , B29C37/00 , B29C41/14 , B29C67/20 , C08J9/26 , C08J9/36
CPC分类号： C08J9/26 , A61F2/06 , A61L27/16 , A61L27/18 , A61L27/56 , B29C33/52 , B29C37/0053 , B29C41/14 , B29C67/202
摘要： A method of making a polymeric body having a porous surface by (a) applying a fluid polymeric composition to a mold surface of a leachable foam having open pores thereon, (b) curing the composition to form the polymeric body, and (c) leaching the foam from the polymeric body with a suitable solvent which does not dissolve the polymeric body. The method is especially suitable for making porous silicone elastomer bodies by using polystyrene foam as the mold material and the method is useful for forming hollow, porous-surfaced polymeric bodies, e.g. mammary and vascular prostheses.

5. 发明授权

US4205401A Mammary prosthesis which resists capsular contracture 失效
标题翻译：乳房假体抵抗荚膜挛缩
公开(公告)号：US4205401A
公开(公告)日：1980-06-03
申请号：US909406
申请日：1978-05-25
申请人： Eldon E. Frisch
发明人： Eldon E. Frisch
IPC分类号： A61F2/12 , A61F1/24 , A41C3/10
CPC分类号： A61F2/12
摘要： A surgically implantable mammary prosthesis comprises a sac containing a filler material. The filler material is present in an amount sufficient to give the sac a relatively low profile shape and a pliant, responsive nature. The prosthesis includes a restraining means for resisting the tendancy of tissue to form the prosthesis into a sphere. The restraining means functions reactive to tissue pressure and does not substantially reduce the pliant, responsive nature of the prosthesis.
摘要翻译：手术可植入的乳房假体包括含有填充材料的囊。填充材料的存在量足以使囊具有相对低的形状和柔顺的响应性质。假体包括用于抵抗组织的倾向以将假体形成球体的约束装置。抑制装置对组织压力起作用，并且基本上不会降低假体的柔韧性，反应性质。

6. 发明授权

US4992312A Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby 失效
标题翻译：形成耐渗透性，含有硅氧烷弹性体的复合层压体的方法和由此制备的装置
公开(公告)号：US4992312A
公开(公告)日：1991-02-12
申请号：US322970
申请日：1989-03-13
申请人： Eldon E. Frisch
发明人： Eldon E. Frisch
IPC分类号： B32B25/20 , A61L27/18 , B32B27/36 , B32B27/40 , B32B43/00 , C08J7/04
CPC分类号： B29C41/06 , A61L27/18 , C08J7/042 , B29K2075/00 , B29K2083/00 , C08J2383/04 , C08J2469/00 , C08J2475/04 , Y10T428/1352 , Y10T428/31507 , Y10T428/31598 , Y10T428/31663
摘要： A method of making a permeation-resistant silicone elastomer-containing laminate useful for making fluid-containing implants such as mammary prostheses and gastric balloons. The method is accomplished by (a) applying a layer of an unvulcanized heat-curable silicone elastomer composition to a cured silicone elastomer substrate, (b) applying a layer of a solvent dispersion of a permeation-resistant elastomer and a solvent on the layer of unvulcanized silicone elastomer composition to form a three-layered laminate, and (c) exposing the three-layered laminate to heat until the unvulcanized silicone elastomer composition is vulcanized. The unvulcanized silicone elastomer composition must be bondable to the cured silicone elastomer substrate, the permeation-resistant elastomer is selected from the group consisting of polyurethane, silicone-polyurethane copolymer, and silicone-polycarbonate copolymer, and the permeation-resistant elastomer solvent must be compatible with both the permeation-resistant elastomer and the unvulcanized silicone elastomer composition.

7. 发明授权

US4908031A Toe implant 失效
标题翻译：脚趾植入
公开(公告)号：US4908031A
公开(公告)日：1990-03-13
申请号：US385619
申请日：1989-07-27
申请人： Eldon E. Frisch
发明人： Eldon E. Frisch
IPC分类号： A61F2/30 , A61F2/42
CPC分类号： A61F2/4225 , A61F2002/30563 , A61F2002/3082 , A61F2002/4233
摘要： The invention provides an improved prosthetic toe joint adapted for replacement of a human toe joint which includes at least one one-piece member for implantation into the bone of the joint. The implant has a concave articulating surface which articulates against another one-piece component having a mating convex surface or against a mating convex bone surface. This one part component is provided with a flexible hinge section at the junction of its stem and the enlarged head portions. The hinge section is formed from a section of the stem which extends laterally outwardly on both sides of the stem portion adjacent the junction with the head. The laterally enlarged section is provided with a longitudinal channel extending through its midsection to form a hinge. Each of the one-piece components is preferably molded of a flexible elastomeric, physiologically inert material, for example medical grade silicone rubber.

8. 发明授权

US4686973A Method of making an intramedullary bone plug and bone plug made thereby 失效
标题翻译：由此制造髓内骨塞和骨塞的方法
公开(公告)号：US4686973A
公开(公告)日：1987-08-18
申请号：US659976
申请日：1984-10-12
申请人： Eldon E. Frisch
发明人： Eldon E. Frisch
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61F2/46 , A61F5/04
CPC分类号： A61F2/30723 , A61F2/4614 , A61F2002/30069 , A61F2002/30581
摘要： This invention relates to a method of making an inflatable bone plug for plugging the open end of an intramedullary bone canal which is capable of restricting the flow of bone cement, particularly, during the insertion of bone cement, particularly during the pressurized injection of such a cement, during an operative procedure involving the fixation of the stem of an artificial joint prosthesis such as a femoral hip joint prosthesis to the end of a bone such as a femur. The bone plug is designed to be pressurized with a biocompatible fluid and to thereafter deflate in a controlled manner after the cement hardens. Preferably, the bone plug is made by forming a hollow expandable container of a silicone elastomer permeable to carbon dioxide gas which has a valve stem attached to one end of the container and an opening at the opposite end of the container. A shrinkable elastomeric band is placed over the valve stem in which a channel has been made to receive a further cooperating injection means such as a needle. The elastomeric band shrinks over the valve stem to form a resealable valve assembly. The valve assembly is located in the hollow interior of the bone plug and the opening opposite the valve stem is sealed to complete construction of the bone plug. When such a plug is inflated with a biocompatible fluid such as carbon dioxide, the plug remains pressurized for a sufficient amount of time to allow the cement to harden, but the pressure drops to a minimum within about 24 hours after inflation.
摘要翻译：本发明涉及一种制造用于堵塞髓内骨管的开口端的可膨胀骨塞的方法，该骨塞能够限制骨粘固剂的流动，特别是在插入骨粘固剂期间，特别是在加压注射骨粘固剂期间水泥，包括将诸如股骨髋关节假体的人造关节假体的杆固定到诸如股骨的骨的末端的手术过程中。骨塞设计成用生物相容性流体加压，然后在水泥硬化后以受控的方式放气。优选地，骨塞是通过形成可渗透二氧化碳气体的硅氧烷弹性体的中空可扩张容器制成的，其具有连接到容器的一端的阀杆和在容器的相对端的开口。将可收缩的弹性体带放置在阀杆上方，在该阀杆上已形成通道以接收进一步协作的注射装置，例如针头。弹性带收缩在阀杆上以形成可重新密封的阀组件。阀组件位于骨塞的中空内部，并且与阀杆相对的开口被密封以完成骨塞的构造。当这样的塞子用诸如二氧化碳的生物相容性流体充气时，塞子保持加压足够的时间以允许水泥硬化，但在充气后约24小时内压力降至最低。

9. 发明授权

US4447237A Valving slit construction and cooperating assembly for penetrating the same 失效
标题翻译：阀门狭缝结构和配套组件穿透
公开(公告)号：US4447237A
公开(公告)日：1984-05-08
申请号：US376002
申请日：1982-05-07
申请人： Eldon E. Frisch , Leon C. Parks
发明人： Eldon E. Frisch , Leon C. Parks
IPC分类号： A61M1/14 , A61M1/36 , A61M39/10 , A61M25/02 , A61M1/03
CPC分类号： A61M1/3655
摘要： An improvement in the implantable shunt device of the type disclosed in U.S. Pat. No. 4,181,132 wherein each valving slit within the elastomeric body of the shunt is formed by a flattened sleeve of woven vascular prosthesis material presenting opposed interior surfaces interengaged when the valving slit is in a closed condition and spaced apart when the valving slit is in an open condition. The opposed surfaces of the sleeve are formed by a material having a coefficient of friction with respect to the material of the cannula insertable therethrough less than that of the elastomeric material of the body. A separate yieldable bias operable in addition to the bias provided by the elastomeric material of the body is provided for yieldably biasing the opposed surfaces of the flattened sleeve into sealed relation when in the closed interengaged condition and into sealed relation to the exterior periphery of the portion of the cannula extending therethrough when in the open spaced apart condition. The additional bias is provided by filling under pressure opposed cavities in the elastomeric body with a yieldable material so located with respect to the flattened sleeve as to transmit the pressure thereof as the additional bias of the opposed surfaces into sealed relation when in the closed interengaged condition and into sealed relation with the exterior periphery of the cannula when in the open spaced apart condition.
摘要翻译：在美国专利公开的类型的可植入分流装置中的改进。其中分流器的弹性体内的每个阀槽由编织的血管假体材料的扁平的套筒形成，当袖带狭缝处于闭合状态时，呈相对的内表面相互接合并且当阀槽开口处于间隔时条件。套筒的相对表面由相对于可从其插入的插管的材料的摩擦系数小于身体的弹性体材料的材料形成。提供了除了由本体的弹性体材料提供的偏压之外可操作的单独的可屈服偏压，用于在处于闭合的相互接合的状态下使扁平套筒的相对表面可靠地偏置成密封的关系，并且与该部分的外周边密封当处于开放间隔开状态时，插管延伸穿过其中。通过在弹性体中的相对的压力下填充相对于扁平套筒的可屈服材料来提供额外的偏压，以便在处于闭合相互接合的状态时将其作为相对表面的附加偏压传递到密封关系中的压力并且当处于开放间隔开的状态时，与套管的外周密封。

10. 发明授权

US4100246A Method of forming a gastrointestinal tube 失效
标题翻译：形成胃肠管的方法
公开(公告)号：US4100246A
公开(公告)日：1978-07-11
申请号：US698396
申请日：1976-06-21
申请人： Eldon E. Frisch
发明人： Eldon E. Frisch
IPC分类号： A61F2/04 , A61J15/00 , A61L27/14 , A61M25/00 , B29C63/00 , B29C13/00
CPC分类号： A61M25/0009 , A61F2/04 , A61J15/0015 , A61J15/0042 , A61J15/0069 , A61L27/14 , B29C63/00 , A61J15/0049 , A61J15/0073 , Y10S264/71
摘要： In accordance with a preferred embodiment of this invention, there is provided a new and improved method of forming a four-lumen gastrointestinal tube. This tube may be characterized as having two lumens which extend nearly the full length of the tube and two lumens which extend through only a portion of the tube. The subject method comprises the steps of: (1) extruding a three-lumen sleeve portion wherein one of the lumens is an insert carrying lumen and the remaining two lumens, in the final gastrointestinal tube assembly, are those lumens which extend the full length of the tube; (2) extruding a two-lumen insert portion, the lumens of which in the final gastrointestinal tube assembly, extend the full length of the assembly, and wherein the external dimensions of the insert portion are slightly larger than the internal dimensions of the insert carrying lumen of the sleeve portion; (3) immersing the sleeve portion in a solvent, preferably chlorothene, to cause it to swell until the internal dimensions of the insert carrying lumen are slightly larger than the external dimensions of the two-lumen insert portion; (4) inserting the insert portion into the insert carrying lumen; and (5) removing the solvent and thereby causing the insert carrying lumen in the sleeve portion to contract around the insert portion forming a "solvent shrink fit."
摘要翻译：根据本发明的优选实施例，提供了形成四腔胃肠管的新的和改进的方法。该管可以被表征为具有两个管腔，其延伸几乎整个管的整个长度，并且两个管腔仅延伸穿过管的一部分。本发明的方法包括以下步骤：（1）挤出三腔套筒部分，其中一个管腔是插入物携带管腔，其余两个管腔在最终胃肠管组件中，是延伸全长管子（2）挤压两腔插入部分，其最终胃肠管组件的内腔延伸组件的全长，并且其中插入部分的外部尺寸略大于插入物的内部尺寸袖子部分的内腔; （3）将套筒部分浸入溶剂（优选氯乙烯）中使其膨胀直到插入物携带内腔的内部尺寸略大于两腔插入部分的外部尺寸; （4）将插入部插入插入物承载内腔中; 和（5）除去溶剂，从而使得套筒部分中的插入物承载内腔在形成“溶剂收缩配合”的插入部分周围收缩。

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