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1. 发明申请

US20060264807A1 Electrode assembly for constant-current electroporation and use 有权
标题翻译：用于恒流电穿孔和使用的电极组件
公开(公告)号：US20060264807A1
公开(公告)日：2006-11-23
申请号：US11495021
申请日：2006-07-28
申请人： Allan Westersten , William Wilkinson , Ruxandra Draghia-Akli , Robert Carpenter , Douglas Kern
发明人： Allan Westersten , William Wilkinson , Ruxandra Draghia-Akli , Robert Carpenter , Douglas Kern
IPC分类号： A61N1/30
CPC分类号： A61N1/327
摘要： The present invention relates to a modular electrode system, and its use, for facilitating the introduction of a macromolecule into cells of a selected tissue in a body or plant. The modular electrode system comprises a non-symmetrically arranged plurality of needle electrodes; a hypodermic needle; an electrical connector that provides a conductive link from a programmable constant-current pulse controller to the plurality of needle electrodes; and a power source. In a preferred embodiment of the present invention, an operator can grasp the plurality of needle electrodes that are mounted on a support structure and firmly insert the them into the selected tissue in a body or plant. The macromolecules are then delivered via the hypodermic needle into the selected tissue. The programmable constant-current pulse controller is activated and constant-current electrical pulse is applied to the plurality of needle electrodes. The applied constant-current electrical pulse facilitates the introduction of the macromolecule into the cell between the plurality of electrodes. Cell death due to overheating of cells is minimized by limiting the power dissipation in the tissue by virtue of constant-current pulses.
摘要翻译：本发明涉及一种模块化电极系统及其用途，用于促进将大分子引入体内或选定组织中的细胞中。模块化电极系统包括非对称布置的多个针电极; 皮下注射针电连接器，其从可编程恒定电流脉冲控制器提供到多个针电极的导电连接; 和电源。在本发明的优选实施例中，操作者可以抓住安装在支撑结构上的多个针电极并将其牢固地插入到身体或植物中的所选择的组织中。然后通过皮下注射针将大分子递送到选定的组织中。可编程恒定电流脉冲控制器被激活，并且多个针电极施加恒流电脉冲。施加的恒流电脉冲有助于将大分子引入多个电极之间的电池中。由于通过恒定电流脉冲限制组织中的功率消耗，使由于细胞过热引起的细胞死亡被最小化。

2. 发明授权

US07664545B2 Electrode assembly for constant-current electroporation and use 有权
标题翻译：用于恒流电穿孔和使用的电极组件
公开(公告)号：US07664545B2
公开(公告)日：2010-02-16
申请号：US11495021
申请日：2006-07-28
申请人： Allan Westersten , William R. Wilkinson , Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern
发明人： Allan Westersten , William R. Wilkinson , Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern
IPC分类号： A61N1/30
CPC分类号： A61N1/327
摘要： The present invention relates to a modular electrode system, and its use, for facilitating the introduction of a macromolecule into cells of a selected tissue in a body or plant. The modular electrode system comprises a non-symmetrically arranged plurality of needle electrodes; a hypodermic needle; an electrical connector that provides a conductive link from a programmable constant-current pulse controller to the plurality of needle electrodes; and a power source. In a preferred embodiment of the present invention, an operator can grasp the plurality of needle electrodes that are mounted on a support structure and firmly insert the them into the selected tissue in a body or plant. The macromolecules are then delivered via the hypodermic needle into the selected tissue. The programmable constant-current pulse controller is activated and constant-current electrical pulse is applied to the plurality of needle electrodes. The applied constant-current electrical pulse facilitates the introduction of the macromolecule into the cell between the plurality of electrodes. Cell death due to overheating of cells is minimized by limiting the power dissipation in the tissue by virtue of constant-current pulses.
摘要翻译：本发明涉及一种模块化电极系统及其用途，用于促进将大分子引入体内或选定组织中的细胞中。模块化电极系统包括非对称布置的多个针电极; 皮下注射针电连接器，其从可编程恒定电流脉冲控制器提供到多个针电极的导电连接; 和电源。在本发明的优选实施例中，操作者可以抓住安装在支撑结构上的多个针电极并将其牢固地插入到身体或植物中的所选择的组织中。然后通过皮下注射针将大分子递送到选定的组织中。可编程恒定电流脉冲控制器被激活，并且多个针电极施加恒流电脉冲。施加的恒流电脉冲有助于将大分子引入多个电极之间的电池中。由于通过恒定电流脉冲限制组织中的功率消耗，使由于细胞过热引起的细胞死亡被最小化。

3. 发明授权

US07245963B2 Electrode assembly for constant-current electroporation and use 有权
标题翻译：用于恒流电穿孔和使用的电极组件
公开(公告)号：US07245963B2
公开(公告)日：2007-07-17
申请号：US10360768
申请日：2002-03-07
申请人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Allan Westersten , William R. Wilkinson
发明人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Allan Westersten , William R. Wilkinson
IPC分类号： A61N1/30
CPC分类号： A61N1/327
摘要： The present invention relates to a modular electrode system, and its use, for facilitating the introduction of a macromolecule into cells of a selected tissue in a body or plant. The modular electrode system comprises a plurality of needle electrodes; a hypodermic needle; an electrical connector that provides a conductive link from a programmable constant-current pulse controller to the plurality of needle electrodes; and a power source. In a preferred embodiment of the present invention, an operator can grasp the plurality of needle electrodes that are mounted on a support structure and firmly insert the them into the selected tissue in a body or plant. The macromolecules are then delivered via the hypodermic needle into the selected tissue. The programmable constant-current pulse controller is activated and constant-current electrical pulse is applied to the plurality of needle electrodes. The applied constant-current electrical pulse facilitates the introduction of the macromolecule into the cell between the plurality of electrodes. Cell death due to overheating of cells is minimized by limiting the power dissipation in the tissue by virtue of constant-current pulses.
摘要翻译：本发明涉及一种模块化电极系统及其用途，用于促进将大分子引入体内或选定组织中的细胞中。模块化电极系统包括多个针电极; 皮下注射针电连接器，其从可编程恒定电流脉冲控制器提供到多个针电极的导电连接; 和电源。在本发明的优选实施例中，操作者可以抓住安装在支撑结构上的多个针电极并将其牢固地插入到身体或植物中的所选择的组织中。然后通过皮下注射针将大分子递送到选定的组织中。可编程恒定电流脉冲控制器被激活，并且多个针电极施加恒流电脉冲。施加的恒流电脉冲有助于将大分子引入多个电极之间的电池中。由于通过恒定电流脉冲限制组织中的功率消耗，使由于细胞过热引起的细胞死亡被最小化。

4. 发明申请

US20060164105A1 Metal detector with improved receiver coil 失效
标题翻译：金属探测器具有改进的接收器线圈
公开(公告)号：US20060164105A1
公开(公告)日：2006-07-27
申请号：US11338486
申请日：2006-01-23
申请人： Allan Westersten
发明人： Allan Westersten
IPC分类号： G01R27/28
CPC分类号： G01V3/107 , H03K17/6874 , H03K17/691
摘要： A pulse-induction-type metal detector in which the receiver coil comprises bifilar windings that are connected in series, opposing during the coil pulse and in series, aiding, following the coil pulse. Pick-up of energy by the receiver coil during the coil pulse is thereby minimized and the duration of oscillations is curtailed. Owing to the rapid recovery of the system from the flux change that is used to charge the target, the signal sampling gate can be positioned very close to the trailing edge of the coil-current pulse, whereby detection of targets with very short time constants is made possible.
摘要翻译：一种脉冲感应型金属检测器，其中接收器线圈包括串联连接的双线圈，在线圈脉冲期间相对，并且在线圈脉冲之后串联耦合。因此，在线圈脉冲期间由接收器线圈拾取能量由此最小化并且减少振荡的持续时间。由于系统从用于对目标充电的磁通变化迅速恢复，信号采样门可以非常接近线圈电流脉冲的后沿，因此以非常短的时间常数检测目标是成为可能

5. 发明授权

US07701337B2 Hybrid-technology metal detector 失效
标题翻译：混合技术金属探测器
公开(公告)号：US07701337B2
公开(公告)日：2010-04-20
申请号：US11514488
申请日：2006-08-31
申请人： Allan Westersten
发明人： Allan Westersten
IPC分类号： G08B13/18
CPC分类号： G01V3/105
摘要： A hybrid-technology metal detector, using pulse-induction and sine-wave excitation of the transmitter coil alternately, in rapid succession.The energy stored in the transmitter coil, in the pulsed mode, is used to shock-excite a high-Q circuit formed by the coil and a parallel capacitor into oscillations in the sine-wave mode.The multiplicative action of the circuit Q causes high currents to flow in the transmitter coil, causing high fluxes to be impressed on the searched area, with increased sensitivity as a result.Using a linear coil-current ramp to assess and minimize the coupling between the transmitter and receiver coils permits effective separation of the reactive and resistive components of the target signals, making accurate identification of targets possible.
摘要翻译：一种混合技术的金属探测器，可以快速连续地使用发射线圈的脉冲感应和正弦波激发。以脉冲模式存储在发射器线圈中的能量用于将由线圈形成的高Q电路和并联电容器以正弦波模式冲击激励振荡。电路Q的乘法运动导致高电流在发射器线圈中流动，导致高通量被打印在搜索区域上，结果增加了灵敏度。使用线性线圈电流斜坡来评估和最小化发射器和接收器线圈之间的耦合可以有效地分离目标信号的无功和电阻部件，从而准确地识别目标。

6. 发明申请

US20080150537A1 Metal detector with discrimination against metal-mimicking minerals 审中-公开
标题翻译：具有金属模拟矿物的金属探测器
公开(公告)号：US20080150537A1
公开(公告)日：2008-06-26
申请号：US11440721
申请日：2006-05-24
申请人： Allan Westersten
发明人： Allan Westersten
IPC分类号： G01V3/08 , G01V3/10
CPC分类号： G01V3/105
摘要： A pulse-induction type metal detector capable of distinguishing between metal targets and minerals that mimic metals owing to absorption and release of energy. The amount of energy being transferred is measured by comparing the signals generated during specified intervals of a coil energizing pulse train that comprises bipolar current ramps that induce identical signals in metallic targets but differing signals in magnetic minerals. The criterion used to make the distinction between the targets is thus an inherent characteristic of the target and not subject to a particular adjustment of the electronic circuitry, as is the case with conventional metal detectors. This property of the detector makes it usable in industrial applications, where periodic readjustment of the detector is impractical.
摘要翻译：一种脉冲感应型金属探测器，能够区分由于吸收和释放能量而模拟金属的金属靶和矿物质。通过比较在线圈激励脉冲串的指定间隔期间产生的信号来测量所传送的能量，所述线圈激励脉冲串包括在金属靶中诱导相同信号但磁性矿物中的不同信号的双极性电流斜坡。用于使目标之间区分的标准因此是目标的固有特性，并且不受电子电路的特定调整的影响，如常规金属探测器的情况。检测器的这种性质使其可用于工业应用，其中检测器的周期性重新调整是不切实际的。

7. 发明申请

US20150157856A1 Apparatus for electroporation 审中-公开
标题翻译：电穿孔仪器
公开(公告)号：US20150157856A1
公开(公告)日：2015-06-11
申请号：US13998299
申请日：2013-10-18
申请人： Allan Westersten
发明人： Allan Westersten
IPC分类号： A61N1/32 , A01G7/04
CPC分类号： A61N1/327 , A61N1/0412 , A61N1/303 , C12M35/02 , C12N13/00
摘要： An apparatus to make cell walls permeable to macromolecules and nanoparticles by creating micropores in cell walls without using metallic electrodes. Electrolysis and over-heating of the target material owing to uneven current distribution is eliminated. The absence of invasive electrodes makes the apparatus suitable for human applications.
摘要翻译：一种使细胞壁可渗透大分子和纳米颗粒的装置，在细胞壁内形成微孔而不使用金属电极。消除了由于不均匀的电流分布引起的目标材料的电解和过热。不存在侵入性电极使得该装置适合于人类应用。

8. 发明授权

US07701204B2 Metal detector with reliable identification of ferrous and non-ferrous metals in soils with varying mineral content 失效
标题翻译：金属探测器，具有不同矿质含量的土壤中有色金属和有色金属的可靠鉴定
公开(公告)号：US07701204B2
公开(公告)日：2010-04-20
申请号：US11223705
申请日：2005-09-09
申请人： Allan Westersten
发明人： Allan Westersten
IPC分类号： G01N27/72 , G01V3/10
CPC分类号： G01V3/104
摘要： A pulse-induction type metal detector that reliably identifies ferrous and non-ferrous targets in soils with varying mineral content. The influence of the background signals from the soil is removed continuously, without the need for manual adjustment of controls by the operator, when the soil mineralization changes. The background signals are removed without affecting the sensitivity of the detector to metallic targets and the background signal removal process does not make the detector insensitive to targets whose time constant coincides with that of the soil.
摘要翻译：一种脉冲感应型金属探测器，可靠地识别矿物质含量不同的土壤中的亚铁和有色金属靶。当土壤矿化发生变化时，土壤背景信号的影响被不断地消除，无需操作人员进行手动调整控制。去除背景信号而不影响检测器对金属靶的灵敏度，并且背景信号去除过程不会使检测器对时间常数与土壤的时间常数一致的目标不敏感。

9. 发明申请

US20070046288A1 Hybrid-technology metal detector 失效
标题翻译：混合技术金属探测器
公开(公告)号：US20070046288A1
公开(公告)日：2007-03-01
申请号：US11514488
申请日：2006-08-31
申请人： Allan Westersten
发明人： Allan Westersten
IPC分类号： G01V3/08
CPC分类号： G01V3/105
摘要： A hybrid-technology metal detector, using pulse-induction and sine-wave excitation of the transmitter coil alternately, in rapid succession. The energy stored in the transmitter coil, in the pulsed mode, is used to shock-excite a high-Q circuit formed by the coil and a parallel capacitor into oscillations in the sine-wave mode. The multiplicative action of the circuit Q causes high currents to flow in the transmitter coil, causing high fluxes to be impressed on the searched area, with increased sensitivity as a result. Using a linear coil-current ramp to assess and minimize the coupling between the transmitter and receiver coils permits effective separation of the reactive and resistive components of the target signals, making accurate identification of targets possible.
摘要翻译：一种混合技术的金属探测器，可以快速连续地使用发射线圈的脉冲感应和正弦波激发。以脉冲模式存储在发射器线圈中的能量用于将由线圈形成的高Q电路和并联电容器以正弦波模式冲击激励振荡。电路Q的乘法运动导致高电流在发射器线圈中流动，导致高通量被打印在搜索区域上，结果增加了灵敏度。使用线性线圈电流斜坡来评估和最小化发射器和接收器线圈之间的耦合可以有效地分离目标信号的无功和电阻部件，从而准确地识别目标。

10. 发明授权

US08988070B2 Metal detector for use with conductive media 有权
标题翻译：用于导电介质的金属探测器
公开(公告)号：US08988070B2
公开(公告)日：2015-03-24
申请号：US13374947
申请日：2012-01-23
申请人： Allan Westersten
发明人： Allan Westersten
IPC分类号： G01N27/72 , G01V3/10 , G01V3/02
CPC分类号： G01V3/15 , G01V3/104
摘要： A pulse-induction type metal detector using a transmitter coil energizing pulse that selectively reduces the amplitude of background signals from conductive soils, ores and salt water. The detector can be operated with higher amplification of the received signals than conventional detectors, without driving the input amplifier into saturation. This makes it possible to detect land mines, tramp metal and gold in media whose characteristics make detection with conventional metal detectors difficult.
摘要翻译：一种使用发射线圈激励脉冲的脉冲感应型金属探测器，其选择性地降低来自导电土壤，矿石和盐水的背景信号的振幅。与常规检测器相比，检测器可以以较高的接收信号放大率进行操作，而无需将输入放大器驱动到饱和状态。这样就可以在传统金属探测器难以进行检测的介质中检测到地雷，金属和金子。

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