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    • 1. 发明申请
    • Electrode assembly for constant-current electroporation and use
    • 用于恒流电穿孔和使用的电极组件
    • US20060264807A1
    • 2006-11-23
    • US11495021
    • 2006-07-28
    • Allan WesterstenWilliam WilkinsonRuxandra Draghia-AkliRobert CarpenterDouglas Kern
    • Allan WesterstenWilliam WilkinsonRuxandra Draghia-AkliRobert CarpenterDouglas Kern
    • A61N1/30
    • A61N1/327
    • The present invention relates to a modular electrode system, and its use, for facilitating the introduction of a macromolecule into cells of a selected tissue in a body or plant. The modular electrode system comprises a non-symmetrically arranged plurality of needle electrodes; a hypodermic needle; an electrical connector that provides a conductive link from a programmable constant-current pulse controller to the plurality of needle electrodes; and a power source. In a preferred embodiment of the present invention, an operator can grasp the plurality of needle electrodes that are mounted on a support structure and firmly insert the them into the selected tissue in a body or plant. The macromolecules are then delivered via the hypodermic needle into the selected tissue. The programmable constant-current pulse controller is activated and constant-current electrical pulse is applied to the plurality of needle electrodes. The applied constant-current electrical pulse facilitates the introduction of the macromolecule into the cell between the plurality of electrodes. Cell death due to overheating of cells is minimized by limiting the power dissipation in the tissue by virtue of constant-current pulses.
    • 本发明涉及一种模块化电极系统及其用途,用于促进将大分子引入体内或选定组织中的细胞中。 模块化电极系统包括非对称布置的多个针电极; 皮下注射针 电连接器,其从可编程恒定电流脉冲控制器提供到多个针电极的导电连接; 和电源。 在本发明的优选实施例中,操作者可以抓住安装在支撑结构上的多个针电极并将其牢固地插入到身体或植物中的所选择的组织中。 然后通过皮下注射针将大分子递送到选定的组织中。 可编程恒定电流脉冲控制器被激活,并且多个针电极施加恒流电脉冲。 施加的恒流电脉冲有助于将大分子引入多个电极之间的电池中。 由于通过恒定电流脉冲限制组织中的功率消耗,使由于细胞过热引起的细胞死亡被最小化。
    • 4. 发明申请
    • PROACTIVE NETWORK ATTACK DEMAND MANAGEMENT
    • 主动网络攻击需求管理
    • US20090077632A1
    • 2009-03-19
    • US11857709
    • 2007-09-19
    • Robert CarpenterHong Li
    • Robert CarpenterHong Li
    • G06F21/00
    • H04L63/1458H04L47/125H04L63/1441H04L67/10H04L2463/141
    • Various embodiments described and illustrated herein provide one or more of systems, methods, software, and firmware to handle attack generated demand proactively using distributed virtualization. One goal of some such embodiments is to provide a time window of stable operational response within which an intrusion detection system may detect an attack and/or cause a countermeasure against the attacks to be activated. Demand excursions which are not caused by an attack are supported during the variability of demand providing transparent response to legitimate users of the system. These embodiments, and others, are described in greater detail below.
    • 本文描述和示出的各种实施例提供主动使用分布式虚拟化来处理攻击生成的需求的一个或多个系统,方法,软件和固件。 一些这样的实施例的一个目标是提供稳定的操作响应的时间窗口,入侵检测系统可以在其中检测攻击和/或引起针对要激活的攻击的对策。 在需求的变化中,对系统的合法用户提供透明的响应,支持不是攻击引起的需求偏移。 这些实施例和其他实施例在下面更详细地描述。